Showing entry for Solute carrier family 22 member 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004141
Protein NameSolute carrier family 22 member 1
Uniport IdO15245
GeneSLC22A1
Gene Id6580
DomainSugar_tr
Pfam PF00083  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.4 Digestive system hsa04976 Bile secretion
6. Human Diseases 6.1 Cancers: Overview hsa05231 Choline metabolism in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0090494 dopamine uptake
Biological Process GO:0006855 drug transmembrane transport
Biological Process GO:0048241 epinephrine transport
Biological Process GO:0010248 establishment or maintenance of transmembrane electrochemical gradient
Biological Process GO:0006836 neurotransmitter transport
Biological Process GO:0015874 norepinephrine transport
Biological Process GO:0015695 organic cation transport
Biological Process GO:0015697 quaternary ammonium group transport
Biological Process GO:0051610 serotonin uptake
Biological Process GO:1901998 toxin transport
Biological Process GO:0150104 transport across blood-brain barrier
Biological Process GO:0042908 xenobiotic transport
Biological Process GO:1990962 xenobiotic transport across blood-brain barrier
molecular function GO:0005277 acetylcholine transmembrane transporter activity
molecular function GO:0005330 dopamine:sodium symporter activity
molecular function GO:0042802 identical protein binding
molecular function GO:0008504 monoamine transmembrane transporter activity
molecular function GO:0005326 neurotransmitter transmembrane transporter activity
molecular function GO:0005334 norepinephrine:sodium symporter activity
molecular function GO:0015101 organic cation transmembrane transporter activity
molecular function GO:0015651 quaternary ammonium group transmembrane transporter activity
molecular function GO:0008513 secondary active organic cation transmembrane transporter activity
molecular function GO:0019534 toxin transmembrane transporter activity
molecular function GO:0042910 xenobiotic transmembrane transporter activity
cellular component GO:0016324 apical plasma membrane
cellular component GO:0016323 basolateral plasma membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0016020 membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0098793 presynapse
Reactome
Pathway Id Pathway Name
R-HSA-112310 Neurotransmitter release cycle
R-HSA-112311 Neurotransmitter clearance
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-1430728 Metabolism
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle
R-HSA-2161517 Abacavir transmembrane transport
R-HSA-2161522 Abacavir transport and metabolism
R-HSA-382551 Transport of small molecules
R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds
R-HSA-425407 SLC-mediated transmembrane transport
R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters
R-HSA-549127 Organic cation transport
R-HSA-549132 Organic cation/anion/zwitterion transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003868 BXGD000233 Arthritis, Gouty Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0005122 BXGD000303 Beriberi Nutritional and Metabolic Diseases
C0005398 BXGD000311 Cholestasis, Extrahepatic Digestive System Diseases
C0005694 BXGD000322 Bladder neck obstruction Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0008312 BXGD000527 Primary biliary cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0008370 BXGD000534 Cholestasis Digestive System Diseases
C0008372 BXGD000535 Intrahepatic Cholestasis Digestive System Diseases
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013295 BXGD000812 Duodenal Ulcer Digestive System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0015230 BXGD000969 Exanthema Skin and Connective Tissue Diseases
C0018099 BXGD001172 Gout Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019348 BXGD001325 Herpes Simplex Infections Infections; Skin and Connective Tissue Diseases
C0020615 BXGD001445 Hypoglycemia Nutritional and Metabolic Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023440 BXGD001646 Acute Erythroblastic Leukemia Neoplasms; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023474 BXGD001662 Leukemia, Myeloid, Chronic-Phase Neoplasms; Hemic and Lymphatic Diseases
C0023530 BXGD001683 Leukopenia Hemic and Lymphatic Diseases
C0024534 BXGD001784 Malaria, Cerebral Infections; Nervous System Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026205 BXGD001891 Miosis disorder Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027947 BXGD002061 Neutropenia Hemic and Lymphatic Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030312 BXGD002207 Pancytopenia Hemic and Lymphatic Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0032584 BXGD002363 polyps Pathological Conditions, Signs and Symptoms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0039841 BXGD002829 Thiamine Deficiency Nutritional and Metabolic Diseases
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0041327 BXGD002916 Tuberculosis, Pulmonary Infections; Respiratory Tract Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085695 BXGD003243 Chronic gastritis Digestive System Diseases
C0151449 BXGD003419 Primary Sjögren's syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0202236 BXGD004086 Triglycerides measurement
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0206708 BXGD004256 Cervical Intraepithelial Neoplasia Neoplasms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0220668 BXGD004317 Congenital contractural arachnodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0334037 BXGD006980 Intestinal metaplasia
C0337438 BXGD007159 Glucose measurement
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376618 BXGD008003 Endotoxemia Pathological Conditions, Signs and Symptoms; Infections
C0428474 BXGD008631 Serum LDL cholesterol measurement
C0495706 BXGD009038 elevated blood glucose level
C0520909 BXGD009123 Postoperative Nausea and Vomiting Pathological Conditions, Signs and Symptoms
C0524910 BXGD009248 Hepatitis C, Chronic Digestive System Diseases; Infections
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0563625 BXGD009484 Agnosia for Pain Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C1096202 BXGD011610 Lipoprotein (a) measurement
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1368683 BXGD012900 Epithelioma Neoplasms
C1445957 BXGD013081 Serum total cholesterol measurement
C1527336 BXGD013271 Sjogren's Syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1608408 BXGD013434 Malignant transformation
C1832232 BXGD013812 Peroxisome Biogenesis Disorder, Complementation Group C Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1853959 BXGD015372 Birdshot chorioretinopathy
C1857231 BXGD015685 LACTASE PERSISTENCE
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2347748 BXGD017041 Adult Erythroleukemia
C2609414 BXGD017182 Acute kidney injury Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2747816 BXGD017577 Complicated malaria Infections
C2931689 BXGD018049 Dystrophia myotonica 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3164344 BXGD018526 Adult onset autosomal dominant leukodystrophy
C3250443 BXGD018584 MYOTONIC DYSTROPHY 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4520840 BXGD023041 Erythroleukemia (Erythroid/Myeloid) Neoplasms; Hemic and Lymphatic Diseases
C4529962 BXGD023178 Fatty Liver Disease
C4684879 BXGD023576 Metastatic Bile Duct Carcinoma Digestive System Diseases; Neoplasms
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000130 Estradiol 272.38
BXGC0000191 Tyramine 137.18
BXGC0000202 Papaverine 339.39
BXGC0000204 Theophylline 180.16
BXGC0000286 L-DOPA 197.19
BXGC0000409 Choline 104.17
BXGC0000537 Acetylsalicylic acid 180.16
BXGC0000663 Papain 206.28
BXGC0001325 Progesterone 314.46
BXGC0001502 Caffeine 194.19
BXGC0002796 Nicotine 162.23
BXGC0002867 Lappaurin 284.74
BXGC0003611 Latex 416.57
BXGC0004285 Agmatine 130.19
BXGC0004358 Thiamine 265.36
BXGC0005870 Codeine 299.36
BXGC0005871 Dopamine 153.18
BXGC0007530 Folic acid 441.4
BXGC0012243 Ukonan D 151.16
BXGC0012292 Creatinine 113.12
BXGC0013854 Histamine 111.08
BXGC0014695 Loratadine 382.14
BXGC0015879 Chlorhexidine 504.2
BXGC0017115 Cephalexin 347.09
BXGC0017757 Androstenedione 286.19
BXGC0021716 (R)-Verapamil 454.28
BXGC0022544 Digoxin 780.43
BXGC0025658 Vinblastine 810.42
BXGC0025862 Levothyroxine 776.69
BXGC0027374 Glyburide 493.14
BXGC0027421 Paclitaxel 853.33
BXGC0030138 Colchicine 399.17
BXGC0030663 Metformin 129.1
BXGC0030901 Morphine 285.14
BXGC0031384 Epinephrine 183.09
BXGC0033112 Acetylcysteine 163.03
BXGC0034941 Combretastatin A4 316.13
BXGC0035201 Quinidine 324.18
BXGC0040042 Warfarin 308.1
BXGC0041240 Atenolol 266.16
BXGC0042179 Atropine 289.17
BXGC0042222 Propranolol 259.16
BXGC0042339 Terbutaline 225.14
BXGC0044017 Verapamil 454.28
BXGC0046518 Chloroquine 319.18
BXGC0047430 Inosine 268.08
BXGC0049801 Thymidine 242.09
BXGC0050471 Fluorouracil 130.02
BXGC0051982 Mannitol 182.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein