adisease

Showing entry for Lynch Syndrome

General Disease Information
BXGD Id	BXGD023488
Disease Name	Lynch Syndrome
Disease CUI Id	C4552100
MeSH Codes	C16 C06 C04 C18
Disease Class Name	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms; Nutritional and Metabolic Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id	DOID:630
Disease Ontology Class Name	genetic disease
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
A0A024RAV5	BXGT000013	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b	3845	unreviewed
O00255	BXGT003903	Menin	4221	reviewed
O14733	BXGT004087	Dual specificity mitogen-activated protein kinase kinase 7	5609	reviewed	Kinase
O96017	BXGT005415	Serine/threonine-protein kinase Chk2	11200	reviewed	Kinase
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P01106	BXGT005730	Myc proto-oncogene protein	4609	reviewed	Transcription factor
P01116	BXGT005733	GTPase KRas	3845	reviewed	Enzyme modulator
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P04626	BXGT006238	Receptor tyrosine-protein kinase erbB-2	2064	reviewed	Kinase
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P04798	BXGT006265	Cytochrome P450 1A1	1543	reviewed	Enzyme
P05093	BXGT006313	Steroid 17-alpha-hydroxylase/17,20 lyase	1586	reviewed
P06731	BXGT006488	Carcinoembryonic antigen-related cell adhesion molecule 5	1048	reviewed
P09211	BXGT006869	Glutathione S-transferase P	2950	reviewed
P09237	BXGT006874	Matrilysin	4316	reviewed	Enzyme
P09874	BXGT006934	Poly [ADP-ribose] polymerase 1	142	reviewed
P12004	BXGT007766	Proliferating cell nuclear antigen	5111	reviewed	Nucleic acid binding
P12830	BXGT007852	Cadherin-1	999	reviewed
P15056	BXGT008075	Serine/threonine-protein kinase B-raf	673	reviewed	Kinase
P16070	BXGT008186	CD44 antigen	960	reviewed
P16410	BXGT008224	Cytotoxic T-lymphocyte protein 4	1493	reviewed
P16455	BXGT008229	Methylated-DNA--protein-cysteine methyltransferase	4255	reviewed
P18074	BXGT008374	General transcription and DNA repair factor IIH helicase subunit XPD	2068	reviewed	Enzyme
P18440	BXGT008404	Arylamine N-acetyltransferase 1	9	reviewed	Enzyme
P21964	BXGT008714	Catechol O-methyltransferase	1312	reviewed	Enzyme
P22897	BXGT008816	Macrophage mannose receptor 1	4360	reviewed
P23470	BXGT008872	Receptor-type tyrosine-protein phosphatase gamma	5793	reviewed	Enzyme
P23975	BXGT008935	Sodium-dependent noradrenaline transporter	6530	reviewed	Transporter
P27695	BXGT009199	DNA-(apurinic or apyrimidinic site) lyase	328	reviewed
P31153	BXGT009512	S-adenosylmethionine synthase isoform type-2	4144	reviewed	Enzyme
P35222	BXGT009799	Catenin beta-1	1499	reviewed
P37173	BXGT009970	TGF-beta receptor type-2	7048	reviewed	Kinase
P38398	BXGT010037	Breast cancer type 1 susceptibility protein	672	reviewed	Enzyme
P40337	BXGT010174	von Hippel-Lindau disease tumor suppressor	7428	reviewed	Enzyme
P40692	BXGT010195	DNA mismatch repair protein Mlh1	4292	reviewed	Nucleic acid binding
P42898	BXGT010344	Methylenetetrahydrofolate reductase	4524	reviewed
P43246	BXGT010371	DNA mismatch repair protein Msh2	4436	reviewed	Nucleic acid binding
P49711	BXGT010728	Transcriptional repressor CTCF	10664	reviewed	Transcription factor
P52701	BXGT010943	DNA mismatch repair protein Msh6	2956	reviewed	Nucleic acid binding
P54278	BXGT011038	Mismatch repair endonuclease PMS2	5395	reviewed	Nucleic acid binding
P54762	BXGT011076	Ephrin type-B receptor 1	2047	reviewed	Kinase
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
Q00987	BXGT012559	E3 ubiquitin-protein ligase Mdm2	4193	reviewed	Nucleic acid binding
Q05823	BXGT012840	2-5A-dependent ribonuclease	6041	reviewed	Kinase
Q13315	BXGT013339	Serine-protein kinase ATM	472	reviewed	Kinase
Q15116	BXGT013539	Programmed cell death protein 1	5133	reviewed
Q15831	BXGT013604	Serine/threonine-protein kinase STK11	6794	reviewed	Kinase
Q16678	BXGT013656	Cytochrome P450 1B1	1545	reviewed	Enzyme
Q86YC2	BXGT017633	Partner and localizer of BRCA2	79728	reviewed
Q92830	BXGT019379	Histone acetyltransferase KAT2A	2648	reviewed
Q9NZQ7	BXGT021281	Programmed cell death 1 ligand 1	29126	reviewed	Receptor
Q9UIF7	BXGT021717	Adenine DNA glycosylase	4595	reviewed	Enzyme
Q9UM73	BXGT021773	ALK tyrosine kinase receptor	238	reviewed	Kinase
Q9Y2Q3	BXGT022242	Glutathione S-transferase kappa 1	373156	reviewed
P25054	BXGT022961	Adenomatous polyposis coli protein	324	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}