Showing entry for von Hippel-Lindau disease tumor suppressor


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010174
Protein Namevon Hippel-Lindau disease tumor suppressor
Uniport IdP40337
GeneVHL
Gene Id7428
DomainVHL; VHL_C
Pfam PF01847   PF17211  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04066 HIF-1 signaling pathway
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa04120 Ubiquitin mediated proteolysis
6. Human Diseases 6.1 Cancers: Overview hsa05200 Pathways in cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05211 Renal cell carcinoma
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0000902 cell morphogenesis
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
Biological Process GO:0045597 positive regulation of cell differentiation
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0043687 post-translational protein modification
Biological Process GO:0050821 protein stabilization
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:0006508 proteolysis
Biological Process GO:0006355 regulation of transcription, DNA-templated
Biological Process GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
molecular function GO:0019899 enzyme binding
molecular function GO:0008134 transcription factor binding
molecular function GO:1990756 ubiquitin ligase-substrate adaptor activity
molecular function GO:0004842 ubiquitin-protein transferase activity
cellular component GO:0005829 cytosol
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0016020 membrane
cellular component GO:0005739 mitochondrion
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1234174 Cellular response to hypoxia
R-HSA-1234174 Cellular response to hypoxia
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-HSA-1280218 Adaptive Immune System
R-HSA-1643685 Disease
R-HSA-1643685 Disease
R-HSA-168256 Immune System
R-HSA-2262752 Cellular responses to stress
R-HSA-2262752 Cellular responses to stress
R-HSA-2990846 SUMOylation
R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins
R-HSA-3232142 SUMOylation of ubiquitinylation proteins
R-HSA-392499 Metabolism of proteins
R-HSA-5663205 Infectious disease
R-HSA-5663205 Infectious disease
R-HSA-597592 Post-translational protein modification
R-HSA-8951664 Neddylation
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-9678108 SARS-CoV-1 Infection
R-HSA-9679506 SARS-CoV Infections
R-HSA-9679506 SARS-CoV Infections
R-HSA-9679514 SARS-CoV-1 Genome Replication and Transcription
R-HSA-9682706 Replication of the SARS-CoV-1 genome
R-HSA-9694516 SARS-CoV-2 Infection
R-HSA-9694682 SARS-CoV-2 Genome Replication and Transcription
R-HSA-9694686 Replication of the SARS-CoV-2 genome
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-983169 Class I MHC mediated antigen processing & presentation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001430 BXGD000054 Adenoma Neoplasms
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0003076 BXGD000171 Aniridia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0003130 BXGD000183 Anoxia Pathological Conditions, Signs and Symptoms
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003857 BXGD000228 Congenital arteriovenous malformation Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004135 BXGD000257 Ataxia Telangiectasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007133 BXGD000442 Carcinoma, Papillary Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007279 BXGD000457 Carotid Body Paraganglioma Neoplasms
C0007766 BXGD000478 Intracranial Aneurysm Nervous System Diseases; Cardiovascular Diseases
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0008031 BXGD000511 Chest Pain Pathological Conditions, Signs and Symptoms
C0008479 BXGD000544 Chondrosarcoma Neoplasms
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010633 BXGD000679 Cystadenoma Neoplasms
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014060 BXGD000882 Encephalitis, St. Louis Infections; Nervous System Diseases
C0014173 BXGD000903 Endometrial Hyperplasia Female Urogenital Diseases and Pregnancy Complications
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0015826 BXGD001022 Fenestration (morphologic abnormality)
C0016382 BXGD001054 Flushing Pathological Conditions, Signs and Symptoms
C0017601 BXGD001125 Glaucoma Eye Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0017658 BXGD001138 Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0018681 BXGD001214 Headache Pathological Conditions, Signs and Symptoms
C0018777 BXGD001217 Conductive hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018790 BXGD001221 Cardiac Arrest Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0018916 BXGD001245 Hemangioma Neoplasms
C0018923 BXGD001248 Hemangiosarcoma Neoplasms
C0018965 BXGD001258 Hematuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0019045 BXGD001269 Hemoglobinopathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0019562 BXGD001336 Von Hippel-Lindau Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Cardiovascular Diseases
C0020255 BXGD001369 Hydrocephalus Nervous System Diseases
C0020437 BXGD001381 Hypercalcemia Nutritional and Metabolic Diseases
C0020458 BXGD001393 Hyperhidrosis disorder Skin and Connective Tissue Diseases
C0020502 BXGD001410 Hyperparathyroidism Endocrine System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020649 BXGD001459 Hypotension Cardiovascular Diseases
C0021841 BXGD001519 Intestinal Neoplasms Digestive System Diseases; Neoplasms
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022665 BXGD001573 Kidney Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022679 BXGD001575 Cystic kidney Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022680 BXGD001576 Polycystic Kidney Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023487 BXGD001669 Acute Promyelocytic Leukemia Neoplasms
C0023492 BXGD001671 Leukemia, T-Cell Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023521 BXGD001679 Globoid cell leukodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025267 BXGD001845 Multiple Endocrine Neoplasia Type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Endocrine System Diseases
C0025268 BXGD001846 Multiple Endocrine Neoplasia Type 2a Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Endocrine System Diseases
C0025286 BXGD001850 Meningioma Neoplasms; Nervous System Diseases
C0025500 BXGD001874 Mesothelioma Neoplasms
C0026640 BXGD001912 Mouth Neoplasms Neoplasms; Stomatognathic Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026821 BXGD001933 Muscle Cramp Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027497 BXGD001993 Nausea Pathological Conditions, Signs and Symptoms
C0027498 BXGD001994 Nausea and vomiting Pathological Conditions, Signs and Symptoms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027662 BXGD002015 Multiple Endocrine Neoplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Endocrine System Diseases
C0027668 BXGD002019 Neoplasms, Vascular Tissue Neoplasms
C0027672 BXGD002020 Neoplastic Syndromes, Hereditary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms
C0027708 BXGD002025 Nephroblastoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027766 BXGD002034 Nervous System Neoplasms Neoplasms; Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0027831 BXGD002047 Neurofibromatosis 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0027832 BXGD002048 Neurofibromatosis 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0029925 BXGD002181 Ovarian Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0030232 BXGD002197 Pallor Pathological Conditions, Signs and Symptoms
C0030252 BXGD002199 Palpitations Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0030283 BXGD002200 Pancreatic Cyst Digestive System Diseases; Neoplasms
C0030297 BXGD002204 Pancreatic Neoplasm Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0030421 BXGD002218 Paraganglioma Neoplasms
C0030472 BXGD002227 Paraneoplastic Syndromes Neoplasms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0031269 BXGD002297 Peutz-Jeghers Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms; Skin and Connective Tissue Diseases
C0031511 BXGD002304 Pheochromocytoma Neoplasms
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0032461 BXGD002356 Polycythemia Hemic and Lymphatic Diseases
C0032580 BXGD002362 Adenomatous Polyposis Coli Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms
C0033687 BXGD002415 Proteinuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0035067 BXGD002504 Renal Artery Stenosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Cardiovascular Diseases
C0035305 BXGD002529 Retinal Detachment Eye Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0035335 BXGD002540 Retinoblastoma Neoplasms; Eye Diseases
C0037822 BXGD002706 Speech Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037859 BXGD002708 Spermatocele Pathological Conditions, Signs and Symptoms; Male Urogenital Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0038644 BXGD002776 Sudden infant death syndrome Pathological Conditions, Signs and Symptoms
C0039231 BXGD002799 Tachycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0039239 BXGD002803 Sinus Tachycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0039590 BXGD002822 Testicular Neoplasms Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C0040053 BXGD002839 Thrombosis Cardiovascular Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0040264 BXGD002857 Tinnitus Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0040411 BXGD002859 Tongue Neoplasms Neoplasms; Stomatognathic Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042345 BXGD002977 Varicosity Cardiovascular Diseases
C0042373 BXGD002978 Vascular Diseases Cardiovascular Diseases
C0042571 BXGD002991 Vertigo Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0042928 BXGD003014 Vocal Cord Paralysis Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C0085136 BXGD003131 Central Nervous System Neoplasms Neoplasms; Nervous System Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0086769 BXGD003310 Panic Attacks Mental Disorders
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0151313 BXGD003413 Sensory neuropathy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151517 BXGD003431 Complete atrioventricular block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151740 BXGD003468 Intracranial Hypertension Nervous System Diseases
C0151864 BXGD003492 Disorder of pregnancy Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0152132 BXGD003547 Hypertensive Retinopathy Eye Diseases; Cardiovascular Diseases
C0152264 BXGD003577 Familial erythrocytosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0153349 BXGD003621 Malignant neoplasm of tongue Neoplasms; Stomatognathic Diseases
C0153381 BXGD003626 Malignant neoplasm of mouth Neoplasms; Stomatognathic Diseases
C0154051 BXGD003695 Hemangioma of retina Neoplasms; Eye Diseases; Cardiovascular Diseases
C0162678 BXGD003974 Neurofibromatoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0178664 BXGD004032 Glomerulosclerosis (disorder) Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Cardiovascular Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205646 BXGD004098 Adenoma, Basal Cell Neoplasms
C0205647 BXGD004099 Follicular adenoma Neoplasms
C0205648 BXGD004100 Adenoma, Microcystic Neoplasms
C0205649 BXGD004101 Adenoma, Monomorphic Neoplasms
C0205650 BXGD004102 Papillary adenoma Neoplasms
C0205651 BXGD004103 Adenoma, Trabecular Neoplasms
C0205696 BXGD004107 Anaplastic carcinoma Neoplasms
C0205697 BXGD004108 Carcinoma, Spindle-Cell Neoplasms
C0205698 BXGD004109 Undifferentiated carcinoma Neoplasms
C0205699 BXGD004110 Carcinomatosis Neoplasms
C0206654 BXGD004217 Leiomyomatosis Neoplasms
C0206663 BXGD004225 Neuroectodermal Tumor, Primitive Neoplasms
C0206681 BXGD004236 Adenocarcinoma, Clear Cell Neoplasms
C0206685 BXGD004240 Acinar Cell Carcinoma Neoplasms
C0206695 BXGD004246 Carcinoma, Neuroendocrine Neoplasms
C0206708 BXGD004256 Cervical Intraepithelial Neoplasia Neoplasms
C0206709 BXGD004257 Cystadenoma, Serous Neoplasms
C0206733 BXGD004278 Strawberry nevus of skin Neoplasms
C0206734 BXGD004279 Hemangioblastoma Neoplasms
C0206754 BXGD004289 Neuroendocrine Tumors Neoplasms
C0220641 BXGD004305 Lip and Oral Cavity Carcinoma Neoplasms; Stomatognathic Diseases
C0220756 BXGD004338 Niemann-Pick Disease, Type C Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Hemic and Lymphatic Diseases
C0221154 BXGD004393 Paroxysmal hypertension Cardiovascular Diseases
C0221239 BXGD004416 Rapidly progressive glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0221263 BXGD004427 Cafe-au-Lait Spots Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0221276 BXGD004433 Relative erythrocytosis Hemic and Lymphatic Diseases
C0232370 BXGD004541 Florid red complexion (finding)
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238198 BXGD004893 Gastrointestinal Stromal Tumors Digestive System Diseases; Neoplasms
C0238246 BXGD004898 Hemangioma of liver Digestive System Diseases; Neoplasms; Cardiovascular Diseases
C0238462 BXGD004937 Medullary carcinoma of thyroid Neoplasms; Endocrine System Diseases
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0239935 BXGD005007 Hematocrit increased
C0240066 BXGD005016 Iron deficiency Nutritional and Metabolic Diseases
C0242350 BXGD005154 Erectile dysfunction Male Urogenital Diseases; Mental Disorders
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242422 BXGD005163 Parkinsonian Disorders Nervous System Diseases
C0260037 BXGD005227 Multiple tumors Neoplasms
C0265316 BXGD005513 Neurocutaneous Syndromes Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Nervous System Diseases
C0267375 BXGD005742 Chronic colitis Digestive System Diseases
C0268731 BXGD006029 Renal glomerular disease Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0272144 BXGD006310 Erythrocytosis due to tissue hypoxemia
C0278678 BXGD006556 Metastatic Renal Cell Cancer
C0278877 BXGD006608 Adult Meningioma Neoplasms; Nervous System Diseases
C0278996 BXGD006621 Malignant Head and Neck Neoplasm Neoplasms
C0279606 BXGD006647 Childhood Hepatocellular Carcinoma Digestive System Diseases; Neoplasms
C0279607 BXGD006648 Adult Hepatocellular Carcinoma Digestive System Diseases; Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280100 BXGD006713 Solid Neoplasm Neoplasms
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0332890 BXGD006909 Congenital hemihypertrophy Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0339505 BXGD007255 Venous retinal branch occlusion Eye Diseases; Cardiovascular Diseases
C0340548 BXGD007346 Pulmonary capillary hemangiomatosis Neoplasms; Cardiovascular Diseases
C0342190 BXGD007440 C-cell hyperplasia of thyroid Pathological Conditions, Signs and Symptoms; Endocrine System Diseases
C0345617 BXGD007741 Neoplasm of middle ear Neoplasms; Otorhinolaryngologic Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0345967 BXGD007756 Malignant mesothelioma Neoplasms; Respiratory Tract Diseases
C0346249 BXGD007803 Cystadenocarcinoma of kidney Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0346255 BXGD007805 Oncocytoma, renal Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349535 BXGD007920 Carcinoid tumor of intestine Digestive System Diseases; Neoplasms
C0375206 BXGD007973 Hemiplegia/hemiparesis
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0391869 BXGD008016 Polycythemia due to excess erythopoetin production Hemic and Lymphatic Diseases
C0431718 BXGD008708 Multiple renal cysts Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0521670 BXGD009160 Cranial nerve compression Nervous System Diseases; Wounds and Injuries
C0522357 BXGD009202 Vertigo, Paroxysmal Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0541719 BXGD009258 Stress polycythemia Hemic and Lymphatic Diseases
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0549448 BXGD009381 Hemoglobin increased Neoplasms; Hemic and Lymphatic Diseases
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0558353 BXGD009451 Tongue Carcinoma Neoplasms; Stomatognathic Diseases
C0575081 BXGD009512 Gait abnormality Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598935 BXGD009674 Tumor Initiation Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677776 BXGD009728 Hereditary Breast and Ovarian Cancer Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0684337 BXGD009796 Ewings sarcoma-primitive neuroectodermal tumor (PNET) Neoplasms
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0730303 BXGD009950 Capillary hemangioma of retina Neoplasms; Cardiovascular Diseases
C0740457 BXGD010000 Malignant neoplasm of kidney Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0751559 BXGD010500 Pulsatile Tinnitus Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0854914 BXGD011048 Retinoblastoma bilateral Neoplasms; Eye Diseases
C0862312 BXGD011259 Epithelioid mesothelioma, malignant Neoplasms
C0865275 BXGD011285 Polycythemia due to fall in plasma volume
C0865276 BXGD011286 Polycythemia due to high altitude
C0878500 BXGD011365 Intraepithelial Neoplasia Neoplasms
C0879257 BXGD011393 Hereditary Papillary Renal Carcinoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0949541 BXGD011578 Hurthle Cell Tumor Neoplasms
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1257877 BXGD011812 Pheochromocytoma, Extra-Adrenal Neoplasms
C1262477 BXGD011882 Weight decreased Pathological Conditions, Signs and Symptoms
C1265994 BXGD011926 Clear cell tumor Neoplasms
C1266042 BXGD011938 Chromophobe Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1266043 BXGD011939 Sarcomatoid Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1266044 BXGD011940 Collecting Duct Carcinoma of the Kidney Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1301357 BXGD012288 Acute Leukemia of Ambiguous Lineage Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1306837 BXGD012377 Papillary Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1318533 BXGD012398 Secondary polycythemia Neoplasms; Hemic and Lymphatic Diseases
C1319315 BXGD012415 Adenocarcinoma of large intestine Digestive System Diseases; Neoplasms
C1332219 BXGD012512 Adult Kidney Wilms Tumor Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1332243 BXGD012516 Adenocarcinoma of ampulla of Vater Neoplasms
C1332900 BXGD012552 Cerebellar hemangioblastoma Neoplasms; Nervous System Diseases
C1333001 BXGD012578 Childhood Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1333015 BXGD012581 Childhood Kidney Wilms Tumor Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1333600 BXGD012636 Hereditary Malignant Neoplasm Neoplasms
C1333944 BXGD012657 Paraganglioma of head and neck Neoplasms
C1333955 BXGD012658 central nervous system hemangioblastoma Neoplasms; Nervous System Diseases
C1333990 BXGD012670 Hereditary Nonpolyposis Colorectal Cancer Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms; Nutritional and Metabolic Diseases
C1333993 BXGD012673 hereditary paraganglioma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms
C1334971 BXGD012751 Nodular Neoplasm
C1334978 BXGD012753 Non-Hereditary Clear Cell Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1337011 BXGD012874 Well Differentiated Pancreatic Endocrine Tumor Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1337013 BXGD012876 Differentiated Thyroid Gland Carcinoma
C1368683 BXGD012900 Epithelioma Neoplasms
C1378050 BXGD012931 Oncocytic Neoplasm
C1378703 BXGD012933 Renal carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1387805 BXGD012958 Episodic paroxysmal anxiety Behavior and Behavior Mechanisms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1510502 BXGD013175 Oxyphilic Adenoma Neoplasms
C1519670 BXGD013241 Tumor Angiogenesis Pathological Conditions, Signs and Symptoms
C1527344 BXGD013275 Dysphonia Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C1527405 BXGD013290 Erythrocytosis Hemic and Lymphatic Diseases
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1567741 BXGD013414 Alport Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Male Urogenital Diseases
C1608408 BXGD013434 Malignant transformation
C1611743 BXGD013456 Familial (FPAH)
C1704327 BXGD013546 Bone Sarcoma Neoplasms; Musculoskeletal Diseases
C1704374 BXGD013550 Carcinoma of Endocrine Gland Neoplasms; Endocrine System Diseases
C1708350 BXGD013598 Hereditary Leiomyomatosis and Renal Cell Cancer Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C1708353 BXGD013599 Hereditary Paraganglioma-Pheochromocytoma Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms
C1762616 BXGD013753 Meningioma, benign, no ICD-O subtype Neoplasms; Nervous System Diseases
C1833929 BXGD013947 THYROID CARCINOMA, SPORADIC MEDULLARY
C1837915 BXGD014286 ERYTHROCYTOSIS, FAMILIAL, 2 Hemic and Lymphatic Diseases
C1840423 BXGD014467 HEREDITARY RENAL CANCER ASSOCIATED 1 Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1847319 BXGD014858 PARAGANGLIOMA AND GASTRIC STROMAL SARCOMA Digestive System Diseases; Neoplasms
C1849749 BXGD015083 Peripheral thrombosis
C1853237 BXGD015319 Isolated cases
C1853288 BXGD015329 Increased red blood cell mass Hemic and Lymphatic Diseases
C1857171 BXGD015680 Episodic hyperhidrosis Skin and Connective Tissue Diseases
C1857175 BXGD015681 Episodic hypertension Cardiovascular Diseases
C1857276 BXGD015688 Trichohepatoenteric Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C1860392 BXGD015982 Renal hemangioblastoma
C1868393 BXGD016498 Elevated urinary epinephrine
C1868394 BXGD016499 Elevated calcitonin
C1959588 BXGD016640 Angioma Neoplasms
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2348239 BXGD017055 Endolymphatic sac tumor Neoplasms; Musculoskeletal Diseases; Otorhinolaryngologic Diseases
C2826323 BXGD017790 Refractory Cytopenia of Childhood
C2873823 BXGD017823 Polycythemia due to erythropoietin
C2873824 BXGD017824 Polycythemia due to stress
C2930471 BXGD017887 Bilateral Wilms Tumor Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2930839 BXGD017902 Bilateral pheochromocytoma and islet cell adenoma of the pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C2931039 BXGD017945 Pancreatic islet cell tumors Neoplasms
C2931352 BXGD018005 Familial renal cell carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2931852 BXGD018079 Clear-cell metastatic renal cell carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2937358 BXGD018159 Cerebral Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C2973725 BXGD018205 Pulmonary arterial hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C3160712 BXGD018467 Palpitations, CTCAE
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3267003 BXGD018608 Vascular endothelial growth factor overexpression
C3279222 BXGD018751 Aplasia/Hypoplasia of the cerebellum
C3280492 BXGD018831 TUMOR PREDISPOSITION SYNDROME
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3665346 BXGD019278 Unspecified visual loss Pathological Conditions, Signs and Symptoms; Eye Diseases
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3665386 BXGD019284 Abnormal vision Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3714581 BXGD019415 Multicystic Dysplastic Kidney Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C3808022 BXGD019536 Episodic abdominal pain Pathological Conditions, Signs and Symptoms
C3887461 BXGD019876 Head and Neck Carcinoma Neoplasms
C3887499 BXGD019884 Renal cyst Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3887524 BXGD019892 Skin Erosion Skin and Connective Tissue Diseases
C3888391 BXGD019969 Nonnuclear polymorphic congenital cataract
C4017161 BXGD020423 RENAL CELL CARCINOMA WITH PARANEOPLASTIC ERYTHROCYTOSIS
C4021780 BXGD020775 Abnormality of the liver
C4021976 BXGD020852 Abnormality of the lymphatic system
C4021977 BXGD020853 Visceral angiomatosis
C4022001 BXGD020863 Abnormality of the cerebral vasculature
C4022018 BXGD020872 Telangiectasia of the skin Cardiovascular Diseases
C4022998 BXGD021058 Arachnoid hemangiomatosis Neoplasms
C4023099 BXGD021105 Elevated urinary dopamine
C4024221 BXGD021309 Papillary cystadenoma of the epididymis
C4024223 BXGD021311 Spinal hemangioblastoma Neoplasms; Nervous System Diseases
C4025594 BXGD021683 Positive regitine blocking test
C4025626 BXGD021701 Elevated urinary norepinephrine
C4048306 BXGD021902 Multiple endocrine neoplasia Type 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Endocrine System Diseases
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4054076 BXGD021973 Renal Angiomyoadenomatous Tumor
C4086152 BXGD022123 Childhood Astrocytoma Neoplasms
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4277690 BXGD022377 Ciliopathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C4293708 BXGD022515 Recurrent paroxysmal headache Pathological Conditions, Signs and Symptoms
C4518333 BXGD023017 Clear cell papillary renal cell carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C4518570 BXGD023028 Aggressive papillary tumor
C4551637 BXGD023379 Erythrocytosis familial, 1 Hemic and Lymphatic Diseases
C4551683 BXGD023389 Adrenal Gland Pheochromocytoma Neoplasms; Endocrine System Diseases
C4551915 BXGD023441 Gait Disturbance, CTCAE
C4552100 BXGD023488 Lynch Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms; Nutritional and Metabolic Diseases
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4721698 BXGD023763 Metastatic Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C4722172 BXGD023791 Primary differentiated carcinoma of thyroid gland
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C4727069 BXGD023850 Advanced Renal Cell Carcinoma
C4744469 BXGD023942 Cerebral Hemangioblastoma
C4749274 BXGD024052 Chuvash erythrocytosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0004266 2-Propanol 60.1
BXGC0004277 Acetic acid 60.05
BXGC0006162 L-Glutamic acid 147.13
BXGC0006368 Formic acid 46.03
BXGC0025746 Hydroxyproline 131.06
BXGC0049200 Arginine 175.12
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein