Showing entry for CCR4-NOT transcription complex subunit 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT001378
Protein NameCCR4-NOT transcription complex subunit 1
Uniport IdA5YKK6
GeneCNOT1
Gene Id23019
DomainCNOT1_CAF1_bind; CNOT1_HEAT; CNOT1_TTP_bind; DUF3819; Not1
Pfam PF16415   PF16418   PF16417   PF12842   PF04054  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa03018 RNA degradation
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
Biological Process GO:0035195 gene silencing by miRNA
Biological Process GO:0007275 multicellular organism development
Biological Process GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway
Biological Process GO:0048387 negative regulation of retinoic acid receptor signaling pathway
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0017148 negative regulation of translation
Biological Process GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Biological Process GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
Biological Process GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly
Biological Process GO:0061014 positive regulation of mRNA catabolic process
Biological Process GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Biological Process GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
Biological Process GO:2000036 regulation of stem cell population maintenance
Biological Process GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
molecular function GO:0070016 armadillo repeat domain binding
molecular function GO:0030331 estrogen receptor binding
molecular function GO:0060090 molecular adaptor activity
molecular function GO:0019904 protein domain specific binding
molecular function GO:0042974 retinoic acid receptor binding
molecular function GO:0003723 RNA binding
cellular component GO:0030014 CCR4-NOT complex
cellular component GO:0030015 CCR4-NOT core complex
cellular component GO:0005829 cytosol
cellular component GO:0005615 extracellular space
cellular component GO:0016020 membrane
cellular component GO:0005634 nucleus
cellular component GO:0000932 P-body
cellular component GO:0005778 peroxisomal membrane
Reactome
Pathway Id Pathway Name
R-HSA-212436 Generic Transcription Pathway
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-429914 Deadenylation-dependent mRNA decay
R-HSA-429947 Deadenylation of mRNA
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-8953854 Metabolism of RNA
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000846 BXGD000015 Agenesis
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0008074 BXGD000519 Child Development Disorders, Pervasive Mental Disorders
C0008354 BXGD000533 Cholera Infections
C0011206 BXGD000703 Delirium Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0014772 BXGD000948 Red Blood Cell Count measurement
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0017636 BXGD001131 Glioblastoma Neoplasms
C0018777 BXGD001217 Conductive hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0037299 BXGD002685 Skin Ulcer Skin and Connective Tissue Diseases
C0079541 BXGD003081 Holoprosencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0152423 BXGD003587 Congenital small ears Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Otorhinolaryngologic Diseases
C0162429 BXGD003942 Malnutrition Nutritional and Metabolic Diseases
C0239234 BXGD004974 Low set ears
C0240635 BXGD005047 Byzanthine arch palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Stomatognathic Diseases
C0242429 BXGD005166 Sore Throat Infections; Respiratory Tract Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C0266449 BXGD005670 Congenital anomaly of brain Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Nervous System Diseases
C0424711 BXGD008541 Orbital separation diminished
C0429028 BXGD008646 QT interval feature (observable entity)
C0557874 BXGD009444 Global developmental delay
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678230 BXGD009750 Congenital Epicanthus
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0751617 BXGD010525 Semilobar Holoprosencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1836542 BXGD014129 Depressed nasal bridge
C1857679 BXGD015735 Sloping forehead
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1865014 BXGD016282 Long philtrum
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein