Showing entry for Conductive hearing loss


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD001217
Disease NameConductive hearing loss
Disease CUI IdC0018777
MeSH Codes C23   C10   C09  
Disease Class NamePathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id HP:0000598  
Human Phenotype Ontology TermAbnormality of the ear
Disease Ontology Id   
Disease Ontology Class Name
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
A5YKK6 BXGT001378 CCR4-NOT transcription complex subunit 1 23019 reviewed Transcription factor
O14764 BXGT004094 Gamma-aminobutyric acid receptor subunit delta 2563 reviewed Ion channel
O15550 BXGT004179 Lysine-specific demethylase 6A 7403 reviewed Epigenetic regulator
O43318 BXGT004586 Mitogen-activated protein kinase kinase kinase 7 6885 reviewed Kinase
O60547 BXGT004881 GDP-mannose 4,6 dehydratase 2762 reviewed Enzyme
O75369 BXGT005119 Filamin-B 2317 reviewed
O75496 BXGT005132 Geminin 51053 reviewed
O75643 BXGT005142 U5 small nuclear ribonucleoprotein 200 kDa helicase 23020 reviewed
O95237 BXGT005361 Lecithin retinol acyltransferase 9227 reviewed
P02452 BXGT005878 Collagen alpha-1(I) chain 1277 reviewed
P02458 BXGT005879 Collagen alpha-1(II) chain 1280 reviewed
P07510 BXGT006631 Acetylcholine receptor subunit gamma 1146 reviewed Ion channel
P07949 BXGT006703 Proto-oncogene tyrosine-protein kinase receptor Ret 5979 reviewed Kinase
P08100 BXGT006725 Rhodopsin 6010 reviewed G-protein coupled receptor
P0CG47 BXGT007467 Polyubiquitin-B 7314 reviewed Nucleic acid binding
P10745 BXGT007608 Retinol-binding protein 3 5949 reviewed
P12271 BXGT007786 Retinaldehyde-binding protein 1 6017 reviewed Transporter
P12643 BXGT007830 Bone morphogenetic protein 2 650 reviewed Signaling
P12830 BXGT007852 Cadherin-1 999 reviewed
P13224 BXGT007890 Platelet glycoprotein Ib beta chain 2812 reviewed
P14678 BXGT008038 Small nuclear ribonucleoprotein-associated proteins B and B' 6628 reviewed Nucleic acid binding
P16157 BXGT008203 Ankyrin-1 286 reviewed
P16435 BXGT008226 NADPH--cytochrome P450 reductase 5447 reviewed
P16499 BXGT008238 Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha 5145 reviewed
P20794 BXGT008600 Serine/threonine-protein kinase MAK 4117 reviewed Kinase
P20839 BXGT008608 Inosine-5'-monophosphate dehydrogenase 1 3614 reviewed Enzyme
P21333 BXGT008638 Filamin-A 2316 reviewed
P21589 BXGT008669 5'-nucleotidase 4907 reviewed Enzyme
P21802 BXGT008691 Fibroblast growth factor receptor 2 2263 reviewed Kinase
P21964 BXGT008714 Catechol O-methyltransferase 1312 reviewed Enzyme
P22413 BXGT008764 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 5167 reviewed Enzyme
P22607 BXGT008784 Fibroblast growth factor receptor 3 2261 reviewed Kinase
P22748 BXGT008802 Carbonic anhydrase 4 762 reviewed
P25101 BXGT009018 Endothelin-1 receptor 1909 reviewed G-protein coupled receptor
P29033 BXGT009308 Gap junction beta-2 protein 2706 reviewed Cell-cell junction
P29973 BXGT009389 cGMP-gated cation channel alpha-1 1259 reviewed Ion channel
P31040 BXGT009503 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 6389 reviewed Enzyme
P35475 BXGT009837 Alpha-L-iduronidase 3425 reviewed Enzyme
P35555 BXGT009845 Fibrillin-1 2200 reviewed Calcium-binding protein
P35869 BXGT009877 Aryl hydrocarbon receptor 196 reviewed Transcription factor
P35913 BXGT009879 Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta 5158 reviewed
P40337 BXGT010174 von Hippel-Lindau disease tumor suppressor 7428 reviewed Enzyme
P40926 BXGT010207 Malate dehydrogenase, mitochondrial 4191 reviewed Enzyme
P43026 BXGT010351 Growth/differentiation factor 5 8200 reviewed Signaling
P48740 BXGT010659 Mannan-binding lectin serine protease 1 5648 reviewed Enzyme
P50213 BXGT010779 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 3419 reviewed Enzyme
P51955 BXGT010908 Serine/threonine-protein kinase Nek2 4751 reviewed Kinase
P56524 BXGT011176 Histone deacetylase 4 9759 reviewed Epigenetic regulator
P61224 BXGT011370 Ras-related protein Rap-1b 5908 reviewed Enzyme modulator
P62266 BXGT011416 40S ribosomal protein S23 6228 reviewed Nucleic acid binding
P62834 BXGT011464 Ras-related protein Rap-1A 5906 reviewed Enzyme modulator
P82279 BXGT011972 Protein crumbs homolog 1 23418 reviewed
P98160 BXGT012228 Basement membrane-specific heparan sulfate proteoglycan core protein 3339 reviewed Enzyme modulator
Q02127 BXGT012635 Dihydroorotate dehydrogenase (quinone), mitochondrial 1723 reviewed Enzyme
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A 4297 reviewed
Q04721 BXGT012777 Neurogenic locus notch homolog protein 2 4853 reviewed
Q04771 BXGT012783 Activin receptor type-1 90 reviewed Kinase
Q12866 BXGT013273 Tyrosine-protein kinase Mer 10461 reviewed Kinase
Q12959 BXGT013283 Disks large homolog 1 1739 reviewed Receptor
Q13303 BXGT013336 Voltage-gated potassium channel subunit beta-2 8514 reviewed Ion channel
Q14683 BXGT013500 Structural maintenance of chromosomes protein 1A 8243 reviewed
Q15029 BXGT013524 116 kDa U5 small nuclear ribonucleoprotein component 9343 reviewed Enzyme
Q15223 BXGT013551 Nectin-1 5818 reviewed
Q15652 BXGT013587 Probable JmjC domain-containing histone demethylation protein 2C 221037 reviewed
Q2M1P5 BXGT014129 Kinesin-like protein KIF7 374654 reviewed
Q6NUK1 BXGT016429 Calcium-binding mitochondrial carrier protein SCaMC-1 29957 reviewed Transporter
Q6P2Q9 BXGT016446 Pre-mRNA-processing-splicing factor 8 10594 reviewed Nucleic acid binding
Q8WWQ0 BXGT019003 PH-interacting protein 55023 reviewed Epigenetic regulator
Q8WWY3 BXGT019006 U4/U6 small nuclear ribonucleoprotein Prp31 26121 reviewed Nucleic acid binding
Q8WZA1 BXGT019024 Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 55624 reviewed
Q92834 BXGT019381 X-linked retinitis pigmentosa GTPase regulator 6103 reviewed
Q96NR8 BXGT019701 Retinol dehydrogenase 12 145226 reviewed Enzyme
Q96PY6 BXGT019712 Serine/threonine-protein kinase Nek1 4750 reviewed Kinase
Q9BY41 BXGT020180 Histone deacetylase 8 55869 reviewed Epigenetic regulator
Q9BYW2 BXGT020192 Histone-lysine N-methyltransferase SETD2 29072 reviewed Epigenetic regulator
Q9H0F7 BXGT020435 ADP-ribosylation factor-like protein 6 84100 reviewed
Q9NRP7 BXGT021192 Serine/threonine-protein kinase 36 27148 reviewed Kinase
Q9UM47 BXGT021772 Neurogenic locus notch homolog protein 3 4854 reviewed
Q9Y2R2 BXGT022243 Tyrosine-protein phosphatase non-receptor type 22 26191 reviewed
Q9Y5X4 BXGT022306 Photoreceptor-specific nuclear receptor 10002 reviewed Nuclear receptor
P07954 BXGT023939 Fumarate hydratase, mitochondrial 2271 reviewed Enzyme
Q96JJ3 BXGT024291 Engulfment and cell motility protein 2 63916 reviewed Signaling
O43837 BXGT024635 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 3420 reviewed Enzyme
Q96L73 BXGT024676 Histone-lysine N-methyltransferase, H3 lysine-36 specific 64324 reviewed Epigenetic regulator
Q96MF2 BXGT025769 SH3 and cysteine-rich domain-containing protein 3 246329 reviewed
Q86SQ9 BXGT025875 Dehydrodolichyl diphosphate synthase complex subunit DHDDS 79947 reviewed Enzyme
Q9UQE7 BXGT025899 Structural maintenance of chromosomes protein 3 9126 reviewed
O43172 BXGT026158 U4/U6 small nuclear ribonucleoprotein Prp4 9128 reviewed Nucleic acid binding
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease