Showing entry for Amyloid-beta A4 precursor protein-binding family B member 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT003896
Protein NameAmyloid-beta A4 precursor protein-binding family B member 1
Uniport IdO00213
GeneAPBB1
Gene Id322
DomainPID; WW
Pfam PF00640   PF00397  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.4 Neurodegenerative diseases hsa05010 Alzheimer disease
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006915 apoptotic process
Biological Process GO:0007409 axonogenesis
Biological Process GO:0007050 cell cycle arrest
Biological Process GO:0006974 cellular response to DNA damage stimulus
Biological Process GO:0006302 double-strand break repair
Biological Process GO:0043967 histone H4 acetylation
Biological Process GO:0030308 negative regulation of cell growth
Biological Process GO:0050760 negative regulation of thymidylate synthase biosynthetic process
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0045739 positive regulation of DNA repair
Biological Process GO:0010976 positive regulation of neuron projection development
Biological Process GO:0050714 positive regulation of protein secretion
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006355 regulation of transcription, DNA-templated
Biological Process GO:0010039 response to iron ion
Biological Process GO:0007165 signal transduction
molecular function GO:0001540 amyloid-beta binding
molecular function GO:0003682 chromatin binding
molecular function GO:0042393 histone binding
molecular function GO:0070064 proline-rich region binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0048156 tau protein binding
molecular function GO:0008134 transcription factor binding
molecular function GO:0031625 ubiquitin protein ligase binding
cellular component GO:0005737 cytoplasm
cellular component GO:0043197 dendritic spine
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0030426 growth cone
cellular component GO:1990812 growth cone filopodium
cellular component GO:1990761 growth cone lamellipodium
cellular component GO:0030027 lamellipodium
cellular component GO:0044304 main axon
cellular component GO:0043025 neuronal cell body
cellular component GO:0016607 nuclear speck
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0005886 plasma membrane
cellular component GO:0045211 postsynaptic membrane
cellular component GO:0042734 presynaptic membrane
cellular component GO:0032991 protein-containing complex
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
R-HSA-5693532 DNA Double-Strand Break Repair
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-HSA-5693606 DNA Double Strand Break Response
R-HSA-73894 DNA Repair
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0023524 BXGD001681 Leukoencephalopathy, Progressive Multifocal Infections; Nervous System Diseases
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0027121 BXGD001973 Myositis Musculoskeletal Diseases; Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028043 BXGD002066 Nicotine Dependence Chemically-Induced Disorders; Mental Disorders
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0276496 BXGD006426 Familial Alzheimer Disease (FAD) Nervous System Diseases; Mental Disorders
C0333463 BXGD006954 Senile Plaques Pathological Conditions, Signs and Symptoms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0494463 BXGD009029 Alzheimer Disease, Late Onset Nervous System Diseases; Mental Disorders
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0750901 BXGD010242 Alzheimer Disease, Early Onset Nervous System Diseases; Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1849157 BXGD015018 Resistance to Insulin-Like Growth Factor I Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0030612 tetraethylene glycol 194.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein