Showing entry for Alzheimer Disease, Late Onset


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD009029
Disease NameAlzheimer Disease, Late Onset
Disease CUI IdC0494463
MeSH Codes C10   F03  
Disease Class NameNervous System Diseases; Mental Disorders
Semantic TypeMental or Behavioral Dysfunction
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id   
Disease Ontology Class Name
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
F7VJQ1 BXGT003310 Alternative prion protein 5621 reviewed
O00206 BXGT003894 Toll-like receptor 4 7099 reviewed
O00213 BXGT003896 Amyloid-beta A4 precursor protein-binding family B member 1 322 reviewed
O00264 BXGT003904 Membrane-associated progesterone receptor component 1 10857 reviewed Signaling
O14556 BXGT004069 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific 26330 reviewed Enzyme
O14672 BXGT004081 Disintegrin and metalloproteinase domain-containing protein 10 102 reviewed
O14773 BXGT004096 Tripeptidyl-peptidase 1 1200 reviewed Enzyme
O15118 BXGT004127 NPC intracellular cholesterol transporter 1 4864 reviewed Transporter
O43914 BXGT004635 TYRO protein tyrosine kinase-binding protein 7305 reviewed
O60240 BXGT004860 Perilipin-1 5346 reviewed
O60603 BXGT004887 Toll-like receptor 2 7097 reviewed
O60760 BXGT004899 Hematopoietic prostaglandin D synthase 27306 reviewed
O75581 BXGT005136 Low-density lipoprotein receptor-related protein 6 4040 reviewed
O94907 BXGT005340 Dickkopf-related protein 1 22943 reviewed
O94925 BXGT005342 Glutaminase kidney isoform, mitochondrial 2744 reviewed Enzyme
O95470 BXGT005382 Sphingosine-1-phosphate lyase 1 8879 reviewed
O95477 BXGT005383 Phospholipid-transporting ATPase ABCA1 19 reviewed Transporter
P00734 BXGT005630 Prothrombin 2147 reviewed Enzyme
P00747 BXGT005639 Plasminogen 5340 reviewed Enzyme
P00749 BXGT005641 Urokinase-type plasminogen activator 5328 reviewed Enzyme
P01011 BXGT005715 Alpha-1-antichymotrypsin 12 reviewed Enzyme modulator
P01023 BXGT005718 Alpha-2-macroglobulin 2 reviewed Enzyme modulator
P01034 BXGT005721 Cystatin-C 1471 reviewed
P01042 BXGT005722 Kininogen-1 3827 reviewed Enzyme modulator
P01130 BXGT005735 Low-density lipoprotein receptor 3949 reviewed
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01138 BXGT005738 Beta-nerve growth factor 4803 reviewed Signaling
P01303 BXGT005748 Pro-neuropeptide Y 4852 reviewed Signaling
P01308 BXGT005749 Insulin 3630 reviewed
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P01903 BXGT005814 HLA class II histocompatibility antigen, DR alpha chain 3122 reviewed Immune response
P01911 BXGT005816 HLA class II histocompatibility antigen, DRB1-15 beta chain 3123 reviewed Immune response
P02545 BXGT005889 Prelamin-A/C 4000 reviewed
P02647 BXGT005908 Apolipoprotein A-I 335 reviewed
P02649 BXGT005909 Apolipoprotein E 348 reviewed
P02654 BXGT005911 Apolipoprotein C-I 341 reviewed
P02753 BXGT005945 Retinol-binding protein 4 5950 reviewed Transporter
P02765 BXGT005952 Alpha-2-HS-glycoprotein 197 reviewed Enzyme modulator
P02787 BXGT005962 Serotransferrin 7018 reviewed Enzyme
P03372 BXGT006059 Estrogen receptor 2099 reviewed Nuclear receptor
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase 3156 reviewed
P04040 BXGT006132 Catalase 847 reviewed Enzyme
P04155 BXGT006155 Trefoil factor 1 7031 reviewed Signaling
P04156 BXGT006156 Major prion protein 5621 reviewed
P04179 BXGT006163 Superoxide dismutase [Mn], mitochondrial 6648 reviewed Enzyme
P04406 BXGT006207 Glyceraldehyde-3-phosphate dehydrogenase 2597 reviewed Enzyme
P04424 BXGT006214 Argininosuccinate lyase 435 reviewed Enzyme
P04440 BXGT006216 HLA class II histocompatibility antigen, DP beta 1 chain 3115 reviewed Immune response
P04818 BXGT006269 Thymidylate synthase 7298 reviewed Enzyme
P05067 BXGT006306 Amyloid-beta precursor protein 351 reviewed Enzyme modulator
P05090 BXGT006311 Apolipoprotein D 347 reviewed
P05091 BXGT006312 Aldehyde dehydrogenase, mitochondrial 217 reviewed Enzyme
P05164 BXGT006333 Myeloperoxidase 4353 reviewed Enzyme
P05231 BXGT006345 Interleukin-6 3569 reviewed
P06213 BXGT006425 Insulin receptor 3643 reviewed Kinase
P06276 BXGT006430 Cholinesterase 590 reviewed
P06493 BXGT006445 Cyclin-dependent kinase 1 983 reviewed Kinase
P06727 BXGT006485 Apolipoprotein A-IV 337 reviewed
P06733 BXGT006490 Alpha-enolase 2023 reviewed Enzyme
P06850 BXGT006511 Corticoliberin 1392 reviewed Signaling
P06858 BXGT006515 Lipoprotein lipase 4023 reviewed Enzyme
P06870 BXGT006518 Kallikrein-1 3816 reviewed Enzyme
P07339 BXGT006604 Cathepsin D 1509 reviewed Enzyme
P08069 BXGT006723 Insulin-like growth factor 1 receptor 3480 reviewed Kinase
P08174 BXGT006739 Complement decay-accelerating factor 1604 reviewed
P08183 BXGT006741 ATP-dependent translocase ABCB1 5243 reviewed Transporter
P08235 BXGT006751 Mineralocorticoid receptor 4306 reviewed Nuclear receptor
P08473 BXGT006773 Neprilysin 4311 reviewed Enzyme
P08603 BXGT006798 Complement factor H 3075 reviewed
P08865 BXGT006832 40S ribosomal protein SA 3921 reviewed Nucleic acid binding
P09211 BXGT006869 Glutathione S-transferase P 2950 reviewed
P09488 BXGT006899 Glutathione S-transferase Mu 1 2944 reviewed
P09601 BXGT006909 Heme oxygenase 1 3162 reviewed
P09917 BXGT006941 Arachidonate 5-lipoxygenase 240 reviewed Enzyme
P0DMV8 BXGT007509 Heat shock 70 kDa protein 1A 3304 reviewed
P0DMV9 BXGT007510 Heat shock 70 kDa protein 1B 3304 reviewed
P0DP23 BXGT007520 Calmodulin-1 808 reviewed
P0DP24 BXGT007521 Calmodulin-2 808 reviewed
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10635 BXGT007595 Cytochrome P450 2D6 1565 reviewed
P10636 BXGT007596 Microtubule-associated protein tau 4137 reviewed
P10909 BXGT007630 Clusterin 1191 reviewed
P10997 BXGT007643 Islet amyloid polypeptide 3375 reviewed Signaling
P11473 BXGT007709 Vitamin D3 receptor 7421 reviewed Nuclear receptor
P11597 BXGT007727 Cholesteryl ester transfer protein 1071 reviewed
P11717 BXGT007740 Cation-independent mannose-6-phosphate receptor 3482 reviewed Receptor
P12821 BXGT007849 Angiotensin-converting enzyme 1636 reviewed Enzyme
P13500 BXGT007916 C-C motif chemokine 2 6347 reviewed Signaling
P13501 BXGT007917 C-C motif chemokine 5 6352 reviewed Signaling
P14416 BXGT008011 D(2) dopamine receptor 1813 reviewed G-protein coupled receptor
P14672 BXGT008037 Solute carrier family 2, facilitated glucose transporter member 4 6517 reviewed Transporter
P14735 BXGT008042 Insulin-degrading enzyme 3416 reviewed Enzyme
P15559 BXGT008139 NAD(P)H dehydrogenase [quinone] 1 1728 reviewed
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P16157 BXGT008203 Ankyrin-1 286 reviewed
P17787 BXGT008341 Neuronal acetylcholine receptor subunit beta-2 1141 reviewed Ion channel
P18146 BXGT008384 Early growth response protein 1 1958 reviewed Nucleic acid binding
P18433 BXGT008403 Receptor-type tyrosine-protein phosphatase alpha 5786 reviewed Enzyme
P18887 BXGT008437 DNA repair protein XRCC1 7515 reviewed
P21397 BXGT008644 Amine oxidase [flavin-containing] A 4128 reviewed
P21709 BXGT008685 Ephrin type-A receptor 1 2041 reviewed Kinase
P21728 BXGT008686 D(1A) dopamine receptor 1812 reviewed G-protein coupled receptor
P21964 BXGT008714 Catechol O-methyltransferase 1312 reviewed Enzyme
P22303 BXGT008751 Acetylcholinesterase 43 reviewed Enzyme
P23560 BXGT008883 Brain-derived neurotrophic factor 627 reviewed Signaling
P25705 BXGT009060 ATP synthase subunit alpha, mitochondrial 498 reviewed Transporter
P26358 BXGT009104 DNA (cytosine-5)-methyltransferase 1 1786 reviewed Epigenetic regulator
P27169 BXGT009161 Serum paraoxonase/arylesterase 1 5444 reviewed
P27338 BXGT009172 Amine oxidase [flavin-containing] B 4129 reviewed
P27986 BXGT009216 Phosphatidylinositol 3-kinase regulatory subunit alpha 5295 reviewed Kinase
P28223 BXGT009239 5-hydroxytryptamine receptor 2A 3356 reviewed G-protein coupled receptor
P28329 BXGT009251 Choline O-acetyltransferase 1103 reviewed Enzyme
P28335 BXGT009255 5-hydroxytryptamine receptor 2C 3358 reviewed G-protein coupled receptor
P28845 BXGT009297 Corticosteroid 11-beta-dehydrogenase isozyme 1 3290 reviewed
P29474 BXGT009352 Nitric oxide synthase, endothelial 4846 reviewed
P30533 BXGT009434 Alpha-2-macroglobulin receptor-associated protein 4043 reviewed
P30711 BXGT009460 Glutathione S-transferase theta-1 2952 reviewed
P30939 BXGT009483 5-hydroxytryptamine receptor 1F 3355 reviewed G-protein coupled receptor
P31645 BXGT009558 Sodium-dependent serotonin transporter 6532 reviewed Transporter
P32418 BXGT009635 Sodium/calcium exchanger 1 6546 reviewed Transporter
P34947 BXGT009774 G protein-coupled receptor kinase 5 2869 reviewed Kinase
P34972 BXGT009779 Cannabinoid receptor 2 1269 reviewed G-protein coupled receptor
P34998 BXGT009781 Corticotropin-releasing factor receptor 1 1394 reviewed
P35462 BXGT009835 D(3) dopamine receptor 1814 reviewed G-protein coupled receptor
P35558 BXGT009847 Phosphoenolpyruvate carboxykinase, cytosolic [GTP] 5105 reviewed Kinase
P36222 BXGT009914 Chitinase-3-like protein 1 1116 reviewed
P36544 BXGT009926 Neuronal acetylcholine receptor subunit alpha-7 89832 reviewed
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma 5468 reviewed Nuclear receptor
P37840 BXGT010015 Alpha-synuclein 6622 reviewed Transporter
P41597 BXGT010268 C-C chemokine receptor type 2 729230 reviewed
P42574 BXGT010317 Caspase-3 836 reviewed Enzyme
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P47712 BXGT010577 Cytosolic phospholipase A2 5321 reviewed Enzyme
P48357 BXGT010627 Leptin receptor 3953 reviewed Signaling
P49418 BXGT010704 Amphiphysin 273 reviewed
P49662 BXGT010724 Caspase-4 837 reviewed Enzyme
P49768 BXGT010740 Presenilin-1 5663 reviewed Enzyme
P49810 BXGT010747 Presenilin-2 5664 reviewed Enzyme
P49841 BXGT010750 Glycogen synthase kinase-3 beta 2932 reviewed Kinase
P50406 BXGT010796 5-hydroxytryptamine receptor 6 3362 reviewed G-protein coupled receptor
P51589 BXGT010867 Cytochrome P450 2J2 1573 reviewed
P51681 BXGT010878 C-C chemokine receptor type 5 1234 reviewed G-protein coupled receptor
P52732 BXGT010948 Kinesin-like protein KIF11 3832 reviewed Cellular structure
P53355 BXGT010985 Death-associated protein kinase 1 1612 reviewed Kinase
P55072 BXGT011103 Transitional endoplasmic reticulum ATPase 7415 reviewed
P55210 BXGT011110 Caspase-7 840 reviewed Enzyme
P56817 BXGT011200 Beta-secretase 1 23621 reviewed Enzyme
P58400 BXGT011235 Neurexin-1-beta 9378 reviewed
P60174 BXGT011294 Triosephosphate isomerase 7167 reviewed Enzyme
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P60880 BXGT011335 Synaptosomal-associated protein 25 6616 reviewed Transporter
P62942 BXGT011474 Peptidyl-prolyl cis-trans isomerase FKBP1A 2280 reviewed Enzyme
P62993 BXGT011480 Growth factor receptor-bound protein 2 2885 reviewed
P63261 BXGT011512 Actin, cytoplasmic 2 71 reviewed Cellular structure
P63279 BXGT011514 SUMO-conjugating enzyme UBC9 7329 reviewed
P78310 BXGT011830 Coxsackievirus and adenovirus receptor 1525 reviewed
P78380 BXGT011841 Oxidized low-density lipoprotein receptor 1 4973 reviewed
P78417 BXGT011843 Glutathione S-transferase omega-1 9446 reviewed
P98155 BXGT012226 Very low-density lipoprotein receptor 7436 reviewed
Q00059 BXGT012512 Transcription factor A, mitochondrial 7019 reviewed
Q01105 BXGT012569 Protein SET 6418 reviewed Enzyme modulator
Q01726 BXGT012610 Melanocyte-stimulating hormone receptor 4157 reviewed G-protein coupled receptor
Q07812 BXGT012940 Apoptosis regulator BAX 581 reviewed Signaling
Q07869 BXGT012945 Peroxisome proliferator-activated receptor alpha 5465 reviewed Nuclear receptor
Q07954 BXGT012950 Prolow-density lipoprotein receptor-related protein 1 4035 reviewed
Q12772 BXGT013262 Sterol regulatory element-binding protein 2 6721 reviewed
Q13093 BXGT013310 Platelet-activating factor acetylhydrolase 7941 reviewed Enzyme
Q13148 BXGT013318 TAR DNA-binding protein 43 23435 reviewed
Q13470 BXGT013359 Non-receptor tyrosine-protein kinase TNK1 8711 reviewed Kinase
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 5300 reviewed
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A 1859 reviewed Kinase
Q13976 BXGT013409 cGMP-dependent protein kinase 1 5592 reviewed Kinase
Q14116 BXGT013442 Interleukin-18 3606 reviewed
Q14289 BXGT013459 Protein-tyrosine kinase 2-beta 2185 reviewed Kinase
Q15303 BXGT013557 Receptor tyrosine-protein kinase erbB-4 2066 reviewed Kinase
Q15392 BXGT013566 Delta(24)-sterol reductase 1718 reviewed Enzyme
Q15848 BXGT013609 Adiponectin 9370 reviewed
Q16555 BXGT013638 Dihydropyrimidinase-related protein 2 1808 reviewed Enzyme
Q30154 BXGT014296 HLA class II histocompatibility antigen, DR beta 5 chain 3127 reviewed Immune response
Q30201 BXGT014297 Hereditary hemochromatosis protein 3077 reviewed
Q5S007 BXGT015650 Leucine-rich repeat serine/threonine-protein kinase 2 120892 reviewed Kinase
Q5TCY1 BXGT015853 Tau-tubulin kinase 1 84630 reviewed Kinase
Q6XZF7 BXGT016615 Dynamin-binding protein 23268 reviewed
Q8IXJ6 BXGT018362 NAD-dependent protein deacetylase sirtuin-2 22933 reviewed Epigenetic regulator
Q8NFU5 BXGT018564 Inositol polyphosphate multikinase 253430 reviewed Kinase
Q92542 BXGT019354 Nicastrin 23385 reviewed
Q92692 BXGT019361 Nectin-2 5819 reviewed
Q92835 BXGT019382 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 3635 reviewed
Q92993 BXGT019403 Histone acetyltransferase KAT5 10524 reviewed
Q96AC1 BXGT019617 Fermitin family homolog 2 10979 reviewed
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 23411 reviewed Epigenetic regulator
Q96FI4 BXGT019658 Endonuclease 8-like 1 79661 reviewed
Q96L34 BXGT019689 MAP/microtubule affinity-regulating kinase 4 57787 reviewed Kinase
Q96P20 BXGT019704 NACHT, LRR and PYD domains-containing protein 3 114548 reviewed
Q96QK1 BXGT019720 Vacuolar protein sorting-associated protein 35 55737 reviewed Transporter
Q9H251 BXGT020449 Cadherin-23 64072 reviewed
Q9H4W6 BXGT020478 Transcription factor COE3 253738 reviewed
Q9NYZ4 BXGT021265 Sialic acid-binding Ig-like lectin 8 27181 reviewed Receptor
Q9NZ42 BXGT021268 Gamma-secretase subunit PEN-2 55851 reviewed
Q9P212 BXGT021297 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 51196 reviewed Enzyme
Q9P2R7 BXGT021304 Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial 8803 reviewed Enzyme
Q9UBC3 BXGT021650 DNA (cytosine-5)-methyltransferase 3B 1789 reviewed
Q9UBK8 BXGT021655 Methionine synthase reductase 4552 reviewed
Q9UHD2 BXGT021697 Serine/threonine-protein kinase TBK1 29110 reviewed Kinase
Q9UHI8 BXGT021701 A disintegrin and metalloproteinase with thrombospondin motifs 1 9510 reviewed Enzyme
Q9UKV5 BXGT021751 E3 ubiquitin-protein ligase AMFR 267 reviewed
Q9Y219 BXGT022206 Protein jagged-2 3714 reviewed
Q9Y2I1 BXGT022235 Nischarin 11188 reviewed Enzyme modulator
Q9Y5Z0 BXGT022310 Beta-secretase 2 25825 reviewed Enzyme
Q9Y6A2 BXGT022324 Cholesterol 24-hydroxylase 10858 reviewed Enzyme
Q9Y6K1 BXGT022331 DNA (cytosine-5)-methyltransferase 3A 1788 reviewed
P04439 BXGT022649 HLA class I histocompatibility antigen, A-3 alpha chain 3105 reviewed
P20138 BXGT023857 Myeloid cell surface antigen CD33 945 reviewed Receptor
Q8IX03 BXGT024000 Protein KIBRA 23286 reviewed
O95140 BXGT024482 Mitofusin-2 9927 reviewed Enzyme
P0DP25 BXGT024595 Calmodulin-3 808 reviewed
Q8IXL7 BXGT025314 Methionine-R-sulfoxide reductase B3 253827 reviewed
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease