Showing entry for Nicotine Dependence


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD002066
Disease NameNicotine Dependence
Disease CUI IdC0028043
MeSH Codes C25   F03  
Disease Class NameChemically-Induced Disorders; Mental Disorders
Semantic TypeMental or Behavioral Dysfunction
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id DOID:150  
Disease Ontology Class Namedisease of mental health
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00213 BXGT003896 Amyloid-beta A4 precursor protein-binding family B member 1 322 reviewed
O00519 BXGT003934 Fatty-acid amide hydrolase 1 2166 reviewed
O14920 BXGT004110 Inhibitor of nuclear factor kappa-B kinase subunit beta 3551 reviewed Kinase
O43612 BXGT004605 Orexin 3060 reviewed
O43614 BXGT004606 Orexin receptor type 2 3062 reviewed G-protein coupled receptor
O60218 BXGT004858 Aldo-keto reductase family 1 member B10 57016 reviewed Enzyme
O60760 BXGT004899 Hematopoietic prostaglandin D synthase 27306 reviewed
O75899 BXGT005161 Gamma-aminobutyric acid type B receptor subunit 2 9568 reviewed G-protein coupled receptor
O95166 BXGT005353 Gamma-aminobutyric acid receptor-associated protein 11337 reviewed Cellular structure
O95264 BXGT005367 5-hydroxytryptamine receptor 3B 9177 reviewed Ion channel
O95398 BXGT005378 Rap guanine nucleotide exchange factor 3 10411 reviewed Enzyme modulator
O95954 BXGT005408 Formimidoyltransferase-cyclodeaminase 10841 reviewed Enzyme
P00325 BXGT005498 Alcohol dehydrogenase 1B 125 reviewed Enzyme
P00326 BXGT005499 Alcohol dehydrogenase 1C 126 reviewed Enzyme
P00747 BXGT005639 Plasminogen 5340 reviewed Enzyme
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P02708 BXGT005927 Acetylcholine receptor subunit alpha 1134 reviewed Ion channel
P02741 BXGT005936 C-reactive protein 1401 reviewed
P02751 BXGT005943 Fibronectin 2335 reviewed Signaling
P04054 BXGT006136 Phospholipase A2 5319 reviewed Enzyme
P04150 BXGT006154 Glucocorticoid receptor 2908 reviewed Nuclear receptor
P05067 BXGT006306 Amyloid-beta precursor protein 351 reviewed Enzyme modulator
P05091 BXGT006312 Aldehyde dehydrogenase, mitochondrial 217 reviewed Enzyme
P05181 BXGT006337 Cytochrome P450 2E1 1571 reviewed
P05231 BXGT006345 Interleukin-6 3569 reviewed
P06850 BXGT006511 Corticoliberin 1392 reviewed Signaling
P07101 BXGT006547 Tyrosine 3-monooxygenase 7054 reviewed
P07510 BXGT006631 Acetylcholine receptor subunit gamma 1146 reviewed Ion channel
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 1129 reviewed G-protein coupled receptor
P09172 BXGT006865 Dopamine beta-hydroxylase 1621 reviewed
P09488 BXGT006899 Glutathione S-transferase Mu 1 2944 reviewed
P10145 BXGT007542 Interleukin-8 3576 reviewed Signaling
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 1128 reviewed G-protein coupled receptor
P11230 BXGT007677 Acetylcholine receptor subunit beta 1140 reviewed Ion channel
P11509 BXGT007716 Cytochrome P450 2A6 1548 reviewed
P12821 BXGT007849 Angiotensin-converting enzyme 1636 reviewed Enzyme
P13796 BXGT007956 Plastin-2 3936 reviewed Cellular structure
P14416 BXGT008011 D(2) dopamine receptor 1813 reviewed G-protein coupled receptor
P14550 BXGT008019 Aldo-keto reductase family 1 member A1 10327 reviewed Enzyme
P17643 BXGT008323 5,6-dihydroxyindole-2-carboxylic acid oxidase 7306 reviewed Enzyme
P17787 BXGT008341 Neuronal acetylcholine receptor subunit beta-2 1141 reviewed Ion channel
P17900 BXGT008353 Ganglioside GM2 activator 2760 reviewed Transporter
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit 4790 reviewed Transcription factor
P20711 BXGT008594 Aromatic-L-amino-acid decarboxylase 1644 reviewed
P20813 BXGT008603 Cytochrome P450 2B6 1555 reviewed
P20815 BXGT008604 Cytochrome P450 3A5 1577 reviewed Enzyme
P21397 BXGT008644 Amine oxidase [flavin-containing] A 4128 reviewed
P21554 BXGT008662 Cannabinoid receptor 1 1268 reviewed G-protein coupled receptor
P21728 BXGT008686 D(1A) dopamine receptor 1812 reviewed G-protein coupled receptor
P21917 BXGT008707 D(4) dopamine receptor 1815 reviewed G-protein coupled receptor
P21918 BXGT008708 D(1B) dopamine receptor 1816 reviewed G-protein coupled receptor
P21964 BXGT008714 Catechol O-methyltransferase 1312 reviewed Enzyme
P22303 BXGT008751 Acetylcholinesterase 43 reviewed Enzyme
P23560 BXGT008883 Brain-derived neurotrophic factor 627 reviewed Signaling
P25116 BXGT009025 Proteinase-activated receptor 1 2149 reviewed G-protein coupled receptor
P25942 BXGT009079 Tumor necrosis factor receptor superfamily member 5 958 reviewed
P27169 BXGT009161 Serum paraoxonase/arylesterase 1 5444 reviewed
P27708 BXGT009202 CAD protein 790 reviewed Enzyme
P28223 BXGT009239 5-hydroxytryptamine receptor 2A 3356 reviewed G-protein coupled receptor
P28329 BXGT009251 Choline O-acetyltransferase 1103 reviewed Enzyme
P30532 BXGT009433 Neuronal acetylcholine receptor subunit alpha-5 1138 reviewed Ion channel
P30711 BXGT009460 Glutathione S-transferase theta-1 2952 reviewed
P30926 BXGT009482 Neuronal acetylcholine receptor subunit beta-4 1143 reviewed Ion channel
P31513 BXGT009546 Dimethylaniline monooxygenase [N-oxide-forming] 3 2328 reviewed Enzyme
P31645 BXGT009558 Sodium-dependent serotonin transporter 6532 reviewed Transporter
P32297 BXGT009616 Neuronal acetylcholine receptor subunit alpha-3 1136 reviewed Ion channel
P34998 BXGT009781 Corticotropin-releasing factor receptor 1 1394 reviewed
P35372 BXGT009823 Mu-type opioid receptor 4988 reviewed G-protein coupled receptor
P35462 BXGT009835 D(3) dopamine receptor 1814 reviewed G-protein coupled receptor
P35869 BXGT009877 Aryl hydrocarbon receptor 196 reviewed Transcription factor
P36544 BXGT009926 Neuronal acetylcholine receptor subunit alpha-7 89832 reviewed
P40394 BXGT010178 Alcohol dehydrogenase class 4 mu/sigma chain 131 reviewed Enzyme
P41145 BXGT010225 Kappa-type opioid receptor 4986 reviewed G-protein coupled receptor
P41594 BXGT010266 Metabotropic glutamate receptor 5 2915 reviewed G-protein coupled receptor
P43681 BXGT010407 Neuronal acetylcholine receptor subunit alpha-4 1137 reviewed Ion channel
P46098 BXGT010507 5-hydroxytryptamine receptor 3A 3359 reviewed Ion channel
P47869 BXGT010590 Gamma-aminobutyric acid receptor subunit alpha-2 2555 reviewed Ion channel
P48051 BXGT010611 G protein-activated inward rectifier potassium channel 2 3763 reviewed Ion channel
P48058 BXGT010614 Glutamate receptor 4 2893 reviewed Ion channel
P48169 BXGT010622 Gamma-aminobutyric acid receptor subunit alpha-4 2557 reviewed Ion channel
P49146 BXGT010681 Neuropeptide Y receptor type 2 4887 reviewed G-protein coupled receptor
P49773 BXGT010741 Histidine triad nucleotide-binding protein 1 3094 reviewed Enzyme
P58400 BXGT011235 Neurexin-1-beta 9378 reviewed
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P60709 BXGT011322 Actin, cytoplasmic 1 60 reviewed Cellular structure
P61586 BXGT011375 Transforming protein RhoA 387 reviewed Enzyme modulator
P78334 BXGT011834 Gamma-aminobutyric acid receptor subunit epsilon 2564 reviewed Ion channel
P78352 BXGT011836 Disks large homolog 4 1742 reviewed Receptor
Q01959 BXGT012624 Sodium-dependent dopamine transporter 6531 reviewed Transporter
Q02083 BXGT012633 N-acylethanolamine-hydrolyzing acid amidase 27163 reviewed Enzyme
Q05193 BXGT012810 Dynamin-1 1759 reviewed Enzyme modulator
Q05901 BXGT012842 Neuronal acetylcholine receptor subunit beta-3 1142 reviewed Ion channel
Q05940 BXGT012846 Synaptic vesicular amine transporter 6571 reviewed Transporter
Q07001 BXGT012907 Acetylcholine receptor subunit delta 1144 reviewed Ion channel
Q07869 BXGT012945 Peroxisome proliferator-activated receptor alpha 5465 reviewed Nuclear receptor
Q13002 BXGT013303 Glutamate receptor ionotropic, kainate 2 2898 reviewed Ion channel
Q14416 BXGT013468 Metabotropic glutamate receptor 2 2912 reviewed G-protein coupled receptor
Q14831 BXGT013506 Metabotropic glutamate receptor 7 2917 reviewed G-protein coupled receptor
Q15303 BXGT013557 Receptor tyrosine-protein kinase erbB-4 2066 reviewed Kinase
Q15822 BXGT013602 Neuronal acetylcholine receptor subunit alpha-2 1135 reviewed Ion channel
Q15825 BXGT013603 Neuronal acetylcholine receptor subunit alpha-6 8973 reviewed Ion channel
Q16566 BXGT013639 Calcium/calmodulin-dependent protein kinase type IV 814 reviewed Kinase
Q16568 BXGT013640 Cocaine- and amphetamine-regulated transcript protein 9607 reviewed
Q16620 BXGT013645 BDNF/NT-3 growth factors receptor 4915 reviewed Kinase
Q16696 BXGT013658 Cytochrome P450 2A13 1553 reviewed
Q8IZS8 BXGT018372 Voltage-dependent calcium channel subunit alpha-2/delta-3 55799 reviewed Ion channel
Q8NFD2 BXGT018559 Ankyrin repeat and protein kinase domain-containing protein 1 255239 reviewed Kinase
Q8TCU5 BXGT018802 Glutamate receptor ionotropic, NMDA 3A 116443 reviewed Ion channel
Q8WZA2 BXGT019025 Rap guanine nucleotide exchange factor 4 11069 reviewed Enzyme modulator
Q96KS0 BXGT019688 Egl nine homolog 2 112398 reviewed
Q96RJ0 BXGT019728 Trace amine-associated receptor 1 134864 reviewed G-protein coupled receptor
Q9GZZ6 BXGT020429 Neuronal acetylcholine receptor subunit alpha-10 57053 reviewed Ion channel
Q9UBC3 BXGT021650 DNA (cytosine-5)-methyltransferase 3B 1789 reviewed
Q9UBS5 BXGT021662 Gamma-aminobutyric acid type B receptor subunit 1 2550 reviewed G-protein coupled receptor
Q9UGM1 BXGT021686 Neuronal acetylcholine receptor subunit alpha-9 55584 reviewed Ion channel
P35240 BXGT022927 Merlin 4771 reviewed
O75976 BXGT022954 Carboxypeptidase D 1362 reviewed
P17752 BXGT023118 Tryptophan 5-hydroxylase 1 7166 reviewed
Q14678 BXGT023543 KN motif and ankyrin repeat domain-containing protein 1 23189 reviewed
Q8N122 BXGT026091 Regulatory-associated protein of mTOR 57521 reviewed
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease