adisease

Showing entry for Senile Plaques

General Disease Information
BXGD Id	BXGD006954
Disease Name	Senile Plaques
Disease CUI Id	C0333463
MeSH Codes	C23
Disease Class Name	Pathological Conditions, Signs and Symptoms
Semantic Type	Acquired Abnormality
Human Phenotype Ontology Id	HP:0000707
Human Phenotype Ontology Term	Abnormality of the nervous system
Disease Ontology Id
Disease Ontology Class Name
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
F7VJQ1	BXGT003310	Alternative prion protein	5621	reviewed
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O00213	BXGT003896	Amyloid-beta A4 precursor protein-binding family B member 1	322	reviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O14558	BXGT004070	Heat shock protein beta-6	126393	reviewed
O14672	BXGT004081	Disintegrin and metalloproteinase domain-containing protein 10	102	reviewed
O15455	BXGT004171	Toll-like receptor 3	7098	reviewed	Receptor
O60760	BXGT004899	Hematopoietic prostaglandin D synthase	27306	reviewed
O75716	BXGT005147	Serine/threonine-protein kinase 16	8576	reviewed	Kinase
O95477	BXGT005383	Phospholipid-transporting ATPase ABCA1	19	reviewed	Transporter
O95631	BXGT005387	Netrin-1	9423	reviewed	Enzyme modulator
P00441	BXGT005540	Superoxide dismutase [Cu-Zn]	6647	reviewed	Enzyme
P00736	BXGT005632	Complement C1r subcomponent	715	reviewed	Enzyme
P01011	BXGT005715	Alpha-1-antichymotrypsin	12	reviewed	Enzyme modulator
P01019	BXGT005717	Angiotensinogen	183	reviewed	Enzyme modulator
P01023	BXGT005718	Alpha-2-macroglobulin	2	reviewed	Enzyme modulator
P01034	BXGT005721	Cystatin-C	1471	reviewed
P01042	BXGT005722	Kininogen-1	3827	reviewed	Enzyme modulator
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01215	BXGT005743	Glycoprotein hormones alpha chain	1081	reviewed
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02766	BXGT005953	Transthyretin	7276	reviewed	Transporter
P02768	BXGT005955	Serum albumin	213	reviewed	Transporter
P04156	BXGT006156	Major prion protein	5621	reviewed
P04271	BXGT006177	Protein S100-B	6285	reviewed	Calcium-binding protein
P04792	BXGT006264	Heat shock protein beta-1	3315	reviewed
P05067	BXGT006306	Amyloid-beta precursor protein	351	reviewed	Enzyme modulator
P05164	BXGT006333	Myeloperoxidase	4353	reviewed	Enzyme
P05230	BXGT006344	Fibroblast growth factor 1	2246	reviewed	Signaling
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05362	BXGT006350	Intercellular adhesion molecule 1	3383	reviewed
P06276	BXGT006430	Cholinesterase	590	reviewed
P06493	BXGT006445	Cyclin-dependent kinase 1	983	reviewed	Kinase
P06702	BXGT006476	Protein S100-A9	6280	reviewed	Calcium-binding protein
P06703	BXGT006477	Protein S100-A6	6277	reviewed	Calcium-binding protein
P06730	BXGT006487	Eukaryotic translation initiation factor 4E	1977	reviewed	Nucleic acid binding
P06744	BXGT006494	Glucose-6-phosphate isomerase	2821	reviewed	Enzyme
P06858	BXGT006515	Lipoprotein lipase	4023	reviewed	Enzyme
P07339	BXGT006604	Cathepsin D	1509	reviewed	Enzyme
P08473	BXGT006773	Neprilysin	4311	reviewed	Enzyme
P09104	BXGT006856	Gamma-enolase	2026	reviewed	Enzyme
P09466	BXGT006892	Glycodelin	5047	reviewed	Enzyme
P09601	BXGT006909	Heme oxygenase 1	3162	reviewed
P09619	BXGT006911	Platelet-derived growth factor receptor beta	5159	reviewed	Kinase
P09917	BXGT006941	Arachidonate 5-lipoxygenase	240	reviewed	Enzyme
P0CG47	BXGT007467	Polyubiquitin-B	7314	reviewed	Nucleic acid binding
P10636	BXGT007596	Microtubule-associated protein tau	4137	reviewed
P10909	BXGT007630	Clusterin	1191	reviewed
P11137	BXGT007656	Microtubule-associated protein 2	4133	reviewed
P11597	BXGT007727	Cholesteryl ester transfer protein	1071	reviewed
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P14735	BXGT008042	Insulin-degrading enzyme	3416	reviewed	Enzyme
P15104	BXGT008081	Glutamine synthetase	2752	reviewed	Enzyme
P17516	BXGT008313	Aldo-keto reductase family 1 member C4	1109	reviewed	Enzyme
P19525	BXGT008492	Interferon-induced, double-stranded RNA-activated protein kinase	5610	reviewed	Kinase
P20591	BXGT008586	Interferon-induced GTP-binding protein Mx1	4599	reviewed	Enzyme modulator
P20810	BXGT008602	Calpastatin	831	reviewed
P22303	BXGT008751	Acetylcholinesterase	43	reviewed	Enzyme
P23297	BXGT008848	Protein S100-A1	6271	reviewed	Calcium-binding protein
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P24385	BXGT008965	G1/S-specific cyclin-D1	595	reviewed	Enzyme modulator
P25713	BXGT009062	Metallothionein-3	4504	reviewed
P27338	BXGT009172	Amine oxidase [flavin-containing] B	4129	reviewed
P28300	BXGT009243	Protein-lysine 6-oxidase	4015	reviewed
P28329	BXGT009251	Choline O-acetyltransferase	1103	reviewed	Enzyme
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P30556	BXGT009441	Type-1 angiotensin II receptor	185	reviewed	G-protein coupled receptor
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P35052	BXGT009788	Glypican-1	2817	reviewed
P35858	BXGT009876	Insulin-like growth factor-binding protein complex acid labile subunit	3483	reviewed	Receptor
P37840	BXGT010015	Alpha-synuclein	6622	reviewed	Transporter
P41222	BXGT010237	Prostaglandin-H2 D-isomerase	5730	reviewed	Enzyme
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P42574	BXGT010317	Caspase-3	836	reviewed	Enzyme
P42858	BXGT010341	Huntingtin	3064	reviewed
P43220	BXGT010367	Glucagon-like peptide 1 receptor	2740	reviewed	G-protein coupled receptor
P43235	BXGT010368	Cathepsin K	1513	reviewed	Enzyme
P43681	BXGT010407	Neuronal acetylcholine receptor subunit alpha-4	1137	reviewed	Ion channel
P45983	BXGT010494	Mitogen-activated protein kinase 8	5599	reviewed	Kinase
P45984	BXGT010495	Mitogen-activated protein kinase 9	5601	reviewed	Kinase
P46108	BXGT010509	Adapter molecule crk	1398	reviewed
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P48775	BXGT010662	Tryptophan 2,3-dioxygenase	6999	reviewed	Enzyme
P49768	BXGT010740	Presenilin-1	5663	reviewed	Enzyme
P49810	BXGT010747	Presenilin-2	5664	reviewed	Enzyme
P50579	BXGT010812	Methionine aminopeptidase 2	10988	reviewed
P55072	BXGT011103	Transitional endoplasmic reticulum ATPase	7415	reviewed
P55087	BXGT011105	Aquaporin-4	361	reviewed	Ion channel
P56817	BXGT011200	Beta-secretase 1	23621	reviewed	Enzyme
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P60568	BXGT011315	Interleukin-2	3558	reviewed
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
P63096	BXGT011496	Guanine nucleotide-binding protein G(i) subunit alpha-1	2770	reviewed	Enzyme modulator
P63261	BXGT011512	Actin, cytoplasmic 2	71	reviewed	Cellular structure
P78380	BXGT011841	Oxidized low-density lipoprotein receptor 1	4973	reviewed
Q04609	BXGT012768	Glutamate carboxypeptidase 2	2346	reviewed	Enzyme
Q05586	BXGT012826	Glutamate receptor ionotropic, NMDA 1	2902	reviewed	Ion channel
Q07869	BXGT012945	Peroxisome proliferator-activated receptor alpha	5465	reviewed	Nuclear receptor
Q07954	BXGT012950	Prolow-density lipoprotein receptor-related protein 1	4035	reviewed
Q13148	BXGT013318	TAR DNA-binding protein 43	23435	reviewed
Q13155	BXGT013320	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	7965	reviewed
Q13315	BXGT013339	Serine-protein kinase ATM	472	reviewed	Kinase
Q14114	BXGT013441	Low-density lipoprotein receptor-related protein 8	7804	reviewed
Q14978	BXGT013517	Nucleolar and coiled-body phosphoprotein 1	9221	reviewed
Q15109	BXGT013537	Advanced glycosylation end product-specific receptor	177	reviewed	Receptor
Q16539	BXGT013634	Mitogen-activated protein kinase 14	1432	reviewed	Kinase
Q92793	BXGT019374	CREB-binding protein	1387	reviewed
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q96P20	BXGT019704	NACHT, LRR and PYD domains-containing protein 3	114548	reviewed
Q99519	BXGT019928	Sialidase-1	4758	reviewed	Enzyme
Q99523	BXGT019929	Sortilin	6272	reviewed	Transporter
Q99572	BXGT019935	P2X purinoceptor 7	5027	reviewed	Ion channel
Q99714	BXGT019954	3-hydroxyacyl-CoA dehydrogenase type-2	3028	reviewed	Enzyme
Q9C000	BXGT020206	NACHT, LRR and PYD domains-containing protein 1	22861	reviewed
Q9H4A3	BXGT020473	Serine/threonine-protein kinase WNK1	65125	reviewed	Kinase
Q9NP58	BXGT021143	ATP-binding cassette sub-family B member 6, mitochondrial	10058	reviewed	Transporter
Q9NP99	BXGT021148	Triggering receptor expressed on myeloid cells 1	54210	reviewed
Q9NQW7	BXGT021171	Xaa-Pro aminopeptidase 1	7511	reviewed
Q9NRF2	BXGT021185	SH2B adapter protein 1	25970	reviewed
Q9P2R7	BXGT021304	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	8803	reviewed	Enzyme
Q9UKV0	BXGT021750	Histone deacetylase 9	9734	reviewed	Epigenetic regulator
Q9UL54	BXGT021755	Serine/threonine-protein kinase TAO2	9344	reviewed	Kinase
Q9UN36	BXGT021780	Protein NDRG2	57447	reviewed	Enzyme
Q9Y251	BXGT022215	Heparanase	10855	reviewed	Enzyme
Q9Y5Z0	BXGT022310	Beta-secretase 2	25825	reviewed	Enzyme
Q9Y6A2	BXGT022324	Cholesterol 24-hydroxylase	10858	reviewed	Enzyme
Q14186	BXGT023367	Transcription factor Dp-1	7027	reviewed	Nucleic acid binding
O60502	BXGT023392	Protein O-GlcNAcase	10724	reviewed
P25090	BXGT025102	N-formyl peptide receptor 2	2358	reviewed	G-protein coupled receptor

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}