Showing entry for Serine palmitoyltransferase 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004146
Protein NameSerine palmitoyltransferase 2
Uniport IdO15270
GeneSPTLC2
Gene Id9517
DomainAminotran_1_2
Pfam PF00155  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00600 Sphingolipid metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
3. Environmental Information Processing 3.2 Signal transduction hsa04071 Sphingolipid signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0060612 adipose tissue development
Biological Process GO:0046513 ceramide biosynthetic process
Biological Process GO:1904504 positive regulation of lipophagy
Biological Process GO:0046511 sphinganine biosynthetic process
Biological Process GO:0030148 sphingolipid biosynthetic process
Biological Process GO:0006686 sphingomyelin biosynthetic process
Biological Process GO:0046512 sphingosine biosynthetic process
molecular function GO:0030170 pyridoxal phosphate binding
molecular function GO:0004758 serine C-palmitoyltransferase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0017059 serine C-palmitoyltransferase complex
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1660661 Sphingolipid de novo biosynthesis
R-HSA-428157 Sphingolipid metabolism
R-HSA-556833 Metabolism of lipids
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003028 BXGD000170 Anhidrosis Skin and Connective Tissue Diseases
C0007959 BXGD000507 Charcot-Marie-Tooth Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013364 BXGD000819 Dysautonomia, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0016506 BXGD001062 Foot Deformities Musculoskeletal Diseases
C0018932 BXGD001251 Hematochezia Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0020071 BXGD001356 Hereditary Sensory Autonomic Neuropathy, Type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027889 BXGD002057 Hereditary Sensory and Autonomic Neuropathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0029443 BXGD002152 Osteomyelitis Infections; Musculoskeletal Diseases
C0031117 BXGD002285 Peripheral Neuropathy Nervous System Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0037299 BXGD002685 Skin Ulcer Skin and Connective Tissue Diseases
C0200635 BXGD004041 Lymphocyte Count measurement
C0206664 BXGD004226 Teratocarcinoma Neoplasms
C0392699 BXGD008064 Dysesthesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0427065 BXGD008604 Distal muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0442874 BXGD008814 Neuropathy Nervous System Diseases
C0699739 BXGD009861 Sensory Neuropathy, Hereditary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1112256 BXGD011655 Sensorimotor neuropathy
C1833222 BXGD013903 Autoamputation
C1836527 BXGD014127 Distal sensory impairment of all modalities
C1847584 BXGD014876 Distal sensory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2932678 BXGD018098 Inherited Peripheral Neuropathy Nervous System Diseases
C3150896 BXGD018348 NEUROPATHY, HEREDITARY SENSORY AND AUTONOMIC, TYPE IC
C4016942 BXGD020392 NEUROPATHY, HEREDITARY SENSORY AND AUTONOMIC, TYPE IC, SEVERE
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0028981 Serine 105.04
BXGC0043088 Pyridoxal Phosphate 247.02
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein