Showing entry for Serine


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0028981
Compound NameSerine
Structure
FormulaC3H7NO3
InchiKeyMTCFGRXMJLQNBG-REOHCLBHSA-N
SMILESOC[C@@H](C(=O)O)N
InchiInChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
IUPAC(2S)-2-azaniumyl-3-hydroxypropanoate
Molecular Weight105.04
Pubchem Id5951
Chembl IdCHEMBL11298
Targets of Information Source
DrugBank DB00133
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P35520 BXGT009842 Cystathionine beta-synthase reviewed - CBS investigational; nutraceutical -
P20132 BXGT008546 L-serine dehydratase/L-threonine deaminase reviewed Enzyme SDS investigational; nutraceutical -
Q9GZT4 BXGT020424 Serine racemase reviewed Enzyme SRR investigational; nutraceutical -
O15270 BXGT004146 Serine palmitoyltransferase 2 reviewed Enzyme SPTLC2 investigational; nutraceutical -
O15269 BXGT004145 Serine palmitoyltransferase 1 reviewed Enzyme SPTLC1 investigational; nutraceutical -
P49591 BXGT010715 Serine--tRNA ligase, cytoplasmic reviewed Enzyme SARS investigational; nutraceutical -
P21549 BXGT008661 Serine--pyruvate aminotransferase reviewed Enzyme AGXT investigational; nutraceutical -
PDB SER
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P0A2K1 BXGT006999 Tryptophan synthase beta chain reviewed trpB - - - - -
P73797 BXGT011727 Slr1257 protein unreviewed slr1257 - - - - -
Q7SIB6 BXGT017110 Serine hydroxymethyltransferase unreviewed glyA - - - - -
P78330 BXGT011833 Phosphoserine phosphatase reviewed PSPH Enzyme - - - -
P11838 BXGT007752 Endothiapepsin reviewed EAPA - - - - -
P0A9T0 BXGT007200 D-3-phosphoglycerate dehydrogenase reviewed serA - - - - -
O31562 BXGT004400 Putative metal-dependent hydrolase YfiT reviewed yfiT - - - - -
P0A8M3 BXGT007148 Threonine--tRNA ligase reviewed thrS - - - - -
O58307 BXGT004788 Alanyl-tRNA editing protein AlaX-S reviewed alaXS - - - - -
P21742 BXGT008688 Beta-hordothionin reviewed THI1.2 - - - - -
Q00022 BXGT012510 Agaricus bisporus lectin reviewed - - - - -
O67323 BXGT004988 Alanine--tRNA ligase reviewed alaS - - - - -
Q46AN5 BXGT014672 Type-2 serine--tRNA ligase reviewed serS2 - - - - -
Q5SI02 BXGT015700 1-pyrroline-5-carboxylate dehydrogenase unreviewed TTHA1578 - - - - -
Q9UZ14 BXGT021845 Threonine--tRNA ligase reviewed thrS - - - - -
P52011 BXGT010916 Peptidyl-prolyl cis-trans isomerase 3 reviewed cyn-3 - - - - -
Q9H5I1 BXGT020480 Histone-lysine N-methyltransferase SUV39H2 reviewed SUV39H2 - - - - -
P0AGL2 BXGT007378 Putative reactive intermediate deaminase TdcF reviewed tdcF - - - - -
Q93AT8 BXGT019479 AcsD unreviewed acsD - - - - -
O59791 BXGT004854 Serine racemase reviewed SRR - - - - -
A7BFV6 BXGT001549 8-amino-7-oxononanoate synthase unreviewed spt - - - - -
P02942 BXGT005995 Methyl-accepting chemotaxis protein I reviewed tsr - - - - -
P33183 BXGT009700 Nigrin b reviewed - - - - -
P62937 BXGT011471 Peptidyl-prolyl cis-trans isomerase A reviewed PPIA - - - - -
P9WNX3 BXGT012430 D-3-phosphoglycerate dehydrogenase reviewed serA - - - - -
P0A6D3 BXGT007048 3-phosphoshikimate 1-carboxyvinyltransferase reviewed aroA - - - - -
Q834W6 BXGT017459 Hydrophobic dipeptide epimerase reviewed EF_1511 - - - - -
P00784 BXGT005655 Papain reviewed - - - - -
Q9ZVL6 BXGT022484 UPF0603 protein At1g54780, chloroplastic reviewed At1g54780 - - - - -
Q9U8X2 BXGT021647 Serine acetyltransferase unreviewed EhSAT - - - - -
P04825 BXGT006271 Aminopeptidase N reviewed pepN - - - - -
O60844 BXGT004902 Zymogen granule membrane protein 16 reviewed ZG16 - - - - -
P14618 BXGT008027 Pyruvate kinase PKM reviewed PKM Kinase - - 200000 -
Q8ZNT7 BXGT019225 D-cysteine desulfhydrase reviewed dcyD - - - - -
R4GRU5 BXGT022494 BEL-beta trefoil unreviewed - - - - -
E9P5T5 BXGT003186 Glutamate receptor 1 unreviewed - - - 24000 -
Q5H4T8 BXGT015393 Cystathionine gamma-lyase-like protein unreviewed metB - - - - -
I1KHY6 BXGT003651 Uncharacterized protein unreviewed 100815091 - - - - -
P53634 BXGT011007 Dipeptidyl peptidase 1 reviewed CTSC Enzyme - - - -
B4ECY9 BXGT002106 Serine hydroxymethyltransferase unreviewed glyA - - - - -
A5K8L9 BXGT001342 Serine hydroxymethyltransferase, putative unreviewed PVX_100730 - - - - -
P49591 BXGT010715 Serine--tRNA ligase, cytoplasmic reviewed SARS1 Enzyme - - - -
A0A0M3KKZ0 BXGT000558 Glucosyltransferase 3 reviewed gtf3 - - - - -
P14618 BXGT008027 Pyruvate kinase PKM reviewed PKM Kinase - - - -
A0A0R4I973 BXGT000600 ML032222a iGluR unreviewed ML032222a - - - - -
Q2MGH6 BXGT014137 Endo-alpha-N-acetylgalactosaminidase reviewed SP_0368 - - - - -
P12821 BXGT007849 Angiotensin-converting enzyme reviewed ACE Enzyme - - - -
A0A0H3AES3 BXGT000372 Methyl-accepting chemotaxis protein unreviewed VC0395_0316 - - - 3600 -
Q9HVM5 BXGT020621 Lipoprotein signal peptidase reviewed lspA - - - - -
Q9U1M8 BXGT021634 Myosin-I heavy chain reviewed myoI - - - - -
A0QJI1 BXGT000866 Phosphoserine phosphatase reviewed serB - - - - -
G8UQY8 BXGT003563 Serpin unreviewed BFO_3114 - - - - -
K5BDL0 BXGT003783 Uncharacterized protein reviewed ggh - - - - -
A0A0H3KGN3 BXGT000452 Trehalose-6-phosphate synthase unreviewed otsA - - - - -
Q8RE94 BXGT018710 Cysteine synthase unreviewed FN1220 - - - - -
D6PBM7 BXGT002982 NAD dependent epimerase/dehydratase family unreviewed - - - - -
P9WNY5 BXGT012431 Probable 3-hydroxyisobutyrate dehydrogenase reviewed mmsB - - - - -
O59010 BXGT004824 Glutamate transporter homolog reviewed PH1295 - - - - -
Q5ZX43 BXGT015949 Cystathionine beta-lyase unreviewed metC - - - - -
Q15465 BXGT013573 Sonic hedgehog protein reviewed SHH - - - - -
D4S0D1 BXGT024227 3-dehydroquinate dehydratase unreviewed aroQ - - - - -
P50383 BXGT010793 Tryptophan synthase beta chain 1 reviewed trpB1 - - - - -
A0A4V8GZY3 BXGT024253 BPa0997 unreviewed - - - - -
A0A4V8GZY4 BXGT024254 BPa0997 unreviewed - - - - -
P03952 BXGT006118 Plasma kallikrein reviewed KLKB1 Enzyme - - - -
Q9KQ43 BXGT024361 Methyl-accepting chemotaxis protein unreviewed VC_2161 - - - 18300 -
A0A2K6VKP7 BXGT000786 Uncharacterized protein unreviewed - - - - -
P31013 BXGT009498 Tyrosine phenol-lyase reviewed tpl - - - - -
Q3K7T6 BXGT025274 Putative methyl-accepting chemotaxis protein unreviewed Pfl01_4431 - - - - -
Q8YYB7 BXGT025517 Type II site-specific deoxyribonuclease unreviewed alr0933 - - - - -
Q94C74 BXGT025589 Serine hydroxymethyltransferase 2, mitochondrial reviewed SHM2 - - - - -
A0A0D6FWC1 BXGT025812 Tryptophan synthase alpha chain unreviewed trpA - - - - -
A0A0F7J6T4 BXGT025813 Tryptophan synthase beta chain unreviewed trpB - - - - -
Binding DB 50357212
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT011959 Cholinesterase reviewed BCHE - 16 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 15 - -
reviewed BXGT017247 Proton-coupled amino acid transporter 1 reviewed Transporter SLC36A1 35000000 - - -
CHEMBL CHEMBL11298
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 AC50 - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 AC50 - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 AC50 - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 AC50 - - -
P07314 BXGT006597 Glutathione hydrolase 1 proenzyme reviewed - Ggt1 Ki '=' 50000 nM
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 100000 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 AC50 - - -
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 63095 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 39810 nM
P19145 BXGT008463 General amino-acid permease GAP1 reviewed - GAP1 Activity - - -
Q91Y77 BXGT019323 Monocarboxylate transporter 10 reviewed - Slc16a10 Activity - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 AC50 '=' 39810 nM
P15917 BXGT008169 Lethal factor reviewed - lef Potency '=' 1000 nM
P43007 BXGT010350 Neutral amino acid transporter A reviewed Transporter SLC1A4 IC50 '=' 292000 nM
P08482 BXGT006775 Muscarinic acetylcholine receptor M1 reviewed - Chrm1 Potency '=' 11 nM
P08482 BXGT006775 Muscarinic acetylcholine receptor M1 reviewed - Chrm1 Potency '=' 19952 nM
Q9Z1J7 BXGT022405 Amino acid transporter unreviewed - Slc1a5 IC50 '=' 57900 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 354 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 15 nM
Q7Z2H8 BXGT017247 Proton-coupled amino acid transporter 1 reviewed Transporter SLC36A1 pKi '=' -1 mM
A0A1I7V8J2 BXGT000726 Uncharacterized protein unreviewed - Ki '=' 400000 nM
Q15758 BXGT013594 Neutral amino acid transporter B(0) reviewed Transporter SLC1A5 IC50 '=' 822000 nM
Q7Z2H8 BXGT017247 Proton-coupled amino acid transporter 1 reviewed Transporter SLC36A1 Ki '=' 35000000 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 16 nM
Q9Z1J7 BXGT022405 Amino acid transporter unreviewed - Slc1a5 IC50 '=' 94000 nM
Q9Z1J7 BXGT022405 Amino acid transporter unreviewed - Slc1a5 Inhibition '>=' 25 %
P63116 BXGT011501 Asc-type amino acid transporter 1 reviewed - Slc7a10 IC50 '=' 9600 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00008 Garlic Allium sativum Herbs and Spices
BXGF00027 Chinese mustard Brassica juncea Vegetables
BXGF00337 Ginkgo nuts Ginkgo biloba Herbs and Spices
BXGF00380 White mustard Sinapis alba Herbs and Spices
BXGF00979 Cistanche deserticola Cistanche deserticola Medicinal Plant
BXGF01140 Angelica gigas Angelica gigas Medicinal Plant
BXGF01426 Cornus officinalis Cornus officinalis Medicinal Plant
BXGF01972 Ficus simplicissima Ficus simplicissima Medicinal Plant
BXGF02049 Angelica sinensis Angelica sinensis Medicinal Plant
BXGF02054 Shorea uliginosa Shorea uliginosa Others
BXGF02275 Trichosanthes kirilowii maxim Trichosanthes kirilowii maxim Others
BXGF02290 Sonchus microcarpus Sonchus microcarpus Others
BXGF02526 Santalum album Santalum album Medicinal Plant
BXGF02815 Pinellia ternata Pinellia ternata Medicinal Plant
BXGF04842 Angelica acutiloba Angelica acutiloba Medicinal Plant
BXGF04889 Pogostemon cablin Pogostemon cablin Medicinal Plant
BXGF05178 Lilium hansonii Lilium hansonii Medicinal Plant
BXGF05330 Arum ternatum thunb Arum ternatum thunb Others
BXGF06126 Strychnos diplotricha Strychnos diplotricha Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease