Showing entry for Branched-chain-amino-acid aminotransferase, mitochondrial


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004160
Protein NameBranched-chain-amino-acid aminotransferase, mitochondrial
Uniport IdO15382
GeneBCAT2
Gene Id587
DomainAminotran_4
Pfam PF01063  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.5 Amino acid metabolism hsa00270 Cysteine and methionine metabolism
1. Metabolism 1.5 Amino acid metabolism hsa00280 Valine, leucine and isoleucine degradation
1. Metabolism 1.5 Amino acid metabolism hsa00290 Valine, leucine and isoleucine biosynthesis
1. Metabolism 1.8 Metabolism of cofactors and vitamins hsa00770 Pantothenate and CoA biosynthesis
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
1. Metabolism 1.0 Global and overview maps hsa01210 2-Oxocarboxylic acid metabolism
1. Metabolism 1.0 Global and overview maps hsa01230 Biosynthesis of amino acids
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0009082 branched-chain amino acid biosynthetic process
Biological Process GO:0009083 branched-chain amino acid catabolic process
Biological Process GO:1990830 cellular response to leukemia inhibitory factor
Biological Process GO:0006550 isoleucine catabolic process
Biological Process GO:0009098 leucine biosynthetic process
Biological Process GO:0010817 regulation of hormone levels
Biological Process GO:0009099 valine biosynthetic process
molecular function GO:0004084 branched-chain-amino-acid transaminase activity
molecular function GO:0052656 L-isoleucine transaminase activity
molecular function GO:0052654 L-leucine transaminase activity
molecular function GO:0052655 L-valine transaminase activity
cellular component GO:0005759 mitochondrial matrix
cellular component GO:0005739 mitochondrion
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-70895 Branched-chain amino acid catabolism
R-HSA-71291 Metabolism of amino acids and derivatives
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0024776 BXGD001802 Maple Syrup Urine Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0032927 BXGD002381 Precancerous Conditions Neoplasms
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0268568 BXGD005989 Classic Maple Syrup Urine Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0268569 BXGD005990 Intermittent Maple Syrup Urine Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0268573 BXGD005991 Valinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0268574 BXGD005992 Hyperleucine-Isoleucinemia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0282313 BXGD006803 Condition, Preneoplastic Neoplasms
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0751285 BXGD010378 Maple Syrup Urine Disease, Thiamine Responsive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C1306587 BXGD012368 Acute encephalopathy Nervous System Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1611743 BXGD013456 Familial (FPAH)
C1621920 BXGD013467 Intermediate Maple Syrup Urine Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1837461 BXGD014234 SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
C3811653 BXGD019662 Experimental Organism Basal Cell Carcinoma Neoplasms
C4721806 BXGD023772 Carcinoma, Basal Cell Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0003705 Chloride 35.45
BXGC0004277 Acetic acid 60.05
BXGC0005944 3-Methyl-2-oxobutanoic acid 116.12
BXGC0006162 L-Glutamic acid 147.13
BXGC0006215 4-Methyl-2-oxopentanoic acid 130.14
BXGC0022652 Isoleucine 131.09
BXGC0032575 Leucine 131.09
BXGC0034206 pyridoxamine phosphate 248.06
BXGC0043088 Pyridoxal Phosphate 247.02
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein