Showing entry for Leucine


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0032575
Compound NameLeucine
Structure
FormulaC6H13NO2
InchiKeyROHFNLRQFUQHCH-YFKPBYRVSA-N
SMILESN[C@H](C(=O)O)CC(C)C
InchiInChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1
IUPAC(2S)-2-amino-4-methylpentanoic acid
Molecular Weight131.09
Pubchem Id6106
Chembl IdCHEMBL291962
Targets of Information Source
DrugBank DB00149
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Q15031 BXGT013525 Probable leucine--tRNA ligase, mitochondrial reviewed Enzyme LARS2 investigational; nutraceutical -
O15382 BXGT004160 Branched-chain-amino-acid aminotransferase, mitochondrial reviewed Enzyme BCAT2 investigational; nutraceutical -
P54687 BXGT011067 Branched-chain-amino-acid aminotransferase, cytosolic reviewed Enzyme BCAT1 investigational; nutraceutical -
O60294 BXGT004868 tRNA wybutosine-synthesizing protein 4 reviewed - LCMT2 investigational; nutraceutical -
Q9UIC8 BXGT021716 Leucine carboxyl methyltransferase 1 reviewed - LCMT1 investigational; nutraceutical -
Q9P2J5 BXGT021301 Leucine--tRNA ligase, cytoplasmic reviewed - LARS investigational; nutraceutical -
PDB LEU
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P15034 BXGT008072 Xaa-Pro aminopeptidase reviewed pepP - - - - -
P69905 BXGT011649 Hemoglobin subunit alpha reviewed HBA1; - - - - -
P23847 BXGT008916 Periplasmic dipeptide transport protein reviewed dppA - - - - -
P80561 BXGT011917 Aminopeptidase S reviewed SGR_5809 - 12400000 - - -
Q7SIE4 BXGT017123 Leucine--tRNA ligase unreviewed leuS - - - - -
P00727 BXGT005628 Cytosol aminopeptidase reviewed LAP3 - 60 - - -
Q72GM3 BXGT016723 Leucine--tRNA ligase unreviewed leuS - - - - -
P00800 BXGT005661 Thermolysin reviewed npr - - - - -
Q9S446 BXGT021560 Class A sortase SrtA unreviewed srtA - - - - -
Q6STF1 BXGT016527 L-amino-acid oxidase reviewed - - - - -
P08254 BXGT006758 Stromelysin-1 reviewed MMP3 Enzyme - - - -
P04816 BXGT006268 Leucine-specific-binding protein reviewed livK - - - 400 -
P96084 BXGT012167 Proline iminopeptidase reviewed pip - - - - -
P0AD96 BXGT007279 Leu/Ile/Val-binding protein reviewed livJ - - - 2300 -
O67854 BXGT005012 Na(+):neurotransmitter symporter (Snf family) unreviewed snf - - - - -
Q9K0L9 BXGT020863 Transcriptional regulator, AsnC family unreviewed NMB0573 - - - - -
P00777 BXGT005650 Streptogrisin-B reviewed sprB - - - - -
P96896 BXGT012192 Leucine-responsive regulatory protein unreviewed lrp - - - - -
Q08787 BXGT013006 Surfactin synthase subunit 3 reviewed srfAC - - - - -
Q72LL6 BXGT016757 2-aminoadipate transaminase reviewed lysN - - - - -
P0A8P1 BXGT007151 Leucyl/phenylalanyl-tRNA--protein transferase reviewed aat - - - - -
Q72IC1 BXGT016738 Glutamate dehydrogenase unreviewed TT_C1211 - - - - -
Q72IC0 BXGT016737 Glutamate dehydrogenase unreviewed TT_C1212 - - - - -
Q01693 BXGT012606 Bacterial leucyl aminopeptidase reviewed - - - - -
Q01693 BXGT012606 Bacterial leucyl aminopeptidase reviewed - 65000 - - -
Q9WXM1 BXGT021955 L-Ala-D/L-Glu epimerase reviewed TM_0006 - - - - -
O67854 BXGT005012 Na(+):neurotransmitter symporter (Snf family) unreviewed snf - 16 - - -
P9WQB3 BXGT012499 2-isopropylmalate synthase reviewed leuA - - - - -
Q7CX36 BXGT016948 ABC transporter, substrate binding protein (Amino acid) unreviewed Atu2422 - - - - -
Q834W6 BXGT017459 Hydrophobic dipeptide epimerase reviewed EF_1511 - - - - -
Q8XUX2 BXGT019060 Probable substrate-binding periplasmic (Pbp) abc transporter protein unreviewed RSc3061 - - - - -
Q9PPK3 BXGT021347 Glycine--tRNA ligase alpha subunit reviewed glyQ - - - - -
P07813 BXGT006679 Leucine--tRNA ligase reviewed leuS - - - - -
P0A988 BXGT007175 Beta sliding clamp reviewed dnaN - - - - -
Q8YEE8 BXGT019122 Leu/Ile/Val-binding protein homolog 3 reviewed BMEI1930 - - - - -
Q3MFZ5 BXGT014504 Amino acid/amide ABC transporter substrate-binding protein, HAAT family unreviewed Ava_0465 - - - - -
Q9HXN1 BXGT020651 Membrane-bound lytic murein transglycosylase F reviewed mltF - - - - -
B8FZ96 BXGT002297 Extracellular ligand-binding receptor unreviewed Dhaf_0110 - - - - -
A7Y7W1 BXGT001643 Periplasmic dipeptide-binding protein unreviewed dppA - - - - -
P04825 BXGT006271 Aminopeptidase N reviewed pepN - - - - -
V5YM14 BXGT022598 Dipeptidyl aminopeptidase BII reviewed dapb2 - - - - -
O75112 BXGT005099 LIM domain-binding protein 3 reviewed LDB3 Cellular structure - - - -
P9WFV1 BXGT012249 Leucine--tRNA ligase reviewed leuS - - - - -
P58004 BXGT011222 Sestrin-2 reviewed SESN2 Enzyme - - - -
Q9SKE2 BXGT021590 Jasmonoyl--L-amino acid synthetase JAR1 reviewed JAR1 - - - - -
P48247 BXGT010624 Glutamate-1-semialdehyde 2,1-aminomutase reviewed hemL - - - - -
P12955 BXGT007865 Xaa-Pro dipeptidase reviewed PEPD Enzyme - - - -
A0A0E3URV8 BXGT000171 Leucine hydroxylase unreviewed griE - - - - -
P01900 BXGT005812 H-2 class I histocompatibility antigen, D-D alpha chain reviewed H2-D1 - - - - -
Q9NTG7 BXGT021211 NAD-dependent protein deacetylase sirtuin-3, mitochondrial reviewed SIRT3 Epigenetic regulator - - - -
Q9NUB1 BXGT021215 Acetyl-coenzyme A synthetase 2-like, mitochondrial reviewed ACSS1 Enzyme - - - -
P15145 BXGT008088 Aminopeptidase N reviewed ANPEP - - - - -
P01901 BXGT005813 H-2 class I histocompatibility antigen, K-B alpha chain reviewed H2-K1 - - - - -
P22262 BXGT008749 Listeriolysin regulatory protein reviewed prfA - - - - -
W1ELP7 BXGT024384 Uncharacterized protein unreviewed - - - - -
Q9RVZ5 BXGT023707 Aminopeptidase N unreviewed DR_0875 - - - - -
Q695T7 BXGT024794 Sodium-dependent neutral amino acid transporter B(0)AT1 reviewed SLC6A19 - - - - -
O84049 BXGT025101 Probable cytosol aminopeptidase reviewed pepA - - - - -
Q3K7T6 BXGT025274 Putative methyl-accepting chemotaxis protein unreviewed Pfl01_4431 - - - - -
R4NRX5 BXGT022503 ATPase YjeE, predicted to have essential role in cell wall biosynthesis unreviewed Tmari_1641 - - - - -
F6IQS1 BXGT025640 MHC class I antigen unreviewed HLA-A - - - - -
Q0P864 BXGT013112 Putative methyl-accepting chemotaxis signal transduction protein unreviewed Cj1564 - - - - -
Q16769 BXGT013665 Glutaminyl-peptide cyclotransferase reviewed QPCT Enzyme - - - -
A0A4Y7X244 BXGT026014 Sodium-dependent transporter unreviewed E2L07_01100 - - - - -
Binding DB 50219348
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT022220 Phospholipase A-2-activating protein reviewed Enzyme modulator PLAA - >5000 - -
reviewed BXGT006338 Alkaline phosphatase, tissue-nonspecific isozyme reviewed Enzyme ALPL - >5000 - -
reviewed BXGT006942 Intestinal-type alkaline phosphatase reviewed Enzyme ALPI - >5000 - -
reviewed BXGT017247 Proton-coupled amino acid transporter 1 reviewed Transporter SLC36A1 100000000 - - -
CHEMBL CHEMBL291962
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 AC50 - - -
Q7Z2H8 BXGT017247 Proton-coupled amino acid transporter 1 reviewed Transporter SLC36A1 Ki '=' 100000000 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Inhibition - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Inhibition - - -
P09923 BXGT006942 Intestinal-type alkaline phosphatase reviewed Enzyme ALPI IC50 '>' 5000 nM
P05186 BXGT006338 Alkaline phosphatase, tissue-nonspecific isozyme reviewed Enzyme ALPL IC50 '>' 5000 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Inhibition - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 AC50 - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 Inhibition - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 AC50 - - -
Q9Y263 BXGT022220 Phospholipase A-2-activating protein reviewed Enzyme modulator PLAA IC50 '>' 5000 nM
Q7Z2H8 BXGT017247 Proton-coupled amino acid transporter 1 reviewed Transporter SLC36A1 pKi '=' 2 mM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 AC50 - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Inhibition - - -
Q91Y77 BXGT019323 Monocarboxylate transporter 10 reviewed - Slc16a10 Activity - - -
Q05BR4 BXGT012851 SLC16A10 protein unreviewed - SLC16A10 Activity - - -
Q8K1P8 BXGT018393 Monocarboxylate transporter 8 reviewed - SLC16A2 Activity - - -
Q01650 BXGT012603 Large neutral amino acids transporter small subunit 1 reviewed Transporter SLC7A5 Inhibition '=' 78 %
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 AC50 - - -
Q01650 BXGT012603 Large neutral amino acids transporter small subunit 1 reviewed Transporter SLC7A5 IC50 '=' 85000 nM
Q01650 BXGT012603 Large neutral amino acids transporter small subunit 1 reviewed Transporter SLC7A5 Activity '=' 3 fmol/min
Q01650 BXGT012603 Large neutral amino acids transporter small subunit 1 reviewed Transporter SLC7A5 Activity '=' 120 %
Q01650 BXGT012603 Large neutral amino acids transporter small subunit 1 reviewed Transporter SLC7A5 Inhibition '=' 73 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00008 Garlic Allium sativum Herbs and Spices
BXGF00027 Chinese mustard Brassica juncea Vegetables
BXGF00337 Ginkgo nuts Ginkgo biloba Herbs and Spices
BXGF00380 White mustard Sinapis alba Herbs and Spices
BXGF02054 Shorea uliginosa Shorea uliginosa Others
BXGF02275 Trichosanthes kirilowii maxim Trichosanthes kirilowii maxim Others
BXGF02290 Sonchus microcarpus Sonchus microcarpus Others
BXGF02526 Santalum album Santalum album Medicinal Plant
BXGF04889 Pogostemon cablin Pogostemon cablin Medicinal Plant
BXGF05178 Lilium hansonii Lilium hansonii Medicinal Plant
BXGF05203 Chlamydomonas reinhardtii Chlamydomonas reinhardtii Others
BXGF05330 Arum ternatum thunb Arum ternatum thunb Others
BXGF05421 Tussilago farfara Tussilago farfara Medicinal Plant
BXGF06108 Centipeda minima Centipeda minima Medicinal Plant
BXGF06126 Strychnos diplotricha Strychnos diplotricha Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease