Showing entry for Glutamate receptor ionotropic, NMDA 3B


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004874
Protein NameGlutamate receptor ionotropic, NMDA 3B
Uniport IdO60391
GeneGRIN3B
Gene Id116444
DomainLig_chan; Lig_chan-Glu_bd
Pfam PF00060   PF10613  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
5. Organismal Systems 5.6 Nervous system hsa04724 Glutamatergic synapse
6. Human Diseases 6.5 Substance dependence hsa05030 Cocaine addiction
6. Human Diseases 6.5 Substance dependence hsa05031 Amphetamine addiction
6. Human Diseases 6.5 Substance dependence hsa05033 Nicotine addiction
6. Human Diseases 6.5 Substance dependence hsa05034 Alcoholism
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0035235 ionotropic glutamate receptor signaling pathway
Biological Process GO:0051205 protein insertion into membrane
Biological Process GO:0051924 regulation of calcium ion transport
molecular function GO:0005262 calcium channel activity
molecular function GO:0005261 cation channel activity
molecular function GO:0016594 glycine binding
molecular function GO:0004970 ionotropic glutamate receptor activity
molecular function GO:0015276 ligand-gated ion channel activity
molecular function GO:0042165 neurotransmitter binding
molecular function GO:0030594 neurotransmitter receptor activity
molecular function GO:0038023 signaling receptor activity
cellular component GO:0043025 neuronal cell body
cellular component GO:0017146 NMDA selective glutamate receptor complex
cellular component GO:0005886 plasma membrane
cellular component GO:0045211 postsynaptic membrane
Reactome
Pathway Id Pathway Name
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-442755 Activation of NMDA receptors and postsynaptic events
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0019337 BXGD001319 Heroin Dependence Chemically-Induced Disorders; Mental Disorders
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0200633 BXGD004040 Neutrophil count (procedure)
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1611743 BXGD013456 Familial (FPAH)
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000226 Glycine 75.07
BXGC0003196 Aripiprazole 448.39
BXGC0006162 L-Glutamic acid 147.13
BXGC0025485 Transtorine 189.04
BXGC0028885 Secobarbital 238.13
BXGC0043578 5-Hydroxy-2-(2-Phenylethyl)Chromen-4-One 266.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein