adisease

Showing entry for Heroin Dependence

General Disease Information
BXGD Id	BXGD001319
Disease Name	Heroin Dependence
Disease CUI Id	C0019337
MeSH Codes	C25 F03
Disease Class Name	Chemically-Induced Disorders; Mental Disorders
Semantic Type	Mental or Behavioral Dysfunction
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id	DOID:150
Disease Ontology Class Name	disease of mental health
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00519	BXGT003934	Fatty-acid amide hydrolase 1	2166	reviewed
O15146	BXGT004131	Muscle, skeletal receptor tyrosine-protein kinase	4593	reviewed	Kinase
O60391	BXGT004874	Glutamate receptor ionotropic, NMDA 3B	116444	reviewed	Ion channel
O95264	BXGT005367	5-hydroxytryptamine receptor 3B	9177	reviewed	Ion channel
P00325	BXGT005498	Alcohol dehydrogenase 1B	125	reviewed	Enzyme
P01011	BXGT005715	Alpha-1-antichymotrypsin	12	reviewed	Enzyme modulator
P01138	BXGT005738	Beta-nerve growth factor	4803	reviewed	Signaling
P01189	BXGT005742	Pro-opiomelanocortin	5443	reviewed
P05091	BXGT006312	Aldehyde dehydrogenase, mitochondrial	217	reviewed	Enzyme
P08183	BXGT006741	ATP-dependent translocase ABCB1	5243	reviewed	Transporter
P08235	BXGT006751	Mineralocorticoid receptor	4306	reviewed	Nuclear receptor
P09104	BXGT006856	Gamma-enolase	2026	reviewed	Enzyme
P09172	BXGT006865	Dopamine beta-hydroxylase	1621	reviewed
P14416	BXGT008011	D(2) dopamine receptor	1813	reviewed	G-protein coupled receptor
P21397	BXGT008644	Amine oxidase [flavin-containing] A	4128	reviewed
P21554	BXGT008662	Cannabinoid receptor 1	1268	reviewed	G-protein coupled receptor
P21728	BXGT008686	D(1A) dopamine receptor	1812	reviewed	G-protein coupled receptor
P21917	BXGT008707	D(4) dopamine receptor	1815	reviewed	G-protein coupled receptor
P21964	BXGT008714	Catechol O-methyltransferase	1312	reviewed	Enzyme
P23415	BXGT008864	Glycine receptor subunit alpha-1	2741	reviewed	Ion channel
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P23975	BXGT008935	Sodium-dependent noradrenaline transporter	6530	reviewed	Transporter
P24387	BXGT008966	Corticotropin-releasing factor-binding protein	1393	reviewed	Signaling
P25116	BXGT009025	Proteinase-activated receptor 1	2149	reviewed	G-protein coupled receptor
P25929	BXGT009078	Neuropeptide Y receptor type 1	4886	reviewed	G-protein coupled receptor
P28222	BXGT009238	5-hydroxytryptamine receptor 1B	3351	reviewed	G-protein coupled receptor
P28223	BXGT009239	5-hydroxytryptamine receptor 2A	3356	reviewed	G-protein coupled receptor
P28472	BXGT009260	Gamma-aminobutyric acid receptor subunit beta-3	2562	reviewed	Ion channel
P30989	BXGT009492	Neurotensin receptor type 1	4923	reviewed	G-protein coupled receptor
P31645	BXGT009558	Sodium-dependent serotonin transporter	6532	reviewed	Transporter
P31943	BXGT009587	Heterogeneous nuclear ribonucleoprotein H	3187	reviewed	Nucleic acid binding
P34130	BXGT009752	Neurotrophin-4	4909	reviewed	Signaling
P34947	BXGT009774	G protein-coupled receptor kinase 5	2869	reviewed	Kinase
P34998	BXGT009781	Corticotropin-releasing factor receptor 1	1394	reviewed
P35372	BXGT009823	Mu-type opioid receptor	4988	reviewed	G-protein coupled receptor
P35462	BXGT009835	D(3) dopamine receptor	1814	reviewed	G-protein coupled receptor
P41143	BXGT010223	Delta-type opioid receptor	4985	reviewed	G-protein coupled receptor
P41145	BXGT010225	Kappa-type opioid receptor	4986	reviewed	G-protein coupled receptor
P45983	BXGT010494	Mitogen-activated protein kinase 8	5599	reviewed	Kinase
P46098	BXGT010507	5-hydroxytryptamine receptor 3A	3359	reviewed	Ion channel
P47869	BXGT010590	Gamma-aminobutyric acid receptor subunit alpha-2	2555	reviewed	Ion channel
P47870	BXGT010591	Gamma-aminobutyric acid receptor subunit beta-2	2561	reviewed	Ion channel
P49674	BXGT010725	Casein kinase I isoform epsilon	1454	reviewed
P54762	BXGT011076	Ephrin type-B receptor 1	2047	reviewed	Kinase
P58335	BXGT011233	Anthrax toxin receptor 2	118429	reviewed	Receptor
P78352	BXGT011836	Disks large homolog 4	1742	reviewed	Receptor
P80404	BXGT011907	4-aminobutyrate aminotransferase, mitochondrial	18	reviewed	Enzyme
Q00535	BXGT012534	Cyclin-dependent-like kinase 5	1020	reviewed	Kinase
Q01718	BXGT012609	Adrenocorticotropic hormone receptor	4158	reviewed	G-protein coupled receptor
Q01959	BXGT012624	Sodium-dependent dopamine transporter	6531	reviewed	Transporter
Q12778	BXGT013263	Forkhead box protein O1	2308	reviewed
Q12879	BXGT013275	Glutamate receptor ionotropic, NMDA 2A	2903	reviewed	Ion channel
Q13224	BXGT013328	Glutamate receptor ionotropic, NMDA 2B	2904	reviewed	Ion channel
Q13324	BXGT013340	Corticotropin-releasing factor receptor 2	1395	reviewed	G-protein coupled receptor
Q13451	BXGT013356	Peptidyl-prolyl cis-trans isomerase FKBP5	2289	reviewed	Enzyme
Q14416	BXGT013468	Metabotropic glutamate receptor 2	2912	reviewed	G-protein coupled receptor
Q14832	BXGT013507	Metabotropic glutamate receptor 3	2913	reviewed	G-protein coupled receptor
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q8IVA8	BXGT018342	Glutamate decarboxylase 1 (Brain, 67kDa)	2571	unreviewed
Q8IWQ3	BXGT018355	Serine/threonine-protein kinase BRSK2	9024	reviewed	Kinase
Q8NFD2	BXGT018559	Ankyrin repeat and protein kinase domain-containing protein 1	255239	reviewed	Kinase
Q8TCU5	BXGT018802	Glutamate receptor ionotropic, NMDA 3A	116443	reviewed	Ion channel
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q99259	BXGT019915	Glutamate decarboxylase 1	2571	reviewed	Enzyme
P17752	BXGT023118	Tryptophan 5-hydroxylase 1	7166	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}