Showing entry for cAMP-dependent protein kinase type II-alpha regulatory subunit



                       
General Target Information
BXGT IdBXGT007961
Protein NamecAMP-dependent protein kinase type II-alpha regulatory subunit
Uniport IdP13861
GenePRKAR2A
Gene Id5576
DomaincNMP_binding; RIIa
Pfam PF00027   PF02197  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.2 Endocrine system hsa04910 Insulin signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0034199 activation of protein kinase A activity
Biological Process GO:0007596 blood coagulation
Biological Process GO:0071377 cellular response to glucagon stimulus
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:2000480 negative regulation of cAMP-dependent protein kinase activity
Biological Process GO:0043949 regulation of cAMP-mediated signaling
Biological Process GO:0010738 regulation of protein kinase A signaling
Biological Process GO:0003091 renal water homeostasis
molecular function GO:0030552 cAMP binding
molecular function GO:0004862 cAMP-dependent protein kinase inhibitor activity
molecular function GO:0008603 cAMP-dependent protein kinase regulator activity
molecular function GO:0019904 protein domain specific binding
molecular function GO:0034236 protein kinase A catalytic subunit binding
molecular function GO:0031625 ubiquitin protein ligase binding
cellular component GO:0005952 cAMP-dependent protein kinase complex
cellular component GO:0005813 centrosome
cellular component GO:0097546 ciliary base
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005925 focal adhesion
cellular component GO:0016020 membrane
cellular component GO:0031588 nucleotide-activated protein kinase complex
cellular component GO:0005886 plasma membrane
cellular component GO:0044853 plasma membrane raft
cellular component GO:0032991 protein-containing complex
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-111885 Opioid Signalling
R-HSA-111885 Opioid Signalling
R-HSA-111931 PKA-mediated phosphorylation of CREB
R-HSA-111931 PKA-mediated phosphorylation of CREB
R-HSA-111933 Calmodulin induced events
R-HSA-111933 Calmodulin induced events
R-HSA-111996 Ca-dependent events
R-HSA-111996 Ca-dependent events
R-HSA-111997 CaM pathway
R-HSA-111997 CaM pathway
R-HSA-112040 G-protein mediated events
R-HSA-112040 G-protein mediated events
R-HSA-112043 PLC beta mediated events
R-HSA-112043 PLC beta mediated events
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-1266738 Developmental Biology
R-HSA-1430728 Metabolism
R-HSA-1430728 Metabolism
R-HSA-1489509 DAG and IP3 signaling
R-HSA-1489509 DAG and IP3 signaling
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-163359 Glucagon signaling in metabolic regulation
R-HSA-163615 PKA activation
R-HSA-163615 PKA activation
R-HSA-163685 Integration of energy metabolism
R-HSA-163685 Integration of energy metabolism
R-HSA-1643685 Disease
R-HSA-164378 PKA activation in glucagon signalling
R-HSA-180024 DARPP-32 events
R-HSA-372790 Signaling by GPCR
R-HSA-372790 Signaling by GPCR
R-HSA-376176 Signaling by ROBO receptors
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-382551 Transport of small molecules
R-HSA-388396 GPCR downstream signalling
R-HSA-388396 GPCR downstream signalling
R-HSA-418594 G alpha (i) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-422356 Regulation of insulin secretion
R-HSA-422475 Axon guidance
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-438064 Post NMDA receptor activation events
R-HSA-442720 CREB1 phosphorylation through the activation of Adenylate Cyclase
R-HSA-442755 Activation of NMDA receptors and postsynaptic events
R-HSA-445717 Aquaporin-mediated transport
R-HSA-5358351 Signaling by Hedgehog
R-HSA-5610787 Hedgehog 'off' state
R-HSA-5663205 Infectious disease
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-9010642 ROBO receptors bind AKAP5
R-HSA-9658195 Leishmania infection
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection
R-HSA-9664323 FCGR3A-mediated IL10 synthesis
R-HSA-9664433 Leishmania parasite growth and survival
R-HSA-9675108 Nervous system development
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0001623 BXGD000066 Adrenal gland hypofunction Endocrine System Diseases
C0005890 BXGD000345 Body Height
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0021704 BXGD001510 Intelligence Behavior and Behavior Mechanisms
C0027651 BXGD002009 Neoplasms Neoplasms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0162809 BXGD003981 Kallmann Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0392885 BXGD008071 High density lipoprotein measurement
C0405580 BXGD008325 Adrenal cortical hypofunction Endocrine System Diseases
C0428472 BXGD008630 Serum HDL cholesterol measurement
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0747845 BXGD010184 early pregnancy
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein