Showing entry for Sodium/potassium-transporting ATPase subunit beta-2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008010
Protein NameSodium/potassium-transporting ATPase subunit beta-2
Uniport IdP14415
GeneATP1B2
Gene Id482
DomainNa_K-ATPase
Pfam PF00287  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04022 cGMP-PKG signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
5. Organismal Systems 5.3 Circulatory system hsa04260 Cardiac muscle contraction
5. Organismal Systems 5.3 Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes
5. Organismal Systems 5.2 Endocrine system hsa04911 Insulin secretion
5. Organismal Systems 5.2 Endocrine system hsa04918 Thyroid hormone synthesis
5. Organismal Systems 5.2 Endocrine system hsa04919 Thyroid hormone signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04925 Aldosterone synthesis and secretion
5. Organismal Systems 5.5 Excretory system hsa04960 Aldosterone-regulated sodium reabsorption
5. Organismal Systems 5.5 Excretory system hsa04961 Endocrine and other factor-regulated calcium reabsorption
5. Organismal Systems 5.5 Excretory system hsa04964 Proximal tubule bicarbonate reclamation
5. Organismal Systems 5.4 Digestive system hsa04970 Salivary secretion
5. Organismal Systems 5.4 Digestive system hsa04971 Gastric acid secretion
5. Organismal Systems 5.4 Digestive system hsa04972 Pancreatic secretion
5. Organismal Systems 5.4 Digestive system hsa04973 Carbohydrate digestion and absorption
5. Organismal Systems 5.4 Digestive system hsa04974 Protein digestion and absorption
5. Organismal Systems 5.4 Digestive system hsa04976 Bile secretion
5. Organismal Systems 5.4 Digestive system hsa04978 Mineral absorption
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0086064 cell communication by electrical coupling involved in cardiac conduction
Biological Process GO:0031589 cell-substrate adhesion
Biological Process GO:0030007 cellular potassium ion homeostasis
Biological Process GO:0006883 cellular sodium ion homeostasis
Biological Process GO:0034220 ion transmembrane transport
Biological Process GO:0021670 lateral ventricle development
Biological Process GO:0050900 leukocyte migration
Biological Process GO:0086009 membrane repolarization
Biological Process GO:0061744 motor behavior
Biological Process GO:1903976 negative regulation of glial cell migration
Biological Process GO:0021944 neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration
Biological Process GO:0045494 photoreceptor cell maintenance
Biological Process GO:0120036 plasma membrane bounded cell projection organization
Biological Process GO:0032781 positive regulation of ATPase activity
Biological Process GO:0010976 positive regulation of neuron projection development
Biological Process GO:1903288 positive regulation of potassium ion import across plasma membrane
Biological Process GO:1901018 positive regulation of potassium ion transmembrane transporter activity
Biological Process GO:1903278 positive regulation of sodium ion export across plasma membrane
Biological Process GO:1990573 potassium ion import across plasma membrane
Biological Process GO:0050821 protein stabilization
Biological Process GO:1903779 regulation of cardiac conduction
Biological Process GO:0001895 retina homeostasis
Biological Process GO:0036376 sodium ion export across plasma membrane
Biological Process GO:0021678 third ventricle development
Biological Process GO:0150104 transport across blood-brain barrier
molecular function GO:0001671 ATPase activator activity
molecular function GO:0051117 ATPase binding
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0005391 sodium:potassium-exchanging ATPase activity
cellular component GO:0016324 apical plasma membrane
cellular component GO:0097450 astrocyte end-foot
cellular component GO:0097449 astrocyte projection
cellular component GO:0044298 cell body membrane
cellular component GO:0071944 cell periphery
cellular component GO:0031253 cell projection membrane
cellular component GO:0005737 cytoplasm
cellular component GO:0009897 external side of plasma membrane
cellular component GO:0016328 lateral plasma membrane
cellular component GO:0016020 membrane
cellular component GO:0098984 neuron to neuron synapse
cellular component GO:0001917 photoreceptor inner segment
cellular component GO:0005886 plasma membrane
cellular component GO:0005890 sodium:potassium-exchanging ATPase complex
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-1643685 Disease
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-210991 Basigin interactions
R-HSA-382551 Transport of small molecules
R-HSA-397014 Muscle contraction
R-HSA-5576891 Cardiac conduction
R-HSA-5578775 Ion homeostasis
R-HSA-5663205 Infectious disease
R-HSA-936837 Ion transport by P-type ATPases
R-HSA-9679191 Potential therapeutics for SARS
R-HSA-9679506 SARS-CoV Infections
R-HSA-983712 Ion channel transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004114 BXGD000255 Astrocytoma Neoplasms
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0259783 BXGD005221 mixed gliomas Neoplasms
C0271091 BXGD006160 Retinoschisis, Juvenile, X-Linked Eye Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0280483 BXGD006750 Adult Anaplastic Astrocytoma Neoplasms
C0334579 BXGD007120 Anaplastic astrocytoma Neoplasms
C0373601 BXGD007961 Dihydrotestosterone Assay
C0523912 BXGD009224 Testosterone measurement
C0555198 BXGD009432 Malignant Glioma Neoplasms
C0596887 BXGD009648 mathematical ability
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1955869 BXGD016612 Malformations of Cortical Development Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C2938983 BXGD018170 Focal cortical dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C2985280 BXGD018223 Blood Protein Measurement
C4551548 BXGD023342 Grade III Childhood Astrocytoma Neoplasms
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003690 Glucokinin 764.94
BXGC0015208 Getiacaulein 288.06
BXGC0020220 panaxatriol 476.39
BXGC0022544 Digoxin 780.43
BXGC0023461 methylswertianin 288.06
BXGC0025733 1,3,5,6-Tetrahydroxyxanthen-9-One 260.03
BXGC0036400 1,3,5-Trihydroxyxanthen-9-One 244.04
BXGC0039507 Digitoxigenin 374.25
BXGC0044158 3,4,5-Trihydroxyxanthen-9-One 244.04
BXGC0048644 1,2,3,7-Tetramethoxyxanthone 316.09
BXGC0050699 \N 260.03
BXGC0051524 Ouabain 584.28
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein