Showing entry for Trifunctional purine biosynthetic protein adenosine-3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008731
Protein NameTrifunctional purine biosynthetic protein adenosine-3
Uniport IdP22102
GeneGART
Gene Id2618
DomainAIRS; AIRS_C; Formyl_trans_N; GARS_A; GARS_C; GARS_N
Pfam PF00586   PF02769   PF00551   PF01071   PF02843   PF02844  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.4 Nucleotide metabolism hsa00230 Purine metabolism
1. Metabolism 1.8 Metabolism of cofactors and vitamins hsa00670 One carbon pool by folate
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
6. Human Diseases 6.12 Drug resistance: Antineoplastic hsa01523 Antifolate resistance
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006189 'de novo' IMP biosynthetic process
Biological Process GO:0046084 adenine biosynthetic process
Biological Process GO:0003360 brainstem development
Biological Process GO:0021549 cerebellum development
Biological Process GO:0021987 cerebral cortex development
Biological Process GO:0006544 glycine metabolic process
Biological Process GO:0006164 purine nucleotide biosynthetic process
Biological Process GO:0009168 purine ribonucleoside monophosphate biosynthetic process
Biological Process GO:0010035 response to inorganic substance
Biological Process GO:0010033 response to organic substance
Biological Process GO:0046654 tetrahydrofolate biosynthetic process
molecular function GO:0005524 ATP binding
molecular function GO:0046872 metal ion binding
molecular function GO:0004637 phosphoribosylamine-glycine ligase activity
molecular function GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity
molecular function GO:0004644 phosphoribosylglycinamide formyltransferase activity
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-15869 Metabolism of nucleotides
R-HSA-73817 Purine ribonucleoside monophosphate biosynthesis
R-HSA-8956320 Nucleobase biosynthesis
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007959 BXGD000507 Charcot-Marie-Tooth Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0018051 BXGD001167 Gonadal Dysgenesis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0026847 BXGD001940 Spinal Muscular Atrophy Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0039585 BXGD002821 Androgen-Insensitivity Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0041408 BXGD002923 Turner Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0151313 BXGD003413 Sensory neuropathy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0175693 BXGD004001 Russell-Silver syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0221032 BXGD004374 Familial generalized lipodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0235025 BXGD004713 Peripheral motor neuropathy Nervous System Diseases
C0268297 BXGD005889 Pseudovaginal Perineoscrotal Hypospadias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0268301 BXGD005890 Reifenstein Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0442874 BXGD008814 Neuropathy Nervous System Diseases
C0598589 BXGD009667 Inherited neuropathies Nervous System Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0751409 BXGD010431 Upper Extremity Paresis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751606 BXGD010523 Adult Acute Lymphocytic Leukemia
C0812413 BXGD010847 Malignant Pleural Mesothelioma Neoplasms; Respiratory Tract Diseases
C0936016 BXGD011475 Testicular Feminization Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C1457873 BXGD013131 Os trigonum disorder
C1832274 BXGD013820 Charcot-Marie-Tooth disease, Type 2D Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1833308 BXGD013910 NEURONOPATHY, DISTAL HEREDITARY MOTOR, TYPE V Nervous System Diseases
C2118460 BXGD016927 Acute colitis Digestive System Diseases
C2751824 BXGD017742 46, XY Disorders of Sex Development Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C2930619 BXGD017890 Sex Differentiation Disorders Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C2931276 BXGD017994 Spastic paraplegia 17 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C3669122 BXGD019324 5-Alpha Reductase Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4237343 BXGD022309 Overweight or obesity
C4521042 BXGD023055 Complete Trisomy 21 Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4551993 BXGD023469 Amyotrophic Lateral Sclerosis, Familial Nutritional and Metabolic Diseases; Nervous System Diseases
C4721579 BXGD023759 Secondary malignant neoplasm of colon and/or rectum Digestive System Diseases; Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein