Showing entry for Secondary malignant neoplasm of colon and/or rectum


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD023759
Disease NameSecondary malignant neoplasm of colon and/or rectum
Disease CUI IdC4721579
MeSH Codes C06   C04  
Disease Class NameDigestive System Diseases; Neoplasms
Semantic TypeNeoplastic Process
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id   
Disease Ontology Class Name
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
A0A024RAV5 BXGT000013 V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b 3845 unreviewed
A1Z1Q3 BXGT001069 ADP-ribose glycohydrolase MACROD2 140733 reviewed
O00206 BXGT003894 Toll-like receptor 4 7099 reviewed
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O00748 BXGT003942 Cocaine esterase 8824 reviewed Enzyme
O14733 BXGT004087 Dual specificity mitogen-activated protein kinase kinase 7 5609 reviewed Kinase
O14746 BXGT004091 Telomerase reverse transcriptase 7015 reviewed Enzyme
O14763 BXGT004093 Tumor necrosis factor receptor superfamily member 10B 8795 reviewed
O14770 BXGT004095 Homeobox protein Meis2 4212 reviewed Enzyme
O14786 BXGT004099 Neuropilin-1 8829 reviewed
O14965 BXGT004117 Aurora kinase A 6790 reviewed Kinase
O15123 BXGT004130 Angiopoietin-2 285 reviewed Signaling
O15151 BXGT004132 Protein Mdm4 4194 reviewed Nucleic acid binding
O15244 BXGT004140 Solute carrier family 22 member 2 6582 reviewed Transporter
O15379 BXGT004159 Histone deacetylase 3 8841 reviewed Epigenetic regulator
O43278 BXGT004581 Kunitz-type protease inhibitor 1 6692 reviewed
O43318 BXGT004586 Mitogen-activated protein kinase kinase kinase 7 6885 reviewed Kinase
O43524 BXGT004599 Forkhead box protein O3 2309 reviewed
O60656 BXGT004889 UDP-glucuronosyltransferase 1-9 54600 reviewed
O60760 BXGT004899 Hematopoietic prostaglandin D synthase 27306 reviewed
O75015 BXGT005095 Low affinity immunoglobulin gamma Fc region receptor III-B 2215 reviewed Cell adhesion
O75129 BXGT005101 Astrotactin-2 23245 reviewed
P00338 BXGT005504 L-lactate dehydrogenase A chain 3939 reviewed Enzyme
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P01011 BXGT005715 Alpha-1-antichymotrypsin 12 reviewed Enzyme modulator
P01111 BXGT005731 GTPase NRas 4893 reviewed Enzyme modulator
P01116 BXGT005733 GTPase KRas 3845 reviewed Enzyme modulator
P01133 BXGT005736 Pro-epidermal growth factor 1950 reviewed
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P02545 BXGT005889 Prelamin-A/C 4000 reviewed
P02647 BXGT005908 Apolipoprotein A-I 335 reviewed
P02741 BXGT005936 C-reactive protein 1401 reviewed
P02766 BXGT005953 Transthyretin 7276 reviewed Transporter
P02768 BXGT005955 Serum albumin 213 reviewed Transporter
P02775 BXGT005960 Platelet basic protein 5473 reviewed Signaling
P03956 BXGT006120 Interstitial collagenase 4312 reviewed Enzyme
P04049 BXGT006133 RAF proto-oncogene serine/threonine-protein kinase 5894 reviewed Kinase
P04183 BXGT006166 Thymidine kinase, cytosolic 7083 reviewed Kinase
P04279 BXGT006183 Semenogelin-1 6406 reviewed
P04406 BXGT006207 Glyceraldehyde-3-phosphate dehydrogenase 2597 reviewed Enzyme
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 2064 reviewed Kinase
P04629 BXGT006239 High affinity nerve growth factor receptor 4914 reviewed Kinase
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P04732 BXGT006252 Metallothionein-1E 4493 reviewed
P04818 BXGT006269 Thymidylate synthase 7298 reviewed Enzyme
P05121 BXGT006320 Plasminogen activator inhibitor 1 5054 reviewed Enzyme modulator
P05231 BXGT006345 Interleukin-6 3569 reviewed
P06213 BXGT006425 Insulin receptor 3643 reviewed Kinase
P06730 BXGT006487 Eukaryotic translation initiation factor 4E 1977 reviewed Nucleic acid binding
P06731 BXGT006488 Carcinoembryonic antigen-related cell adhesion molecule 5 1048 reviewed
P06733 BXGT006490 Alpha-enolase 2023 reviewed Enzyme
P07195 BXGT006563 L-lactate dehydrogenase B chain 3945 reviewed Enzyme
P07204 BXGT006567 Thrombomodulin 7056 reviewed
P07741 BXGT006666 Adenine phosphoribosyltransferase 353 reviewed
P07900 BXGT006696 Heat shock protein HSP 90-alpha 3320 reviewed Chaperone
P07949 BXGT006703 Proto-oncogene tyrosine-protein kinase receptor Ret 5979 reviewed Kinase
P07996 BXGT006710 Thrombospondin-1 7057 reviewed
P08069 BXGT006723 Insulin-like growth factor 1 receptor 3480 reviewed Kinase
P08133 BXGT006727 Annexin A6 309 reviewed
P08183 BXGT006741 ATP-dependent translocase ABCB1 5243 reviewed Transporter
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C 5788 reviewed Enzyme
P08581 BXGT006794 Hepatocyte growth factor receptor 4233 reviewed Kinase
P08637 BXGT006802 Low affinity immunoglobulin gamma Fc region receptor III-A 2214 reviewed Cell adhesion
P08684 BXGT006812 Cytochrome P450 3A4 1576 reviewed Enzyme
P08758 BXGT006821 Annexin A5 308 reviewed
P08922 BXGT006843 Proto-oncogene tyrosine-protein kinase ROS 6098 reviewed Kinase
P09211 BXGT006869 Glutathione S-transferase P 2950 reviewed
P09237 BXGT006874 Matrilysin 4316 reviewed Enzyme
P09327 BXGT006877 Villin-1 7429 reviewed Cellular structure
P09488 BXGT006899 Glutathione S-transferase Mu 1 2944 reviewed
P09525 BXGT006901 Annexin A4 307 reviewed
P10145 BXGT007542 Interleukin-8 3576 reviewed Signaling
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P11166 BXGT007661 Solute carrier family 2, facilitated glucose transporter member 1 6513 reviewed Transporter
P11169 BXGT007664 Solute carrier family 2, facilitated glucose transporter member 3 6515 reviewed Transporter
P11172 BXGT007665 Uridine 5'-monophosphate synthase 7372 reviewed
P11387 BXGT007696 DNA topoisomerase 1 7150 reviewed Enzyme
P11388 BXGT007697 DNA topoisomerase 2-alpha 7153 reviewed
P11509 BXGT007716 Cytochrome P450 2A6 1548 reviewed
P12318 BXGT007799 Low affinity immunoglobulin gamma Fc region receptor II-a 2212 reviewed Cell adhesion
P12830 BXGT007852 Cadherin-1 999 reviewed
P13236 BXGT007891 C-C motif chemokine 4 6351 reviewed
P13500 BXGT007916 C-C motif chemokine 2 6347 reviewed Signaling
P13501 BXGT007917 C-C motif chemokine 5 6352 reviewed Signaling
P13688 BXGT007943 Carcinoembryonic antigen-related cell adhesion molecule 1 634 reviewed
P14210 BXGT007994 Hepatocyte growth factor 3082 reviewed Enzyme
P14618 BXGT008027 Pyruvate kinase PKM 5315 reviewed Kinase
P14625 BXGT008029 Endoplasmin 7184 reviewed Chaperone
P14780 BXGT008053 Matrix metalloproteinase-9 4318 reviewed Enzyme
P15056 BXGT008075 Serine/threonine-protein kinase B-raf 673 reviewed Kinase
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P15941 BXGT008176 Mucin-1 4582 reviewed
P16070 BXGT008186 CD44 antigen 960 reviewed
P16410 BXGT008224 Cytotoxic T-lymphocyte protein 4 1493 reviewed
P16455 BXGT008229 Methylated-DNA--protein-cysteine methyltransferase 4255 reviewed
P16662 BXGT008253 UDP-glucuronosyltransferase 2B7 7364 reviewed
P17342 BXGT008302 Atrial natriuretic peptide receptor 3 4883 reviewed
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 2321 reviewed Kinase
P18074 BXGT008374 General transcription and DNA repair factor IIH helicase subunit XPD 2068 reviewed Enzyme
P18146 BXGT008384 Early growth response protein 1 1958 reviewed Nucleic acid binding
P18887 BXGT008437 DNA repair protein XRCC1 7515 reviewed
P19224 BXGT008468 UDP-glucuronosyltransferase 1-6 54578 reviewed
P19971 BXGT008537 Thymidine phosphorylase 1890 reviewed Enzyme
P20061 BXGT008542 Transcobalamin-1 6947 reviewed
P20815 BXGT008604 Cytochrome P450 3A5 1577 reviewed Enzyme
P21549 BXGT008661 Serine--pyruvate aminotransferase 189 reviewed Enzyme
P21589 BXGT008669 5'-nucleotidase 4907 reviewed Enzyme
P21860 BXGT008698 Receptor tyrosine-protein kinase erbB-3 2065 reviewed Kinase
P22102 BXGT008731 Trifunctional purine biosynthetic protein adenosine-3 2618 reviewed Enzyme
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 54658 reviewed
P22310 BXGT008754 UDP-glucuronosyltransferase 1-4 54657 reviewed
P22897 BXGT008816 Macrophage mannose receptor 1 4360 reviewed
P23921 BXGT008927 Ribonucleoside-diphosphate reductase large subunit 6240 reviewed Enzyme
P24385 BXGT008965 G1/S-specific cyclin-D1 595 reviewed Enzyme modulator
P24666 BXGT008986 Low molecular weight phosphotyrosine protein phosphatase 52 reviewed
P24928 BXGT009001 DNA-directed RNA polymerase II subunit RPB1 5430 reviewed Enzyme
P25025 BXGT009006 C-X-C chemokine receptor type 2 3579 reviewed G-protein coupled receptor
P25311 BXGT009036 Zinc-alpha-2-glycoprotein 563 reviewed
P27708 BXGT009202 CAD protein 790 reviewed Enzyme
P28161 BXGT009234 Glutathione S-transferase Mu 2 2946 reviewed
P28482 BXGT009263 Mitogen-activated protein kinase 1 5594 reviewed Kinase
P28562 BXGT009270 Dual specificity protein phosphatase 1 1843 reviewed
P29317 BXGT009331 Ephrin type-A receptor 2 1969 reviewed Kinase
P29323 BXGT009334 Ephrin type-B receptor 2 2048 reviewed Kinase
P29350 BXGT009335 Tyrosine-protein phosphatase non-receptor type 6 5777 reviewed
P29474 BXGT009352 Nitric oxide synthase, endothelial 4846 reviewed
P30711 BXGT009460 Glutathione S-transferase theta-1 2952 reviewed
P31260 BXGT009519 Homeobox protein Hox-A10 3206 reviewed
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P31751 BXGT009576 RAC-beta serine/threonine-protein kinase 208 reviewed Kinase
P33527 BXGT009728 Multidrug resistance-associated protein 1 4363 reviewed Transporter
P34896 BXGT009767 Serine hydroxymethyltransferase, cytosolic 6470 reviewed Enzyme
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35228 BXGT009800 Nitric oxide synthase, inducible 4843 reviewed
P35354 BXGT009816 Prostaglandin G/H synthase 2 5743 reviewed Enzyme
P35442 BXGT009832 Thrombospondin-2 7058 reviewed
P35503 BXGT009840 UDP-glucuronosyltransferase 1-3 54659 reviewed
P35968 BXGT009887 Vascular endothelial growth factor receptor 2 3791 reviewed Kinase
P37023 BXGT009953 Serine/threonine-protein kinase receptor R3 94 reviewed Kinase
P37840 BXGT010015 Alpha-synuclein 6622 reviewed Transporter
P38398 BXGT010037 Breast cancer type 1 susceptibility protein 672 reviewed Enzyme
P39060 BXGT010088 Collagen alpha-1(XVIII) chain 80781 reviewed
P40692 BXGT010195 DNA mismatch repair protein Mlh1 4292 reviewed Nucleic acid binding
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P41208 BXGT010233 Centrin-2 1069 reviewed Calcium-binding protein
P41440 BXGT010261 Folate transporter 1 6573 reviewed Transporter
P41597 BXGT010268 C-C chemokine receptor type 2 729230 reviewed
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P43246 BXGT010371 DNA mismatch repair protein Msh2 4436 reviewed Nucleic acid binding
P46531 BXGT010526 Neurogenic locus notch homolog protein 1 4851 reviewed
P46937 BXGT010554 Transcriptional coactivator YAP1 10413 reviewed Enzyme modulator
P48061 BXGT010616 Stromal cell-derived factor 1 6387 reviewed
P48357 BXGT010627 Leptin receptor 3953 reviewed Signaling
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P49116 BXGT010678 Nuclear receptor subfamily 2 group C member 2 7182 reviewed Nuclear receptor
P49368 BXGT010701 T-complex protein 1 subunit gamma 7203 reviewed Chaperone
P49763 BXGT010737 Placenta growth factor 5228 reviewed Signaling
P49789 BXGT010742 Bis(5'-adenosyl)-triphosphatase 2272 reviewed
P49917 BXGT010765 DNA ligase 4 3981 reviewed
P50750 BXGT010818 Cyclin-dependent kinase 9 1025 reviewed Kinase
P51532 BXGT010852 Transcription activator BRG1 6597 reviewed Epigenetic regulator
P51681 BXGT010878 C-C chemokine receptor type 5 1234 reviewed G-protein coupled receptor
P51993 BXGT010914 Alpha-(1,3)-fucosyltransferase 6 2528 reviewed Enzyme
P54278 BXGT011038 Mismatch repair endonuclease PMS2 5395 reviewed Nucleic acid binding
P54762 BXGT011076 Ephrin type-B receptor 1 2047 reviewed Kinase
P54764 BXGT011078 Ephrin type-A receptor 4 2043 reviewed Kinase
P55040 BXGT011099 GTP-binding protein GEM 2669 reviewed
P55957 BXGT011137 BH3-interacting domain death agonist 637 reviewed
P60174 BXGT011294 Triosephosphate isomerase 7167 reviewed Enzyme
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P61073 BXGT011352 C-X-C chemokine receptor type 4 7852 reviewed G-protein coupled receptor
P61769 BXGT011383 Beta-2-microglobulin 567 reviewed Immune response
P63261 BXGT011512 Actin, cytoplasmic 2 71 reviewed Cellular structure
P78536 BXGT011847 Disintegrin and metalloproteinase domain-containing protein 17 6868 reviewed
Q01105 BXGT012569 Protein SET 6418 reviewed Enzyme modulator
Q02750 BXGT012662 Dual specificity mitogen-activated protein kinase kinase 1 5604 reviewed Kinase
Q02763 BXGT012667 Angiopoietin-1 receptor 7010 reviewed Kinase
Q07812 BXGT012940 Apoptosis regulator BAX 581 reviewed Signaling
Q07912 BXGT012947 Activated CDC42 kinase 1 10188 reviewed Kinase
Q08050 BXGT012958 Forkhead box protein M1 2305 reviewed
Q08345 BXGT012982 Epithelial discoidin domain-containing receptor 1 780 reviewed Kinase
Q12882 BXGT013276 Dihydropyrimidine dehydrogenase [NADP(+)] 1806 reviewed Enzyme
Q13315 BXGT013339 Serine-protein kinase ATM 472 reviewed Kinase
Q13485 BXGT013363 Mothers against decapentaplegic homolog 4 4089 reviewed Transcription factor
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 5300 reviewed
Q14002 BXGT013433 Carcinoembryonic antigen-related cell adhesion molecule 7 1087 reviewed
Q14191 BXGT013452 Werner syndrome ATP-dependent helicase 7486 reviewed Enzyme
Q14627 BXGT013492 Interleukin-13 receptor subunit alpha-2 3598 reviewed Signaling
Q15046 BXGT013527 Lysine--tRNA ligase 3735 reviewed Enzyme
Q15116 BXGT013539 Programmed cell death protein 1 5133 reviewed
Q15139 BXGT013546 Serine/threonine-protein kinase D1 5587 reviewed Kinase
Q15257 BXGT013554 Serine/threonine-protein phosphatase 2A activator 5524 reviewed Enzyme modulator
Q15303 BXGT013557 Receptor tyrosine-protein kinase erbB-4 2066 reviewed Kinase
Q15389 BXGT013564 Angiopoietin-1 284 reviewed Signaling
Q15910 BXGT013612 Histone-lysine N-methyltransferase EZH2 2146 reviewed Epigenetic regulator
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha 3091 reviewed Transcription factor
Q16790 BXGT013670 Carbonic anhydrase 9 768 reviewed
Q8IXJ6 BXGT018362 NAD-dependent protein deacetylase sirtuin-2 22933 reviewed Epigenetic regulator
Q92887 BXGT019389 Canalicular multispecific organic anion transporter 1 1244 reviewed Transporter
Q96F46 BXGT019656 Interleukin-17 receptor A 23765 reviewed
Q96GD4 BXGT019667 Aurora kinase B 9212 reviewed Kinase
Q96KB5 BXGT019685 Lymphokine-activated killer T-cell-originated protein kinase 55872 reviewed Kinase
Q9BUB5 BXGT020133 MAP kinase-interacting serine/threonine-protein kinase 1 8569 reviewed Kinase
Q9BZS1 BXGT020203 Forkhead box protein P3 50943 reviewed
Q9H0P0 BXGT020439 Cytosolic 5'-nucleotidase 3A 51251 reviewed Enzyme
Q9HAW7 BXGT020508 UDP-glucuronosyltransferase 1-7 54577 reviewed
Q9HAW8 BXGT020509 UDP-glucuronosyltransferase 1-10 54575 reviewed
Q9HAW9 BXGT020510 UDP-glucuronosyltransferase 1-8 54576 reviewed
Q9NR96 BXGT021181 Toll-like receptor 9 54106 reviewed
Q9NYK1 BXGT021258 Toll-like receptor 7 51284 reviewed
Q9NZQ7 BXGT021281 Programmed cell death 1 ligand 1 29126 reviewed Receptor
Q9UM73 BXGT021773 ALK tyrosine kinase receptor 238 reviewed Kinase
Q9UNQ0 BXGT021792 ATP-binding cassette sub-family G member 2 9429 reviewed Transporter
Q9UPY3 BXGT021802 Endoribonuclease Dicer 23405 reviewed Enzyme
Q9Y275 BXGT022223 Tumor necrosis factor ligand superfamily member 13B 10673 reviewed
Q9Y5K3 BXGT022294 Choline-phosphate cytidylyltransferase B 9468 reviewed
Q9Y5Y6 BXGT022308 Suppressor of tumorigenicity 14 protein 6768 reviewed Enzyme
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 10599 reviewed Transporter
P35240 BXGT022927 Merlin 4771 reviewed
Q9UM82 BXGT023181 Spermatogenesis-associated protein 2 9825 reviewed
O60502 BXGT023392 Protein O-GlcNAcase 10724 reviewed
Q16552 BXGT023419 Interleukin-17A 3605 reviewed
P40198 BXGT023750 Carcinoembryonic antigen-related cell adhesion molecule 3 1084 reviewed
Q12888 BXGT024878 TP53-binding protein 1 7158 reviewed Epigenetic regulator
Q92832 BXGT025242 Protein kinase C-binding protein NELL1 4745 reviewed Calcium-binding protein
A8K7I4 BXGT025277 Calcium-activated chloride channel regulator 1 1179 reviewed Ion channel
Q86SQ9 BXGT025875 Dehydrodolichyl diphosphate synthase complex subunit DHDDS 79947 reviewed Enzyme
V9HWB9 BXGT026149 L-lactate dehydrogenase 3939 unreviewed
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease