Showing entry for 14-3-3 protein theta


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009173
Protein Name14-3-3 protein theta
Uniport IdP27348
GeneYWHAQ
Gene Id10971
Domain41701
Pfam PF00244  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.2 Cell growth and death hsa04110 Cell cycle
4. Cellular Processes 4.2 Cell growth and death hsa04114 Oocyte meiosis
3. Environmental Information Processing 3.2 Signal transduction hsa04151 PI3K-Akt signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04390 Hippo signaling pathway
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05130 Pathogenic Escherichia coli infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05160 Hepatitis C
6. Human Diseases 6.9 Infectious diseases: Viral hsa05161 Hepatitis B
6. Human Diseases 6.1 Cancers: Overview hsa05203 Viral carcinogenesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0061024 membrane organization
Biological Process GO:0034766 negative regulation of ion transmembrane transport
Biological Process GO:0045892 negative regulation of transcription, DNA-templated
Biological Process GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
Biological Process GO:0006605 protein targeting
Biological Process GO:0007264 small GTPase mediated signal transduction
Biological Process GO:0021762 substantia nigra development
molecular function GO:0071889 14-3-3 protein binding
molecular function GO:0042802 identical protein binding
molecular function GO:0044325 ion channel binding
molecular function GO:0008022 protein C-terminus binding
molecular function GO:0019904 protein domain specific binding
molecular function GO:0047485 protein N-terminus binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005925 focal adhesion
cellular component GO:0016020 membrane
cellular component GO:0005739 mitochondrion
cellular component GO:0032991 protein-containing complex
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
R-HSA-109581 Apoptosis
R-HSA-109606 Intrinsic Pathway for Apoptosis
R-HSA-111447 Activation of BAD and translocation to mitochondria
R-HSA-114452 Activation of BH3-only proteins
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-162582 Signal Transduction
R-HSA-1640170 Cell Cycle
R-HSA-194315 Signaling by Rho GTPases
R-HSA-195258 RHO GTPase Effectors
R-HSA-199991 Membrane Trafficking
R-HSA-212436 Generic Transcription Pathway
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-5357801 Programmed Cell Death
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-5653656 Vesicle-mediated transport
R-HSA-69473 G2/M DNA damage checkpoint
R-HSA-69481 G2/M Checkpoints
R-HSA-69620 Cell Cycle Checkpoints
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
R-HSA-9614085 FOXO-mediated transcription
R-HSA-9614399 Regulation of localization of FOXO transcription factors
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0016059 BXGD001043 Fibrosis Pathological Conditions, Signs and Symptoms
C0018378 BXGD001190 Guillain-Barre Syndrome Immune System Diseases; Nervous System Diseases
C0018800 BXGD001225 Cardiomegaly Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0022336 BXGD001535 Creutzfeldt-Jakob disease Infections; Nervous System Diseases; Mental Disorders
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0037369 BXGD002691 Smoking Behavior and Behavior Mechanisms
C0086743 BXGD003308 Osteoarthrosis Deformans Musculoskeletal Diseases
C0162534 BXGD003953 Prion Diseases Infections; Nervous System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C1519383 BXGD013237 Smoking Behaviors Behavior and Behavior Mechanisms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3714514 BXGD019409 Infection Infections
C4310512 BXGD022597 Sporadic CJD Infections; Nervous System Diseases; Mental Disorders; Animal Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002588 Magnesium 24.31
BXGC0002953 2-Phenethyl isothiocyanate 163.24
BXGC0030612 tetraethylene glycol 194.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein