adisease

Showing entry for Cardiomegaly

General Disease Information
BXGD Id	BXGD001225
Disease Name	Cardiomegaly
Disease CUI Id	C0018800
MeSH Codes	C23 C14
Disease Class Name	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
Semantic Type	Finding
Human Phenotype Ontology Id	HP:0001626
Human Phenotype Ontology Term	Abnormality of the cardiovascular system
Disease Ontology Id
Disease Ontology Class Name
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O14832	BXGT004104	Phytanoyl-CoA dioxygenase, peroxisomal	5264	reviewed
O14939	BXGT004115	Phospholipase D2	5338	reviewed
O15247	BXGT004142	Chloride intracellular channel protein 2	1193	reviewed	Ion channel
O15294	BXGT004147	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit	8473	reviewed
O60313	BXGT004871	Dynamin-like 120 kDa protein, mitochondrial	4976	reviewed	Enzyme modulator
O60706	BXGT004896	ATP-binding cassette sub-family C member 9	10060	reviewed	Transporter
O60895	BXGT004907	Receptor activity-modifying protein 2	10266	reviewed	Receptor
O75116	BXGT005100	Rho-associated protein kinase 2	9475	reviewed	Kinase
O75489	BXGT005131	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	4722	reviewed
O75923	BXGT005166	Dysferlin	8291	reviewed	Transporter
O76003	BXGT005170	Glutaredoxin-3	10539	reviewed	Enzyme
O76082	BXGT005175	Solute carrier family 22 member 5	6584	reviewed	Transporter
O94766	BXGT005330	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3	26229	reviewed	Enzyme
O95398	BXGT005378	Rap guanine nucleotide exchange factor 3	10411	reviewed	Enzyme modulator
P00749	BXGT005641	Urokinase-type plasminogen activator	5328	reviewed	Enzyme
P00797	BXGT005658	Renin	5972	reviewed	Enzyme
P01019	BXGT005717	Angiotensinogen	183	reviewed	Enzyme modulator
P01023	BXGT005718	Alpha-2-macroglobulin	2	reviewed	Enzyme modulator
P01106	BXGT005730	Myc proto-oncogene protein	4609	reviewed	Transcription factor
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01189	BXGT005742	Pro-opiomelanocortin	5443	reviewed
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02766	BXGT005953	Transthyretin	7276	reviewed	Transporter
P02795	BXGT005968	Metallothionein-2	4502	reviewed
P04049	BXGT006133	RAF proto-oncogene serine/threonine-protein kinase	5894	reviewed	Kinase
P04062	BXGT006140	Lysosomal acid glucosylceramidase	2629	reviewed
P04066	BXGT006142	Tissue alpha-L-fucosidase	2517	reviewed
P04179	BXGT006163	Superoxide dismutase [Mn], mitochondrial	6648	reviewed	Enzyme
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P04798	BXGT006265	Cytochrome P450 1A1	1543	reviewed	Enzyme
P05108	BXGT006317	Cholesterol side-chain cleavage enzyme, mitochondrial	1583	reviewed
P05181	BXGT006337	Cytochrome P450 2E1	1571	reviewed
P05230	BXGT006344	Fibroblast growth factor 1	2246	reviewed	Signaling
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05771	BXGT006384	Protein kinase C beta type	5579	reviewed	Kinase
P06396	BXGT006435	Gelsolin	2934	reviewed	Cellular structure
P07355	BXGT006609	Annexin A2	302	reviewed
P07686	BXGT006657	Beta-hexosaminidase subunit beta	3074	reviewed	Enzyme
P07948	BXGT006702	Tyrosine-protein kinase Lyn	4067	reviewed	Kinase
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P08581	BXGT006794	Hepatocyte growth factor receptor	4233	reviewed	Kinase
P08758	BXGT006821	Annexin A5	308	reviewed
P08913	BXGT006841	Alpha-2A adrenergic receptor	150	reviewed	G-protein coupled receptor
P09038	BXGT006851	Fibroblast growth factor 2	2247	reviewed	Signaling
P09601	BXGT006909	Heme oxygenase 1	3162	reviewed
P09619	BXGT006911	Platelet-derived growth factor receptor beta	5159	reviewed	Kinase
P09874	BXGT006934	Poly [ADP-ribose] polymerase 1	142	reviewed
P10253	BXGT007550	Lysosomal alpha-glucosidase	2548	reviewed	Enzyme
P10600	BXGT007584	Transforming growth factor beta-3 proprotein	7043	reviewed	Signaling
P10644	BXGT007597	cAMP-dependent protein kinase type I-alpha regulatory subunit	5573	reviewed
P10828	BXGT007624	Thyroid hormone receptor beta	7068	reviewed	Nuclear receptor
P11217	BXGT007674	Glycogen phosphorylase, muscle form	5837	reviewed	Enzyme
P12235	BXGT007774	ADP/ATP translocase 1	291	reviewed	Transporter
P12643	BXGT007830	Bone morphogenetic protein 2	650	reviewed	Signaling
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P12931	BXGT007859	Proto-oncogene tyrosine-protein kinase Src	6714	reviewed	Kinase
P14672	BXGT008037	Solute carrier family 2, facilitated glucose transporter member 4	6517	reviewed	Transporter
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P14923	BXGT008069	Junction plakoglobin	3728	reviewed
P15531	BXGT008136	Nucleoside diphosphate kinase A	4830	reviewed	Kinase
P15538	BXGT008137	Cytochrome P450 11B1, mitochondrial	1584	reviewed
P16066	BXGT008185	Atrial natriuretic peptide receptor 1	4881	reviewed	Kinase
P16070	BXGT008186	CD44 antigen	960	reviewed
P17050	BXGT008277	Alpha-N-acetylgalactosaminidase	4668	reviewed
P17252	BXGT008294	Protein kinase C alpha type	5578	reviewed	Kinase
P18206	BXGT008389	Vinculin	7414	reviewed
P18825	BXGT008426	Alpha-2C adrenergic receptor	152	reviewed	G-protein coupled receptor
P19099	BXGT008456	Cytochrome P450 11B2, mitochondrial	1585	reviewed
P19320	BXGT008470	Vascular cell adhesion protein 1	7412	reviewed
P19429	BXGT008479	Troponin I, cardiac muscle	7137	reviewed	Cellular structure
P19634	BXGT008504	Sodium/hydrogen exchanger 1	6548	reviewed	Transporter
P19801	BXGT008516	Amiloride-sensitive amine oxidase [copper-containing]	26	reviewed
P21453	BXGT008654	Sphingosine 1-phosphate receptor 1	1901	reviewed	G-protein coupled receptor
P23297	BXGT008848	Protein S100-A1	6271	reviewed	Calcium-binding protein
P23443	BXGT008866	Ribosomal protein S6 kinase beta-1	6198	reviewed	Kinase
P23786	BXGT008906	Carnitine O-palmitoyltransferase 2, mitochondrial	1376	reviewed	Enzyme
P25098	BXGT009015	Beta-adrenergic receptor kinase 1	156	reviewed	Kinase
P27348	BXGT009173	14-3-3 protein theta	10971	reviewed	Chaperone
P27361	BXGT009176	Mitogen-activated protein kinase 3	5595	reviewed	Kinase
P28300	BXGT009243	Protein-lysine 6-oxidase	4015	reviewed
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P28907	BXGT009301	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	952	reviewed	Enzyme
P29474	BXGT009352	Nitric oxide synthase, endothelial	4846	reviewed
P29475	BXGT009353	Nitric oxide synthase, brain	4842	reviewed
P30279	BXGT009415	G1/S-specific cyclin-D2	894	reviewed	Enzyme modulator
P30556	BXGT009441	Type-1 angiotensin II receptor	185	reviewed	G-protein coupled receptor
P31153	BXGT009512	S-adenosylmethionine synthase isoform type-2	4144	reviewed	Enzyme
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P32418	BXGT009635	Sodium/calcium exchanger 1	6546	reviewed	Transporter
P35368	BXGT009822	Alpha-1B adrenergic receptor	147	reviewed	G-protein coupled receptor
P35555	BXGT009845	Fibrillin-1	2200	reviewed	Calcium-binding protein
P35869	BXGT009877	Aryl hydrocarbon receptor	196	reviewed	Transcription factor
P36897	BXGT009941	TGF-beta receptor type-1	7046	reviewed	Kinase
P37173	BXGT009970	TGF-beta receptor type-2	7048	reviewed	Kinase
P37288	BXGT009977	Vasopressin V1a receptor	552	reviewed	G-protein coupled receptor
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P41595	BXGT010267	5-hydroxytryptamine receptor 2B	3357	reviewed	G-protein coupled receptor
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P45379	BXGT010459	Troponin T, cardiac muscle	7139	reviewed	Cellular structure
P48735	BXGT010657	Isocitrate dehydrogenase [NADP], mitochondrial	3418	reviewed
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P49841	BXGT010750	Glycogen synthase kinase-3 beta	2932	reviewed	Kinase
P50416	BXGT010797	Carnitine O-palmitoyltransferase 1, liver isoform	1374	reviewed	Enzyme
P50993	BXGT010826	Sodium/potassium-transporting ATPase subunit alpha-2	477	reviewed	Transporter
P51787	BXGT010889	Potassium voltage-gated channel subfamily KQT member 1	3784	reviewed	Ion channel
P52952	BXGT010966	Homeobox protein Nkx-2.5	1482	reviewed	Transcription factor
P53667	BXGT011008	LIM domain kinase 1	3984	reviewed	Kinase
P54646	BXGT011062	5'-AMP-activated protein kinase catalytic subunit alpha-2	5563	reviewed	Kinase
P54802	BXGT011081	Alpha-N-acetylglucosaminidase	4669	reviewed
P55042	BXGT011100	GTP-binding protein RAD	6236	reviewed
P55265	BXGT011117	Double-stranded RNA-specific adenosine deaminase	103	reviewed	Enzyme
P56524	BXGT011176	Histone deacetylase 4	9759	reviewed	Epigenetic regulator
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P61586	BXGT011375	Transforming protein RhoA	387	reviewed	Enzyme modulator
P62508	BXGT011431	Estrogen-related receptor gamma	2104	reviewed	Nuclear receptor
P62736	BXGT011452	Actin, aortic smooth muscle	59	reviewed	Cellular structure
P68871	BXGT011615	Hemoglobin subunit beta	3043	reviewed
P81172	BXGT011935	Hepcidin	57817	reviewed
P84022	BXGT012027	Mothers against decapentaplegic homolog 3	4088	reviewed	Transcription factor
P98155	BXGT012226	Very low-density lipoprotein receptor	7436	reviewed
Q00613	BXGT012540	Heat shock factor protein 1	3297	reviewed	Transcription factor
Q02156	BXGT012639	Protein kinase C epsilon type	5581	reviewed	Kinase
Q03181	BXGT012701	Peroxisome proliferator-activated receptor delta	5467	reviewed	Nuclear receptor
Q04206	BXGT012754	Transcription factor p65	5970	reviewed	Transcription factor
Q05513	BXGT012820	Protein kinase C zeta type	5590	reviewed	Kinase
Q05655	BXGT012832	Protein kinase C delta type	5580	reviewed	Kinase
Q07021	BXGT012915	Complement component 1 Q subcomponent-binding protein, mitochondrial	708	reviewed
Q07869	BXGT012945	Peroxisome proliferator-activated receptor alpha	5465	reviewed	Nuclear receptor
Q09472	BXGT013038	Histone acetyltransferase p300	2033	reviewed
Q13393	BXGT013346	Phospholipase D1	5337	reviewed
Q13557	BXGT013376	Calcium/calmodulin-dependent protein kinase type II subunit delta	817	reviewed	Kinase
Q13976	BXGT013409	cGMP-dependent protein kinase 1	5592	reviewed	Kinase
Q14116	BXGT013442	Interleukin-18	3606	reviewed
Q14393	BXGT013466	Growth arrest-specific protein 6	2621	reviewed	Extracellular structure
Q14457	BXGT013472	Beclin-1	8678	reviewed	Enzyme modulator
Q14524	BXGT013478	Sodium channel protein type 5 subunit alpha	6331	reviewed	Ion channel
Q14571	BXGT013485	Inositol 1,4,5-trisphosphate receptor type 2	3709	reviewed	Ion channel
Q15063	BXGT013531	Periostin	10631	reviewed	Signaling
Q15746	BXGT013591	Myosin light chain kinase, smooth muscle	4638	reviewed	Kinase
Q15831	BXGT013604	Serine/threonine-protein kinase STK11	6794	reviewed	Kinase
Q15842	BXGT013607	ATP-sensitive inward rectifier potassium channel 8	3764	reviewed	Ion channel
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q16678	BXGT013656	Cytochrome P450 1B1	1545	reviewed	Enzyme
Q30201	BXGT014297	Hereditary hemochromatosis protein	3077	reviewed
Q676U5	BXGT016177	Autophagy-related protein 16-1	55054	reviewed
Q8N6T7	BXGT018525	NAD-dependent protein deacetylase sirtuin-6	51548	reviewed	Epigenetic regulator
Q8TD19	BXGT018804	Serine/threonine-protein kinase Nek9	91754	reviewed	Kinase
Q8TD43	BXGT018806	Transient receptor potential cation channel subfamily M member 4	54795	reviewed	Ion channel
Q92769	BXGT019370	Histone deacetylase 2	3066	reviewed	Epigenetic regulator
Q92934	BXGT019396	Bcl2-associated agonist of cell death	572	reviewed
Q969Q1	BXGT019610	E3 ubiquitin-protein ligase TRIM63	84676	reviewed
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q99519	BXGT019928	Sialidase-1	4758	reviewed	Enzyme
Q9BY41	BXGT020180	Histone deacetylase 8	55869	reviewed	Epigenetic regulator
Q9H492	BXGT020472	Microtubule-associated proteins 1A/1B light chain 3A	84557	reviewed	Cellular structure
Q9NRM7	BXGT021190	Serine/threonine-protein kinase LATS2	26524	reviewed	Kinase
Q9UGJ0	BXGT021683	5'-AMP-activated protein kinase subunit gamma-2	51422	reviewed	Enzyme modulator
Q9UGN5	BXGT021688	Poly [ADP-ribose] polymerase 2	10038	reviewed
Q9Y243	BXGT022214	RAC-gamma serine/threonine-protein kinase	10000	reviewed	Kinase
Q9Y3Z3	BXGT022268	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	25939	reviewed
P16615	BXGT023653	Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	488	reviewed	Transporter
O95140	BXGT024482	Mitofusin-2	9927	reviewed	Enzyme
P35250	BXGT025854	Replication factor C subunit 2	5982	reviewed	Enzyme

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}