adisease

Showing entry for Prion Diseases

General Disease Information
BXGD Id	BXGD003953
Disease Name	Prion Diseases
Disease CUI Id	C0162534
MeSH Codes	C01 C10
Disease Class Name	Infections; Nervous System Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
F7VJQ1	BXGT003310	Alternative prion protein	5621	reviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O00429	BXGT003919	Dynamin-1-like protein	10059	reviewed	Enzyme modulator
O14672	BXGT004081	Disintegrin and metalloproteinase domain-containing protein 10	102	reviewed
O15527	BXGT004176	N-glycosylase/DNA lyase	4968	reviewed
O43854	BXGT004630	EGF-like repeat and discoidin I-like domain-containing protein 3	10085	reviewed	Enzyme
O60260	BXGT004864	E3 ubiquitin-protein ligase parkin	5071	reviewed	Enzyme
O60603	BXGT004887	Toll-like receptor 2	7097	reviewed
O76096	BXGT005178	Cystatin-F	8530	reviewed
O94811	BXGT005336	Tubulin polymerization-promoting protein	11076	reviewed	Cellular structure
O94925	BXGT005342	Glutaminase kidney isoform, mitochondrial	2744	reviewed	Enzyme
O95477	BXGT005383	Phospholipid-transporting ATPase ABCA1	19	reviewed	Transporter
P00441	BXGT005540	Superoxide dismutase [Cu-Zn]	6647	reviewed	Enzyme
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P01011	BXGT005715	Alpha-1-antichymotrypsin	12	reviewed	Enzyme modulator
P01138	BXGT005738	Beta-nerve growth factor	4803	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P02511	BXGT005885	Alpha-crystallin B chain	1410	reviewed
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P02743	BXGT005937	Serum amyloid P-component	325	reviewed
P04003	BXGT006124	C4b-binding protein alpha chain	722	reviewed
P04156	BXGT006156	Major prion protein	5621	reviewed
P04179	BXGT006163	Superoxide dismutase [Mn], mitochondrial	6648	reviewed	Enzyme
P04626	BXGT006238	Receptor tyrosine-protein kinase erbB-2	2064	reviewed	Kinase
P04839	BXGT006273	Cytochrome b-245 heavy chain	1536	reviewed	Ion channel
P05067	BXGT006306	Amyloid-beta precursor protein	351	reviewed	Enzyme modulator
P05231	BXGT006345	Interleukin-6	3569	reviewed
P06396	BXGT006435	Gelsolin	2934	reviewed	Cellular structure
P06744	BXGT006494	Glucose-6-phosphate isomerase	2821	reviewed	Enzyme
P07237	BXGT006576	Protein disulfide-isomerase	5034	reviewed
P07333	BXGT006602	Macrophage colony-stimulating factor 1 receptor	1436	reviewed	Kinase
P07339	BXGT006604	Cathepsin D	1509	reviewed	Enzyme
P08047	BXGT006720	Transcription factor Sp1	6667	reviewed	Nucleic acid binding
P08603	BXGT006798	Complement factor H	3075	reviewed
P09382	BXGT006882	Galectin-1	3956	reviewed	Signaling
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10600	BXGT007584	Transforming growth factor beta-3 proprotein	7043	reviewed	Signaling
P10636	BXGT007596	Microtubule-associated protein tau	4137	reviewed
P10747	BXGT007609	T-cell-specific surface glycoprotein CD28	940	reviewed
P10809	BXGT007617	60 kDa heat shock protein, mitochondrial	3329	reviewed
P10826	BXGT007622	Retinoic acid receptor beta	5915	reviewed	Nuclear receptor
P10909	BXGT007630	Clusterin	1191	reviewed
P10997	BXGT007643	Islet amyloid polypeptide	3375	reviewed	Signaling
P11021	BXGT007644	Endoplasmic reticulum chaperone BiP	3309	reviewed
P11229	BXGT007676	Muscarinic acetylcholine receptor M1	1128	reviewed	G-protein coupled receptor
P16070	BXGT008186	CD44 antigen	960	reviewed
P19838	BXGT008526	Nuclear factor NF-kappa-B p105 subunit	4790	reviewed	Transcription factor
P20472	BXGT008578	Parvalbumin alpha	5816	reviewed	Calcium-binding protein
P21730	BXGT008687	C5a anaphylatoxin chemotactic receptor 1	728	reviewed	G-protein coupled receptor
P22303	BXGT008751	Acetylcholinesterase	43	reviewed	Enzyme
P23528	BXGT008879	Cofilin-1	1072	reviewed
P25942	BXGT009079	Tumor necrosis factor receptor superfamily member 5	958	reviewed
P27348	BXGT009173	14-3-3 protein theta	10971	reviewed	Chaperone
P29466	BXGT009349	Caspase-1	834	reviewed	Enzyme
P29965	BXGT009388	CD40 ligand	959	reviewed	Signaling
P30101	BXGT009402	Protein disulfide-isomerase A3	2923	reviewed
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P31948	BXGT009590	Stress-induced-phosphoprotein 1	10963	reviewed
P32119	BXGT009600	Peroxiredoxin-2	7001	reviewed	Enzyme
P32302	BXGT009619	C-X-C chemokine receptor type 5	643	reviewed	G-protein coupled receptor
P34932	BXGT009772	Heat shock 70 kDa protein 4	3308	reviewed
P35354	BXGT009816	Prostaglandin G/H synthase 2	5743	reviewed	Enzyme
P35858	BXGT009876	Insulin-like growth factor-binding protein complex acid labile subunit	3483	reviewed	Receptor
P36222	BXGT009914	Chitinase-3-like protein 1	1116	reviewed
P37840	BXGT010015	Alpha-synuclein	6622	reviewed	Transporter
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P43003	BXGT010347	Excitatory amino acid transporter 1	6507	reviewed	Transporter
P48637	BXGT010649	Glutathione synthetase	2937	reviewed	Enzyme
P48723	BXGT010653	Heat shock 70 kDa protein 13	6782	reviewed
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P49768	BXGT010740	Presenilin-1	5663	reviewed	Enzyme
P54646	BXGT011062	5'-AMP-activated protein kinase catalytic subunit alpha-2	5563	reviewed	Kinase
P55087	BXGT011105	Aquaporin-4	361	reviewed	Ion channel
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
P62937	BXGT011471	Peptidyl-prolyl cis-trans isomerase A	5478	reviewed
P78536	BXGT011847	Disintegrin and metalloproteinase domain-containing protein 17	6868	reviewed
Q10588	BXGT013202	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2	683	reviewed	Enzyme
Q13131	BXGT013314	5'-AMP-activated protein kinase catalytic subunit alpha-1	5562	reviewed	Kinase
Q13526	BXGT013369	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	5300	reviewed
Q14653	BXGT013494	Interferon regulatory factor 3	3661	reviewed	Transcription factor
Q15046	BXGT013527	Lysine--tRNA ligase	3735	reviewed	Enzyme
Q15116	BXGT013539	Programmed cell death protein 1	5133	reviewed
Q15118	BXGT013540	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	5163	reviewed	Kinase
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q16595	BXGT013643	Frataxin, mitochondrial	2395	reviewed	Enzyme
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q16698	BXGT013659	2,4-dienoyl-CoA reductase, mitochondrial	1666	reviewed	Enzyme
Q92736	BXGT019367	Ryanodine receptor 2	6262	reviewed	Ion channel
Q96L34	BXGT019689	MAP/microtubule affinity-regulating kinase 4	57787	reviewed	Kinase
Q96NI6	BXGT019699	Leucine-rich repeat and fibronectin type-III domain-containing protein 5	145581	reviewed
Q96P20	BXGT019704	NACHT, LRR and PYD domains-containing protein 3	114548	reviewed
Q99707	BXGT019952	Methionine synthase	4548	reviewed
Q9GZT9	BXGT020425	Egl nine homolog 1	54583	reviewed
Q9H4B4	BXGT020474	Serine/threonine-protein kinase PLK3	1263	reviewed	Kinase
Q9NP58	BXGT021143	ATP-binding cassette sub-family B member 6, mitochondrial	10058	reviewed	Transporter
Q9NTG7	BXGT021211	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	23410	reviewed	Epigenetic regulator
Q9NZD4	BXGT021271	Alpha-hemoglobin-stabilizing protein	51327	reviewed	Chaperone
Q9Y251	BXGT022215	Heparanase	10855	reviewed	Enzyme
Q9Y478	BXGT022271	5'-AMP-activated protein kinase subunit beta-1	5564	reviewed	Kinase
P46379	BXGT023748	Large proline-rich protein BAG6	7917	reviewed	Enzyme modulator
P21926	BXGT024578	CD9 antigen	928	reviewed
Q6SZW1	BXGT025034	NAD(+) hydrolase SARM1	23098	reviewed
Q7Z3B1	BXGT025707	Neuronal growth regulator 1	257194	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}