Showing entry for DnaJ homolog subfamily A member 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009569
Protein NameDnaJ homolog subfamily A member 1
Uniport IdP31689
GeneDNAJA1
Gene Id3301
DomainDnaJ; DnaJ_C; DnaJ_CXXCXGXG
Pfam PF00226   PF01556   PF00684  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa04141 Protein processing in endoplasmic reticulum
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030521 androgen receptor signaling pathway
Biological Process GO:0042769 DNA damage response, detection of DNA damage
Biological Process GO:0030317 flagellated sperm motility
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:1903748 negative regulation of establishment of protein localization to mitochondrion
Biological Process GO:0043508 negative regulation of JUN kinase activity
Biological Process GO:1905259 negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
Biological Process GO:0031397 negative regulation of protein ubiquitination
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0006457 protein folding
Biological Process GO:0070585 protein localization to mitochondrion
Biological Process GO:0051223 regulation of protein transport
Biological Process GO:0009408 response to heat
Biological Process GO:0006986 response to unfolded protein
Biological Process GO:0007283 spermatogenesis
Biological Process GO:1901998 toxin transport
molecular function GO:0001671 ATPase activator activity
molecular function GO:0005524 ATP binding
molecular function GO:0055131 C3HC4-type RING finger domain binding
molecular function GO:0051087 chaperone binding
molecular function GO:0001664 G protein-coupled receptor binding
molecular function GO:0030544 Hsp70 protein binding
molecular function GO:0050750 low-density lipoprotein particle receptor binding
molecular function GO:0046872 metal ion binding
molecular function GO:0030957 Tat protein binding
molecular function GO:0031625 ubiquitin protein ligase binding
molecular function GO:0051082 unfolded protein binding
cellular component GO:0098554 cytoplasmic side of endoplasmic reticulum membrane
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0016020 membrane
cellular component GO:0015630 microtubule cytoskeleton
cellular component GO:0005739 mitochondrion
cellular component GO:0005634 nucleus
cellular component GO:0048471 perinuclear region of cytoplasm
Reactome
Pathway Id Pathway Name
R-HSA-2262752 Cellular responses to stress
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-8953897 Cellular responses to external stimuli
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0014057 BXGD000880 Japanese Encephalitis Infections; Nervous System Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0026636 BXGD001911 Mouth Diseases Stomatognathic Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234233 BXGD004636 Sore to touch Pathological Conditions, Signs and Symptoms; Mental Disorders
C0270952 BXGD006139 Muscular Dystrophy, Oculopharyngeal Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0752125 BXGD010673 Spinocerebellar Ataxia Type 7 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0812413 BXGD010847 Malignant Pleural Mesothelioma Neoplasms; Respiratory Tract Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1839259 BXGD014363 Bulbo-Spinal Atrophy, X-Linked Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein