Showing entry for Phosphatidylinositol 4-kinase alpha


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010305
Protein NamePhosphatidylinositol 4-kinase alpha
Uniport IdP42356
GenePI4KA
Gene Id5297
DomainPI3Ka; PI3_PI4_kinase
Pfam PF00454   PF00613  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.1 Carbohydrate metabolism hsa00562 Inositol phosphate metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
3. Environmental Information Processing 3.2 Signal transduction hsa04070 Phosphatidylinositol signaling system
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0044803 multi-organism membrane organization
Biological Process GO:0006661 phosphatidylinositol biosynthetic process
Biological Process GO:0048015 phosphatidylinositol-mediated signaling
Biological Process GO:0046854 phosphatidylinositol phosphorylation
Biological Process GO:0016310 phosphorylation
Biological Process GO:0007165 signal transduction
Biological Process GO:0046786 viral replication complex formation and maintenance
Biological Process GO:0039694 viral RNA genome replication
molecular function GO:0004430 1-phosphatidylinositol 4-kinase activity
molecular function GO:0005524 ATP binding
molecular function GO:0045296 cadherin binding
molecular function GO:0016301 kinase activity
molecular function GO:0052742 phosphatidylinositol kinase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005925 focal adhesion
cellular component GO:0030660 Golgi-associated vesicle membrane
cellular component GO:0016020 membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0019034 viral replication complex
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1483248 Synthesis of PIPs at the ER membrane
R-HSA-1483255 PI Metabolism
R-HSA-1483257 Phospholipid metabolism
R-HSA-1660514 Synthesis of PIPs at the Golgi membrane
R-HSA-556833 Metabolism of lipids
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0003886 BXGD000238 Arthrogryposis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0004936 BXGD000295 Mental disorders Mental Disorders
C0009081 BXGD000581 Congenital clubfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0014378 BXGD000912 Enterovirus Infections Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0025990 BXGD001884 Micrognathism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0221358 BXGD004450 Long narrow head
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0266464 BXGD005676 Polymicrogyria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0266470 BXGD005678 Cerebellar Hypoplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0398626 BXGD008204 Heparin cofactor II deficiency (disorder) Cardiovascular Diseases
C0521158 BXGD009130 Recurrent tumor
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1446712 BXGD013083 Overlapping fingers
C1836033 BXGD014072 Cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Nervous System Diseases
C1837355 BXGD014224 Leukodystrophy, Hypomyelinating, 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C1845668 BXGD014757 Perisylvian syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C1846339 BXGD014798 Externally rotated hips
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2243080 BXGD017009 Intestinal necrosis Digestive System Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3266101 BXGD018596 22q11 partial monosomy syndrome
C3278322 BXGD018736 Cerebellar dysplasia
C4225295 BXGD022212 POLYMICROGYRIA, PERISYLVIAN, WITH CEREBELLAR HYPOPLASIA AND ARTHROGRYPOSIS
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002605 Adenosine 267.24
BXGC0003943 Purine 120.11
BXGC0010354 Cytokinin B 225.25
BXGC0022630 7-methyladenine 149.07
BXGC0024261 Adenosine Phosphate 347.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein