Showing entry for Congenital clubfoot


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD000581
Disease NameCongenital clubfoot
Disease CUI IdC0009081
MeSH Codes C16   C05  
Disease Class NameCongenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
Semantic TypeCongenital Abnormality
Human Phenotype Ontology Id HP:0040064  
Human Phenotype Ontology TermAbnormality of limbs
Disease Ontology Id DOID:7  
Disease Ontology Class Namedisease of anatomical entity
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00189 BXGT003891 AP-4 complex subunit mu-1 9179 reviewed Extracellular structure
O00238 BXGT003900 Bone morphogenetic protein receptor type-1B 658 reviewed Kinase
O00469 BXGT003926 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 5352 reviewed Enzyme
O00755 BXGT003945 Protein Wnt-7a 7476 reviewed Signaling
O15146 BXGT004131 Muscle, skeletal receptor tyrosine-protein kinase 4593 reviewed Kinase
O43318 BXGT004586 Mitogen-activated protein kinase kinase kinase 7 6885 reviewed Kinase
O60568 BXGT004885 Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 8985 reviewed Enzyme
O75369 BXGT005119 Filamin-B 2317 reviewed
O75530 BXGT005135 Polycomb protein EED 8726 reviewed
O94766 BXGT005330 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 26229 reviewed Enzyme
O95363 BXGT005375 Phenylalanine--tRNA ligase, mitochondrial 10667 reviewed Enzyme
O96028 BXGT005417 Histone-lysine N-methyltransferase NSD2 7468 reviewed Epigenetic regulator
P01112 BXGT005732 GTPase HRas 3265 reviewed Enzyme modulator
P01236 BXGT005744 Prolactin 5617 reviewed Signaling
P02452 BXGT005878 Collagen alpha-1(I) chain 1277 reviewed
P02458 BXGT005879 Collagen alpha-1(II) chain 1280 reviewed
P02461 BXGT005880 Collagen alpha-1(III) chain 1281 reviewed
P04792 BXGT006264 Heat shock protein beta-1 3315 reviewed
P06753 BXGT006498 Tropomyosin alpha-3 chain 7170 reviewed Cellular structure
P07101 BXGT006547 Tyrosine 3-monooxygenase 7054 reviewed
P07510 BXGT006631 Acetylcholine receptor subunit gamma 1146 reviewed Ion channel
P07949 BXGT006703 Proto-oncogene tyrosine-protein kinase receptor Ret 5979 reviewed Kinase
P08236 BXGT006752 Beta-glucuronidase 2990 reviewed
P09493 BXGT006900 Tropomyosin alpha-1 chain 7168 reviewed Cellular structure
P10412 BXGT007566 Histone H1.4 3008 reviewed Nucleic acid binding
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P13224 BXGT007890 Platelet glycoprotein Ib beta chain 2812 reviewed
P16157 BXGT008203 Ankyrin-1 286 reviewed
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 1131 reviewed G-protein coupled receptor
P21333 BXGT008638 Filamin-A 2316 reviewed
P21817 BXGT008693 Ryanodine receptor 1 6261 reviewed Ion channel
P21964 BXGT008714 Catechol O-methyltransferase 1312 reviewed Enzyme
P30793 BXGT009466 GTP cyclohydrolase 1 2643 reviewed Enzyme
P32004 BXGT009594 Neural cell adhesion molecule L1 3897 reviewed
P32929 BXGT009682 Cystathionine gamma-lyase 1491 reviewed Enzyme
P35555 BXGT009845 Fibrillin-1 2200 reviewed Calcium-binding protein
P36897 BXGT009941 TGF-beta receptor type-1 7046 reviewed Kinase
P36969 BXGT009949 Phospholipid hydroperoxide glutathione peroxidase 2879 reviewed Enzyme
P37173 BXGT009970 TGF-beta receptor type-2 7048 reviewed Kinase
P37840 BXGT010015 Alpha-synuclein 6622 reviewed Transporter
P38919 BXGT010072 Eukaryotic initiation factor 4A-III 9775 reviewed
P41229 BXGT010239 Lysine-specific demethylase 5C 8242 reviewed
P42356 BXGT010305 Phosphatidylinositol 4-kinase alpha 5297 reviewed Kinase
P42702 BXGT010335 Leukemia inhibitory factor receptor 3977 reviewed Signaling
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P43026 BXGT010351 Growth/differentiation factor 5 8200 reviewed Signaling
P46100 BXGT010508 Transcriptional regulator ATRX 546 reviewed
P48061 BXGT010616 Stromal cell-derived factor 1 6387 reviewed
P48067 BXGT010619 Sodium- and chloride-dependent glycine transporter 1 6536 reviewed Transporter
P49327 BXGT010694 Fatty acid synthase 2194 reviewed Enzyme
P50542 BXGT010808 Peroxisomal targeting signal 1 receptor 5830 reviewed Transporter
P52788 BXGT010953 Spermine synthase 6611 reviewed
P54886 BXGT011092 Delta-1-pyrroline-5-carboxylate synthase 5832 reviewed Enzyme
P55201 BXGT011109 Peregrin 7862 reviewed
P61073 BXGT011352 C-X-C chemokine receptor type 4 7852 reviewed G-protein coupled receptor
P68133 BXGT011578 Actin, alpha skeletal muscle 58 reviewed Cellular structure
P69905 BXGT011649 Hemoglobin subunit alpha 3040 reviewed
P98160 BXGT012228 Basement membrane-specific heparan sulfate proteoglycan core protein 3339 reviewed Enzyme modulator
Q02809 BXGT012674 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 5351 reviewed Enzyme
Q04721 BXGT012777 Neurogenic locus notch homolog protein 2 4853 reviewed
Q04828 BXGT012787 Aldo-keto reductase family 1 member C1 1645 reviewed Enzyme
Q13363 BXGT013344 C-terminal-binding protein 1 1487 reviewed Transcription factor
Q13415 BXGT013350 Origin recognition complex subunit 1 4998 reviewed Nucleic acid binding
Q14004 BXGT013435 Cyclin-dependent kinase 13 8621 reviewed Kinase
Q14117 BXGT013443 Dihydropyrimidinase 1807 reviewed Enzyme
Q14623 BXGT013490 Indian hedgehog protein 3549 reviewed
Q15022 BXGT013523 Polycomb protein SUZ12 23512 reviewed Nucleic acid binding
Q15125 BXGT013543 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 10682 reviewed Enzyme
Q15223 BXGT013551 Nectin-1 5818 reviewed
Q15582 BXGT013581 Transforming growth factor-beta-induced protein ig-h3 7045 reviewed Signaling
Q15652 BXGT013587 Probable JmjC domain-containing histone demethylation protein 2C 221037 reviewed
Q15907 BXGT013611 Ras-related protein Rab-11B 9230 reviewed
Q15910 BXGT013612 Histone-lysine N-methyltransferase EZH2 2146 reviewed Epigenetic regulator
Q16637 BXGT013646 Survival motor neuron protein 6607 reviewed Epigenetic regulator
Q16719 BXGT013662 Kynureninase 8942 reviewed Enzyme
Q53EZ4 BXGT015010 Centrosomal protein of 55 kDa 55165 reviewed
Q6PI48 BXGT016471 Aspartate--tRNA ligase, mitochondrial 55157 reviewed Enzyme
Q7Z406 BXGT017251 Myosin-14 79784 reviewed
Q8TD19 BXGT018804 Serine/threonine-protein kinase Nek9 91754 reviewed Kinase
Q8WVQ1 BXGT018996 Soluble calcium-activated nucleotidase 1 124583 reviewed
Q8WZ42 BXGT019023 Titin 7273 reviewed Kinase
Q9HBA0 BXGT020516 Transient receptor potential cation channel subfamily V member 4 59341 reviewed Ion channel
Q9HD42 BXGT020543 Charged multivesicular body protein 1a 5119 reviewed
Q9NRR6 BXGT021193 Phosphatidylinositol polyphosphate 5-phosphatase type IV 56623 reviewed
Q9NYL2 BXGT021259 Mitogen-activated protein kinase kinase kinase 20 51776 reviewed Kinase
Q9UBM7 BXGT021657 7-dehydrocholesterol reductase 1717 reviewed Enzyme
Q9Y3I1 BXGT022260 F-box only protein 7 25793 reviewed
Q9Y4D7 BXGT022275 Plexin-D1 23129 reviewed
Q9Y618 BXGT022315 Nuclear receptor corepressor 2 9612 reviewed Transcription factor
Q9Y5W7 BXGT022783 Sorting nexin-14 57231 reviewed Enzyme modulator
O14793 BXGT023280 Growth/differentiation factor 8 2660 reviewed Signaling
Q53GS7 BXGT023762 Nucleoporin GLE1 2733 reviewed Transporter
Q96L73 BXGT024676 Histone-lysine N-methyltransferase, H3 lysine-36 specific 64324 reviewed Epigenetic regulator
P28715 BXGT025675 DNA repair protein complementing XP-G cells 2073 reviewed
Q96MF2 BXGT025769 SH3 and cysteine-rich domain-containing protein 3 246329 reviewed
Q86SG6 BXGT026136 Serine/threonine-protein kinase Nek8 284086 reviewed Kinase
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease