Showing entry for Acetylserotonin O-methyltransferase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010528
Protein NameAcetylserotonin O-methyltransferase
Uniport IdP46597
GeneASMT
Gene Id438
DomainDimerisation2; Methyltransf_2
Pfam PF16864   PF00891  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.5 Amino acid metabolism hsa00380 Tryptophan metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0019438 aromatic compound biosynthetic process
Biological Process GO:0046219 indolalkylamine biosynthetic process
Biological Process GO:0030187 melatonin biosynthetic process
Biological Process GO:0032259 methylation
Biological Process GO:0006412 translation
molecular function GO:0017096 acetylserotonin O-methyltransferase activity
molecular function GO:0042802 identical protein binding
molecular function GO:0008171 O-methyltransferase activity
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
molecular function GO:0008172 S-methyltransferase activity
cellular component GO:0005829 cytosol
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-209776 Metabolism of amine-derived hormones
R-HSA-209931 Serotonin and melatonin biosynthesis
R-HSA-71291 Metabolism of amino acids and derivatives
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0004936 BXGD000295 Mental disorders Mental Disorders
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0019202 BXGD001302 Hepatolenticular Degeneration Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Nervous System Diseases
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0031941 BXGD002317 Pineal Gland Neoplasm Neoplasms; Nervous System Diseases
C0035335 BXGD002540 Retinoblastoma Neoplasms; Eye Diseases
C0205898 BXGD004139 pineoblastoma Neoplasms; Nervous System Diseases
C0206663 BXGD004225 Neuroectodermal Tumor, Primitive Neoplasms
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0281331 BXGD006772 Adult Pineocytoma Neoplasms; Nervous System Diseases
C0281332 BXGD006773 Adult Pineoblastoma Neoplasms; Nervous System Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0349218 BXGD007895 Recurrent depressive disorder Mental Disorders
C0917890 BXGD011421 Pineocytoma Neoplasms; Nervous System Diseases
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1527352 BXGD013278 Hepatic Form of Wilson Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Nervous System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3887520 BXGD019890 Childhood Pineoblastoma Neoplasms; Nervous System Diseases
C4285716 BXGD022449 Melatonin deficiency
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002916 Melatonin 232.28
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein