adisease

Showing entry for Medulloblastoma

General Disease Information
BXGD Id	BXGD001826
Disease Name	Medulloblastoma
Disease CUI Id	C0025149
MeSH Codes	C04
Disease Class Name	Neoplasms
Semantic Type	Neoplastic Process
Human Phenotype Ontology Id	HP:0000707 HP:0002664
Human Phenotype Ontology Term	Abnormality of the nervous system; Neoplasm
Disease Ontology Id	DOID:7 DOID:14566
Disease Ontology Class Name	disease of anatomical entity; disease of cellular proliferation
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00141	BXGT003882	Serine/threonine-protein kinase Sgk1	6446	reviewed	Kinase
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O00418	BXGT003918	Eukaryotic elongation factor 2 kinase	29904	reviewed	Kinase
O00444	BXGT003921	Serine/threonine-protein kinase PLK4	10733	reviewed	Kinase
O00571	BXGT003938	ATP-dependent RNA helicase DDX3X	1654	reviewed
O14641	BXGT004078	Segment polarity protein dishevelled homolog DVL-2	1856	reviewed	Signaling
O14733	BXGT004087	Dual specificity mitogen-activated protein kinase kinase 7	5609	reviewed	Kinase
O14744	BXGT004089	Protein arginine N-methyltransferase 5	10419	reviewed	Epigenetic regulator
O14746	BXGT004091	Telomerase reverse transcriptase	7015	reviewed	Enzyme
O14757	BXGT004092	Serine/threonine-protein kinase Chk1	1111	reviewed	Kinase
O14786	BXGT004099	Neuropilin-1	8829	reviewed
O14965	BXGT004117	Aurora kinase A	6790	reviewed	Kinase
O15054	BXGT004121	Lysine-specific demethylase 6B	23135	reviewed	Epigenetic regulator
O15151	BXGT004132	Protein Mdm4	4194	reviewed	Nucleic acid binding
O15169	BXGT004134	Axin-1	8312	reviewed
O15297	BXGT004149	Protein phosphatase 1D	8493	reviewed	Enzyme
O15350	BXGT004154	Tumor protein p73	7161	reviewed	Transcription factor
O15392	BXGT004162	Baculoviral IAP repeat-containing protein 5	332	reviewed	Enzyme modulator
O15438	BXGT004168	Canalicular multispecific organic anion transporter 2	8714	reviewed	Transporter
O15550	BXGT004179	Lysine-specific demethylase 6A	7403	reviewed	Epigenetic regulator
O43280	BXGT004582	Trehalase	11181	reviewed
O60341	BXGT004873	Lysine-specific histone demethylase 1A	23028	reviewed	Epigenetic regulator
O60462	BXGT004876	Neuropilin-2	8828	reviewed
O60674	BXGT004892	Tyrosine-protein kinase JAK2	3717	reviewed	Kinase
O60760	BXGT004899	Hematopoietic prostaglandin D synthase	27306	reviewed
O60858	BXGT004903	E3 ubiquitin-protein ligase TRIM13	10206	reviewed
O60885	BXGT004906	Bromodomain-containing protein 4	23476	reviewed	Epigenetic regulator
O75469	BXGT005128	Nuclear receptor subfamily 1 group I member 2	8856	reviewed	Nuclear receptor
O75475	BXGT005130	PC4 and SFRS1-interacting protein	11168	reviewed	Signaling
O75874	BXGT005157	Isocitrate dehydrogenase [NADP] cytoplasmic	3417	reviewed
O76064	BXGT005173	E3 ubiquitin-protein ligase RNF8	9025	reviewed
O94813	BXGT005337	Slit homolog 2 protein	9353	reviewed
O94907	BXGT005340	Dickkopf-related protein 1	22943	reviewed
O95271	BXGT005369	Poly [ADP-ribose] polymerase tankyrase-1	8658	reviewed
O95631	BXGT005387	Netrin-1	9423	reviewed	Enzyme modulator
O95718	BXGT005392	Steroid hormone receptor ERR2	2103	reviewed	Nuclear receptor
O95819	BXGT005398	Mitogen-activated protein kinase kinase kinase kinase 4	9448	reviewed	Kinase
P00338	BXGT005504	L-lactate dehydrogenase A chain	3939	reviewed	Enzyme
P00374	BXGT005520	Dihydrofolate reductase	1719	reviewed	Enzyme
P00390	BXGT005526	Glutathione reductase, mitochondrial	2936	reviewed	Enzyme
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P00740	BXGT005634	Coagulation factor IX	2158	reviewed	Enzyme
P00749	BXGT005641	Urokinase-type plasminogen activator	5328	reviewed	Enzyme
P00797	BXGT005658	Renin	5972	reviewed	Enzyme
P00966	BXGT005707	Argininosuccinate synthase	445	reviewed	Enzyme
P01024	BXGT005719	Complement C3	718	reviewed	Enzyme modulator
P01106	BXGT005730	Myc proto-oncogene protein	4609	reviewed	Transcription factor
P01111	BXGT005731	GTPase NRas	4893	reviewed	Enzyme modulator
P01133	BXGT005736	Pro-epidermal growth factor	1950	reviewed
P01138	BXGT005738	Beta-nerve growth factor	4803	reviewed	Signaling
P01148	BXGT005739	Progonadoliberin-1	2796	reviewed
P01236	BXGT005744	Prolactin	5617	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01574	BXGT005768	Interferon beta	3456	reviewed
P01579	BXGT005770	Interferon gamma	3458	reviewed
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P02766	BXGT005953	Transthyretin	7276	reviewed	Transporter
P02786	BXGT005961	Transferrin receptor protein 1	7037	reviewed	Enzyme
P02787	BXGT005962	Serotransferrin	7018	reviewed	Enzyme
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P04049	BXGT006133	RAF proto-oncogene serine/threonine-protein kinase	5894	reviewed	Kinase
P04271	BXGT006177	Protein S100-B	6285	reviewed	Calcium-binding protein
P04626	BXGT006238	Receptor tyrosine-protein kinase erbB-2	2064	reviewed	Kinase
P04629	BXGT006239	High affinity nerve growth factor receptor	4914	reviewed	Kinase
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P04798	BXGT006265	Cytochrome P450 1A1	1543	reviewed	Enzyme
P04818	BXGT006269	Thymidylate synthase	7298	reviewed	Enzyme
P05121	BXGT006320	Plasminogen activator inhibitor 1	5054	reviewed	Enzyme modulator
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05556	BXGT006368	Integrin beta-1	3688	reviewed	Receptor
P05937	BXGT006396	Calbindin	793	reviewed	Calcium-binding protein
P06396	BXGT006435	Gelsolin	2934	reviewed	Cellular structure
P06493	BXGT006445	Cyclin-dependent kinase 1	983	reviewed	Kinase
P06702	BXGT006476	Protein S100-A9	6280	reviewed	Calcium-binding protein
P06703	BXGT006477	Protein S100-A6	6277	reviewed	Calcium-binding protein
P06730	BXGT006487	Eukaryotic translation initiation factor 4E	1977	reviewed	Nucleic acid binding
P06746	BXGT006496	DNA polymerase beta	5423	reviewed	Enzyme
P06753	BXGT006498	Tropomyosin alpha-3 chain	7170	reviewed	Cellular structure
P06756	BXGT006499	Integrin alpha-V	3685	reviewed
P06850	BXGT006511	Corticoliberin	1392	reviewed	Signaling
P07099	BXGT006546	Epoxide hydrolase 1	2052	reviewed
P07195	BXGT006563	L-lactate dehydrogenase B chain	3945	reviewed	Enzyme
P07333	BXGT006602	Macrophage colony-stimulating factor 1 receptor	1436	reviewed	Kinase
P07741	BXGT006666	Adenine phosphoribosyltransferase	353	reviewed
P07858	BXGT006689	Cathepsin B	1508	reviewed	Enzyme
P07900	BXGT006696	Heat shock protein HSP 90-alpha	3320	reviewed	Chaperone
P07949	BXGT006703	Proto-oncogene tyrosine-protein kinase receptor Ret	5979	reviewed	Kinase
P07996	BXGT006710	Thrombospondin-1	7057	reviewed
P08069	BXGT006723	Insulin-like growth factor 1 receptor	3480	reviewed	Kinase
P08138	BXGT006729	Tumor necrosis factor receptor superfamily member 16	4804	reviewed	Receptor
P08151	BXGT006731	Zinc finger protein GLI1	2735	reviewed
P08172	BXGT006737	Muscarinic acetylcholine receptor M2	1129	reviewed	G-protein coupled receptor
P08183	BXGT006741	ATP-dependent translocase ABCB1	5243	reviewed	Transporter
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P08581	BXGT006794	Hepatocyte growth factor receptor	4233	reviewed	Kinase
P08648	BXGT006804	Integrin alpha-5	3678	reviewed
P08670	BXGT006810	Vimentin	7431	reviewed
P08865	BXGT006832	40S ribosomal protein SA	3921	reviewed	Nucleic acid binding
P09038	BXGT006851	Fibroblast growth factor 2	2247	reviewed	Signaling
P09211	BXGT006869	Glutathione S-transferase P	2950	reviewed
P09429	BXGT006889	High mobility group protein B1	3146	reviewed	Nucleic acid binding
P09486	BXGT006897	SPARC	6678	reviewed	Signaling
P09488	BXGT006899	Glutathione S-transferase Mu 1	2944	reviewed
P09601	BXGT006909	Heme oxygenase 1	3162	reviewed
P09619	BXGT006911	Platelet-derived growth factor receptor beta	5159	reviewed	Kinase
P09874	BXGT006934	Poly [ADP-ribose] polymerase 1	142	reviewed
P09917	BXGT006941	Arachidonate 5-lipoxygenase	240	reviewed	Enzyme
P10070	BXGT007534	Zinc finger protein GLI2	2736	reviewed
P10275	BXGT007552	Androgen receptor	367	reviewed	Nuclear receptor
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10644	BXGT007597	cAMP-dependent protein kinase type I-alpha regulatory subunit	5573	reviewed
P10721	BXGT007605	Mast/stem cell growth factor receptor Kit	3815	reviewed	Kinase
P11086	BXGT007652	Phenylethanolamine N-methyltransferase	5409	reviewed	Enzyme
P11137	BXGT007656	Microtubule-associated protein 2	4133	reviewed
P11274	BXGT007681	Breakpoint cluster region protein	613	reviewed	Enzyme modulator
P11362	BXGT007693	Fibroblast growth factor receptor 1	2260	reviewed	Kinase
P11387	BXGT007696	DNA topoisomerase 1	7150	reviewed	Enzyme
P11388	BXGT007697	DNA topoisomerase 2-alpha	7153	reviewed
P11802	BXGT007750	Cyclin-dependent kinase 4	1019	reviewed	Kinase
P12004	BXGT007766	Proliferating cell nuclear antigen	5111	reviewed	Nucleic acid binding
P12643	BXGT007830	Bone morphogenetic protein 2	650	reviewed	Signaling
P12830	BXGT007852	Cadherin-1	999	reviewed
P12931	BXGT007859	Proto-oncogene tyrosine-protein kinase Src	6714	reviewed	Kinase
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P13726	BXGT007950	Tissue factor	2152	reviewed	Receptor
P14210	BXGT007994	Hepatocyte growth factor	3082	reviewed	Enzyme
P14618	BXGT008027	Pyruvate kinase PKM	5315	reviewed	Kinase
P14635	BXGT008031	G2/mitotic-specific cyclin-B1	891	reviewed	Enzyme modulator
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P14784	BXGT008054	Interleukin-2 receptor subunit beta	3560	reviewed	Receptor
P14902	BXGT008065	Indoleamine 2,3-dioxygenase 1	3620	reviewed
P15056	BXGT008075	Serine/threonine-protein kinase B-raf	673	reviewed	Kinase
P15090	BXGT008079	Fatty acid-binding protein, adipocyte	2167	reviewed
P15151	BXGT008089	Poliovirus receptor	5817	reviewed
P15309	BXGT008105	Prostatic acid phosphatase	55	reviewed	Enzyme
P15311	BXGT008106	Ezrin	7430	reviewed	Cellular structure
P15328	BXGT008108	Folate receptor alpha	2348	reviewed
P15498	BXGT008133	Proto-oncogene vav	7409	reviewed
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P15813	BXGT008158	Antigen-presenting glycoprotein CD1d	912	reviewed
P15884	BXGT008166	Transcription factor 4	6925	reviewed	Transcription factor
P16234	BXGT008209	Platelet-derived growth factor receptor alpha	5156	reviewed	Kinase
P16455	BXGT008229	Methylated-DNA--protein-cysteine methyltransferase	4255	reviewed
P17301	BXGT008299	Integrin alpha-2	3673	reviewed
P17342	BXGT008302	Atrial natriuretic peptide receptor 3	4883	reviewed
P17936	BXGT008357	Insulin-like growth factor-binding protein 3	3486	reviewed	Enzyme modulator
P18089	BXGT008379	Alpha-2B adrenergic receptor	151	reviewed	G-protein coupled receptor
P18433	BXGT008403	Receptor-type tyrosine-protein phosphatase alpha	5786	reviewed	Enzyme
P18827	BXGT008427	Syndecan-1	6382	reviewed	Extracellular structure
P18887	BXGT008437	DNA repair protein XRCC1	7515	reviewed
P19544	BXGT008494	Wilms tumor protein	7490	reviewed	Nucleic acid binding
P20618	BXGT008589	Proteasome subunit beta type-1	5689	reviewed
P20813	BXGT008603	Cytochrome P450 2B6	1555	reviewed
P20815	BXGT008604	Cytochrome P450 3A5	1577	reviewed	Enzyme
P21579	BXGT008665	Synaptotagmin-1	6857	reviewed	Transporter
P21589	BXGT008669	5'-nucleotidase	4907	reviewed	Enzyme
P21709	BXGT008685	Ephrin type-A receptor 1	2041	reviewed	Kinase
P21917	BXGT008707	D(4) dopamine receptor	1815	reviewed	G-protein coupled receptor
P22033	BXGT008721	Methylmalonyl-CoA mutase, mitochondrial	4594	reviewed	Enzyme
P22083	BXGT008727	Alpha-(1,3)-fucosyltransferase 4	2526	reviewed	Enzyme
P22303	BXGT008751	Acetylcholinesterase	43	reviewed	Enzyme
P22736	BXGT008800	Nuclear receptor subfamily 4 group A member 1	3164	reviewed	Nuclear receptor
P22830	BXGT008809	Ferrochelatase, mitochondrial	2235	reviewed	Enzyme
P23297	BXGT008848	Protein S100-A1	6271	reviewed	Calcium-binding protein
P23443	BXGT008866	Ribosomal protein S6 kinase beta-1	6198	reviewed	Kinase
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P23921	BXGT008927	Ribonucleoside-diphosphate reductase large subunit	6240	reviewed	Enzyme
P24385	BXGT008965	G1/S-specific cyclin-D1	595	reviewed	Enzyme modulator
P24864	BXGT009000	G1/S-specific cyclin-E1	898	reviewed	Enzyme modulator
P24941	BXGT009002	Cyclin-dependent kinase 2	1017	reviewed	Kinase
P25098	BXGT009015	Beta-adrenergic receptor kinase 1	156	reviewed	Kinase
P25101	BXGT009018	Endothelin-1 receptor	1909	reviewed	G-protein coupled receptor
P25116	BXGT009025	Proteinase-activated receptor 1	2149	reviewed	G-protein coupled receptor
P25440	BXGT009044	Bromodomain-containing protein 2	6046	reviewed	Epigenetic regulator
P25963	BXGT009080	NF-kappa-B inhibitor alpha	4792	reviewed
P26358	BXGT009104	DNA (cytosine-5)-methyltransferase 1	1786	reviewed	Epigenetic regulator
P26447	BXGT009114	Protein S100-A4	6275	reviewed	Calcium-binding protein
P27361	BXGT009176	Mitogen-activated protein kinase 3	5595	reviewed	Kinase
P27695	BXGT009199	DNA-(apurinic or apyrimidinic site) lyase	328	reviewed
P28072	BXGT009231	Proteasome subunit beta type-6	5694	reviewed
P28161	BXGT009234	Glutathione S-transferase Mu 2	2946	reviewed
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P29033	BXGT009308	Gap junction beta-2 protein	2706	reviewed	Cell-cell junction
P29034	BXGT009309	Protein S100-A2	6273	reviewed	Calcium-binding protein
P29320	BXGT009332	Ephrin type-A receptor 3	2042	reviewed	Kinase
P29323	BXGT009334	Ephrin type-B receptor 2	2048	reviewed	Kinase
P29373	BXGT009337	Cellular retinoic acid-binding protein 2	1382	reviewed
P29475	BXGT009353	Nitric oxide synthase, brain	4842	reviewed
P30279	BXGT009415	G1/S-specific cyclin-D2	894	reviewed	Enzyme modulator
P30291	BXGT009417	Wee1-like protein kinase	7465	reviewed	Kinase
P30304	BXGT009418	M-phase inducer phosphatase 1	993	reviewed	Enzyme
P30711	BXGT009460	Glutathione S-transferase theta-1	2952	reviewed
P30874	BXGT009475	Somatostatin receptor type 2	6752	reviewed	G-protein coupled receptor
P31260	BXGT009519	Homeobox protein Hox-A10	3206	reviewed
P31391	BXGT009535	Somatostatin receptor type 4	6754	reviewed	G-protein coupled receptor
P31644	BXGT009557	Gamma-aminobutyric acid receptor subunit alpha-5	2558	reviewed	Ion channel
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P32418	BXGT009635	Sodium/calcium exchanger 1	6546	reviewed	Transporter
P33527	BXGT009728	Multidrug resistance-associated protein 1	4363	reviewed	Transporter
P33981	BXGT009744	Dual specificity protein kinase TTK	7272	reviewed	Kinase
P33991	BXGT009745	DNA replication licensing factor MCM4	4173	reviewed	Enzyme
P34947	BXGT009774	G protein-coupled receptor kinase 5	2869	reviewed	Kinase
P35222	BXGT009799	Catenin beta-1	1499	reviewed
P35228	BXGT009800	Nitric oxide synthase, inducible	4843	reviewed
P35348	BXGT009814	Alpha-1A adrenergic receptor	148	reviewed	G-protein coupled receptor
P35354	BXGT009816	Prostaglandin G/H synthase 2	5743	reviewed	Enzyme
P35442	BXGT009832	Thrombospondin-2	7058	reviewed
P35475	BXGT009837	Alpha-L-iduronidase	3425	reviewed	Enzyme
P35869	BXGT009877	Aryl hydrocarbon receptor	196	reviewed	Transcription factor
P35968	BXGT009887	Vascular endothelial growth factor receptor 2	3791	reviewed	Kinase
P36507	BXGT009923	Dual specificity mitogen-activated protein kinase kinase 2	5605	reviewed	Kinase
P36955	BXGT009946	Pigment epithelium-derived factor	5176	reviewed	Enzyme modulator
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P37840	BXGT010015	Alpha-synuclein	6622	reviewed	Transporter
P38398	BXGT010037	Breast cancer type 1 susceptibility protein	672	reviewed	Enzyme
P39060	BXGT010088	Collagen alpha-1(XVIII) chain	80781	reviewed
P40189	BXGT010164	Interleukin-6 receptor subunit beta	3572	reviewed	Signaling
P40692	BXGT010195	DNA mismatch repair protein Mlh1	4292	reviewed	Nucleic acid binding
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P41180	BXGT010230	Extracellular calcium-sensing receptor	846	reviewed	G-protein coupled receptor
P41222	BXGT010237	Prostaglandin-H2 D-isomerase	5730	reviewed	Enzyme
P41235	BXGT010241	Hepatocyte nuclear factor 4-alpha	3172	reviewed	Nuclear receptor
P41279	BXGT010254	Mitogen-activated protein kinase kinase kinase 8	1326	reviewed	Kinase
P41597	BXGT010268	C-C chemokine receptor type 2	729230	reviewed
P42261	BXGT010293	Glutamate receptor 1	2890	reviewed	Ion channel
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P42574	BXGT010317	Caspase-3	836	reviewed	Enzyme
P42702	BXGT010335	Leukemia inhibitory factor receptor	3977	reviewed	Signaling
P43004	BXGT010348	Excitatory amino acid transporter 2	6506	reviewed	Transporter
P43246	BXGT010371	DNA mismatch repair protein Msh2	4436	reviewed	Nucleic acid binding
P43250	BXGT010372	G protein-coupled receptor kinase 6	2870	reviewed	Kinase
P43652	BXGT010405	Afamin	173	reviewed	Transporter
P45983	BXGT010494	Mitogen-activated protein kinase 8	5599	reviewed	Kinase
P46100	BXGT010508	Transcriptional regulator ATRX	546	reviewed
P46108	BXGT010509	Adapter molecule crk	1398	reviewed
P46527	BXGT010525	Cyclin-dependent kinase inhibitor 1B	1027	reviewed
P46531	BXGT010526	Neurogenic locus notch homolog protein 1	4851	reviewed
P46597	BXGT010528	Acetylserotonin O-methyltransferase	438	reviewed
P46937	BXGT010554	Transcriptional coactivator YAP1	10413	reviewed	Enzyme modulator
P48023	BXGT010604	Tumor necrosis factor ligand superfamily member 6	356	reviewed	Signaling
P48061	BXGT010616	Stromal cell-derived factor 1	6387	reviewed
P48729	BXGT010655	Casein kinase I isoform alpha	1452	reviewed	Kinase
P48735	BXGT010657	Isocitrate dehydrogenase [NADP], mitochondrial	3418	reviewed
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P49585	BXGT010712	Choline-phosphate cytidylyltransferase A	5130	reviewed
P49747	BXGT010732	Cartilage oligomeric matrix protein	1311	reviewed
P49789	BXGT010742	Bis(5'-adenosyl)-triphosphatase	2272	reviewed
P49841	BXGT010750	Glycogen synthase kinase-3 beta	2932	reviewed	Kinase
P49888	BXGT010756	Estrogen sulfotransferase	6783	reviewed
P49917	BXGT010765	DNA ligase 4	3981	reviewed
P50120	BXGT010773	Retinol-binding protein 2	5948	reviewed
P50281	BXGT010788	Matrix metalloproteinase-14	4323	reviewed	Enzyme
P50579	BXGT010812	Methionine aminopeptidase 2	10988	reviewed
P50591	BXGT010814	Tumor necrosis factor ligand superfamily member 10	8743	reviewed	Signaling
P50750	BXGT010818	Cyclin-dependent kinase 9	1025	reviewed	Kinase
P51532	BXGT010852	Transcription activator BRG1	6597	reviewed	Epigenetic regulator
P52701	BXGT010943	DNA mismatch repair protein Msh6	2956	reviewed	Nucleic acid binding
P52788	BXGT010953	Spermine synthase	6611	reviewed
P52789	BXGT010954	Hexokinase-2	3099	reviewed	Kinase
P52803	BXGT010958	Ephrin-A5	1946	reviewed	Signaling
P53350	BXGT010984	Serine/threonine-protein kinase PLK1	5347	reviewed	Kinase
P53355	BXGT010985	Death-associated protein kinase 1	1612	reviewed	Kinase
P53370	BXGT010987	Nucleoside diphosphate-linked moiety X motif 6	11162	reviewed	Enzyme
P53985	BXGT011022	Monocarboxylate transporter 1	6566	reviewed	Transporter
P54278	BXGT011038	Mismatch repair endonuclease PMS2	5395	reviewed	Nucleic acid binding
P54687	BXGT011067	Branched-chain-amino-acid aminotransferase, cytosolic	586	reviewed	Enzyme
P54762	BXGT011076	Ephrin type-B receptor 1	2047	reviewed	Kinase
P55201	BXGT011109	Peregrin	7862	reviewed
P55211	BXGT011111	Caspase-9	842	reviewed	Enzyme
P58004	BXGT011222	Sestrin-2	83667	reviewed	Enzyme
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
P60880	BXGT011335	Synaptosomal-associated protein 25	6616	reviewed	Transporter
P60903	BXGT011339	Protein S100-A10	6281	reviewed	Calcium-binding protein
P61073	BXGT011352	C-X-C chemokine receptor type 4	7852	reviewed	G-protein coupled receptor
P62888	BXGT011469	60S ribosomal protein L30	6156	reviewed	Nucleic acid binding
P62993	BXGT011480	Growth factor receptor-bound protein 2	2885	reviewed
P63000	BXGT011481	Ras-related C3 botulinum toxin substrate 1	5879	reviewed	Enzyme modulator
P63092	BXGT011495	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	2778	reviewed
P68431	BXGT011601	Histone H3.1	8968	reviewed
P78310	BXGT011830	Coxsackievirus and adenovirus receptor	1525	reviewed
P78325	BXGT011832	Disintegrin and metalloproteinase domain-containing protein 8	101	reviewed	Enzyme
P78504	BXGT011844	Protein jagged-1	182	reviewed
P84022	BXGT012027	Mothers against decapentaplegic homolog 3	4088	reviewed	Transcription factor
P84243	BXGT012052	Histone H3.3	3021	reviewed
Q00534	BXGT012533	Cyclin-dependent kinase 6	1021	reviewed	Kinase
Q00535	BXGT012534	Cyclin-dependent-like kinase 5	1020	reviewed	Kinase
Q00536	BXGT012535	Cyclin-dependent kinase 16	5127	reviewed	Kinase
Q00987	BXGT012559	E3 ubiquitin-protein ligase Mdm2	4193	reviewed	Nucleic acid binding
Q01094	BXGT012568	Transcription factor E2F1	1869	reviewed	Nucleic acid binding
Q01105	BXGT012569	Protein SET	6418	reviewed	Enzyme modulator
Q01453	BXGT012588	Peripheral myelin protein 22	5376	reviewed	Cellular structure
Q01650	BXGT012603	Large neutral amino acids transporter small subunit 1	8140	reviewed	Transporter
Q01974	BXGT012628	Tyrosine-protein kinase transmembrane receptor ROR2	4920	reviewed	Kinase
Q02750	BXGT012662	Dual specificity mitogen-activated protein kinase kinase 1	5604	reviewed	Kinase
Q02880	BXGT012677	DNA topoisomerase 2-beta	7155	reviewed
Q03181	BXGT012701	Peroxisome proliferator-activated receptor delta	5467	reviewed	Nuclear receptor
Q04206	BXGT012754	Transcription factor p65	5970	reviewed	Transcription factor
Q04637	BXGT012771	Eukaryotic translation initiation factor 4 gamma 1	1981	reviewed	Nucleic acid binding
Q04721	BXGT012777	Neurogenic locus notch homolog protein 2	4853	reviewed
Q06124	BXGT012856	Tyrosine-protein phosphatase non-receptor type 11	5781	reviewed
Q06609	BXGT012884	DNA repair protein RAD51 homolog 1	5888	reviewed
Q06830	BXGT012894	Peroxiredoxin-1	5052	reviewed	Enzyme
Q07812	BXGT012940	Apoptosis regulator BAX	581	reviewed	Signaling
Q07820	BXGT012942	Induced myeloid leukemia cell differentiation protein Mcl-1	4170	reviewed	Signaling
Q07869	BXGT012945	Peroxisome proliferator-activated receptor alpha	5465	reviewed	Nuclear receptor
Q07954	BXGT012950	Prolow-density lipoprotein receptor-related protein 1	4035	reviewed
Q08050	BXGT012958	Forkhead box protein M1	2305	reviewed
Q09428	BXGT013036	ATP-binding cassette sub-family C member 8	6833	reviewed	Transporter
Q09470	BXGT013037	Potassium voltage-gated channel subfamily A member 1	3736	reviewed	Ion channel
Q09472	BXGT013038	Histone acetyltransferase p300	2033	reviewed
Q12797	BXGT013266	Aspartyl/asparaginyl beta-hydroxylase	444	reviewed
Q13155	BXGT013320	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	7965	reviewed
Q13163	BXGT013321	Dual specificity mitogen-activated protein kinase kinase 5	5607	reviewed	Kinase
Q13164	BXGT013322	Mitogen-activated protein kinase 7	5598	reviewed	Kinase
Q13233	BXGT013330	Mitogen-activated protein kinase kinase kinase 1	4214	reviewed	Kinase
Q13309	BXGT013338	S-phase kinase-associated protein 2	6502	reviewed
Q13315	BXGT013339	Serine-protein kinase ATM	472	reviewed	Kinase
Q13509	BXGT013366	Tubulin beta-3 chain	10381	reviewed	Cellular structure
Q13526	BXGT013369	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	5300	reviewed
Q13541	BXGT013371	Eukaryotic translation initiation factor 4E-binding protein 1	1978	reviewed	Nucleic acid binding
Q13547	BXGT013373	Histone deacetylase 1	3065	reviewed	Epigenetic regulator
Q13569	BXGT013378	G/T mismatch-specific thymine DNA glycosylase	6996	reviewed
Q14012	BXGT013437	Calcium/calmodulin-dependent protein kinase type 1	8536	reviewed	Kinase
Q14118	BXGT013444	Dystroglycan	1605	reviewed	Receptor
Q14191	BXGT013452	Werner syndrome ATP-dependent helicase	7486	reviewed	Enzyme
Q14240	BXGT013458	Eukaryotic initiation factor 4A-II	1974	reviewed
Q14289	BXGT013459	Protein-tyrosine kinase 2-beta	2185	reviewed	Kinase
Q14332	BXGT013462	Frizzled-2	2535	reviewed	G-protein coupled receptor
Q14457	BXGT013472	Beclin-1	8678	reviewed	Enzyme modulator
Q14469	BXGT013473	Transcription factor HES-1	3280	reviewed	Transcription factor
Q14680	BXGT013499	Maternal embryonic leucine zipper kinase	9833	reviewed	Kinase
Q14790	BXGT013505	Caspase-8	841	reviewed	Enzyme
Q14833	BXGT013508	Metabotropic glutamate receptor 4	2914	reviewed	G-protein coupled receptor
Q14994	BXGT013519	Nuclear receptor subfamily 1 group I member 3	9970	reviewed	Nuclear receptor
Q15059	BXGT013530	Bromodomain-containing protein 3	8019	reviewed	Epigenetic regulator
Q15149	BXGT013547	Plectin	5339	reviewed	Cellular structure
Q15257	BXGT013554	Serine/threonine-protein phosphatase 2A activator	5524	reviewed	Enzyme modulator
Q15303	BXGT013557	Receptor tyrosine-protein kinase erbB-4	2066	reviewed	Kinase
Q15375	BXGT013562	Ephrin type-A receptor 7	2045	reviewed	Kinase
Q15465	BXGT013573	Sonic hedgehog protein	6469	reviewed
Q15561	BXGT013578	Transcriptional enhancer factor TEF-3	7004	reviewed	Transcription factor
Q15717	BXGT013589	ELAV-like protein 1	1994	reviewed
Q15910	BXGT013612	Histone-lysine N-methyltransferase EZH2	2146	reviewed	Epigenetic regulator
Q16288	BXGT013625	NT-3 growth factor receptor	4916	reviewed	Kinase
Q16539	BXGT013634	Mitogen-activated protein kinase 14	1432	reviewed	Kinase
Q16620	BXGT013645	BDNF/NT-3 growth factors receptor	4915	reviewed	Kinase
Q16637	BXGT013646	Survival motor neuron protein	6607	reviewed	Epigenetic regulator
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q16678	BXGT013656	Cytochrome P450 1B1	1545	reviewed	Enzyme
Q2M385	BXGT014131	Macrophage-expressed gene 1 protein	219972	reviewed
Q53EL6	BXGT015008	Programmed cell death protein 4	27250	reviewed	Nucleic acid binding
Q5T6L4	BXGT015848	Argininosuccinate synthase 1 isoform 1	445	unreviewed
Q5T7N2	BXGT015849	LINE-1 type transposase domain-containing protein 1	54596	reviewed
Q676U5	BXGT016177	Autophagy-related protein 16-1	55054	reviewed
Q6ZN17	BXGT016631	Protein lin-28 homolog B	389421	reviewed
Q7KZI7	BXGT016990	Serine/threonine-protein kinase MARK2	2011	reviewed	Kinase
Q7RTN6	BXGT017085	STE20-related kinase adapter protein alpha	92335	reviewed	Kinase
Q86T82	BXGT017605	Ubiquitin carboxyl-terminal hydrolase 37	57695	reviewed	Enzyme
Q86XP3	BXGT017630	ATP-dependent RNA helicase DDX42	11325	reviewed
Q86YC2	BXGT017633	Partner and localizer of BRCA2	79728	reviewed
Q8IUF8	BXGT018334	Ribosomal oxygenase 2	84864	reviewed
Q8IV61	BXGT018340	Ras guanyl-releasing protein 3	25780	reviewed	Enzyme modulator
Q8WZA1	BXGT019024	Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1	55624	reviewed
Q92616	BXGT019358	eIF-2-alpha kinase activator GCN1	10985	reviewed	Enzyme modulator
Q92731	BXGT019366	Estrogen receptor beta	2100	reviewed	Nuclear receptor
Q92793	BXGT019374	CREB-binding protein	1387	reviewed
Q92794	BXGT019375	Histone acetyltransferase KAT6A	7994	reviewed	Enzyme
Q92831	BXGT019380	Histone acetyltransferase KAT2B	8850	reviewed
Q92918	BXGT019394	Mitogen-activated protein kinase kinase kinase kinase 1	11184	reviewed	Kinase
Q92945	BXGT019397	Far upstream element-binding protein 2	8570	reviewed	Enzyme
Q93009	BXGT019455	Ubiquitin carboxyl-terminal hydrolase 7	7874	reviewed	Enzyme
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q96GD4	BXGT019667	Aurora kinase B	9212	reviewed	Kinase
Q96QV1	BXGT019722	Hedgehog-interacting protein	64399	reviewed
Q96T88	BXGT019747	E3 ubiquitin-protein ligase UHRF1	29128	reviewed
Q99759	BXGT019960	Mitogen-activated protein kinase kinase kinase 3	4215	reviewed	Kinase
Q99814	BXGT019965	Endothelial PAS domain-containing protein 1	2034	reviewed	Transcription factor
Q99828	BXGT019967	Calcium and integrin-binding protein 1	10519	reviewed
Q99835	BXGT019969	Smoothened homolog	6608	reviewed	G-protein coupled receptor
Q9BSQ5	BXGT020123	Cerebral cavernous malformations 2 protein	83605	reviewed
Q9BUB5	BXGT020133	MAP kinase-interacting serine/threonine-protein kinase 1	8569	reviewed	Kinase
Q9H3R0	BXGT020465	Lysine-specific demethylase 4C	23081	reviewed
Q9H4A3	BXGT020473	Serine/threonine-protein kinase WNK1	65125	reviewed	Kinase
Q9H4W6	BXGT020478	Transcription factor COE3	253738	reviewed
Q9H6W3	BXGT020485	Ribosomal oxygenase 1	79697	reviewed
Q9H7Z6	BXGT020493	Histone acetyltransferase KAT8	84148	reviewed
Q9H9B1	BXGT020501	Histone-lysine N-methyltransferase EHMT1	79813	reviewed	Epigenetic regulator
Q9HBH9	BXGT020521	MAP kinase-interacting serine/threonine-protein kinase 2	2872	reviewed	Kinase
Q9NRR6	BXGT021193	Phosphatidylinositol polyphosphate 5-phosphatase type IV	56623	reviewed
Q9NYL2	BXGT021259	Mitogen-activated protein kinase kinase kinase 20	51776	reviewed	Kinase
Q9NZQ7	BXGT021281	Programmed cell death 1 ligand 1	29126	reviewed	Receptor
Q9UBB5	BXGT021649	Methyl-CpG-binding domain protein 2	8932	reviewed	Epigenetic regulator
Q9UBC3	BXGT021650	DNA (cytosine-5)-methyltransferase 3B	1789	reviewed
Q9UH99	BXGT021693	SUN domain-containing protein 2	25777	reviewed	Cellular structure
Q9UKV0	BXGT021750	Histone deacetylase 9	9734	reviewed	Epigenetic regulator
Q9UM73	BXGT021773	ALK tyrosine kinase receptor	238	reviewed	Kinase
Q9UMX1	BXGT021778	Suppressor of fused homolog	51684	reviewed
Q9UNQ0	BXGT021792	ATP-binding cassette sub-family G member 2	9429	reviewed	Transporter
Q9UPZ9	BXGT021804	Serine/threonine-protein kinase ICK	22858	reviewed	Kinase
Q9UQD0	BXGT021811	Sodium channel protein type 8 subunit alpha	6334	reviewed	Ion channel
Q9UQL6	BXGT021813	Histone deacetylase 5	10014	reviewed	Epigenetic regulator
Q9Y219	BXGT022206	Protein jagged-2	3714	reviewed
Q9Y251	BXGT022215	Heparanase	10855	reviewed	Enzyme
Q9Y286	BXGT022225	Sialic acid-binding Ig-like lectin 7	27036	reviewed	Receptor
Q9Y2D1	BXGT022230	Cyclic AMP-dependent transcription factor ATF-5	22809	reviewed
Q9Y2Q3	BXGT022242	Glutathione S-transferase kappa 1	373156	reviewed
Q9Y2U5	BXGT022248	Mitogen-activated protein kinase kinase kinase 2	10746	reviewed	Kinase
Q9Y3B4	BXGT022255	Splicing factor 3B subunit 6	51639	reviewed
Q9Y6K1	BXGT022331	DNA (cytosine-5)-methyltransferase 3A	1788	reviewed
Q9Y6X2	BXGT022343	E3 SUMO-protein ligase PIAS3	10401	reviewed
P04439	BXGT022649	HLA class I histocompatibility antigen, A-3 alpha chain	3105	reviewed
Q92911	BXGT022650	Sodium/iodide cotransporter	6528	reviewed	Transporter
Q13029	BXGT022688	PR domain zinc finger protein 2	7799	reviewed
P19235	BXGT022895	Erythropoietin receptor	2057	reviewed	Receptor
P35240	BXGT022927	Merlin	4771	reviewed
P25054	BXGT022961	Adenomatous polyposis coli protein	324	reviewed
P16284	BXGT022972	Platelet endothelial cell adhesion molecule	5175	reviewed	Cell adhesion
Q13330	BXGT023103	Metastasis-associated protein MTA1	9112	reviewed	Nucleic acid binding
Q01543	BXGT023137	Friend leukemia integration 1 transcription factor	2313	reviewed	Transcription factor
Q9GZQ8	BXGT023414	Microtubule-associated proteins 1A/1B light chain 3B	81631	reviewed	Cellular structure
Q16552	BXGT023419	Interleukin-17A	3605	reviewed
Q9BQQ3	BXGT024065	Golgi reassembly-stacking protein 1	64689	reviewed
P63167	BXGT024120	Dynein light chain 1, cytoplasmic	8655	reviewed	Cellular structure
O60232	BXGT024169	Protein ZNRD2	10534	reviewed
P08123	BXGT024477	Collagen alpha-2(I) chain	1278	reviewed
P16104	BXGT024571	Histone H2AX	3014	reviewed	Nucleic acid binding
Q9Y297	BXGT024812	F-box/WD repeat-containing protein 1A	8945	reviewed
Q8NEZ4	BXGT024850	Histone-lysine N-methyltransferase 2C	58508	reviewed
Q12888	BXGT024878	TP53-binding protein 1	7158	reviewed	Epigenetic regulator
Q13635	BXGT024910	Protein patched homolog 1	5727	reviewed
Q14807	BXGT024966	Kinesin-like protein KIF22	3835	reviewed	Cellular structure
Q9UGM3	BXGT025543	Deleted in malignant brain tumors 1 protein	1755	reviewed	Enzyme
Q9P2E7	BXGT025815	Protocadherin-10	57575	reviewed
Q86SQ9	BXGT025875	Dehydrodolichyl diphosphate synthase complex subunit DHDDS	79947	reviewed	Enzyme
P33993	BXGT025970	DNA replication licensing factor MCM7	4176	reviewed	Enzyme
P00403	BXGT026137	Cytochrome c oxidase subunit 2	4513	reviewed	Enzyme
V9HWB9	BXGT026149	L-lactate dehydrogenase	3939	unreviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}