Showing entry for Rho GDP-dissociation inhibitor 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010933
Protein NameRho GDP-dissociation inhibitor 1
Uniport IdP52565
GeneARHGDIA
Gene Id396
DomainRho_GDI
Pfam PF02115  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.6 Nervous system hsa04722 Neurotrophin signaling pathway
5. Organismal Systems 5.5 Excretory system hsa04962 Vasopressin-regulated water reabsorption
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0050771 negative regulation of axonogenesis
Biological Process GO:0007162 negative regulation of cell adhesion
Biological Process GO:0050772 positive regulation of axonogenesis
Biological Process GO:2000249 regulation of actin cytoskeleton reorganization
Biological Process GO:0035023 regulation of Rho protein signal transduction
Biological Process GO:0051056 regulation of small GTPase mediated signal transduction
Biological Process GO:0007266 Rho protein signal transduction
Biological Process GO:0071526 semaphorin-plexin signaling pathway
molecular function GO:0005096 GTPase activator activity
molecular function GO:0048365 Rac GTPase binding
molecular function GO:0005094 Rho GDP-dissociation inhibitor activity
cellular component GO:0005856 cytoskeleton
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0016020 membrane
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-193634 Axonal growth inhibition (RHOA activation)
R-HSA-193697 p75NTR regulates axonogenesis
R-HSA-193704 p75 NTR receptor-mediated signalling
R-HSA-194315 Signaling by Rho GTPases
R-HSA-194840 Rho GTPase cycle
R-HSA-209563 Axonal growth stimulation
R-HSA-73887 Death Receptor Signalling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0013604 BXGD000859 Edema Pathological Conditions, Signs and Symptoms
C0017638 BXGD001132 Glioma Neoplasms
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0022548 BXGD001551 Keloid Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027726 BXGD002030 Nephrotic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0028945 BXGD002099 oligodendroglioma Neoplasms
C0033687 BXGD002415 Proteinuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037116 BXGD002666 Silicosis Respiratory Tract Diseases; Occupational Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0239981 BXGD005011 Hypoalbuminemia Hemic and Lymphatic Diseases
C0268747 BXGD006034 Diffuse mesangial sclerosis (disorder) Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0340970 BXGD007379 Congenital neutropenia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0410207 BXGD008419 Tubular Aggregate Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1134719 BXGD011688 Invasive Ductal Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1257931 BXGD011815 Mammary Neoplasms, Human Neoplasms; Skin and Connective Tissue Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1834582 BXGD013982 MYELOPROLIFERATIVE SYNDROME, TRANSIENT Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Hemic and Lymphatic Diseases
C1838681 BXGD014337 Rapidly progressive
C1853118 BXGD015302 Severe congenital neutropenia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1855106 BXGD015459 Neonatal onset
C1868672 BXGD016519 NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3276821 BXGD018697 Thin glomerular basement membrane
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3808874 BXGD019555 ADVANCED SLEEP PHASE SYNDROME, FAMILIAL, 2
C3808953 BXGD019561 NEPHROTIC SYNDROME, TYPE 8
C3810365 BXGD019652 Central visual impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4048268 BXGD021896 Cortical visual impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C4505456 BXGD022964 HIV Coinfection Infections; Immune System Diseases
C4704874 BXGD023682 Mammary Carcinoma, Human Neoplasms; Skin and Connective Tissue Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0006368 Formic acid 46.03
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein