Showing entry for Invasive Ductal Breast Carcinoma


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD011688
Disease NameInvasive Ductal Breast Carcinoma
Disease CUI IdC1134719
MeSH Codes C04   C17  
Disease Class NameNeoplasms; Skin and Connective Tissue Diseases
Semantic TypeNeoplastic Process
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id DOID:7   DOID:14566  
Disease Ontology Class Namedisease of anatomical entity; disease of cellular proliferation
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
A0A024RAV5 BXGT000013 V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b 3845 unreviewed
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O00482 BXGT003929 Nuclear receptor subfamily 5 group A member 2 2494 reviewed Nuclear receptor
O14745 BXGT004090 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 9368 reviewed
O14965 BXGT004117 Aurora kinase A 6790 reviewed Kinase
O15111 BXGT004126 Inhibitor of nuclear factor kappa-B kinase subunit alpha 1147 reviewed Kinase
O15379 BXGT004159 Histone deacetylase 3 8841 reviewed Epigenetic regulator
O43524 BXGT004599 Forkhead box protein O3 2309 reviewed
O43707 BXGT004616 Alpha-actinin-4 81 reviewed
O60331 BXGT004872 Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma 23396 reviewed Kinase
O60566 BXGT004884 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta 701 reviewed Kinase
O60760 BXGT004899 Hematopoietic prostaglandin D synthase 27306 reviewed
O75475 BXGT005130 PC4 and SFRS1-interacting protein 11168 reviewed Signaling
O75489 BXGT005131 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial 4722 reviewed
O75874 BXGT005157 Isocitrate dehydrogenase [NADP] cytoplasmic 3417 reviewed
O94813 BXGT005337 Slit homolog 2 protein 9353 reviewed
O95407 BXGT005380 Tumor necrosis factor receptor superfamily member 6B 8771 reviewed
O95931 BXGT005407 Chromobox protein homolog 7 23492 reviewed Epigenetic regulator
P00325 BXGT005498 Alcohol dehydrogenase 1B 125 reviewed Enzyme
P00352 BXGT005510 Retinal dehydrogenase 1 216 reviewed Enzyme
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P00749 BXGT005641 Urokinase-type plasminogen activator 5328 reviewed Enzyme
P01106 BXGT005730 Myc proto-oncogene protein 4609 reviewed Transcription factor
P01116 BXGT005733 GTPase KRas 3845 reviewed Enzyme modulator
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P02462 BXGT005881 Collagen alpha-1(IV) chain 1282 reviewed
P02545 BXGT005889 Prelamin-A/C 4000 reviewed
P02647 BXGT005908 Apolipoprotein A-I 335 reviewed
P02654 BXGT005911 Apolipoprotein C-I 341 reviewed
P02751 BXGT005943 Fibronectin 2335 reviewed Signaling
P03372 BXGT006059 Estrogen receptor 2099 reviewed Nuclear receptor
P03956 BXGT006120 Interstitial collagenase 4312 reviewed Enzyme
P04155 BXGT006155 Trefoil factor 1 7031 reviewed Signaling
P04179 BXGT006163 Superoxide dismutase [Mn], mitochondrial 6648 reviewed Enzyme
P04275 BXGT006180 von Willebrand factor 7450 reviewed Enzyme modulator
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 2064 reviewed Kinase
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P04732 BXGT006252 Metallothionein-1E 4493 reviewed
P04733 BXGT006253 Metallothionein-1F 4494 reviewed
P05121 BXGT006320 Plasminogen activator inhibitor 1 5054 reviewed Enzyme modulator
P05771 BXGT006384 Protein kinase C beta type 5579 reviewed Kinase
P05787 BXGT006385 Keratin, type II cytoskeletal 8 3856 reviewed
P06126 BXGT006412 T-cell surface glycoprotein CD1a 909 reviewed
P06401 BXGT006436 Progesterone receptor 5241 reviewed Nuclear receptor
P06703 BXGT006477 Protein S100-A6 6277 reviewed Calcium-binding protein
P06730 BXGT006487 Eukaryotic translation initiation factor 4E 1977 reviewed Nucleic acid binding
P06731 BXGT006488 Carcinoembryonic antigen-related cell adhesion molecule 5 1048 reviewed
P06733 BXGT006490 Alpha-enolase 2023 reviewed Enzyme
P07339 BXGT006604 Cathepsin D 1509 reviewed Enzyme
P07996 BXGT006710 Thrombospondin-1 7057 reviewed
P08069 BXGT006723 Insulin-like growth factor 1 receptor 3480 reviewed Kinase
P08133 BXGT006727 Annexin A6 309 reviewed
P08151 BXGT006731 Zinc finger protein GLI1 2735 reviewed
P08183 BXGT006741 ATP-dependent translocase ABCB1 5243 reviewed Transporter
P08253 BXGT006757 72 kDa type IV collagenase 4313 reviewed Enzyme
P08319 BXGT006764 Alcohol dehydrogenase 4 127 reviewed Enzyme
P08922 BXGT006843 Proto-oncogene tyrosine-protein kinase ROS 6098 reviewed Kinase
P09211 BXGT006869 Glutathione S-transferase P 2950 reviewed
P09382 BXGT006882 Galectin-1 3956 reviewed Signaling
P09488 BXGT006899 Glutathione S-transferase Mu 1 2944 reviewed
P10070 BXGT007534 Zinc finger protein GLI2 2736 reviewed
P10145 BXGT007542 Interleukin-8 3576 reviewed Signaling
P10275 BXGT007552 Androgen receptor 367 reviewed Nuclear receptor
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10721 BXGT007605 Mast/stem cell growth factor receptor Kit 3815 reviewed Kinase
P10747 BXGT007609 T-cell-specific surface glycoprotein CD28 940 reviewed
P10827 BXGT007623 Thyroid hormone receptor alpha 7067 reviewed Nuclear receptor
P11021 BXGT007644 Endoplasmic reticulum chaperone BiP 3309 reviewed
P11362 BXGT007693 Fibroblast growth factor receptor 1 2260 reviewed Kinase
P11511 BXGT007717 Aromatase 1588 reviewed Enzyme
P12004 BXGT007766 Proliferating cell nuclear antigen 5111 reviewed Nucleic acid binding
P12830 BXGT007852 Cadherin-1 999 reviewed
P13500 BXGT007916 C-C motif chemokine 2 6347 reviewed Signaling
P14210 BXGT007994 Hepatocyte growth factor 3082 reviewed Enzyme
P14780 BXGT008053 Matrix metalloproteinase-9 4318 reviewed Enzyme
P14921 BXGT008068 Protein C-ets-1 2113 reviewed Transcription factor
P15056 BXGT008075 Serine/threonine-protein kinase B-raf 673 reviewed Kinase
P15090 BXGT008079 Fatty acid-binding protein, adipocyte 2167 reviewed
P15531 BXGT008136 Nucleoside diphosphate kinase A 4830 reviewed Kinase
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P15941 BXGT008176 Mucin-1 4582 reviewed
P16070 BXGT008186 CD44 antigen 960 reviewed
P16442 BXGT008227 Histo-blood group ABO system transferase 28 reviewed Enzyme
P16455 BXGT008229 Methylated-DNA--protein-cysteine methyltransferase 4255 reviewed
P16471 BXGT008233 Prolactin receptor 5618 reviewed Signaling
P16581 BXGT008245 E-selectin 6401 reviewed
P17252 BXGT008294 Protein kinase C alpha type 5578 reviewed Kinase
P17844 BXGT008346 Probable ATP-dependent RNA helicase DDX5 1655 reviewed
P17931 BXGT008356 Galectin-3 3958 reviewed Signaling
P18848 BXGT008432 Cyclic AMP-dependent transcription factor ATF-4 468 reviewed
P19883 BXGT008528 Follistatin 10468 reviewed Enzyme modulator
P20936 BXGT008619 Ras GTPase-activating protein 1 5921 reviewed Enzyme modulator
P21397 BXGT008644 Amine oxidase [flavin-containing] A 4128 reviewed
P21802 BXGT008691 Fibroblast growth factor receptor 2 2263 reviewed Kinase
P21860 BXGT008698 Receptor tyrosine-protein kinase erbB-3 2065 reviewed Kinase
P22087 BXGT008729 rRNA 2'-O-methyltransferase fibrillarin 2091 reviewed Enzyme
P22352 BXGT008758 Glutathione peroxidase 3 2878 reviewed Enzyme
P22455 BXGT008772 Fibroblast growth factor receptor 4 2264 reviewed Kinase
P23946 BXGT008932 Chymase 1215 reviewed Enzyme
P24385 BXGT008965 G1/S-specific cyclin-D1 595 reviewed Enzyme modulator
P25025 BXGT009006 C-X-C chemokine receptor type 2 3579 reviewed G-protein coupled receptor
P25098 BXGT009015 Beta-adrenergic receptor kinase 1 156 reviewed Kinase
P26358 BXGT009104 DNA (cytosine-5)-methyltransferase 1 1786 reviewed Epigenetic regulator
P28300 BXGT009243 Protein-lysine 6-oxidase 4015 reviewed
P29033 BXGT009308 Gap junction beta-2 protein 2706 reviewed Cell-cell junction
P29373 BXGT009337 Cellular retinoic acid-binding protein 2 1382 reviewed
P30279 BXGT009415 G1/S-specific cyclin-D2 894 reviewed Enzyme modulator
P30711 BXGT009460 Glutathione S-transferase theta-1 2952 reviewed
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P35030 BXGT009784 Trypsin-3 5646 reviewed Enzyme
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35354 BXGT009816 Prostaglandin G/H synthase 2 5743 reviewed Enzyme
P35869 BXGT009877 Aryl hydrocarbon receptor 196 reviewed Transcription factor
P36222 BXGT009914 Chitinase-3-like protein 1 1116 reviewed
P36955 BXGT009946 Pigment epithelium-derived factor 5176 reviewed Enzyme modulator
P36969 BXGT009949 Phospholipid hydroperoxide glutathione peroxidase 2879 reviewed Enzyme
P37840 BXGT010015 Alpha-synuclein 6622 reviewed Transporter
P38398 BXGT010037 Breast cancer type 1 susceptibility protein 672 reviewed Enzyme
P38936 BXGT010074 Cyclin-dependent kinase inhibitor 1 1026 reviewed
P40692 BXGT010195 DNA mismatch repair protein Mlh1 4292 reviewed Nucleic acid binding
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P42574 BXGT010317 Caspase-3 836 reviewed Enzyme
P43246 BXGT010371 DNA mismatch repair protein Msh2 4436 reviewed Nucleic acid binding
P43405 BXGT010386 Tyrosine-protein kinase SYK 6850 reviewed Kinase
P43490 BXGT010395 Nicotinamide phosphoribosyltransferase 10135 reviewed Signaling
P45983 BXGT010494 Mitogen-activated protein kinase 8 5599 reviewed Kinase
P46531 BXGT010526 Neurogenic locus notch homolog protein 1 4851 reviewed
P48061 BXGT010616 Stromal cell-derived factor 1 6387 reviewed
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P49711 BXGT010728 Transcriptional repressor CTCF 10664 reviewed Transcription factor
P49789 BXGT010742 Bis(5'-adenosyl)-triphosphatase 2272 reviewed
P50281 BXGT010788 Matrix metalloproteinase-14 4323 reviewed Enzyme
P50583 BXGT010813 Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] 318 reviewed Enzyme
P51532 BXGT010852 Transcription activator BRG1 6597 reviewed Epigenetic regulator
P51955 BXGT010908 Serine/threonine-protein kinase Nek2 4751 reviewed Kinase
P52565 BXGT010933 Rho GDP-dissociation inhibitor 1 396 reviewed Enzyme modulator
P53985 BXGT011022 Monocarboxylate transporter 1 6566 reviewed Transporter
P55087 BXGT011105 Aquaporin-4 361 reviewed Ion channel
P56937 BXGT011205 3-keto-steroid reductase 51478 reviewed
P57735 BXGT011214 Ras-related protein Rab-25 57111 reviewed
P60709 BXGT011322 Actin, cytoplasmic 1 60 reviewed Cellular structure
P61073 BXGT011352 C-X-C chemokine receptor type 4 7852 reviewed G-protein coupled receptor
P61604 BXGT011380 10 kDa heat shock protein, mitochondrial 3336 reviewed Chaperone
P63000 BXGT011481 Ras-related C3 botulinum toxin substrate 1 5879 reviewed Enzyme modulator
P67936 BXGT011570 Tropomyosin alpha-4 chain 7171 reviewed Cellular structure
P78504 BXGT011844 Protein jagged-1 182 reviewed
P80188 BXGT011882 Neutrophil gelatinase-associated lipocalin 3934 reviewed Enzyme
P98170 BXGT012231 E3 ubiquitin-protein ligase XIAP 331 reviewed Enzyme modulator
Q00722 BXGT012546 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 5330 reviewed Enzyme
Q00987 BXGT012559 E3 ubiquitin-protein ligase Mdm2 4193 reviewed Nucleic acid binding
Q01469 BXGT012590 Fatty acid-binding protein 5 2171 reviewed
Q03431 BXGT012714 Parathyroid hormone/parathyroid hormone-related peptide receptor 5745 reviewed G-protein coupled receptor
Q04721 BXGT012777 Neurogenic locus notch homolog protein 2 4853 reviewed
Q05513 BXGT012820 Protein kinase C zeta type 5590 reviewed Kinase
Q06124 BXGT012856 Tyrosine-protein phosphatase non-receptor type 11 5781 reviewed
Q06418 BXGT012875 Tyrosine-protein kinase receptor TYRO3 7301 reviewed Kinase
Q06609 BXGT012884 DNA repair protein RAD51 homolog 1 5888 reviewed
Q08050 BXGT012958 Forkhead box protein M1 2305 reviewed
Q13009 BXGT013305 T-lymphoma invasion and metastasis-inducing protein 1 7074 reviewed
Q13177 BXGT013323 Serine/threonine-protein kinase PAK 2 5062 reviewed Kinase
Q13257 BXGT013333 Mitotic spindle assembly checkpoint protein MAD2A 4085 reviewed
Q13309 BXGT013338 S-phase kinase-associated protein 2 6502 reviewed
Q13315 BXGT013339 Serine-protein kinase ATM 472 reviewed Kinase
Q13363 BXGT013344 C-terminal-binding protein 1 1487 reviewed Transcription factor
Q13485 BXGT013363 Mothers against decapentaplegic homolog 4 4089 reviewed Transcription factor
Q13501 BXGT013365 Sequestosome-1 8878 reviewed
Q13510 BXGT013367 Acid ceramidase 427 reviewed Enzyme
Q13882 BXGT013399 Protein-tyrosine kinase 6 5753 reviewed Kinase
Q14457 BXGT013472 Beclin-1 8678 reviewed Enzyme modulator
Q14498 BXGT013475 RNA-binding protein 39 9584 reviewed
Q15063 BXGT013531 Periostin 10631 reviewed Signaling
Q15116 BXGT013539 Programmed cell death protein 1 5133 reviewed
Q15139 BXGT013546 Serine/threonine-protein kinase D1 5587 reviewed Kinase
Q15303 BXGT013557 Receptor tyrosine-protein kinase erbB-4 2066 reviewed Kinase
Q15392 BXGT013566 Delta(24)-sterol reductase 1718 reviewed Enzyme
Q15493 BXGT013575 Regucalcin 9104 reviewed Enzyme
Q15746 BXGT013591 Myosin light chain kinase, smooth muscle 4638 reviewed Kinase
Q15910 BXGT013612 Histone-lysine N-methyltransferase EZH2 2146 reviewed Epigenetic regulator
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha 3091 reviewed Transcription factor
Q16739 BXGT013663 Ceramide glucosyltransferase 7357 reviewed Enzyme
Q495A1 BXGT014764 T-cell immunoreceptor with Ig and ITIM domains 201633 reviewed
Q53EL6 BXGT015008 Programmed cell death protein 4 27250 reviewed Nucleic acid binding
Q53GQ0 BXGT015013 Very-long-chain 3-oxoacyl-CoA reductase 51144 reviewed
Q5GJ75 BXGT015386 Tumor necrosis factor alpha-induced protein 8-like protein 3 388121 reviewed
Q6N021 BXGT016378 Methylcytosine dioxygenase TET2 54790 reviewed
Q6UWP2 BXGT016567 Dehydrogenase/reductase SDR family member 11 79154 reviewed Enzyme
Q6ZN17 BXGT016631 Protein lin-28 homolog B 389421 reviewed
Q7Z7D3 BXGT017262 V-set domain-containing T-cell activation inhibitor 1 79679 reviewed Enzyme modulator
Q86Z14 BXGT017639 Beta-klotho 152831 reviewed Enzyme
Q8IVS2 BXGT018349 Malonyl-CoA-acyl carrier protein transacylase, mitochondrial 27349 reviewed
Q8NEM0 BXGT018555 Microcephalin 79648 reviewed Nucleic acid binding
Q8TDQ0 BXGT018810 Hepatitis A virus cellular receptor 2 84868 reviewed
Q92731 BXGT019366 Estrogen receptor beta 2100 reviewed Nuclear receptor
Q92918 BXGT019394 Mitogen-activated protein kinase kinase kinase kinase 1 11184 reviewed Kinase
Q96KS0 BXGT019688 Egl nine homolog 2 112398 reviewed
Q99519 BXGT019928 Sialidase-1 4758 reviewed Enzyme
Q99527 BXGT019930 G-protein coupled estrogen receptor 1 2852 reviewed G-protein coupled receptor
Q99933 BXGT019976 BAG family molecular chaperone regulator 1 573 reviewed
Q9BUB5 BXGT020133 MAP kinase-interacting serine/threonine-protein kinase 1 8569 reviewed Kinase
Q9BZ95 BXGT020196 Histone-lysine N-methyltransferase NSD3 54904 reviewed Epigenetic regulator
Q9BZS1 BXGT020203 Forkhead box protein P3 50943 reviewed
Q9H488 BXGT020471 GDP-fucose protein O-fucosyltransferase 1 23509 reviewed
Q9NRW3 BXGT021195 DNA dC->dU-editing enzyme APOBEC-3C 27350 reviewed Enzyme
Q9NVS9 BXGT021228 Pyridoxine-5'-phosphate oxidase 55163 reviewed Enzyme
Q9NYA1 BXGT021254 Sphingosine kinase 1 8877 reviewed Kinase
Q9NZQ7 BXGT021281 Programmed cell death 1 ligand 1 29126 reviewed Receptor
Q9UBG0 BXGT021654 C-type mannose receptor 2 9902 reviewed
Q9UGL1 BXGT021685 Lysine-specific demethylase 5B 10765 reviewed Epigenetic regulator
Q9ULC4 BXGT021757 Malignant T-cell-amplified sequence 1 28985 reviewed Receptor
Q9UM47 BXGT021772 Neurogenic locus notch homolog protein 3 4854 reviewed
Q9UNN8 BXGT021791 Endothelial protein C receptor 10544 reviewed Enzyme modulator
Q9Y251 BXGT022215 Heparanase 10855 reviewed Enzyme
Q9Y2K7 BXGT022239 Lysine-specific demethylase 2A 22992 reviewed
P25054 BXGT022961 Adenomatous polyposis coli protein 324 reviewed
P16284 BXGT022972 Platelet endothelial cell adhesion molecule 5175 reviewed Cell adhesion
Q13330 BXGT023103 Metastasis-associated protein MTA1 9112 reviewed Nucleic acid binding
Q9UM82 BXGT023181 Spermatogenesis-associated protein 2 9825 reviewed
Q16552 BXGT023419 Interleukin-17A 3605 reviewed
Q9HAU4 BXGT024040 E3 ubiquitin-protein ligase SMURF2 64750 reviewed Enzyme
Q96RU2 BXGT024174 Ubiquitin carboxyl-terminal hydrolase 28 57646 reviewed Enzyme
Q9BYE2 BXGT024631 Transmembrane protease serine 13 84000 reviewed Enzyme
Q9P2E7 BXGT025815 Protocadherin-10 57575 reviewed
P00403 BXGT026137 Cytochrome c oxidase subunit 2 4513 reviewed Enzyme
Q8WXI2 BXGT026145 Connector enhancer of kinase suppressor of ras 2 22866 reviewed
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease