Showing entry for Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011072
Protein NameCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Uniport IdP54750
GenePDE1A
Gene Id5136
DomainPDEase_I; PDEase_I_N
Pfam PF00233   PF08499  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.4 Nucleotide metabolism hsa00230 Purine metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
3. Environmental Information Processing 3.2 Signal transduction hsa04020 Calcium signaling pathway
5. Organismal Systems 5.7 Sensory system hsa04740 Olfactory transduction
5. Organismal Systems 5.7 Sensory system hsa04742 Taste transduction
5. Organismal Systems 5.2 Endocrine system hsa04924 Renin secretion
6. Human Diseases 6.5 Substance dependence hsa05032 Morphine addiction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0046069 cGMP catabolic process
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0034391 regulation of smooth muscle cell apoptotic process
Biological Process GO:0048660 regulation of smooth muscle cell proliferation
molecular function GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity
molecular function GO:0005516 calmodulin binding
molecular function GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
molecular function GO:0046872 metal ion binding
cellular component GO:0005829 cytosol
cellular component GO:0043025 neuronal cell body
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-111885 Opioid Signalling
R-HSA-111933 Calmodulin induced events
R-HSA-111957 Cam-PDE 1 activation
R-HSA-111996 Ca-dependent events
R-HSA-111997 CaM pathway
R-HSA-112040 G-protein mediated events
R-HSA-112043 PLC beta mediated events
R-HSA-1489509 DAG and IP3 signaling
R-HSA-162582 Signal Transduction
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-392154 Nitric oxide stimulates guanylate cyclase
R-HSA-418346 Platelet homeostasis
R-HSA-418457 cGMP effects
R-HSA-418555 G alpha (s) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-9006925 Intracellular signaling by second messengers
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0022650 BXGD001568 Kidney Calculi Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022679 BXGD001575 Cystic kidney Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0085413 BXGD003171 Polycystic Kidney, Autosomal Dominant Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0149721 BXGD003349 Left Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0270549 BXGD006079 Generalized Anxiety Disorder Mental Disorders
C0392525 BXGD008052 Nephrolithiasis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1961102 BXGD016673 Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C3887499 BXGD019884 Renal cyst Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000202 Papaverine 339.39
BXGC0000204 Theophylline 180.16
BXGC0001502 Caffeine 194.19
BXGC0043126 Nicardipine 479.21
BXGC0046737 Berbamine 608.29
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein