Showing entry for Hydroxymethylglutaryl-CoA synthase, mitochondrial


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011090
Protein NameHydroxymethylglutaryl-CoA synthase, mitochondrial
Uniport IdP54868
GeneHMGCS2
Gene Id3158
DomainHMG_CoA_synt_C; HMG_CoA_synt_N
Pfam PF08540   PF01154  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00072 Synthesis and degradation of ketone bodies
1. Metabolism 1.5 Amino acid metabolism hsa00280 Valine, leucine and isoleucine degradation
1. Metabolism 1.1 Carbohydrate metabolism hsa00650 Butanoate metabolism
1. Metabolism 1.9 Metabolism of terpenoids and polyketides hsa00900 Terpenoid backbone biosynthesis
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
5. Organismal Systems 5.2 Endocrine system hsa03320 PPAR signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006084 acetyl-CoA metabolic process
Biological Process GO:0006695 cholesterol biosynthetic process
Biological Process GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway
Biological Process GO:0046951 ketone body biosynthetic process
Biological Process GO:0019216 regulation of lipid metabolic process
molecular function GO:0004421 hydroxymethylglutaryl-CoA synthase activity
molecular function GO:0042802 identical protein binding
cellular component GO:0005759 mitochondrial matrix
cellular component GO:0005739 mitochondrion
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1989781 PPARA activates gene expression
R-HSA-400206 Regulation of lipid metabolism by PPARalpha
R-HSA-556833 Metabolism of lipids
R-HSA-74182 Ketone body metabolism
R-HSA-77111 Synthesis of Ketone Bodies
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0005398 BXGD000311 Cholestasis, Extrahepatic Digestive System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007113 BXGD000430 Rectal Carcinoma Digestive System Diseases; Neoplasms
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013364 BXGD000819 Dysautonomia, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020615 BXGD001445 Hypoglycemia Nutritional and Metabolic Diseases
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0026640 BXGD001912 Mouth Neoplasms Neoplasms; Stomatognathic Diseases
C0027626 BXGD002005 Neoplasm Invasiveness Pathological Conditions, Signs and Symptoms; Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0034885 BXGD002490 Rectal Neoplasms Digestive System Diseases; Neoplasms
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042963 BXGD003018 Vomiting Pathological Conditions, Signs and Symptoms
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0153381 BXGD003626 Malignant neoplasm of mouth Neoplasms; Stomatognathic Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0220641 BXGD004305 Lip and Oral Cavity Carcinoma Neoplasms; Stomatognathic Diseases
C0242350 BXGD005154 Erectile dysfunction Male Urogenital Diseases; Mental Disorders
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0337438 BXGD007159 Glucose measurement
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0495706 BXGD009038 elevated blood glucose level
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598935 BXGD009674 Tumor Initiation Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1519670 BXGD013241 Tumor Angiogenesis Pathological Conditions, Signs and Symptoms
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2751532 BXGD017722 3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein