Showing entry for Calcineurin subunit B type 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011497
Protein NameCalcineurin subunit B type 1
Uniport IdP63098
GenePPP3R1
Gene Id5534
DomainEF-hand_7
Pfam PF13499  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04020 Calcium signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04022 cGMP-PKG signaling pathway
4. Cellular Processes 4.2 Cell growth and death hsa04114 Oocyte meiosis
4. Cellular Processes 4.2 Cell growth and death hsa04218 Cellular senescence
3. Environmental Information Processing 3.2 Signal transduction hsa04310 Wnt signaling pathway
5. Organismal Systems 5.8 Development hsa04360 Axon guidance
3. Environmental Information Processing 3.2 Signal transduction hsa04370 VEGF signaling pathway
5. Organismal Systems 5.8 Development hsa04380 Osteoclast differentiation
5. Organismal Systems 5.1 Immune system hsa04625 C-type lectin receptor signaling pathway
5. Organismal Systems 5.1 Immune system hsa04650 Natural killer cell mediated cytotoxicity
5. Organismal Systems 5.1 Immune system hsa04658 Th1 and Th2 cell differentiation
5. Organismal Systems 5.1 Immune system hsa04659 Th17 cell differentiation
5. Organismal Systems 5.1 Immune system hsa04660 T cell receptor signaling pathway
5. Organismal Systems 5.1 Immune system hsa04662 B cell receptor signaling pathway
5. Organismal Systems 5.6 Nervous system hsa04720 Long-term potentiation
5. Organismal Systems 5.6 Nervous system hsa04724 Glutamatergic synapse
5. Organismal Systems 5.2 Endocrine system hsa04921 Oxytocin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04922 Glucagon signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04924 Renin secretion
6. Human Diseases 6.4 Neurodegenerative diseases hsa05010 Alzheimer disease
6. Human Diseases 6.4 Neurodegenerative diseases hsa05014 Amyotrophic lateral sclerosis (ALS)
6. Human Diseases 6.5 Substance dependence hsa05031 Amphetamine addiction
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05152 Tuberculosis
6. Human Diseases 6.9 Infectious diseases: Viral hsa05163 Human cytomegalovirus infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05166 Human T-cell leukemia virus 1 infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05167 Kaposi sarcoma-associated herpesvirus infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05170 Human immunodeficiency virus 1 infection
6. Human Diseases 6.1 Cancers: Overview hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0033173 calcineurin-NFAT signaling cascade
Biological Process GO:0038095 Fc-epsilon receptor signaling pathway
Biological Process GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0007223 Wnt signaling pathway, calcium modulating pathway
molecular function GO:0004723 calcium-dependent protein serine/threonine phosphatase activity
molecular function GO:0005509 calcium ion binding
molecular function GO:0005516 calmodulin binding
molecular function GO:0016018 cyclosporin A binding
molecular function GO:0019902 phosphatase binding
molecular function GO:0019904 protein domain specific binding
cellular component GO:0005955 calcineurin complex
cellular component GO:0005829 cytosol
cellular component GO:0005739 mitochondrion
cellular component GO:0005654 nucleoplasm
cellular component GO:0042383 sarcolemma
Reactome
Pathway Id Pathway Name
R-HSA-109581 Apoptosis
R-HSA-109606 Intrinsic Pathway for Apoptosis
R-HSA-111447 Activation of BAD and translocation to mitochondria
R-HSA-111885 Opioid Signalling
R-HSA-114452 Activation of BH3-only proteins
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR)
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR)
R-HSA-1280218 Adaptive Immune System
R-HSA-1280218 Adaptive Immune System
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168256 Immune System
R-HSA-180024 DARPP-32 events
R-HSA-195721 Signaling by WNT
R-HSA-2025928 Calcineurin activates NFAT
R-HSA-2025928 Calcineurin activates NFAT
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-372790 Signaling by GPCR
R-HSA-3858494 Beta-catenin independent WNT signaling
R-HSA-388396 GPCR downstream signalling
R-HSA-4086398 Ca2+ pathway
R-HSA-418594 G alpha (i) signalling events
R-HSA-5357801 Programmed Cell Death
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-5621481 C-type lectin receptors (CLRs)
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009319 BXGD000596 Colitis Digestive System Diseases
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021704 BXGD001510 Intelligence Behavior and Behavior Mechanisms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0030486 BXGD002229 Paraplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0040137 BXGD002846 Thyroid Nodule Neoplasms; Endocrine System Diseases
C0086445 BXGD003285 Idiopathic Membranous Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0149721 BXGD003349 Left Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0202194 BXGD004081 Potassium measurement
C0205682 BXGD004105 Waist-Hip Ratio
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0235592 BXGD004758 Cervical lymphadenopathy Hemic and Lymphatic Diseases
C0340279 BXGD007314 Ventricular hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0344529 BXGD007687 Cornea plana Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0489786 BXGD009018 Height
C0598428 BXGD009665 genetic hypertension Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0740391 BXGD009987 Middle Cerebral Artery Occlusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0752130 BXGD010674 Spinal Cord Ischemia Nervous System Diseases; Cardiovascular Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332347 BXGD012527 Atypical Ductal Breast Hyperplasia Neoplasms
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002144 Tetradecanoic acid 228.37
BXGC0002586 Calcium 40.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein