Showing entry for Histone H3.1



                       
General Target Information
BXGT IdBXGT011601
Protein NameHistone H3.1
Uniport IdP68431
GeneH3C1
Gene Id8350;8351;8352;8353;8354;8355;8356;8357;8358;8968
DomainHistone
Pfam PF00125  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.5 Substance dependence hsa05034 Alcoholism
6. Human Diseases 6.1 Cancers: Overview hsa05202 Transcriptional misregulation in cancer
6. Human Diseases 6.3 Immune diseases hsa05322 Systemic lupus erythematosus
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007596 blood coagulation
Biological Process GO:0044267 cellular protein metabolic process
Biological Process GO:0006325 chromatin organization
Biological Process GO:0006335 DNA replication-dependent nucleosome assembly
Biological Process GO:0038111 interleukin-7-mediated signaling pathway
Biological Process GO:0045814 negative regulation of gene expression, epigenetic
Biological Process GO:0006334 nucleosome assembly
Biological Process GO:0000183 rDNA heterochromatin assembly
Biological Process GO:0060968 regulation of gene silencing
Biological Process GO:0060964 regulation of gene silencing by miRNA
Biological Process GO:0045652 regulation of megakaryocyte differentiation
Biological Process GO:0032200 telomere organization
molecular function GO:0045296 cadherin binding
molecular function GO:0003677 DNA binding
molecular function GO:0046982 protein heterodimerization activity
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0016020 membrane
cellular component GO:0000228 nuclear chromosome
cellular component GO:0000788 nuclear nucleosome
cellular component GO:0005654 nucleoplasm
cellular component GO:0000786 nucleosome
cellular component GO:0005634 nucleus
cellular component GO:0032991 protein-containing complex
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-1266695 Interleukin-7 signaling
R-HSA-1266695 Interleukin-7 signaling
R-HSA-1266738 Developmental Biology
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1474165 Reproduction
R-HSA-1500620 Meiosis
R-HSA-157118 Signaling by NOTCH
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-1640170 Cell Cycle
R-HSA-1640170 Cell Cycle
R-HSA-1643685 Disease
R-HSA-168256 Immune System
R-HSA-168256 Immune System
R-HSA-1912408 Pre-NOTCH Transcription and Translation
R-HSA-1912422 Pre-NOTCH Expression and Processing
R-HSA-194315 Signaling by Rho GTPases
R-HSA-195258 RHO GTPase Effectors
R-HSA-195721 Signaling by WNT
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex
R-HSA-211000 Gene Silencing by RNA
R-HSA-212165 Epigenetic regulation of gene expression
R-HSA-212165 Epigenetic regulation of gene expression
R-HSA-212300 PRC2 methylates histones and DNA
R-HSA-212436 Generic Transcription Pathway
R-HSA-212436 Generic Transcription Pathway
R-HSA-2262752 Cellular responses to stress
R-HSA-2299718 Condensation of Prophase Chromosomes
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-2559583 Cellular Senescence
R-HSA-3214815 HDACs deacetylate histones
R-HSA-3214841 PKMTs methylate histone lysines
R-HSA-3214842 HDMs demethylate histones
R-HSA-3214847 HATs acetylate histones
R-HSA-3214847 HATs acetylate histones
R-HSA-3214858 RMTs methylate histone arginines
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-392499 Metabolism of proteins
R-HSA-427359 SIRT1 negatively regulates rRNA expression
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-449147 Signaling by Interleukins
R-HSA-449147 Signaling by Interleukins
R-HSA-4839726 Chromatin organization
R-HSA-4839726 Chromatin organization
R-HSA-5250913 Positive epigenetic regulation of rRNA expression
R-HSA-5250913 Positive epigenetic regulation of rRNA expression
R-HSA-5250924 B-WICH complex positively regulates rRNA expression
R-HSA-5250941 Negative epigenetic regulation of rRNA expression
R-HSA-5250941 Negative epigenetic regulation of rRNA expression
R-HSA-5334118 DNA methylation
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-5619507 Activation of HOX genes during differentiation
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-HSA-5663205 Infectious disease
R-HSA-68875 Mitotic Prophase
R-HSA-68886 M Phase
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-73728 RNA Polymerase I Promoter Opening
R-HSA-73772 RNA Polymerase I Promoter Escape
R-HSA-73854 RNA Polymerase I Promoter Clearance
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-73864 RNA Polymerase I Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-74160 Gene expression (Transcription)
R-HSA-8878171 Transcriptional regulation by RUNX1
R-HSA-8878171 Transcriptional regulation by RUNX1
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-8939211 ESR-mediated signaling
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-9018519 Estrogen-dependent gene expression
R-HSA-912446 Meiotic recombination
R-HSA-9609646 HCMV Infection
R-HSA-9609690 HCMV Early Events
R-HSA-9610379 HCMV Late Events
R-HSA-9616222 Transcriptional regulation of granulopoiesis
R-HSA-977225 Amyloid fiber formation
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007766 BXGD000478 Intracranial Aneurysm Nervous System Diseases; Cardiovascular Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028945 BXGD002099 oligodendroglioma Neoplasms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0085409 BXGD003168 Polyendocrinopathies, Autoimmune Immune System Diseases; Endocrine System Diseases
C0149782 BXGD003365 Squamous cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0238198 BXGD004893 Gastrointestinal Stromal Tumors Digestive System Diseases; Neoplasms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0278510 BXGD006526 Childhood Medulloblastoma Neoplasms
C0278876 BXGD006607 Adult Medulloblastoma Neoplasms
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279070 BXGD006625 Adult Oligodendroglioma Neoplasms
C0280475 BXGD006749 Childhood Oligodendroglioma Neoplasms
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0751396 BXGD010425 Well Differentiated Oligodendroglioma Neoplasms
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1861172 BXGD016016 Venous Thromboembolism Cardiovascular Diseases
C2986658 BXGD018234 Diffuse Intrinsic Pontine Glioma
C4324563 BXGD022772 Neutrophil extracellular trap formation
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000246 NG,N'G-Dimethyl-L-arginine 202.25
BXGC0000436 Glycerol 92.09
BXGC0001380 Succinic acid 118.09
BXGC0002588 Magnesium 24.31
BXGC0003705 Chloride 35.45
BXGC0003744 L-(-)-Homoserine 119.12
BXGC0004275 Acetaldehyde 44.05
BXGC0024661 Norleucine 131.09
BXGC0026123 Biotin 244.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein