Showing entry for ADP-ribosylation factor 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012031
Protein NameADP-ribosylation factor 1
Uniport IdP84077
GeneARF1
Gene Id375
DomainArf
Pfam PF00025  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04072 Phospholipase D signaling pathway
4. Cellular Processes 4.1 Transport and catabolism hsa04144 Endocytosis
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05110 Vibrio cholerae infection
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05134 Legionellosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007015 actin filament organization
Biological Process GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
Biological Process GO:0006878 cellular copper ion homeostasis
Biological Process GO:0098586 cellular response to virus
Biological Process GO:0097061 dendritic spine organization
Biological Process GO:0055108 Golgi to transport vesicle transport
Biological Process GO:0035722 interleukin-12-mediated signaling pathway
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0060292 long-term synaptic depression
Biological Process GO:0097212 lysosomal membrane organization
Biological Process GO:1990386 mitotic cleavage furrow ingression
Biological Process GO:0006661 phosphatidylinositol biosynthetic process
Biological Process GO:0045956 positive regulation of calcium ion-dependent exocytosis
Biological Process GO:0060999 positive regulation of dendritic spine development
Biological Process GO:0045807 positive regulation of endocytosis
Biological Process GO:1902953 positive regulation of ER to Golgi vesicle-mediated transport
Biological Process GO:1902824 positive regulation of late endosome to lysosome transport
Biological Process GO:0050714 positive regulation of protein secretion
Biological Process GO:1902307 positive regulation of sodium ion transmembrane transport
Biological Process GO:0098974 postsynaptic actin cytoskeleton organization
Biological Process GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation
Biological Process GO:0050690 regulation of defense response to virus by virus
Biological Process GO:1903725 regulation of phospholipid metabolic process
Biological Process GO:0002090 regulation of receptor internalization
Biological Process GO:0070142 synaptic vesicle budding
Biological Process GO:0034379 very-low-density lipoprotein particle assembly
Biological Process GO:0016192 vesicle-mediated transport
molecular function GO:0019003 GDP binding
molecular function GO:0003924 GTPase activity
molecular function GO:0005525 GTP binding
molecular function GO:0000287 magnesium ion binding
molecular function GO:1990583 phospholipase D activator activity
molecular function GO:0019904 protein domain specific binding
molecular function GO:0003723 RNA binding
cellular component GO:0031252 cell leading edge
cellular component GO:0030137 COPI-coated vesicle
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005925 focal adhesion
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0000139 Golgi membrane
cellular component GO:0005770 late endosome
cellular component GO:0043005 neuron projection
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0005778 peroxisomal membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0014069 postsynaptic density
cellular component GO:0032991 protein-containing complex
cellular component GO:0030017 sarcomere
cellular component GO:0005802 trans-Golgi network
Reactome
Pathway Id Pathway Name
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1280218 Adaptive Immune System
R-HSA-1430728 Metabolism
R-HSA-1483255 PI Metabolism
R-HSA-1483257 Phospholipid metabolism
R-HSA-162906 HIV Infection
R-HSA-162909 Host Interactions of HIV factors
R-HSA-1643685 Disease
R-HSA-164938 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis
R-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-1660514 Synthesis of PIPs at the Golgi membrane
R-HSA-167590 Nef Mediated CD4 Down-regulation
R-HSA-168256 Immune System
R-HSA-199977 ER to Golgi Anterograde Transport
R-HSA-199991 Membrane Trafficking
R-HSA-199992 trans-Golgi Network Vesicle Budding
R-HSA-2132295 MHC class II antigen presentation
R-HSA-392499 Metabolism of proteins
R-HSA-432720 Lysosome Vesicle Biogenesis
R-HSA-432722 Golgi Associated Vesicle Biogenesis
R-HSA-446203 Asparagine N-linked glycosylation
R-HSA-447115 Interleukin-12 family signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-556833 Metabolism of lipids
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5663205 Infectious disease
R-HSA-597592 Post-translational protein modification
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-6811438 Intra-Golgi traffic
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-8856688 Golgi-to-ER retrograde transport
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
R-HSA-9020591 Interleukin-12 signaling
R-HSA-948021 Transport to the Golgi and subsequent modification
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003486 BXGD000197 Aortic Aneurysm Cardiovascular Diseases
C0003504 BXGD000202 Aortic Valve Insufficiency Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0013274 BXGD000809 Patent ductus arteriosus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0014378 BXGD000912 Enterovirus Infections Infections
C0017168 BXGD001101 Gastroesophageal reflux disease Digestive System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019270 BXGD001311 Hernia Pathological Conditions, Signs and Symptoms
C0022336 BXGD001535 Creutzfeldt-Jakob disease Infections; Nervous System Diseases; Mental Disorders
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027626 BXGD002005 Neoplasm Invasiveness Pathological Conditions, Signs and Symptoms; Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029454 BXGD002155 Osteopetrosis Musculoskeletal Diseases
C0034194 BXGD002472 Pyloric Stenosis Digestive System Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0085109 BXGD003125 Corneal Neovascularization Pathological Conditions, Signs and Symptoms; Eye Diseases
C0086437 BXGD003282 Joint laxity Musculoskeletal Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0206695 BXGD004246 Carcinoma, Neuroendocrine Neoplasms
C0206754 BXGD004289 Neuroendocrine Tumors Neoplasms
C0241654 BXGD005104 Abnormal heart valve morphology Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0274306 BXGD006368 Cutaneous anaphylaxis Immune System Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0423757 BXGD008504 Thin skin
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0751495 BXGD010473 Seizures, Focal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1257931 BXGD011815 Mammary Neoplasms, Human Neoplasms; Skin and Connective Tissue Diseases
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1277241 BXGD012110 Delayed myelination Mental Disorders
C1333064 BXGD012587 Classical Hodgkin's Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1458140 BXGD013134 Bleeding tendency Hemic and Lymphatic Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1837461 BXGD014234 SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
C1868720 BXGD016531 Periventricular Nodular Heterotopia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C2347747 BXGD017040 Adult Classical Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2900450 BXGD017854 Other Creutzfeldt-Jakob disease Infections; Nervous System Diseases; Mental Disorders
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3642347 BXGD019246 Basal-Like Breast Carcinoma
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4553743 BXGD023548 Spasticity, CTCAE
C4704874 BXGD023682 Mammary Carcinoma, Human Neoplasms; Skin and Connective Tissue Diseases
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C4748602 BXGD024006 PERIVENTRICULAR NODULAR HETEROTOPIA 8
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002144 Tetradecanoic acid 228.37
BXGC0002588 Magnesium 24.31
BXGC0006198 Citric acid 192.12
BXGC0031449 1,3-propanediol 76.05
BXGC0048845 Guanosine Triphosphate 522.99
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein