Showing entry for Gastroesophageal reflux disease


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD001101
Disease NameGastroesophageal reflux disease
Disease CUI IdC0017168
MeSH Codes C06  
Disease Class NameDigestive System Diseases
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id HP:0025031  
Human Phenotype Ontology TermAbnormality of the digestive system
Disease Ontology Id DOID:7  
Disease Ontology Class Namedisease of anatomical entity
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
A0A024RAV5 BXGT000013 V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b 3845 unreviewed
O00206 BXGT003894 Toll-like receptor 4 7099 reviewed
O00222 BXGT003899 Metabotropic glutamate receptor 8 2918 reviewed G-protein coupled receptor
O00482 BXGT003929 Nuclear receptor subfamily 5 group A member 2 2494 reviewed Nuclear receptor
O00555 BXGT003936 Voltage-dependent P/Q-type calcium channel subunit alpha-1A 773 reviewed Ion channel
O14746 BXGT004091 Telomerase reverse transcriptase 7015 reviewed Enzyme
O14764 BXGT004094 Gamma-aminobutyric acid receptor subunit delta 2563 reviewed Ion channel
O14770 BXGT004095 Homeobox protein Meis2 4212 reviewed Enzyme
O15297 BXGT004149 Protein phosphatase 1D 8493 reviewed Enzyme
O15399 BXGT004164 Glutamate receptor ionotropic, NMDA 2D 2906 reviewed Ion channel
O15409 BXGT004166 Forkhead box protein P2 93986 reviewed
O43175 BXGT004575 D-3-phosphoglycerate dehydrogenase 26227 reviewed Enzyme
O43318 BXGT004586 Mitogen-activated protein kinase kinase kinase 7 6885 reviewed Kinase
O43929 BXGT004638 Origin recognition complex subunit 4 5000 reviewed Nucleic acid binding
O60741 BXGT004897 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 348980 reviewed
O75469 BXGT005128 Nuclear receptor subfamily 1 group I member 2 8856 reviewed Nuclear receptor
O75628 BXGT005140 GTP-binding protein REM 1 28954 reviewed
O75899 BXGT005161 Gamma-aminobutyric acid type B receptor subunit 2 9568 reviewed G-protein coupled receptor
O76039 BXGT005171 Cyclin-dependent kinase-like 5 6792 reviewed Kinase
O94907 BXGT005340 Dickkopf-related protein 1 22943 reviewed
O95639 BXGT005388 Cleavage and polyadenylation specificity factor subunit 4 10898 reviewed Enzyme
O96028 BXGT005417 Histone-lysine N-methyltransferase NSD2 7468 reviewed Epigenetic regulator
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P00846 BXGT005674 ATP synthase subunit a 4508 reviewed Transporter
P00915 BXGT005689 Carbonic anhydrase 1 759 reviewed
P01100 BXGT005727 Proto-oncogene c-Fos 2353 reviewed Transcription factor
P01112 BXGT005732 GTPase HRas 3265 reviewed Enzyme modulator
P01116 BXGT005733 GTPase KRas 3845 reviewed Enzyme modulator
P01133 BXGT005736 Pro-epidermal growth factor 1950 reviewed
P01138 BXGT005738 Beta-nerve growth factor 4803 reviewed Signaling
P01270 BXGT005746 Parathyroid hormone 5741 reviewed
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01583 BXGT005771 Interleukin-1 alpha 3552 reviewed
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P01911 BXGT005816 HLA class II histocompatibility antigen, DRB1-15 beta chain 3123 reviewed Immune response
P02461 BXGT005880 Collagen alpha-1(III) chain 1281 reviewed
P03956 BXGT006120 Interstitial collagenase 4312 reviewed Enzyme
P04049 BXGT006133 RAF proto-oncogene serine/threonine-protein kinase 5894 reviewed Kinase
P04155 BXGT006155 Trefoil factor 1 7031 reviewed Signaling
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P04792 BXGT006264 Heat shock protein beta-1 3315 reviewed
P04818 BXGT006269 Thymidylate synthase 7298 reviewed Enzyme
P05109 BXGT006318 Protein S100-A8 6279 reviewed Calcium-binding protein
P05155 BXGT006328 Plasma protease C1 inhibitor 710 reviewed Enzyme modulator
P05231 BXGT006345 Interleukin-6 3569 reviewed
P05412 BXGT006354 Transcription factor AP-1 3725 reviewed Transcription factor
P06727 BXGT006485 Apolipoprotein A-IV 337 reviewed
P07237 BXGT006576 Protein disulfide-isomerase 5034 reviewed
P07550 BXGT006636 Beta-2 adrenergic receptor 154 reviewed G-protein coupled receptor
P07949 BXGT006703 Proto-oncogene tyrosine-protein kinase receptor Ret 5979 reviewed Kinase
P08069 BXGT006723 Insulin-like growth factor 1 receptor 3480 reviewed Kinase
P08254 BXGT006758 Stromelysin-1 4314 reviewed Enzyme
P08684 BXGT006812 Cytochrome P450 3A4 1576 reviewed Enzyme
P09486 BXGT006897 SPARC 6678 reviewed Signaling
P0CG29 BXGT007465 Glutathione S-transferase theta-2 2953 reviewed
P10145 BXGT007542 Interleukin-8 3576 reviewed Signaling
P10153 BXGT007544 Non-secretory ribonuclease 6036 reviewed
P12235 BXGT007774 ADP/ATP translocase 1 291 reviewed Transporter
P12821 BXGT007849 Angiotensin-converting enzyme 1636 reviewed Enzyme
P13224 BXGT007890 Platelet glycoprotein Ib beta chain 2812 reviewed
P14678 BXGT008038 Small nuclear ribonucleoprotein-associated proteins B and B' 6628 reviewed Nucleic acid binding
P15056 BXGT008075 Serine/threonine-protein kinase B-raf 673 reviewed Kinase
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P15884 BXGT008166 Transcription factor 4 6925 reviewed Transcription factor
P15924 BXGT008171 Desmoplakin 1832 reviewed Cellular structure
P16389 BXGT008221 Potassium voltage-gated channel subfamily A member 2 3737 reviewed Ion channel
P16455 BXGT008229 Methylated-DNA--protein-cysteine methyltransferase 4255 reviewed
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 2321 reviewed Kinase
P18074 BXGT008374 General transcription and DNA repair factor IIH helicase subunit XPD 2068 reviewed Enzyme
P18507 BXGT008411 Gamma-aminobutyric acid receptor subunit gamma-2 2566 reviewed Ion channel
P18887 BXGT008437 DNA repair protein XRCC1 7515 reviewed
P19438 BXGT008480 Tumor necrosis factor receptor superfamily member 1A 7132 reviewed
P19971 BXGT008537 Thymidine phosphorylase 1890 reviewed Enzyme
P20711 BXGT008594 Aromatic-L-amino-acid decarboxylase 1644 reviewed
P20930 BXGT008616 Filaggrin 2312 reviewed Cellular structure
P21333 BXGT008638 Filamin-A 2316 reviewed
P21579 BXGT008665 Synaptotagmin-1 6857 reviewed Transporter
P21589 BXGT008669 5'-nucleotidase 4907 reviewed Enzyme
P21964 BXGT008714 Catechol O-methyltransferase 1312 reviewed Enzyme
P23219 BXGT008837 Prostaglandin G/H synthase 1 5742 reviewed Enzyme
P23415 BXGT008864 Glycine receptor subunit alpha-1 2741 reviewed Ion channel
P24385 BXGT008965 G1/S-specific cyclin-D1 595 reviewed Enzyme modulator
P27635 BXGT009194 60S ribosomal protein L10 6134 reviewed Nucleic acid binding
P27797 BXGT009206 Calreticulin 811 reviewed Calcium-binding protein
P28223 BXGT009239 5-hydroxytryptamine receptor 2A 3356 reviewed G-protein coupled receptor
P28329 BXGT009251 Choline O-acetyltransferase 1103 reviewed Enzyme
P31025 BXGT009500 Lipocalin-1 3933 reviewed Enzyme
P32322 BXGT009624 Pyrroline-5-carboxylate reductase 1, mitochondrial 5831 reviewed
P33261 BXGT009707 Cytochrome P450 2C19 1557 reviewed
P34932 BXGT009772 Heat shock 70 kDa protein 4 3308 reviewed
P35354 BXGT009816 Prostaglandin G/H synthase 2 5743 reviewed Enzyme
P35555 BXGT009845 Fibrillin-1 2200 reviewed Calcium-binding protein
P35658 BXGT009859 Nuclear pore complex protein Nup214 8021 reviewed Nucleic acid binding
P36507 BXGT009923 Dual specificity mitogen-activated protein kinase kinase 2 5605 reviewed Kinase
P39900 BXGT010148 Macrophage metalloelastase 4321 reviewed Enzyme
P40692 BXGT010195 DNA mismatch repair protein Mlh1 4292 reviewed Nucleic acid binding
P41594 BXGT010266 Metabotropic glutamate receptor 5 2915 reviewed G-protein coupled receptor
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P43004 BXGT010348 Excitatory amino acid transporter 2 6506 reviewed Transporter
P45381 BXGT010460 Aspartoacylase 443 reviewed
P46100 BXGT010508 Transcriptional regulator ATRX 546 reviewed
P46821 BXGT010542 Microtubule-associated protein 1B 4131 reviewed Cellular structure
P47870 BXGT010591 Gamma-aminobutyric acid receptor subunit beta-2 2561 reviewed Ion channel
P48167 BXGT010621 Glycine receptor subunit beta 2743 reviewed Ion channel
P49588 BXGT010713 Alanine--tRNA ligase, cytoplasmic 16 reviewed Nucleic acid binding
P51684 BXGT010880 C-C chemokine receptor type 6 1235 reviewed G-protein coupled receptor
P52799 BXGT010956 Ephrin-B2 1948 reviewed Signaling
P53667 BXGT011008 LIM domain kinase 1 3984 reviewed Kinase
P54098 BXGT011030 DNA polymerase subunit gamma-1 5428 reviewed Enzyme
P54707 BXGT011068 Potassium-transporting ATPase alpha chain 2 479 reviewed Transporter
P54886 BXGT011092 Delta-1-pyrroline-5-carboxylate synthase 5832 reviewed Enzyme
P55085 BXGT011104 Proteinase-activated receptor 2 2150 reviewed G-protein coupled receptor
P55265 BXGT011117 Double-stranded RNA-specific adenosine deaminase 103 reviewed Enzyme
P56537 BXGT011177 Eukaryotic translation initiation factor 6 3692 reviewed Nucleic acid binding
P58400 BXGT011235 Neurexin-1-beta 9378 reviewed
P60880 BXGT011335 Synaptosomal-associated protein 25 6616 reviewed Transporter
P61981 BXGT011400 14-3-3 protein gamma 7532 reviewed Chaperone
P78330 BXGT011833 Phosphoserine phosphatase 5723 reviewed Enzyme
P80404 BXGT011907 4-aminobutyrate aminotransferase, mitochondrial 18 reviewed Enzyme
P84077 BXGT012031 ADP-ribosylation factor 1 375 reviewed
Q00610 BXGT012539 Clathrin heavy chain 1 1213 reviewed Transporter
Q00975 BXGT012558 Voltage-dependent N-type calcium channel subunit alpha-1B 774 reviewed Ion channel
Q00987 BXGT012559 E3 ubiquitin-protein ligase Mdm2 4193 reviewed Nucleic acid binding
Q01959 BXGT012624 Sodium-dependent dopamine transporter 6531 reviewed Transporter
Q01968 BXGT012626 Inositol polyphosphate 5-phosphatase OCRL-1 4952 reviewed Enzyme
Q02750 BXGT012662 Dual specificity mitogen-activated protein kinase kinase 1 5604 reviewed Kinase
Q02880 BXGT012677 DNA topoisomerase 2-beta 7155 reviewed
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A 4297 reviewed
Q03403 BXGT012712 Trefoil factor 2 7032 reviewed Signaling
Q05193 BXGT012810 Dynamin-1 1759 reviewed Enzyme modulator
Q06124 BXGT012856 Tyrosine-protein phosphatase non-receptor type 11 5781 reviewed
Q06787 BXGT012890 Synaptic functional regulator FMR1 2332 reviewed Nucleic acid binding
Q07343 BXGT012926 cAMP-specific 3',5'-cyclic phosphodiesterase 4B 5142 reviewed
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform 5530 reviewed
Q12756 BXGT013261 Kinesin-like protein KIF1A 547 reviewed Cellular structure
Q12882 BXGT013276 Dihydropyrimidine dehydrogenase [NADP(+)] 1806 reviewed Enzyme
Q13153 BXGT013319 Serine/threonine-protein kinase PAK 1 5058 reviewed Kinase
Q13303 BXGT013336 Voltage-gated potassium channel subunit beta-2 8514 reviewed Ion channel
Q13363 BXGT013344 C-terminal-binding protein 1 1487 reviewed Transcription factor
Q13415 BXGT013350 Origin recognition complex subunit 1 4998 reviewed Nucleic acid binding
Q13478 BXGT013362 Interleukin-18 receptor 1 8809 reviewed Receptor
Q13554 BXGT013374 Calcium/calmodulin-dependent protein kinase type II subunit beta 816 reviewed Kinase
Q14116 BXGT013442 Interleukin-18 3606 reviewed
Q14683 BXGT013500 Structural maintenance of chromosomes protein 1A 8243 reviewed
Q14721 BXGT013502 Potassium voltage-gated channel subfamily B member 1 3745 reviewed Ion channel
Q15063 BXGT013531 Periostin 10631 reviewed Signaling
Q15233 BXGT013552 Non-POU domain-containing octamer-binding protein 4841 reviewed Nucleic acid binding
Q15652 BXGT013587 Probable JmjC domain-containing histone demethylation protein 2C 221037 reviewed
Q15858 BXGT013610 Sodium channel protein type 9 subunit alpha 6335 reviewed Ion channel
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 4780 reviewed Enzyme
Q16445 BXGT013629 Gamma-aminobutyric acid receptor subunit alpha-6 2559 reviewed Ion channel
Q16620 BXGT013645 BDNF/NT-3 growth factors receptor 4915 reviewed Kinase
Q59FK2 BXGT015276 Selenocysteine lyase variant 51540 unreviewed
Q6NUK1 BXGT016429 Calcium-binding mitochondrial carrier protein SCaMC-1 29957 reviewed Transporter
Q7L3T8 BXGT016994 Probable proline--tRNA ligase, mitochondrial 25973 reviewed Enzyme
Q7LG56 BXGT016999 Ribonucleoside-diphosphate reductase subunit M2 B 50484 reviewed Enzyme
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 7442 reviewed Ion channel
Q92794 BXGT019375 Histone acetyltransferase KAT6A 7994 reviewed Enzyme
Q96EQ8 BXGT019652 E3 ubiquitin-protein ligase RNF125 54941 reviewed
Q96I15 BXGT019674 Selenocysteine lyase 51540 reviewed Enzyme
Q96PE7 BXGT019707 Methylmalonyl-CoA epimerase, mitochondrial 84693 reviewed Enzyme
Q96PU5 BXGT019711 E3 ubiquitin-protein ligase NEDD4-like 23327 reviewed Enzyme
Q99572 BXGT019935 P2X purinoceptor 7 5027 reviewed Ion channel
Q99700 BXGT019949 Ataxin-2 6311 reviewed Nucleic acid binding
Q9BY41 BXGT020180 Histone deacetylase 8 55869 reviewed Epigenetic regulator
Q9BZS1 BXGT020203 Forkhead box protein P3 50943 reviewed
Q9GZV3 BXGT020427 High affinity choline transporter 1 60482 reviewed Transporter
Q9GZX6 BXGT020428 Interleukin-22 50616 reviewed
Q9GZZ9 BXGT020430 Ubiquitin-like modifier-activating enzyme 5 79876 reviewed Enzyme
Q9H4A3 BXGT020473 Serine/threonine-protein kinase WNK1 65125 reviewed Kinase
Q9H4W6 BXGT020478 Transcription factor COE3 253738 reviewed
Q9HBA0 BXGT020516 Transient receptor potential cation channel subfamily V member 4 59341 reviewed Ion channel
Q9NQX3 BXGT021172 Gephyrin 10243 reviewed
Q9NRF2 BXGT021185 SH2B adapter protein 1 25970 reviewed
Q9NRH2 BXGT021188 SNF-related serine/threonine-protein kinase 54861 reviewed Kinase
Q9NSD9 BXGT021206 Phenylalanine--tRNA ligase beta subunit 10056 reviewed Enzyme
Q9NW15 BXGT021229 Anoctamin-10 55129 reviewed
Q9NWT6 BXGT021234 Hypoxia-inducible factor 1-alpha inhibitor 55662 reviewed
Q9NY46 BXGT021248 Sodium channel protein type 3 subunit alpha 6328 reviewed Ion channel
Q9NYN1 BXGT021260 Ras-like protein family member 12 51285 reviewed Enzyme modulator
Q9UBM7 BXGT021657 7-dehydrocholesterol reductase 1717 reviewed Enzyme
Q9UHX1 BXGT021707 Poly(U)-binding-splicing factor PUF60 22827 reviewed
Q9UQD0 BXGT021811 Sodium channel protein type 8 subunit alpha 6334 reviewed Ion channel
Q9Y223 BXGT022207 Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase 10020 reviewed Enzyme
Q9Y2I2 BXGT022236 Netrin-G1 22854 reviewed Enzyme modulator
Q9Y2Q3 BXGT022242 Glutathione S-transferase kappa 1 373156 reviewed
Q7Z2W4 BXGT022875 Zinc finger CCCH-type antiviral protein 1 56829 reviewed
Q7L0Y3 BXGT023259 tRNA methyltransferase 10 homolog C 54931 reviewed
P00395 BXGT023596 Cytochrome c oxidase subunit 1 4512 reviewed Enzyme
Q9H0W8 BXGT024746 Protein SMG9 56006 reviewed
Q8IZA0 BXGT025026 Dyslexia-associated protein KIAA0319-like protein 79932 reviewed
P51608 BXGT025073 Methyl-CpG-binding protein 2 4204 reviewed Epigenetic regulator
P19474 BXGT025520 E3 ubiquitin-protein ligase TRIM21 6737 reviewed
Q9P121 BXGT025711 Neurotrimin 50863 reviewed
Q96MF2 BXGT025769 SH3 and cysteine-rich domain-containing protein 3 246329 reviewed
P35250 BXGT025854 Replication factor C subunit 2 5982 reviewed Enzyme
Q86SQ9 BXGT025875 Dehydrodolichyl diphosphate synthase complex subunit DHDDS 79947 reviewed Enzyme
Q9UQE7 BXGT025899 Structural maintenance of chromosomes protein 3 9126 reviewed
P00403 BXGT026137 Cytochrome c oxidase subunit 2 4513 reviewed Enzyme
Q8WXI2 BXGT026145 Connector enhancer of kinase suppressor of ras 2 22866 reviewed
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease