Showing entry for Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012564
Protein NameCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
Uniport IdQ01064
GenePDE1B
Gene Id5153
DomainPDEase_I; PDEase_I_N
Pfam PF00233   PF08499  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.4 Nucleotide metabolism hsa00230 Purine metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
3. Environmental Information Processing 3.2 Signal transduction hsa04020 Calcium signaling pathway
5. Organismal Systems 5.7 Sensory system hsa04740 Olfactory transduction
5. Organismal Systems 5.7 Sensory system hsa04742 Taste transduction
5. Organismal Systems 5.2 Endocrine system hsa04924 Renin secretion
6. Human Diseases 6.5 Substance dependence hsa05032 Morphine addiction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006915 apoptotic process
Biological Process GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus
Biological Process GO:0036006 cellular response to macrophage colony-stimulating factor stimulus
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0007626 locomotory behavior
Biological Process GO:0030224 monocyte differentiation
Biological Process GO:0042053 regulation of dopamine metabolic process
Biological Process GO:0001505 regulation of neurotransmitter levels
Biological Process GO:0001975 response to amphetamine
Biological Process GO:0042428 serotonin metabolic process
Biological Process GO:0008542 visual learning
molecular function GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
molecular function GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
molecular function GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity
molecular function GO:0005516 calmodulin binding
molecular function GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
molecular function GO:0046872 metal ion binding
cellular component GO:0005829 cytosol
cellular component GO:0043025 neuronal cell body
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-111885 Opioid Signalling
R-HSA-111933 Calmodulin induced events
R-HSA-111957 Cam-PDE 1 activation
R-HSA-111996 Ca-dependent events
R-HSA-111997 CaM pathway
R-HSA-112040 G-protein mediated events
R-HSA-112043 PLC beta mediated events
R-HSA-1489509 DAG and IP3 signaling
R-HSA-162582 Signal Transduction
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-392154 Nitric oxide stimulates guanylate cyclase
R-HSA-418346 Platelet homeostasis
R-HSA-418457 cGMP effects
R-HSA-418555 G alpha (s) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-9006925 Intracellular signaling by second messengers
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0023186 BXGD001613 Learning Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0085413 BXGD003171 Polycystic Kidney, Autosomal Dominant Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0242422 BXGD005163 Parkinsonian Disorders Nervous System Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0426980 BXGD008599 Motor symptoms
C0542476 BXGD009276 Forgetful Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0751262 BXGD010368 Adult Learning Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0751263 BXGD010369 Learning Disturbance Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0751265 BXGD010370 Learning Disabilities Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C1330966 BXGD012478 Developmental Academic Disorder Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000202 Papaverine 339.39
BXGC0000204 Theophylline 180.16
BXGC0000436 Glycerol 92.09
BXGC0001502 Caffeine 194.19
BXGC0002588 Magnesium 24.31
BXGC0043126 Nicardipine 479.21
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein