Showing entry for Parkinsonian Disorders


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD005163
Disease NameParkinsonian Disorders
Disease CUI IdC0242422
MeSH Codes C10  
Disease Class NameNervous System Diseases
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id HP:0000707  
Human Phenotype Ontology TermAbnormality of the nervous system
Disease Ontology Id DOID:7  
Disease Ontology Class Namedisease of anatomical entity
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
F7VJQ1 BXGT003310 Alternative prion protein 5621 reviewed
O00141 BXGT003882 Serine/threonine-protein kinase Sgk1 6446 reviewed Kinase
O00222 BXGT003899 Metabotropic glutamate receptor 8 2918 reviewed G-protein coupled receptor
O00429 BXGT003919 Dynamin-1-like protein 10059 reviewed Enzyme modulator
O00451 BXGT003923 GDNF family receptor alpha-2 2675 reviewed
O00555 BXGT003936 Voltage-dependent P/Q-type calcium channel subunit alpha-1A 773 reviewed Ion channel
O14578 BXGT004072 Citron Rho-interacting kinase 11113 reviewed Kinase
O14656 BXGT004080 Torsin-1A 1861 reviewed Chaperone
O14976 BXGT004118 Cyclin-G-associated kinase 2580 reviewed Kinase
O15118 BXGT004127 NPC intracellular cholesterol transporter 1 4864 reviewed Transporter
O43181 BXGT004576 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial 4724 reviewed
O43464 BXGT004595 Serine protease HTRA2, mitochondrial 27429 reviewed
O43612 BXGT004605 Orexin 3060 reviewed
O60260 BXGT004864 E3 ubiquitin-protein ligase parkin 5071 reviewed Enzyme
O60313 BXGT004871 Dynamin-like 120 kDa protein, mitochondrial 4976 reviewed Enzyme modulator
O60706 BXGT004896 ATP-binding cassette sub-family C member 9 10060 reviewed Transporter
O60760 BXGT004899 Hematopoietic prostaglandin D synthase 27306 reviewed
O75489 BXGT005131 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial 4722 reviewed
O75628 BXGT005140 GTP-binding protein REM 1 28954 reviewed
O94788 BXGT005333 Retinal dehydrogenase 2 8854 reviewed Enzyme
O95263 BXGT005366 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B 8622 reviewed
P00156 BXGT005469 Cytochrome b 4519 reviewed
P00326 BXGT005499 Alcohol dehydrogenase 1C 126 reviewed Enzyme
P00352 BXGT005510 Retinal dehydrogenase 1 216 reviewed Enzyme
P00390 BXGT005526 Glutathione reductase, mitochondrial 2936 reviewed Enzyme
P00441 BXGT005540 Superoxide dismutase [Cu-Zn] 6647 reviewed Enzyme
P00450 BXGT005544 Ceruloplasmin 1356 reviewed Enzyme
P00519 BXGT005570 Tyrosine-protein kinase ABL1 25 reviewed Kinase
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P00749 BXGT005641 Urokinase-type plasminogen activator 5328 reviewed Enzyme
P00797 BXGT005658 Renin 5972 reviewed Enzyme
P01023 BXGT005718 Alpha-2-macroglobulin 2 reviewed Enzyme modulator
P01034 BXGT005721 Cystatin-C 1471 reviewed
P01138 BXGT005738 Beta-nerve growth factor 4803 reviewed Signaling
P01236 BXGT005744 Prolactin 5617 reviewed Signaling
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P01889 BXGT005809 HLA class I histocompatibility antigen, B-7 alpha chain 3106 reviewed
P02649 BXGT005909 Apolipoprotein E 348 reviewed
P02749 BXGT005941 Beta-2-glycoprotein 1 350 reviewed
P02792 BXGT005966 Ferritin light chain 2512 reviewed Storage
P03372 BXGT006059 Estrogen receptor 2099 reviewed Nuclear receptor
P03923 BXGT006115 NADH-ubiquinone oxidoreductase chain 6 4541 reviewed
P03950 BXGT006116 Angiogenin 283 reviewed
P04054 BXGT006136 Phospholipase A2 5319 reviewed Enzyme
P04062 BXGT006140 Lysosomal acid glucosylceramidase 2629 reviewed
P04156 BXGT006156 Major prion protein 5621 reviewed
P04179 BXGT006163 Superoxide dismutase [Mn], mitochondrial 6648 reviewed Enzyme
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P04818 BXGT006269 Thymidylate synthase 7298 reviewed Enzyme
P05067 BXGT006306 Amyloid-beta precursor protein 351 reviewed Enzyme modulator
P05129 BXGT006322 Protein kinase C gamma type 5582 reviewed Kinase
P05164 BXGT006333 Myeloperoxidase 4353 reviewed Enzyme
P05177 BXGT006336 Cytochrome P450 1A2 1544 reviewed Enzyme
P05231 BXGT006345 Interleukin-6 3569 reviewed
P05937 BXGT006396 Calbindin 793 reviewed Calcium-binding protein
P06241 BXGT006429 Tyrosine-protein kinase Fyn 2534 reviewed Kinase
P06276 BXGT006430 Cholinesterase 590 reviewed
P07101 BXGT006547 Tyrosine 3-monooxygenase 7054 reviewed
P07202 BXGT006565 Thyroid peroxidase 7173 reviewed Enzyme
P07948 BXGT006702 Tyrosine-protein kinase Lyn 4067 reviewed Kinase
P07949 BXGT006703 Proto-oncogene tyrosine-protein kinase receptor Ret 5979 reviewed Kinase
P08183 BXGT006741 ATP-dependent translocase ABCB1 5243 reviewed Transporter
P08254 BXGT006758 Stromelysin-1 4314 reviewed Enzyme
P09104 BXGT006856 Gamma-enolase 2026 reviewed Enzyme
P09172 BXGT006865 Dopamine beta-hydroxylase 1621 reviewed
P09382 BXGT006882 Galectin-1 3956 reviewed Signaling
P09466 BXGT006892 Glycodelin 5047 reviewed Enzyme
P09601 BXGT006909 Heme oxygenase 1 3162 reviewed
P09619 BXGT006911 Platelet-derived growth factor receptor beta 5159 reviewed Kinase
P09874 BXGT006934 Poly [ADP-ribose] polymerase 1 142 reviewed
P09936 BXGT006943 Ubiquitin carboxyl-terminal hydrolase isozyme L1 7345 reviewed Enzyme
P10635 BXGT007595 Cytochrome P450 2D6 1565 reviewed
P10636 BXGT007596 Microtubule-associated protein tau 4137 reviewed
P11166 BXGT007661 Solute carrier family 2, facilitated glucose transporter member 1 6513 reviewed Transporter
P11308 BXGT007684 Transcriptional regulator ERG 2078 reviewed Transcription factor
P11511 BXGT007717 Aromatase 1588 reviewed Enzyme
P12235 BXGT007774 ADP/ATP translocase 1 291 reviewed Transporter
P12931 BXGT007859 Proto-oncogene tyrosine-protein kinase Src 6714 reviewed Kinase
P13500 BXGT007916 C-C motif chemokine 2 6347 reviewed Signaling
P13501 BXGT007917 C-C motif chemokine 5 6352 reviewed Signaling
P13637 BXGT007933 Sodium/potassium-transporting ATPase subunit alpha-3 478 reviewed Transporter
P14416 BXGT008011 D(2) dopamine receptor 1813 reviewed G-protein coupled receptor
P14625 BXGT008029 Endoplasmin 7184 reviewed Chaperone
P15104 BXGT008081 Glutamine synthetase 2752 reviewed Enzyme
P15144 BXGT008087 Aminopeptidase N 290 reviewed Enzyme
P15559 BXGT008139 NAD(P)H dehydrogenase [quinone] 1 1728 reviewed
P16278 BXGT008213 Beta-galactosidase 2720 reviewed Enzyme
P17516 BXGT008313 Aldo-keto reductase family 1 member C4 1109 reviewed Enzyme
P20711 BXGT008594 Aromatic-L-amino-acid decarboxylase 1644 reviewed
P21397 BXGT008644 Amine oxidase [flavin-containing] A 4128 reviewed
P21554 BXGT008662 Cannabinoid receptor 1 1268 reviewed G-protein coupled receptor
P21675 BXGT008678 Transcription initiation factor TFIID subunit 1 6872 reviewed Kinase
P21964 BXGT008714 Catechol O-methyltransferase 1312 reviewed Enzyme
P22303 BXGT008751 Acetylcholinesterase 43 reviewed Enzyme
P23381 BXGT008860 Tryptophan--tRNA ligase, cytoplasmic 7453 reviewed Enzyme
P23560 BXGT008883 Brain-derived neurotrophic factor 627 reviewed Signaling
P23975 BXGT008935 Sodium-dependent noradrenaline transporter 6530 reviewed Transporter
P27338 BXGT009172 Amine oxidase [flavin-containing] B 4129 reviewed
P28329 BXGT009251 Choline O-acetyltransferase 1103 reviewed Enzyme
P28331 BXGT009252 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial 4719 reviewed Enzyme
P28335 BXGT009255 5-hydroxytryptamine receptor 2C 3358 reviewed G-protein coupled receptor
P29274 BXGT009327 Adenosine receptor A2a 135 reviewed G-protein coupled receptor
P29474 BXGT009352 Nitric oxide synthase, endothelial 4846 reviewed
P29475 BXGT009353 Nitric oxide synthase, brain 4842 reviewed
P30536 BXGT009435 Translocator protein 706 reviewed
P30542 BXGT009436 Adenosine receptor A1 134 reviewed G-protein coupled receptor
P30556 BXGT009441 Type-1 angiotensin II receptor 185 reviewed G-protein coupled receptor
P30793 BXGT009466 GTP cyclohydrolase 1 2643 reviewed Enzyme
P31645 BXGT009558 Sodium-dependent serotonin transporter 6532 reviewed Transporter
P34932 BXGT009772 Heat shock 70 kDa protein 4 3308 reviewed
P35270 BXGT009807 Sepiapterin reductase 6697 reviewed
P35354 BXGT009816 Prostaglandin G/H synthase 2 5743 reviewed Enzyme
P35462 BXGT009835 D(3) dopamine receptor 1814 reviewed G-protein coupled receptor
P35858 BXGT009876 Insulin-like growth factor-binding protein complex acid labile subunit 3483 reviewed Receptor
P37840 BXGT010015 Alpha-synuclein 6622 reviewed Transporter
P40337 BXGT010174 von Hippel-Lindau disease tumor suppressor 7428 reviewed Enzyme
P42345 BXGT010304 Serine/threonine-protein kinase mTOR 2475 reviewed Kinase
P42574 BXGT010317 Caspase-3 836 reviewed Enzyme
P42858 BXGT010341 Huntingtin 3064 reviewed
P43220 BXGT010367 Glucagon-like peptide 1 receptor 2740 reviewed G-protein coupled receptor
P43354 BXGT010381 Nuclear receptor subfamily 4 group A member 2 4929 reviewed Nuclear receptor
P45983 BXGT010494 Mitogen-activated protein kinase 8 5599 reviewed Kinase
P49281 BXGT010689 Natural resistance-associated macrophage protein 2 4891 reviewed Transporter
P49448 BXGT010709 Glutamate dehydrogenase 2, mitochondrial 2747 reviewed Enzyme
P49768 BXGT010740 Presenilin-1 5663 reviewed Enzyme
P49810 BXGT010747 Presenilin-2 5664 reviewed Enzyme
P49840 BXGT010749 Glycogen synthase kinase-3 alpha 2931 reviewed Kinase
P49841 BXGT010750 Glycogen synthase kinase-3 beta 2932 reviewed Kinase
P50897 BXGT010823 Palmitoyl-protein thioesterase 1 5538 reviewed Enzyme
P53634 BXGT011007 Dipeptidyl peptidase 1 1075 reviewed Enzyme
P54098 BXGT011030 DNA polymerase subunit gamma-1 5428 reviewed Enzyme
P54762 BXGT011076 Ephrin type-B receptor 1 2047 reviewed Kinase
P55072 BXGT011103 Transitional endoplasmic reticulum ATPase 7415 reviewed
P55211 BXGT011111 Caspase-9 842 reviewed Enzyme
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P61086 BXGT011357 Ubiquitin-conjugating enzyme E2 K 3093 reviewed
P62258 BXGT011415 14-3-3 protein epsilon 7531 reviewed Chaperone
P62942 BXGT011474 Peptidyl-prolyl cis-trans isomerase FKBP1A 2280 reviewed Enzyme
P63104 BXGT011499 14-3-3 protein zeta/delta 7534 reviewed Chaperone
P78352 BXGT011836 Disks large homolog 4 1742 reviewed Receptor
P80404 BXGT011907 4-aminobutyrate aminotransferase, mitochondrial 18 reviewed Enzyme
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 4088 reviewed Transcription factor
P98164 BXGT012230 Low-density lipoprotein receptor-related protein 2 4036 reviewed
Q00059 BXGT012512 Transcription factor A, mitochondrial 7019 reviewed
Q00653 BXGT012541 Nuclear factor NF-kappa-B p100 subunit 4791 reviewed Transcription factor
Q01064 BXGT012564 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 5153 reviewed
Q01959 BXGT012624 Sodium-dependent dopamine transporter 6531 reviewed Transporter
Q03393 BXGT012711 6-pyruvoyl tetrahydrobiopterin synthase 5805 reviewed
Q04206 BXGT012754 Transcription factor p65 5970 reviewed Transcription factor
Q04637 BXGT012771 Eukaryotic translation initiation factor 4 gamma 1 1981 reviewed Nucleic acid binding
Q05329 BXGT012814 Glutamate decarboxylase 2 2572 reviewed Enzyme
Q05655 BXGT012832 Protein kinase C delta type 5580 reviewed Kinase
Q05940 BXGT012846 Synaptic vesicular amine transporter 6571 reviewed Transporter
Q06787 BXGT012890 Synaptic functional regulator FMR1 2332 reviewed Nucleic acid binding
Q09428 BXGT013036 ATP-binding cassette sub-family C member 8 6833 reviewed Transporter
Q12840 BXGT013269 Kinesin heavy chain isoform 5A 3798 reviewed Cellular structure
Q13148 BXGT013318 TAR DNA-binding protein 43 23435 reviewed
Q13224 BXGT013328 Glutamate receptor ionotropic, NMDA 2B 2904 reviewed Ion channel
Q13501 BXGT013365 Sequestosome-1 8878 reviewed
Q14203 BXGT013455 Dynactin subunit 1 1639 reviewed Chaperone
Q14457 BXGT013472 Beclin-1 8678 reviewed Enzyme modulator
Q14654 BXGT013495 ATP-sensitive inward rectifier potassium channel 11 3767 reviewed Ion channel
Q14833 BXGT013508 Metabotropic glutamate receptor 4 2914 reviewed G-protein coupled receptor
Q15109 BXGT013537 Advanced glycosylation end product-specific receptor 177 reviewed Receptor
Q15389 BXGT013564 Angiopoietin-1 284 reviewed Signaling
Q15465 BXGT013573 Sonic hedgehog protein 6469 reviewed
Q15842 BXGT013607 ATP-sensitive inward rectifier potassium channel 8 3764 reviewed Ion channel
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 4780 reviewed Enzyme
Q16637 BXGT013646 Survival motor neuron protein 6607 reviewed Epigenetic regulator
Q30201 BXGT014297 Hereditary hemochromatosis protein 3077 reviewed
Q5S007 BXGT015650 Leucine-rich repeat serine/threonine-protein kinase 2 120892 reviewed Kinase
Q5VZ30 BXGT015894 Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa) 2572 unreviewed
Q6N021 BXGT016378 Methylcytosine dioxygenase TET2 54790 reviewed
Q8IXJ6 BXGT018362 NAD-dependent protein deacetylase sirtuin-2 22933 reviewed Epigenetic regulator
Q8TDX5 BXGT018816 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase 130013 reviewed
Q8TE04 BXGT018818 Pantothenate kinase 1 53354 reviewed Kinase
Q92934 BXGT019396 Bcl2-associated agonist of cell death 572 reviewed
Q96QK1 BXGT019720 Vacuolar protein sorting-associated protein 35 55737 reviewed Transporter
Q99497 BXGT019926 Protein/nucleic acid deglycase DJ-1 11315 reviewed Enzyme
Q99700 BXGT019949 Ataxin-2 6311 reviewed Nucleic acid binding
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 10280 reviewed
Q9BXM7 BXGT020172 Serine/threonine-protein kinase PINK1, mitochondrial 65018 reviewed Kinase
Q9BZ23 BXGT020194 Pantothenate kinase 2, mitochondrial 80025 reviewed Kinase
Q9NTG7 BXGT021211 NAD-dependent protein deacetylase sirtuin-3, mitochondrial 23410 reviewed Epigenetic regulator
Q9UGM6 BXGT021687 Tryptophan--tRNA ligase, mitochondrial 10352 reviewed
Q9UHD2 BXGT021697 Serine/threonine-protein kinase TBK1 29110 reviewed Kinase
Q9UKU7 BXGT021749 Isobutyryl-CoA dehydrogenase, mitochondrial 27034 reviewed Enzyme
Q9UM47 BXGT021772 Neurogenic locus notch homolog protein 3 4854 reviewed
Q9Y233 BXGT022210 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 10846 reviewed
Q9Y2Q3 BXGT022242 Glutathione S-transferase kappa 1 373156 reviewed
Q9Y3I1 BXGT022260 F-box only protein 7 25793 reviewed
Q9Y5N1 BXGT022297 Histamine H3 receptor 11255 reviewed G-protein coupled receptor
P04439 BXGT022649 HLA class I histocompatibility antigen, A-3 alpha chain 3105 reviewed
P35240 BXGT022927 Merlin 4771 reviewed
O60502 BXGT023392 Protein O-GlcNAcase 10724 reviewed
P00395 BXGT023596 Cytochrome c oxidase subunit 1 4512 reviewed Enzyme
P35670 BXGT023695 Copper-transporting ATPase 2 540 reviewed Transporter
Q96M98 BXGT024941 Parkin coregulated gene protein 135138 reviewed
P38646 BXGT024954 Stress-70 protein, mitochondrial 3313 reviewed
Q9Y4W6 BXGT025025 AFG3-like protein 2 10939 reviewed Enzyme
P51608 BXGT025073 Methyl-CpG-binding protein 2 4204 reviewed Epigenetic regulator
Q96DA2 BXGT025522 Ras-related protein Rab-39B 116442 reviewed
Q86SQ9 BXGT025875 Dehydrodolichyl diphosphate synthase complex subunit DHDDS 79947 reviewed Enzyme
P09471 BXGT026153 Guanine nucleotide-binding protein G(o) subunit alpha 2775 reviewed Enzyme modulator
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease