Showing entry for Diacylglycerol kinase zeta


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013379
Protein NameDiacylglycerol kinase zeta
Uniport IdQ13574
GeneDGKZ
Gene Id8525
DomainC1_1; DAGK_acc; DAGK_cat
Pfam PF12796   PF00130   PF00609   PF00781  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00561 Glycerolipid metabolism
1. Metabolism 1.3 Lipid metabolism hsa00564 Glycerophospholipid metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
3. Environmental Information Processing 3.2 Signal transduction hsa04070 Phosphatidylinositol signaling system
3. Environmental Information Processing 3.2 Signal transduction hsa04072 Phospholipase D signaling pathway
6. Human Diseases 6.1 Cancers: Overview hsa05231 Choline metabolism in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0016477 cell migration
Biological Process GO:0046339 diacylglycerol metabolic process
Biological Process GO:0046486 glycerolipid metabolic process
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0046834 lipid phosphorylation
Biological Process GO:0031571 mitotic G1 DNA damage checkpoint
Biological Process GO:0045930 negative regulation of mitotic cell cycle
Biological Process GO:0050860 negative regulation of T cell receptor signaling pathway
Biological Process GO:0006654 phosphatidic acid biosynthetic process
Biological Process GO:0030168 platelet activation
Biological Process GO:0090216 positive regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity
Biological Process GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway
Biological Process GO:0051966 regulation of synaptic transmission, glutamatergic
molecular function GO:0005524 ATP binding
molecular function GO:0004143 diacylglycerol kinase activity
molecular function GO:0016301 kinase activity
molecular function GO:0001727 lipid kinase activity
molecular function GO:0046872 metal ion binding
molecular function GO:0003951 NAD+ kinase activity
molecular function GO:0008022 protein C-terminus binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0030027 lamellipodium
cellular component GO:0016607 nuclear speck
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-114508 Effects of PIP2 hydrolysis
R-HSA-162582 Signal Transduction
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-416476 G alpha (q) signalling events
R-HSA-76002 Platelet activation, signaling and aggregation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002874 BXGD000134 Aplastic Anemia Hemic and Lymphatic Diseases
C0005938 BXGD000351 Bone Density
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0023418 BXGD001642 leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030312 BXGD002207 Pancytopenia Hemic and Lymphatic Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0175754 BXGD004015 Agenesis of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0238790 BXGD004956 bone destruction
C0242184 BXGD005140 Hypoxia Pathological Conditions, Signs and Symptoms
C0271907 BXGD006279 Acquired aplastic anemia Hemic and Lymphatic Diseases
C0278484 BXGD006511 Malignant neoplasm of colon stage IV Digestive System Diseases; Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0282160 BXGD006797 Aplasia Cutis Congenita Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0919747 BXGD011439 Cytokine storm
C0940937 BXGD011490 precancerous lesions
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1861452 BXGD016048 Storm Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases; Cardiovascular Diseases
C3495559 BXGD018994 Juvenile arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3714757 BXGD019430 Juvenile rheumatoid arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0030612 tetraethylene glycol 194.12
BXGC0037274 (+)-Alpha-Tocopheryl Succinate 530.4
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein