adisease

Showing entry for bone destruction

General Disease Information
BXGD Id	BXGD004956
Disease Name	bone destruction
Disease CUI Id	C0238790
MeSH Codes
Disease Class Name
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id
Disease Ontology Class Name
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O00429	BXGT003919	Dynamin-1-like protein	10059	reviewed	Enzyme modulator
O14786	BXGT004099	Neuropilin-1	8829	reviewed
O14788	BXGT004100	Tumor necrosis factor ligand superfamily member 11	8600	reviewed	Signaling
O14920	BXGT004110	Inhibitor of nuclear factor kappa-B kinase subunit beta	3551	reviewed	Kinase
O15440	BXGT004170	Multidrug resistance-associated protein 5	10057	reviewed	Transporter
O15455	BXGT004171	Toll-like receptor 3	7098	reviewed	Receptor
O43318	BXGT004586	Mitogen-activated protein kinase kinase kinase 7	6885	reviewed	Kinase
O43557	BXGT004600	Tumor necrosis factor ligand superfamily member 14	8740	reviewed	Signaling
O60603	BXGT004887	Toll-like receptor 2	7097	reviewed
O75581	BXGT005136	Low-density lipoprotein receptor-related protein 6	4040	reviewed
O94811	BXGT005336	Tubulin polymerization-promoting protein	11076	reviewed	Cellular structure
O94907	BXGT005340	Dickkopf-related protein 1	22943	reviewed
O95631	BXGT005387	Netrin-1	9423	reviewed	Enzyme modulator
O95644	BXGT005389	Nuclear factor of activated T-cells, cytoplasmic 1	4772	reviewed	Transcription factor
P00740	BXGT005634	Coagulation factor IX	2158	reviewed	Enzyme
P00747	BXGT005639	Plasminogen	5340	reviewed	Enzyme
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01236	BXGT005744	Prolactin	5617	reviewed	Signaling
P01270	BXGT005746	Parathyroid hormone	5741	reviewed
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01911	BXGT005816	HLA class II histocompatibility antigen, DRB1-15 beta chain	3123	reviewed	Immune response
P02008	BXGT005832	Hemoglobin subunit zeta	3050	reviewed
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02751	BXGT005943	Fibronectin	2335	reviewed	Signaling
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P04049	BXGT006133	RAF proto-oncogene serine/threonine-protein kinase	5894	reviewed	Kinase
P04629	BXGT006239	High affinity nerve growth factor receptor	4914	reviewed	Kinase
P05106	BXGT006315	Integrin beta-3	3690	reviewed	Receptor
P05231	BXGT006345	Interleukin-6	3569	reviewed
P06744	BXGT006494	Glucose-6-phosphate isomerase	2821	reviewed	Enzyme
P07333	BXGT006602	Macrophage colony-stimulating factor 1 receptor	1436	reviewed	Kinase
P07949	BXGT006703	Proto-oncogene tyrosine-protein kinase receptor Ret	5979	reviewed	Kinase
P08254	BXGT006758	Stromelysin-1	4314	reviewed	Enzyme
P08581	BXGT006794	Hepatocyte growth factor receptor	4233	reviewed	Kinase
P08631	BXGT006801	Tyrosine-protein kinase HCK	3055	reviewed	Kinase
P08637	BXGT006802	Low affinity immunoglobulin gamma Fc region receptor III-A	2214	reviewed	Cell adhesion
P08700	BXGT006816	Interleukin-3	3562	reviewed
P09237	BXGT006874	Matrilysin	4316	reviewed	Enzyme
P09429	BXGT006889	High mobility group protein B1	3146	reviewed	Nucleic acid binding
P09601	BXGT006909	Heme oxygenase 1	3162	reviewed
P10070	BXGT007534	Zinc finger protein GLI2	2736	reviewed
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10147	BXGT007543	C-C motif chemokine 3	6348	reviewed	Signaling
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P14210	BXGT007994	Hepatocyte growth factor	3082	reviewed	Enzyme
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P15529	BXGT008134	Membrane cofactor protein	4179	reviewed
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P16410	BXGT008224	Cytotoxic T-lymphocyte protein 4	1493	reviewed
P18827	BXGT008427	Syndecan-1	6382	reviewed	Extracellular structure
P19971	BXGT008537	Thymidine phosphorylase	1890	reviewed	Enzyme
P22004	BXGT008718	Bone morphogenetic protein 6	654	reviewed	Signaling
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P25024	BXGT009005	C-X-C chemokine receptor type 1	3577	reviewed	G-protein coupled receptor
P26447	BXGT009114	Protein S100-A4	6275	reviewed	Calcium-binding protein
P27361	BXGT009176	Mitogen-activated protein kinase 3	5595	reviewed	Kinase
P28300	BXGT009243	Protein-lysine 6-oxidase	4015	reviewed
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P29323	BXGT009334	Ephrin type-B receptor 2	2048	reviewed	Kinase
P32119	BXGT009600	Peroxiredoxin-2	7001	reviewed	Enzyme
P33681	BXGT009739	T-lymphocyte activation antigen CD80	941	reviewed
P34972	BXGT009779	Cannabinoid receptor 2	1269	reviewed	G-protein coupled receptor
P35398	BXGT009825	Nuclear receptor ROR-alpha	6095	reviewed	Nuclear receptor
P35613	BXGT009856	Basigin	682	reviewed
P35869	BXGT009877	Aryl hydrocarbon receptor	196	reviewed	Transcription factor
P36222	BXGT009914	Chitinase-3-like protein 1	1116	reviewed
P36894	BXGT009939	Bone morphogenetic protein receptor type-1A	657	reviewed	Kinase
P36897	BXGT009941	TGF-beta receptor type-1	7046	reviewed	Kinase
P39019	BXGT010082	40S ribosomal protein S19	6223	reviewed	Nucleic acid binding
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P40967	BXGT010212	Melanocyte protein PMEL	6490	reviewed	Signaling
P41240	BXGT010242	Tyrosine-protein kinase CSK	1445	reviewed	Kinase
P43235	BXGT010368	Cathepsin K	1513	reviewed	Enzyme
P43405	BXGT010386	Tyrosine-protein kinase SYK	6850	reviewed	Kinase
P43490	BXGT010395	Nicotinamide phosphoribosyltransferase	10135	reviewed	Signaling
P45452	BXGT010462	Collagenase 3	4322	reviewed	Enzyme
P45983	BXGT010494	Mitogen-activated protein kinase 8	5599	reviewed	Kinase
P46108	BXGT010509	Adapter molecule crk	1398	reviewed
P46939	BXGT010555	Utrophin	7402	reviewed
P48061	BXGT010616	Stromal cell-derived factor 1	6387	reviewed
P49116	BXGT010678	Nuclear receptor subfamily 2 group C member 2	7182	reviewed	Nuclear receptor
P49841	BXGT010750	Glycogen synthase kinase-3 beta	2932	reviewed	Kinase
P50281	BXGT010788	Matrix metalloproteinase-14	4323	reviewed	Enzyme
P53350	BXGT010984	Serine/threonine-protein kinase PLK1	5347	reviewed	Kinase
P55263	BXGT011115	Adenosine kinase	132	reviewed	Kinase
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P61073	BXGT011352	C-X-C chemokine receptor type 4	7852	reviewed	G-protein coupled receptor
P61769	BXGT011383	Beta-2-microglobulin	567	reviewed	Immune response
P62937	BXGT011471	Peptidyl-prolyl cis-trans isomerase A	5478	reviewed
P78325	BXGT011832	Disintegrin and metalloproteinase domain-containing protein 8	101	reviewed	Enzyme
P78536	BXGT011847	Disintegrin and metalloproteinase domain-containing protein 17	6868	reviewed
Q00653	BXGT012541	Nuclear factor NF-kappa-B p100 subunit	4791	reviewed	Transcription factor
Q04912	BXGT012790	Macrophage-stimulating protein receptor	4486	reviewed	Kinase
Q06187	BXGT012860	Tyrosine-protein kinase BTK	695	reviewed	Kinase
Q13155	BXGT013320	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	7965	reviewed
Q13283	BXGT013334	Ras GTPase-activating protein-binding protein 1	10146	reviewed	Nucleic acid binding
Q13393	BXGT013346	Phospholipase D1	5337	reviewed
Q13547	BXGT013373	Histone deacetylase 1	3065	reviewed	Epigenetic regulator
Q13574	BXGT013379	Diacylglycerol kinase zeta	8525	reviewed	Enzyme
Q15020	BXGT013522	Squamous cell carcinoma antigen recognized by T-cells 3	9733	reviewed	Nucleic acid binding
Q15257	BXGT013554	Serine/threonine-protein phosphatase 2A activator	5524	reviewed	Enzyme modulator
Q15759	BXGT013595	Mitogen-activated protein kinase 11	5600	reviewed	Kinase
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q16539	BXGT013634	Mitogen-activated protein kinase 14	1432	reviewed	Kinase
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q16698	BXGT013659	2,4-dienoyl-CoA reductase, mitochondrial	1666	reviewed	Enzyme
Q7KZF4	BXGT016989	Staphylococcal nuclease domain-containing protein 1	27044	reviewed	Transcription factor
Q7Z4W1	BXGT017257	L-xylulose reductase	51181	reviewed
Q8N6T7	BXGT018525	NAD-dependent protein deacetylase sirtuin-6	51548	reviewed	Epigenetic regulator
Q92854	BXGT019385	Semaphorin-4D	10507	reviewed	Signaling
Q99538	BXGT019931	Legumain	5641	reviewed	Enzyme
Q99572	BXGT019935	P2X purinoceptor 7	5027	reviewed	Ion channel
Q99653	BXGT019945	Calcineurin B homologous protein 1	11261	reviewed
Q9BZS1	BXGT020203	Forkhead box protein P3	50943	reviewed
Q9GZX6	BXGT020428	Interleukin-22	50616	reviewed
Q9NYK1	BXGT021258	Toll-like receptor 7	51284	reviewed
Q9UIK4	BXGT021720	Death-associated protein kinase 2	23604	reviewed	Kinase
Q9UKV0	BXGT021750	Histone deacetylase 9	9734	reviewed	Epigenetic regulator
Q9ULW0	BXGT021766	Targeting protein for Xklp2	22974	reviewed	Cellular structure
Q9UN36	BXGT021780	Protein NDRG2	57447	reviewed	Enzyme
Q9Y239	BXGT022213	Nucleotide-binding oligomerization domain-containing protein 1	10392	reviewed	Enzyme
Q9Y251	BXGT022215	Heparanase	10855	reviewed	Enzyme
Q9Y5W5	BXGT022303	Wnt inhibitory factor 1	11197	reviewed	Calcium-binding protein
Q9Y6K9	BXGT022333	NF-kappa-B essential modulator	8517	reviewed	Kinase
P16284	BXGT022972	Platelet endothelial cell adhesion molecule	5175	reviewed	Cell adhesion
Q16552	BXGT023419	Interleukin-17A	3605	reviewed
Q9Y294	BXGT023981	Histone chaperone ASF1A	25842	reviewed	Nucleic acid binding
P21926	BXGT024578	CD9 antigen	928	reviewed
O43583	BXGT024866	Density-regulated protein	8562	reviewed	Enzyme
Q14807	BXGT024966	Kinesin-like protein KIF22	3835	reviewed	Cellular structure
P20809	BXGT025043	Interleukin-11	3589	reviewed
Q969H8	BXGT025606	Myeloid-derived growth factor	56005	reviewed
Q9BY76	BXGT025687	Angiopoietin-related protein 4	51129	reviewed	Signaling
P00403	BXGT026137	Cytochrome c oxidase subunit 2	4513	reviewed	Enzyme

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}