Showing entry for Endoplasmic reticulum membrane sensor NFE2L1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013474
Protein NameEndoplasmic reticulum membrane sensor NFE2L1
Uniport IdQ14494
GeneNFE2L1
Gene Id4779
DomainbZIP_Maf
Pfam PF03131  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0009653 anatomical structure morphogenesis
Biological Process GO:0045454 cell redox homeostasis
Biological Process GO:0019725 cellular homeostasis
Biological Process GO:0071397 cellular response to cholesterol
Biological Process GO:0070417 cellular response to cold
Biological Process GO:0071280 cellular response to copper ion
Biological Process GO:0034599 cellular response to oxidative stress
Biological Process GO:0042632 cholesterol homeostasis
Biological Process GO:0008203 cholesterol metabolic process
Biological Process GO:0042883 cysteine transport
Biological Process GO:0030218 erythrocyte differentiation
Biological Process GO:0006002 fructose 6-phosphate metabolic process
Biological Process GO:0021781 glial cell fate commitment
Biological Process GO:0051156 glucose 6-phosphate metabolic process
Biological Process GO:0006749 glutathione metabolic process
Biological Process GO:0006783 heme biosynthetic process
Biological Process GO:0055088 lipid homeostasis
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress
Biological Process GO:0000209 protein polyubiquitination
Biological Process GO:0019217 regulation of fatty acid metabolic process
Biological Process GO:0010906 regulation of glucose metabolic process
Biological Process GO:0050727 regulation of inflammatory response
Biological Process GO:0007088 regulation of mitotic nuclear division
Biological Process GO:1903353 regulation of nucleus organization
Biological Process GO:1901329 regulation of odontoblast differentiation
Biological Process GO:0061136 regulation of proteasomal protein catabolic process
Biological Process GO:1905897 regulation of response to endoplasmic reticulum stress
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0034976 response to endoplasmic reticulum stress
Biological Process GO:0021522 spinal cord motor neuron differentiation
molecular function GO:0015485 cholesterol binding
molecular function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
molecular function GO:0003700 DNA-binding transcription factor activity
molecular function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
molecular function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
molecular function GO:1990841 promoter-specific chromatin binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0019904 protein domain specific binding
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
molecular function GO:0000976 transcription regulatory region sequence-specific DNA binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0042025 host cell nucleus
cellular component GO:0030176 integral component of endoplasmic reticulum membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0000790 nuclear chromatin
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0032991 protein-containing complex
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0010823 BXGD000690 Cytomegalovirus Infections Infections
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0014772 BXGD000948 Red Blood Cell Count measurement
C0016667 BXGD001072 Fragile X Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0021670 BXGD001509 insulinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0023492 BXGD001671 Leukemia, T-Cell Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023493 BXGD001672 Adult T-Cell Lymphoma/Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0026010 BXGD001886 Microphthalmos Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0035335 BXGD002540 Retinoblastoma Neoplasms; Eye Diseases
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0206624 BXGD004190 Hepatoblastoma Neoplasms
C0338508 BXGD007196 Optic Atrophy 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Nervous System Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0877015 BXGD011327 Pelvic Organ Prolapse Pathological Conditions, Signs and Symptoms
C1269955 BXGD012005 Tumor Cell Invasion
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2676033 BXGD017322 Hepatoblastoma Caused By Somatic Mutation Digestive System Diseases; Neoplasms
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0042373 N,N-Dimethyldodecan-1-Amine Oxide 229.24
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein