adisease

Showing entry for insulinoma

General Disease Information
BXGD Id	BXGD001509
Disease Name	insulinoma
Disease CUI Id	C0021670
MeSH Codes	C06 C04 C19
Disease Class Name	Digestive System Diseases; Neoplasms; Endocrine System Diseases
Semantic Type	Neoplastic Process
Human Phenotype Ontology Id	HP:0025031 HP:0000818 HP:0000707 HP:0002664
Human Phenotype Ontology Term	Abnormality of the digestive system; Abnormality of the endocrine system; Abnormality of the nervous system; Neoplasm
Disease Ontology Id	DOID:7 DOID:14566
Disease Ontology Class Name	disease of anatomical entity; disease of cellular proliferation
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00255	BXGT003903	Menin	4221	reviewed
O00330	BXGT003910	Pyruvate dehydrogenase protein X component, mitochondrial	8050	reviewed	Enzyme
O14842	BXGT004106	Free fatty acid receptor 1	2864	reviewed	G-protein coupled receptor
O15123	BXGT004130	Angiopoietin-2	285	reviewed	Signaling
O15357	BXGT004156	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	3636	reviewed
O60313	BXGT004871	Dynamin-like 120 kDa protein, mitochondrial	4976	reviewed	Enzyme modulator
O60341	BXGT004873	Lysine-specific histone demethylase 1A	23028	reviewed	Epigenetic regulator
O95271	BXGT005369	Poly [ADP-ribose] polymerase tankyrase-1	8658	reviewed
P00390	BXGT005526	Glutathione reductase, mitochondrial	2936	reviewed	Enzyme
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P01009	BXGT005714	Alpha-1-antitrypsin	5265	reviewed	Enzyme modulator
P01133	BXGT005736	Pro-epidermal growth factor	1950	reviewed
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01236	BXGT005744	Prolactin	5617	reviewed	Signaling
P01275	BXGT005747	Glucagon	2641	reviewed
P01308	BXGT005749	Insulin	3630	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01920	BXGT005817	HLA class II histocompatibility antigen, DQ beta 1 chain	3119	reviewed	Immune response
P02655	BXGT005912	Apolipoprotein C-II	344	reviewed
P04040	BXGT006132	Catalase	847	reviewed	Enzyme
P04626	BXGT006238	Receptor tyrosine-protein kinase erbB-2	2064	reviewed	Kinase
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P05109	BXGT006318	Protein S100-A8	6279	reviewed	Calcium-binding protein
P05787	BXGT006385	Keratin, type II cytoskeletal 8	3856	reviewed
P06213	BXGT006425	Insulin receptor	3643	reviewed	Kinase
P06493	BXGT006445	Cyclin-dependent kinase 1	983	reviewed	Kinase
P07204	BXGT006567	Thrombomodulin	7056	reviewed
P07477	BXGT006629	Trypsin-1	5644	reviewed	Enzyme
P07858	BXGT006689	Cathepsin B	1508	reviewed	Enzyme
P08581	BXGT006794	Hepatocyte growth factor receptor	4233	reviewed	Kinase
P08779	BXGT006824	Keratin, type I cytoskeletal 16	3868	reviewed
P08833	BXGT006827	Insulin-like growth factor-binding protein 1	3484	reviewed	Enzyme modulator
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10599	BXGT007583	Thioredoxin	7295	reviewed
P10636	BXGT007596	Microtubule-associated protein tau	4137	reviewed
P10809	BXGT007617	60 kDa heat shock protein, mitochondrial	3329	reviewed
P10997	BXGT007643	Islet amyloid polypeptide	3375	reviewed	Signaling
P11166	BXGT007661	Solute carrier family 2, facilitated glucose transporter member 1	6513	reviewed	Transporter
P11168	BXGT007663	Solute carrier family 2, facilitated glucose transporter member 2	6514	reviewed	Transporter
P11473	BXGT007709	Vitamin D3 receptor	7421	reviewed	Nuclear receptor
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P15056	BXGT008075	Serine/threonine-protein kinase B-raf	673	reviewed	Kinase
P15531	BXGT008136	Nucleoside diphosphate kinase A	4830	reviewed	Kinase
P17643	BXGT008323	5,6-dihydroxyindole-2-carboxylic acid oxidase	7306	reviewed	Enzyme
P17931	BXGT008356	Galectin-3	3958	reviewed	Signaling
P18146	BXGT008384	Early growth response protein 1	1958	reviewed	Nucleic acid binding
P18850	BXGT008433	Cyclic AMP-dependent transcription factor ATF-6 alpha	22926	reviewed
P19367	BXGT008476	Hexokinase-1	3098	reviewed	Kinase
P21359	BXGT008640	Neurofibromin	4763	reviewed	Enzyme modulator
P21980	BXGT008715	Protein-glutamine gamma-glutamyltransferase 2	7052	reviewed	Enzyme
P22413	BXGT008764	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	5167	reviewed	Enzyme
P22897	BXGT008816	Macrophage mannose receptor 1	4360	reviewed
P23946	BXGT008932	Chymase	1215	reviewed	Enzyme
P23975	BXGT008935	Sodium-dependent noradrenaline transporter	6530	reviewed	Transporter
P24385	BXGT008965	G1/S-specific cyclin-D1	595	reviewed	Enzyme modulator
P24863	BXGT008999	Cyclin-C	892	reviewed	Enzyme modulator
P25791	BXGT009072	Rhombotin-2	4005	reviewed
P27361	BXGT009176	Mitogen-activated protein kinase 3	5595	reviewed	Kinase
P27487	BXGT009187	Dipeptidyl peptidase 4	1803	reviewed	Enzyme
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P29323	BXGT009334	Ephrin type-B receptor 2	2048	reviewed	Kinase
P29401	BXGT009344	Transketolase	7086	reviewed	Enzyme
P30281	BXGT009416	G1/S-specific cyclin-D3	896	reviewed	Enzyme modulator
P30520	BXGT009430	Adenylosuccinate synthetase isozyme 2	159	reviewed	Enzyme
P30874	BXGT009475	Somatostatin receptor type 2	6752	reviewed	G-protein coupled receptor
P31391	BXGT009535	Somatostatin receptor type 4	6754	reviewed	G-protein coupled receptor
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P32745	BXGT009663	Somatostatin receptor type 3	6753	reviewed	G-protein coupled receptor
P34998	BXGT009781	Corticotropin-releasing factor receptor 1	1394	reviewed
P35222	BXGT009799	Catenin beta-1	1499	reviewed
P35346	BXGT009813	Somatostatin receptor type 5	6755	reviewed	G-protein coupled receptor
P35555	BXGT009845	Fibrillin-1	2200	reviewed	Calcium-binding protein
P35557	BXGT009846	Glucokinase	2645	reviewed	Kinase
P38398	BXGT010037	Breast cancer type 1 susceptibility protein	672	reviewed	Enzyme
P38936	BXGT010074	Cyclin-dependent kinase inhibitor 1	1026	reviewed
P40692	BXGT010195	DNA mismatch repair protein Mlh1	4292	reviewed	Nucleic acid binding
P41180	BXGT010230	Extracellular calcium-sensing receptor	846	reviewed	G-protein coupled receptor
P41235	BXGT010241	Hepatocyte nuclear factor 4-alpha	3172	reviewed	Nuclear receptor
P42224	BXGT010286	Signal transducer and activator of transcription 1-alpha/beta	6772	reviewed	Nucleic acid binding
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P42574	BXGT010317	Caspase-3	836	reviewed	Enzyme
P43220	BXGT010367	Glucagon-like peptide 1 receptor	2740	reviewed	G-protein coupled receptor
P45983	BXGT010494	Mitogen-activated protein kinase 8	5599	reviewed	Kinase
P46527	BXGT010525	Cyclin-dependent kinase inhibitor 1B	1027	reviewed
P46934	BXGT010553	E3 ubiquitin-protein ligase NEDD4	4734	reviewed	Enzyme
P48048	BXGT010610	ATP-sensitive inward rectifier potassium channel 1	3758	reviewed	Ion channel
P48051	BXGT010611	G protein-activated inward rectifier potassium channel 2	3763	reviewed	Ion channel
P48061	BXGT010616	Stromal cell-derived factor 1	6387	reviewed
P48357	BXGT010627	Leptin receptor	3953	reviewed	Signaling
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P49792	BXGT010743	E3 SUMO-protein ligase RanBP2	5903	reviewed	Enzyme modulator
P49810	BXGT010747	Presenilin-2	5664	reviewed	Enzyme
P49841	BXGT010750	Glycogen synthase kinase-3 beta	2932	reviewed	Kinase
P51692	BXGT010885	Signal transducer and activator of transcription 5B	6777	reviewed	Nucleic acid binding
P53985	BXGT011022	Monocarboxylate transporter 1	6566	reviewed	Transporter
P54762	BXGT011076	Ephrin type-B receptor 1	2047	reviewed	Kinase
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P60953	BXGT011342	Cell division control protein 42 homolog	998	reviewed	Enzyme modulator
P61006	BXGT011345	Ras-related protein Rab-8A	4218	reviewed
P62834	BXGT011464	Ras-related protein Rap-1A	5906	reviewed	Enzyme modulator
P81172	BXGT011935	Hepcidin	57817	reviewed
P84022	BXGT012027	Mothers against decapentaplegic homolog 3	4088	reviewed	Transcription factor
Q01668	BXGT012605	Voltage-dependent L-type calcium channel subunit alpha-1D	776	reviewed	Ion channel
Q01718	BXGT012609	Adrenocorticotropic hormone receptor	4158	reviewed	G-protein coupled receptor
Q05329	BXGT012814	Glutamate decarboxylase 2	2572	reviewed	Enzyme
Q08050	BXGT012958	Forkhead box protein M1	2305	reviewed
Q09428	BXGT013036	ATP-binding cassette sub-family C member 8	6833	reviewed	Transporter
Q13485	BXGT013363	Mothers against decapentaplegic homolog 4	4089	reviewed	Transcription factor
Q13501	BXGT013365	Sequestosome-1	8878	reviewed
Q13546	BXGT013372	Receptor-interacting serine/threonine-protein kinase 1	8737	reviewed	Kinase
Q14397	BXGT013467	Glucokinase regulatory protein	2646	reviewed
Q14494	BXGT013474	Endoplasmic reticulum membrane sensor NFE2L1	4779	reviewed	Enzyme
Q14790	BXGT013505	Caspase-8	841	reviewed	Enzyme
Q15796	BXGT013599	Mothers against decapentaplegic homolog 2	4087	reviewed	Transcription factor
Q16698	BXGT013659	2,4-dienoyl-CoA reductase, mitochondrial	1666	reviewed	Enzyme
Q16849	BXGT013680	Receptor-type tyrosine-protein phosphatase-like N	5798	reviewed
Q5D1E8	BXGT015318	Endoribonuclease ZC3H12A	80149	reviewed	Nucleic acid binding
Q5VZ30	BXGT015894	Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa)	2572	unreviewed
Q5Y7D3	BXGT015912	HLA class II histocompatibility antigen DQ beta chain	3119	unreviewed
Q8IVA8	BXGT018342	Glutamate decarboxylase 1 (Brain, 67kDa)	2571	unreviewed
Q8IVS2	BXGT018349	Malonyl-CoA-acyl carrier protein transacylase, mitochondrial	27349	reviewed
Q8NBS9	BXGT018543	Thioredoxin domain-containing protein 5	81567	reviewed
Q8TDS4	BXGT018812	Hydroxycarboxylic acid receptor 2	338442	reviewed
Q92731	BXGT019366	Estrogen receptor beta	2100	reviewed	Nuclear receptor
Q92932	BXGT019395	Receptor-type tyrosine-protein phosphatase N2	5799	reviewed
Q96S37	BXGT019737	Solute carrier family 22 member 12	116085	reviewed	Transporter
Q99259	BXGT019915	Glutamate decarboxylase 1	2571	reviewed	Enzyme
Q99798	BXGT019962	Aconitate hydratase, mitochondrial	50	reviewed	Enzyme
Q9BQE4	BXGT020110	Selenoprotein S	55829	reviewed
Q9BS26	BXGT020120	Endoplasmic reticulum resident protein 44	23071	reviewed
Q9H9B1	BXGT020501	Histone-lysine N-methyltransferase EHMT1	79813	reviewed	Epigenetic regulator
Q9ULC4	BXGT021757	Malignant T-cell-amplified sequence 1	28985	reviewed	Receptor
O60232	BXGT024169	Protein ZNRD2	10534	reviewed
Q96A54	BXGT024681	Adiponectin receptor protein 1	51094	reviewed	Receptor

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}