Showing entry for Intersectin-1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013600
Protein NameIntersectin-1
Uniport IdQ15811
GeneITSN1
Gene Id6453
DomainC2; EF-hand_4; INTAP; PH_13; RhoGEF; SH3_1; SH3_9
Pfam PF00168   PF12763   PF16652   PF00621   PF00018   PF14604  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007420 brain development
Biological Process GO:0034613 cellular protein localization
Biological Process GO:0150007 clathrin-dependent synaptic vesicle endocytosis
Biological Process GO:0006897 endocytosis
Biological Process GO:0016197 endosomal transport
Biological Process GO:0048013 ephrin receptor signaling pathway
Biological Process GO:0006887 exocytosis
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0061024 membrane organization
Biological Process GO:0043524 negative regulation of neuron apoptotic process
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:2001288 positive regulation of caveolin-mediated endocytosis
Biological Process GO:0060999 positive regulation of dendritic spine development
Biological Process GO:0060124 positive regulation of growth hormone secretion
Biological Process GO:0051897 positive regulation of protein kinase B signaling
Biological Process GO:0015031 protein transport
Biological Process GO:1905274 regulation of modification of postsynaptic actin cytoskeleton
Biological Process GO:0051056 regulation of small GTPase mediated signal transduction
Biological Process GO:0007264 small GTPase mediated signal transduction
Biological Process GO:0016032 viral process
molecular function GO:0005509 calcium ion binding
molecular function GO:0005085 guanyl-nucleotide exchange factor activity
molecular function GO:0019209 kinase activator activity
molecular function GO:0060090 molecular adaptor activity
molecular function GO:0070064 proline-rich region binding
cellular component GO:0097440 apical dendrite
cellular component GO:0044305 calyx of Held
cellular component GO:0005905 clathrin-coated pit
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0043197 dendritic spine
cellular component GO:0030139 endocytic vesicle
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0030027 lamellipodium
cellular component GO:0043025 neuronal cell body
cellular component GO:0005635 nuclear envelope
cellular component GO:0005886 plasma membrane
cellular component GO:0098833 presynaptic endocytic zone
cellular component GO:0055037 recycling endosome
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-1266738 Developmental Biology
R-HSA-162582 Signal Transduction
R-HSA-193648 NRAGE signals death through JNK
R-HSA-193704 p75 NTR receptor-mediated signalling
R-HSA-194315 Signaling by Rho GTPases
R-HSA-194840 Rho GTPase cycle
R-HSA-199991 Membrane Trafficking
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE
R-HSA-2682334 EPH-Ephrin signaling
R-HSA-2682334 EPH-Ephrin signaling
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-3928662 EPHB-mediated forward signaling
R-HSA-3928662 EPHB-mediated forward signaling
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-422475 Axon guidance
R-HSA-422475 Axon guidance
R-HSA-5653656 Vesicle-mediated transport
R-HSA-73887 Death Receptor Signalling
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-9675108 Nervous system development
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0014772 BXGD000948 Red Blood Cell Count measurement
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0024115 BXGD001732 Lung diseases Respiratory Tract Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0036857 BXGD002638 Severe intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0039585 BXGD002821 Androgen-Insensitivity Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0266464 BXGD005676 Polymicrogyria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0302142 BXGD006831 Deformity Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0344482 BXGD007678 Hypoplasia of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0427460 BXGD008616 Red cell distribution width determination
C0429028 BXGD008646 QT interval feature (observable entity)
C0524587 BXGD009232 Mean Corpuscular Volume (result)
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0748168 BXGD010192 Pulmonary Pathology
C0795875 BXGD010756 Chromosome 21 monosomy Pathological Conditions, Signs and Symptoms
C0852949 BXGD010957 Arteriopathic disease Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0871470 BXGD011316 Systolic Pressure
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1261502 BXGD011856 Finding of Mean Corpuscular Hemoglobin
C1269955 BXGD012005 Tumor Cell Invasion
C1304746 BXGD012343 RDW - Red blood cell distribution width result
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2973725 BXGD018205 Pulmonary arterial hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4521042 BXGD023055 Complete Trisomy 21 Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0003705 Chloride 35.45
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein