Showing entry for DNA damage-binding protein 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013633
Protein NameDNA damage-binding protein 1
Uniport IdQ16531
GeneDDB1
Gene Id1642
DomainCPSF_A; MMS1_N
Pfam PF03178  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.4 Replication and repair hsa03420 Nucleotide excision repair
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa04120 Ubiquitin mediated proteolysis
6. Human Diseases 6.9 Infectious diseases: Viral hsa05161 Hepatitis B
6. Human Diseases 6.9 Infectious diseases: Viral hsa05170 Human immunodeficiency virus 1 infection
6. Human Diseases 6.1 Cancers: Overview hsa05203 Viral carcinogenesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006974 cellular response to DNA damage stimulus
Biological Process GO:0042769 DNA damage response, detection of DNA damage
Biological Process GO:0006281 DNA repair
Biological Process GO:0070911 global genome nucleotide-excision repair
Biological Process GO:0035518 histone H2A monoubiquitination
Biological Process GO:0051702 interaction with symbiont
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0006289 nucleotide-excision repair
Biological Process GO:0000715 nucleotide-excision repair, DNA damage recognition
Biological Process GO:0000717 nucleotide-excision repair, DNA duplex unwinding
Biological Process GO:0033683 nucleotide-excision repair, DNA incision
Biological Process GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion
Biological Process GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion
Biological Process GO:0006294 nucleotide-excision repair, preincision complex assembly
Biological Process GO:0006293 nucleotide-excision repair, preincision complex stabilization
Biological Process GO:0046726 positive regulation by virus of viral protein levels in host cell
Biological Process GO:0045722 positive regulation of gluconeogenesis
Biological Process GO:0045732 positive regulation of protein catabolic process
Biological Process GO:0045070 positive regulation of viral genome replication
Biological Process GO:1902188 positive regulation of viral release from host cell
Biological Process GO:0043687 post-translational protein modification
Biological Process GO:0010498 proteasomal protein catabolic process
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:0042752 regulation of circadian rhythm
Biological Process GO:1901990 regulation of mitotic cell cycle phase transition
Biological Process GO:0048511 rhythmic process
Biological Process GO:0006283 transcription-coupled nucleotide-excision repair
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process
Biological Process GO:0070914 UV-damage excision repair
Biological Process GO:0016032 viral process
Biological Process GO:0016055 Wnt signaling pathway
molecular function GO:0097602 cullin family protein binding
molecular function GO:0003684 damaged DNA binding
molecular function GO:0003677 DNA binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0030674 protein-macromolecule adaptor activity
molecular function GO:0071987 WD40-repeat domain binding
cellular component GO:0031464 Cul4A-RING E3 ubiquitin ligase complex
cellular component GO:0031465 Cul4B-RING E3 ubiquitin ligase complex
cellular component GO:0080008 Cul4-RING E3 ubiquitin ligase complex
cellular component GO:0031461 cullin-RING ubiquitin ligase complex
cellular component GO:0005737 cytoplasm
cellular component GO:0070062 extracellular exosome
cellular component GO:0005615 extracellular space
cellular component GO:0000784 nuclear chromosome, telomeric region
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0032991 protein-containing complex
Reactome
Pathway Id Pathway Name
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex
R-HSA-392499 Metabolism of proteins
R-HSA-5696394 DNA Damage Recognition in GG-NER
R-HSA-5696395 Formation of Incision Complex in GG-NER
R-HSA-5696398 Nucleotide Excision Repair
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER)
R-HSA-5696400 Dual Incision in GG-NER
R-HSA-597592 Post-translational protein modification
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
R-HSA-6782135 Dual incision in TC-NER
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-73893 DNA Damage Bypass
R-HSA-73894 DNA Repair
R-HSA-8951664 Neddylation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019193 BXGD001299 Hepatitis, Toxic Digestive System Diseases; Chemically-Induced Disorders
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
C0043346 BXGD003043 Xeroderma Pigmentosum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0235874 BXGD004781 Disease Exacerbation Pathological Conditions, Signs and Symptoms
C0339510 BXGD007257 Vitelliform Macular Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0860207 BXGD011220 Drug-Induced Liver Disease Digestive System Diseases; Chemically-Induced Disorders
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1262760 BXGD011886 Hepatitis, Drug-Induced Digestive System Diseases; Chemically-Induced Disorders
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1708349 BXGD013597 Hereditary Diffuse Gastric Cancer Digestive System Diseases; Neoplasms
C1848411 BXGD014923 XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP E Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3658290 BXGD019256 Drug-Induced Acute Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4277682 BXGD022376 Chemical and Drug Induced Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C4279912 BXGD022378 Chemically-Induced Liver Toxicity Digestive System Diseases; Chemically-Induced Disorders
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0004266 2-Propanol 60.1
BXGC0030612 tetraethylene glycol 194.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein