adisease

Showing entry for Hepatitis, Toxic

General Disease Information
BXGD Id	BXGD001299
Disease Name	Hepatitis, Toxic
Disease CUI Id	C0019193
MeSH Codes	C06 C25
Disease Class Name	Digestive System Diseases; Chemically-Induced Disorders
Semantic Type	Injury or Poisoning
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id
Disease Ontology Class Name
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00204	BXGT003893	Sulfotransferase family cytosolic 2B member 1	6820	reviewed
O00401	BXGT003915	Neural Wiskott-Aldrich syndrome protein	8976	reviewed	Cellular structure
O00482	BXGT003929	Nuclear receptor subfamily 5 group A member 2	2494	reviewed	Nuclear receptor
O15217	BXGT004137	Glutathione S-transferase A4	2941	reviewed
O15254	BXGT004143	Peroxisomal acyl-coenzyme A oxidase 3	8310	reviewed	Enzyme
O43707	BXGT004616	Alpha-actinin-4	81	reviewed
O60427	BXGT004875	Acyl-CoA (8-3)-desaturase	3992	reviewed
O60656	BXGT004889	UDP-glucuronosyltransferase 1-9	54600	reviewed
O60885	BXGT004906	Bromodomain-containing protein 4	23476	reviewed	Epigenetic regulator
O75460	BXGT005127	Serine/threonine-protein kinase/endoribonuclease IRE1	2081	reviewed	Kinase
O75469	BXGT005128	Nuclear receptor subfamily 1 group I member 2	8856	reviewed	Nuclear receptor
O75489	BXGT005131	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	4722	reviewed
O76094	BXGT005177	Signal recognition particle subunit SRP72	6731	reviewed
O95237	BXGT005361	Lecithin retinol acyltransferase	9227	reviewed
O95831	BXGT005399	Apoptosis-inducing factor 1, mitochondrial	9131	reviewed	Enzyme
O95861	BXGT005402	3'(2'),5'-bisphosphate nucleotidase 1	10380	reviewed	Enzyme
O95864	BXGT005403	Acyl-CoA 6-desaturase	9415	reviewed
P00374	BXGT005520	Dihydrofolate reductase	1719	reviewed	Enzyme
P00390	BXGT005526	Glutathione reductase, mitochondrial	2936	reviewed	Enzyme
P00439	BXGT005539	Phenylalanine-4-hydroxylase	5053	reviewed
P00441	BXGT005540	Superoxide dismutase [Cu-Zn]	6647	reviewed	Enzyme
P00450	BXGT005544	Ceruloplasmin	1356	reviewed	Enzyme
P00491	BXGT005555	Purine nucleoside phosphorylase	4860	reviewed	Enzyme
P00492	BXGT005556	Hypoxanthine-guanine phosphoribosyltransferase	3251	reviewed	Enzyme
P00747	BXGT005639	Plasminogen	5340	reviewed	Enzyme
P00750	BXGT005642	Tissue-type plasminogen activator	5327	reviewed	Enzyme
P00973	BXGT005711	2'-5'-oligoadenylate synthase 1	4938	reviewed	Enzyme
P01019	BXGT005717	Angiotensinogen	183	reviewed	Enzyme modulator
P01024	BXGT005719	Complement C3	718	reviewed	Enzyme modulator
P01042	BXGT005722	Kininogen-1	3827	reviewed	Enzyme modulator
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01889	BXGT005809	HLA class I histocompatibility antigen, B-7 alpha chain	3106	reviewed
P01911	BXGT005816	HLA class II histocompatibility antigen, DRB1-15 beta chain	3123	reviewed	Immune response
P01920	BXGT005817	HLA class II histocompatibility antigen, DQ beta 1 chain	3119	reviewed	Immune response
P02461	BXGT005880	Collagen alpha-1(III) chain	1281	reviewed
P02647	BXGT005908	Apolipoprotein A-I	335	reviewed
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P02671	BXGT005914	Fibrinogen alpha chain	2243	reviewed
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02749	BXGT005941	Beta-2-glycoprotein 1	350	reviewed
P02760	BXGT005948	Protein AMBP	259	reviewed
P02766	BXGT005953	Transthyretin	7276	reviewed	Transporter
P02768	BXGT005955	Serum albumin	213	reviewed	Transporter
P02774	BXGT005959	Vitamin D-binding protein	2638	reviewed	Transporter
P02787	BXGT005962	Serotransferrin	7018	reviewed	Enzyme
P02788	BXGT005963	Lactotransferrin	4057	reviewed	Enzyme
P02792	BXGT005966	Ferritin light chain	2512	reviewed	Storage
P04040	BXGT006132	Catalase	847	reviewed	Enzyme
P04179	BXGT006163	Superoxide dismutase [Mn], mitochondrial	6648	reviewed	Enzyme
P04275	BXGT006180	von Willebrand factor	7450	reviewed	Enzyme modulator
P05062	BXGT006305	Fructose-bisphosphate aldolase B	229	reviewed
P05089	BXGT006310	Arginase-1	383	reviewed	Enzyme
P05155	BXGT006328	Plasma protease C1 inhibitor	710	reviewed	Enzyme modulator
P05177	BXGT006336	Cytochrome P450 1A2	1544	reviewed	Enzyme
P05181	BXGT006337	Cytochrome P450 2E1	1571	reviewed
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05787	BXGT006385	Keratin, type II cytoskeletal 8	3856	reviewed
P06396	BXGT006435	Gelsolin	2934	reviewed	Cellular structure
P06733	BXGT006490	Alpha-enolase	2023	reviewed	Enzyme
P06737	BXGT006492	Glycogen phosphorylase, liver form	5836	reviewed	Enzyme
P07099	BXGT006546	Epoxide hydrolase 1	2052	reviewed
P07237	BXGT006576	Protein disulfide-isomerase	5034	reviewed
P07355	BXGT006609	Annexin A2	302	reviewed
P07451	BXGT006627	Carbonic anhydrase 3	761	reviewed
P08133	BXGT006727	Annexin A6	309	reviewed
P08183	BXGT006741	ATP-dependent translocase ABCB1	5243	reviewed	Transporter
P08185	BXGT006742	Corticosteroid-binding globulin	866	reviewed	Enzyme modulator
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P08603	BXGT006798	Complement factor H	3075	reviewed
P08670	BXGT006810	Vimentin	7431	reviewed
P08684	BXGT006812	Cytochrome P450 3A4	1576	reviewed	Enzyme
P09211	BXGT006869	Glutathione S-transferase P	2950	reviewed
P09429	BXGT006889	High mobility group protein B1	3146	reviewed	Nucleic acid binding
P09455	BXGT006890	Retinol-binding protein 1	5947	reviewed
P09488	BXGT006899	Glutathione S-transferase Mu 1	2944	reviewed
P09601	BXGT006909	Heme oxygenase 1	3162	reviewed
P10909	BXGT007630	Clusterin	1191	reviewed
P11021	BXGT007644	Endoplasmic reticulum chaperone BiP	3309	reviewed
P11498	BXGT007714	Pyruvate carboxylase, mitochondrial	5091	reviewed	Enzyme
P11509	BXGT007716	Cytochrome P450 2A6	1548	reviewed
P11712	BXGT007738	Cytochrome P450 2C9	1559	reviewed
P12277	BXGT007789	Creatine kinase B-type	1152	reviewed	Kinase
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P13726	BXGT007950	Tissue factor	2152	reviewed	Receptor
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P17174	BXGT008289	Aspartate aminotransferase, cytoplasmic	2805	reviewed
P17931	BXGT008356	Galectin-3	3958	reviewed	Signaling
P17948	BXGT008358	Vascular endothelial growth factor receptor 1	2321	reviewed	Kinase
P20309	BXGT008562	Muscarinic acetylcholine receptor M3	1131	reviewed	G-protein coupled receptor
P20813	BXGT008603	Cytochrome P450 2B6	1555	reviewed
P20936	BXGT008619	Ras GTPase-activating protein 1	5921	reviewed	Enzyme modulator
P21266	BXGT008632	Glutathione S-transferase Mu 3	2947	reviewed
P21583	BXGT008667	Kit ligand	4254	reviewed
P21695	BXGT008682	Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic	2819	reviewed	Enzyme
P24298	BXGT008960	Alanine aminotransferase 1	2875	reviewed	Enzyme
P24468	BXGT008969	COUP transcription factor 2	7026	reviewed	Nuclear receptor
P25021	BXGT009004	Histamine H2 receptor	3274	reviewed	G-protein coupled receptor
P27169	BXGT009161	Serum paraoxonase/arylesterase 1	5444	reviewed
P27540	BXGT009190	Aryl hydrocarbon receptor nuclear translocator	405	reviewed	Transcription factor
P28161	BXGT009234	Glutathione S-transferase Mu 2	2946	reviewed
P28838	BXGT009295	Cytosol aminopeptidase	51056	reviewed	Enzyme
P30043	BXGT009394	Flavin reductase (NADPH)	645	reviewed	Enzyme
P30084	BXGT009398	Enoyl-CoA hydratase, mitochondrial	1892	reviewed	Enzyme
P30305	BXGT009419	M-phase inducer phosphatase 2	994	reviewed	Enzyme
P30411	BXGT009424	B2 bradykinin receptor	624	reviewed	G-protein coupled receptor
P30711	BXGT009460	Glutathione S-transferase theta-1	2952	reviewed
P31327	BXGT009523	Carbamoyl-phosphate synthase [ammonia], mitochondrial	1373	reviewed	Enzyme
P31513	BXGT009546	Dimethylaniline monooxygenase [N-oxide-forming] 3	2328	reviewed	Enzyme
P32298	BXGT009617	G protein-coupled receptor kinase 4	2868	reviewed	Kinase
P32754	BXGT009664	4-hydroxyphenylpyruvate dioxygenase	3242	reviewed	Enzyme
P33121	BXGT009692	Long-chain-fatty-acid--CoA ligase 1	2180	reviewed	Enzyme
P33261	BXGT009707	Cytochrome P450 2C19	1557	reviewed
P33527	BXGT009728	Multidrug resistance-associated protein 1	4363	reviewed	Transporter
P35222	BXGT009799	Catenin beta-1	1499	reviewed
P35354	BXGT009816	Prostaglandin G/H synthase 2	5743	reviewed	Enzyme
P35869	BXGT009877	Aryl hydrocarbon receptor	196	reviewed	Transcription factor
P36871	BXGT009936	Phosphoglucomutase-1	5236	reviewed
P36897	BXGT009941	TGF-beta receptor type-1	7046	reviewed	Kinase
P37802	BXGT010013	Transgelin-2	8407	reviewed	Cellular structure
P40925	BXGT010206	Malate dehydrogenase, cytoplasmic	4190	reviewed	Enzyme
P41597	BXGT010268	C-C chemokine receptor type 2	729230	reviewed
P42898	BXGT010344	Methylenetetrahydrofolate reductase	4524	reviewed
P45974	BXGT010493	Ubiquitin carboxyl-terminal hydrolase 5	8078	reviewed	Enzyme
P46531	BXGT010526	Neurogenic locus notch homolog protein 1	4851	reviewed
P48506	BXGT010635	Glutamate--cysteine ligase catalytic subunit	2729	reviewed	Enzyme
P48507	BXGT010636	Glutamate--cysteine ligase regulatory subunit	2730	reviewed	Enzyme
P48643	BXGT010650	T-complex protein 1 subunit epsilon	22948	reviewed	Chaperone
P49327	BXGT010694	Fatty acid synthase	2194	reviewed	Enzyme
P49368	BXGT010701	T-complex protein 1 subunit gamma	7203	reviewed	Chaperone
P49585	BXGT010712	Choline-phosphate cytidylyltransferase A	5130	reviewed
P49888	BXGT010756	Estrogen sulfotransferase	6783	reviewed
P51617	BXGT010868	Interleukin-1 receptor-associated kinase 1	3654	reviewed	Kinase
P51687	BXGT010882	Sulfite oxidase, mitochondrial	6821	reviewed
P54098	BXGT011030	DNA polymerase subunit gamma-1	5428	reviewed	Enzyme
P58004	BXGT011222	Sestrin-2	83667	reviewed	Enzyme
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
P61158	BXGT011364	Actin-related protein 3	10096	reviewed	Cellular structure
P68371	BXGT011597	Tubulin beta-4B chain	10383	reviewed	Cellular structure
P69905	BXGT011649	Hemoglobin subunit alpha	3040	reviewed
P78325	BXGT011832	Disintegrin and metalloproteinase domain-containing protein 8	101	reviewed	Enzyme
P78417	BXGT011843	Glutathione S-transferase omega-1	9446	reviewed
P78527	BXGT011846	DNA-dependent protein kinase catalytic subunit	5591	reviewed	Kinase
P80188	BXGT011882	Neutrophil gelatinase-associated lipocalin	3934	reviewed	Enzyme
Q00266	BXGT012515	S-adenosylmethionine synthase isoform type-1	4143	reviewed	Enzyme
Q00796	BXGT012549	Sorbitol dehydrogenase	6652	reviewed	Enzyme
Q01094	BXGT012568	Transcription factor E2F1	1869	reviewed	Nucleic acid binding
Q02487	BXGT012656	Desmocollin-2	1824	reviewed	Cell adhesion
Q03013	BXGT012685	Glutathione S-transferase Mu 4	2948	reviewed
Q04912	BXGT012790	Macrophage-stimulating protein receptor	4486	reviewed	Kinase
Q05655	BXGT012832	Protein kinase C delta type	5580	reviewed	Kinase
Q07812	BXGT012940	Apoptosis regulator BAX	581	reviewed	Signaling
Q07869	BXGT012945	Peroxisome proliferator-activated receptor alpha	5465	reviewed	Nuclear receptor
Q13133	BXGT013315	Oxysterols receptor LXR-alpha	10062	reviewed	Nuclear receptor
Q14116	BXGT013442	Interleukin-18	3606	reviewed
Q14643	BXGT013493	Inositol 1,4,5-trisphosphate receptor type 1	3708	reviewed	Ion channel
Q14671	BXGT013496	Pumilio homolog 1	9698	reviewed	Nucleic acid binding
Q14697	BXGT013501	Neutral alpha-glucosidase AB	23193	reviewed	Enzyme
Q14994	BXGT013519	Nuclear receptor subfamily 1 group I member 3	9970	reviewed	Nuclear receptor
Q15113	BXGT013538	Procollagen C-endopeptidase enhancer 1	5118	reviewed
Q15493	BXGT013575	Regucalcin	9104	reviewed	Enzyme
Q15722	BXGT013590	Leukotriene B4 receptor 1	1241	reviewed	G-protein coupled receptor
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q16531	BXGT013633	DNA damage-binding protein 1	1642	reviewed	Nucleic acid binding
Q16654	BXGT013650	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial	5166	reviewed	Kinase
Q5Y7D3	BXGT015912	HLA class II histocompatibility antigen DQ beta chain	3119	unreviewed
Q71U36	BXGT016705	Tubulin alpha-1A chain	7846	reviewed	Cellular structure
Q8N8R3	BXGT018530	Mitochondrial basic amino acids transporter	123096	reviewed	Transporter
Q8NBN7	BXGT018540	Retinol dehydrogenase 13	112724	reviewed
Q8TCC7	BXGT018794	Solute carrier family 22 member 8	9376	reviewed	Transporter
Q92887	BXGT019389	Canalicular multispecific organic anion transporter 1	1244	reviewed	Transporter
Q96D42	BXGT019636	Hepatitis A virus cellular receptor 1	26762	reviewed
Q96ES7	BXGT019654	SAGA-associated factor 29	112869	reviewed
Q96HC4	BXGT019671	PDZ and LIM domain protein 5	10611	reviewed	Cellular structure
Q96RI1	BXGT019727	Bile acid receptor	9971	reviewed	Nuclear receptor
Q96RQ3	BXGT019732	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial	56922	reviewed	Enzyme
Q99497	BXGT019926	Protein/nucleic acid deglycase DJ-1	11315	reviewed	Enzyme
Q99683	BXGT019947	Mitogen-activated protein kinase kinase kinase 5	4217	reviewed	Kinase
Q9BQI3	BXGT020113	Eukaryotic translation initiation factor 2-alpha kinase 1	27102	reviewed	Kinase
Q9GZX6	BXGT020428	Interleukin-22	50616	reviewed
Q9GZZ9	BXGT020430	Ubiquitin-like modifier-activating enzyme 5	79876	reviewed	Enzyme
Q9NPH5	BXGT021159	NADPH oxidase 4	50507	reviewed	Enzyme
Q9UDR5	BXGT021667	Alpha-aminoadipic semialdehyde synthase, mitochondrial	10157	reviewed
Q9UNI1	BXGT021788	Chymotrypsin-like elastase family member 1	1990	reviewed	Enzyme
Q9Y2T3	BXGT022246	Guanine deaminase	9615	reviewed	Enzyme
Q9Y572	BXGT022289	Receptor-interacting serine/threonine-protein kinase 3	11035	reviewed	Kinase
P04439	BXGT022649	HLA class I histocompatibility antigen, A-3 alpha chain	3105	reviewed
Q9GZQ8	BXGT023414	Microtubule-associated proteins 1A/1B light chain 3B	81631	reviewed	Cellular structure
Q16552	BXGT023419	Interleukin-17A	3605	reviewed
P17535	BXGT023437	Transcription factor jun-D	3727	reviewed	Transcription factor
O75208	BXGT023882	Ubiquinone biosynthesis protein COQ9, mitochondrial	57017	reviewed
P20809	BXGT025043	Interleukin-11	3589	reviewed
Q96RD7	BXGT025890	Pannexin-1	24145	reviewed	Ion channel
P21731	BXGT026174	Thromboxane A2 receptor	6915	reviewed	G-protein coupled receptor

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}