Showing entry for Hereditary Diffuse Gastric Cancer


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD013597
Disease NameHereditary Diffuse Gastric Cancer
Disease CUI IdC1708349
MeSH Codes C06   C04  
Disease Class NameDigestive System Diseases; Neoplasms
Semantic TypeNeoplastic Process
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id DOID:7   DOID:14566  
Disease Ontology Class Namedisease of anatomical entity; disease of cellular proliferation
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
A0A024RAV5 BXGT000013 V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b 3845 unreviewed
F7VJQ1 BXGT003310 Alternative prion protein 5621 reviewed
O15119 BXGT004128 T-box transcription factor TBX3 6926 reviewed Transcription factor
O15392 BXGT004162 Baculoviral IAP repeat-containing protein 5 332 reviewed Enzyme modulator
O15427 BXGT004167 Monocarboxylate transporter 4 9123 reviewed Transporter
O43678 BXGT004613 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 4695 reviewed Enzyme
O60427 BXGT004875 Acyl-CoA (8-3)-desaturase 3992 reviewed
O76096 BXGT005178 Cystatin-F 8530 reviewed
O95382 BXGT005376 Mitogen-activated protein kinase kinase kinase 6 9064 reviewed Kinase
O96017 BXGT005415 Serine/threonine-protein kinase Chk2 11200 reviewed Kinase
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P00749 BXGT005641 Urokinase-type plasminogen activator 5328 reviewed Enzyme
P00915 BXGT005689 Carbonic anhydrase 1 759 reviewed
P00918 BXGT005690 Carbonic anhydrase 2 760 reviewed
P01009 BXGT005714 Alpha-1-antitrypsin 5265 reviewed Enzyme modulator
P01106 BXGT005730 Myc proto-oncogene protein 4609 reviewed Transcription factor
P01112 BXGT005732 GTPase HRas 3265 reviewed Enzyme modulator
P01116 BXGT005733 GTPase KRas 3845 reviewed Enzyme modulator
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P02647 BXGT005908 Apolipoprotein A-I 335 reviewed
P02679 BXGT005918 Fibrinogen gamma chain 2266 reviewed Signaling
P02753 BXGT005945 Retinol-binding protein 4 5950 reviewed Transporter
P02768 BXGT005955 Serum albumin 213 reviewed Transporter
P02795 BXGT005968 Metallothionein-2 4502 reviewed
P04156 BXGT006156 Major prion protein 5621 reviewed
P04179 BXGT006163 Superoxide dismutase [Mn], mitochondrial 6648 reviewed Enzyme
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 2064 reviewed Kinase
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P04792 BXGT006264 Heat shock protein beta-1 3315 reviewed
P04818 BXGT006269 Thymidylate synthase 7298 reviewed Enzyme
P05062 BXGT006305 Fructose-bisphosphate aldolase B 229 reviewed
P05120 BXGT006319 Plasminogen activator inhibitor 2 5055 reviewed Enzyme modulator
P05121 BXGT006320 Plasminogen activator inhibitor 1 5054 reviewed Enzyme modulator
P05231 BXGT006345 Interleukin-6 3569 reviewed
P05412 BXGT006354 Transcription factor AP-1 3725 reviewed Transcription factor
P05771 BXGT006384 Protein kinase C beta type 5579 reviewed Kinase
P05787 BXGT006385 Keratin, type II cytoskeletal 8 3856 reviewed
P06241 BXGT006429 Tyrosine-protein kinase Fyn 2534 reviewed Kinase
P06733 BXGT006490 Alpha-enolase 2023 reviewed Enzyme
P06748 BXGT006497 Nucleophosmin 4869 reviewed Chaperone
P06753 BXGT006498 Tropomyosin alpha-3 chain 7170 reviewed Cellular structure
P07204 BXGT006567 Thrombomodulin 7056 reviewed
P07550 BXGT006636 Beta-2 adrenergic receptor 154 reviewed G-protein coupled receptor
P07711 BXGT006661 Cathepsin L1 1514 reviewed Enzyme
P08559 BXGT006788 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 5160 reviewed
P08581 BXGT006794 Hepatocyte growth factor receptor 4233 reviewed Kinase
P08588 BXGT006795 Beta-1 adrenergic receptor 153 reviewed G-protein coupled receptor
P08648 BXGT006804 Integrin alpha-5 3678 reviewed
P08758 BXGT006821 Annexin A5 308 reviewed
P08887 BXGT006835 Interleukin-6 receptor subunit alpha 3570 reviewed Signaling
P08908 BXGT006837 5-hydroxytryptamine receptor 1A 3350 reviewed G-protein coupled receptor
P09211 BXGT006869 Glutathione S-transferase P 2950 reviewed
P09237 BXGT006874 Matrilysin 4316 reviewed Enzyme
P09238 BXGT006875 Stromelysin-2 4319 reviewed Enzyme
P09455 BXGT006890 Retinol-binding protein 1 5947 reviewed
P09467 BXGT006893 Fructose-1,6-bisphosphatase 1 2203 reviewed Enzyme
P09601 BXGT006909 Heme oxygenase 1 3162 reviewed
P09917 BXGT006941 Arachidonate 5-lipoxygenase 240 reviewed Enzyme
P10145 BXGT007542 Interleukin-8 3576 reviewed Signaling
P10586 BXGT007581 Receptor-type tyrosine-protein phosphatase F 5792 reviewed Enzyme
P10809 BXGT007617 60 kDa heat shock protein, mitochondrial 3329 reviewed
P10826 BXGT007622 Retinoic acid receptor beta 5915 reviewed Nuclear receptor
P11142 BXGT007658 Heat shock cognate 71 kDa protein 3312 reviewed
P11172 BXGT007665 Uridine 5'-monophosphate synthase 7372 reviewed
P11509 BXGT007716 Cytochrome P450 2A6 1548 reviewed
P11802 BXGT007750 Cyclin-dependent kinase 4 1019 reviewed Kinase
P12277 BXGT007789 Creatine kinase B-type 1152 reviewed Kinase
P12643 BXGT007830 Bone morphogenetic protein 2 650 reviewed Signaling
P12821 BXGT007849 Angiotensin-converting enzyme 1636 reviewed Enzyme
P12830 BXGT007852 Cadherin-1 999 reviewed
P14678 BXGT008038 Small nuclear ribonucleoprotein-associated proteins B and B' 6628 reviewed Nucleic acid binding
P14866 BXGT008060 Heterogeneous nuclear ribonucleoprotein L 3191 reviewed
P14923 BXGT008069 Junction plakoglobin 3728 reviewed
P15941 BXGT008176 Mucin-1 4582 reviewed
P16070 BXGT008186 CD44 antigen 960 reviewed
P17931 BXGT008356 Galectin-3 3958 reviewed Signaling
P17936 BXGT008357 Insulin-like growth factor-binding protein 3 3486 reviewed Enzyme modulator
P18074 BXGT008374 General transcription and DNA repair factor IIH helicase subunit XPD 2068 reviewed Enzyme
P18075 BXGT008375 Bone morphogenetic protein 7 655 reviewed Signaling
P18669 BXGT008419 Phosphoglycerate mutase 1 5223 reviewed
P18887 BXGT008437 DNA repair protein XRCC1 7515 reviewed
P19883 BXGT008528 Follistatin 10468 reviewed Enzyme modulator
P19971 BXGT008537 Thymidine phosphorylase 1890 reviewed Enzyme
P20591 BXGT008586 Interferon-induced GTP-binding protein Mx1 4599 reviewed Enzyme modulator
P21589 BXGT008669 5'-nucleotidase 4907 reviewed Enzyme
P21802 BXGT008691 Fibroblast growth factor receptor 2 2263 reviewed Kinase
P22897 BXGT008816 Macrophage mannose receptor 1 4360 reviewed
P23470 BXGT008872 Receptor-type tyrosine-protein phosphatase gamma 5793 reviewed Enzyme
P23560 BXGT008883 Brain-derived neurotrophic factor 627 reviewed Signaling
P24385 BXGT008965 G1/S-specific cyclin-D1 595 reviewed Enzyme modulator
P25116 BXGT009025 Proteinase-activated receptor 1 2149 reviewed G-protein coupled receptor
P26358 BXGT009104 DNA (cytosine-5)-methyltransferase 1 1786 reviewed Epigenetic regulator
P27361 BXGT009176 Mitogen-activated protein kinase 3 5595 reviewed Kinase
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase 328 reviewed
P28331 BXGT009252 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial 4719 reviewed Enzyme
P28482 BXGT009263 Mitogen-activated protein kinase 1 5594 reviewed Kinase
P28702 BXGT009287 Retinoic acid receptor RXR-beta 6257 reviewed Nuclear receptor
P29474 BXGT009352 Nitric oxide synthase, endothelial 4846 reviewed
P30043 BXGT009394 Flavin reductase (NADPH) 645 reviewed Enzyme
P30044 BXGT009395 Peroxiredoxin-5, mitochondrial 25824 reviewed
P30084 BXGT009398 Enoyl-CoA hydratase, mitochondrial 1892 reviewed Enzyme
P30153 BXGT009409 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 5518 reviewed Enzyme
P35221 BXGT009798 Catenin alpha-1 1495 reviewed Cellular structure
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35354 BXGT009816 Prostaglandin G/H synthase 2 5743 reviewed Enzyme
P35398 BXGT009825 Nuclear receptor ROR-alpha 6095 reviewed Nuclear receptor
P35869 BXGT009877 Aryl hydrocarbon receptor 196 reviewed Transcription factor
P37173 BXGT009970 TGF-beta receptor type-2 7048 reviewed Kinase
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma 5468 reviewed Nuclear receptor
P38398 BXGT010037 Breast cancer type 1 susceptibility protein 672 reviewed Enzyme
P38936 BXGT010074 Cyclin-dependent kinase inhibitor 1 1026 reviewed
P39019 BXGT010082 40S ribosomal protein S19 6223 reviewed Nucleic acid binding
P40692 BXGT010195 DNA mismatch repair protein Mlh1 4292 reviewed Nucleic acid binding
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P41273 BXGT010251 Tumor necrosis factor ligand superfamily member 9 8744 reviewed
P42330 BXGT010301 Aldo-keto reductase family 1 member C3 8644 reviewed Enzyme
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P43004 BXGT010348 Excitatory amino acid transporter 2 6506 reviewed Transporter
P45877 BXGT010488 Peptidyl-prolyl cis-trans isomerase C 5480 reviewed
P45983 BXGT010494 Mitogen-activated protein kinase 8 5599 reviewed Kinase
P46527 BXGT010525 Cyclin-dependent kinase inhibitor 1B 1027 reviewed
P47895 BXGT010593 Aldehyde dehydrogenase family 1 member A3 220 reviewed Enzyme
P48147 BXGT010620 Prolyl endopeptidase 5550 reviewed Enzyme
P49419 BXGT010705 Alpha-aminoadipic semialdehyde dehydrogenase 501 reviewed Enzyme
P49789 BXGT010742 Bis(5'-adenosyl)-triphosphatase 2272 reviewed
P49821 BXGT010748 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial 4723 reviewed
P49959 BXGT010766 Double-strand break repair protein MRE11 4361 reviewed
P50052 BXGT010768 Type-2 angiotensin II receptor 186 reviewed G-protein coupled receptor
P51790 BXGT010890 H(+)/Cl(-) exchange transporter 3 1182 reviewed Ion channel
P53634 BXGT011007 Dipeptidyl peptidase 1 1075 reviewed Enzyme
P55957 BXGT011137 BH3-interacting domain death agonist 637 reviewed
P61586 BXGT011375 Transforming protein RhoA 387 reviewed Enzyme modulator
P62753 BXGT011454 40S ribosomal protein S6 6194 reviewed Nucleic acid binding
P62937 BXGT011471 Peptidyl-prolyl cis-trans isomerase A 5478 reviewed
P68104 BXGT011575 Elongation factor 1-alpha 1 1915 reviewed Enzyme
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A 4297 reviewed
Q03403 BXGT012712 Trefoil factor 2 7032 reviewed Signaling
Q04721 BXGT012777 Neurogenic locus notch homolog protein 2 4853 reviewed
Q07011 BXGT012912 Tumor necrosis factor receptor superfamily member 9 3604 reviewed
Q07020 BXGT012914 60S ribosomal protein L18 6141 reviewed Nucleic acid binding
Q07817 BXGT012941 Bcl-2-like protein 1 598 reviewed Signaling
Q12772 BXGT013262 Sterol regulatory element-binding protein 2 6721 reviewed
Q12882 BXGT013276 Dihydropyrimidine dehydrogenase [NADP(+)] 1806 reviewed Enzyme
Q12931 BXGT013282 Heat shock protein 75 kDa, mitochondrial 10131 reviewed Chaperone
Q13131 BXGT013314 5'-AMP-activated protein kinase catalytic subunit alpha-1 5562 reviewed Kinase
Q13315 BXGT013339 Serine-protein kinase ATM 472 reviewed Kinase
Q13485 BXGT013363 Mothers against decapentaplegic homolog 4 4089 reviewed Transcription factor
Q14126 BXGT013446 Desmoglein-2 1829 reviewed Cell adhesion
Q14790 BXGT013505 Caspase-8 841 reviewed Enzyme
Q15257 BXGT013554 Serine/threonine-protein phosphatase 2A activator 5524 reviewed Enzyme modulator
Q16531 BXGT013633 DNA damage-binding protein 1 1642 reviewed Nucleic acid binding
Q16674 BXGT013655 Melanoma-derived growth regulatory protein 8190 reviewed
Q2TU34 BXGT014223 Fructose-1,6-bisphosphatase 1 2203 unreviewed
Q86YC2 BXGT017633 Partner and localizer of BRCA2 79728 reviewed
Q96EP1 BXGT019651 E3 ubiquitin-protein ligase CHFR 55743 reviewed Enzyme
Q96GD4 BXGT019667 Aurora kinase B 9212 reviewed Kinase
Q9BQE3 BXGT020109 Tubulin alpha-1C chain 84790 reviewed Cellular structure
Q9H3H5 BXGT020461 UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 1798 reviewed Enzyme
Q9H3N8 BXGT020463 Histamine H4 receptor 59340 reviewed G-protein coupled receptor
Q9P0L2 BXGT021289 Serine/threonine-protein kinase MARK1 4139 reviewed Kinase
Q9P212 BXGT021297 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 51196 reviewed Enzyme
Q9P2T1 BXGT021305 GMP reductase 2 51292 reviewed
Q9UBC3 BXGT021650 DNA (cytosine-5)-methyltransferase 3B 1789 reviewed
Q9UIF7 BXGT021717 Adenine DNA glycosylase 4595 reviewed Enzyme
Q9UKU7 BXGT021749 Isobutyryl-CoA dehydrogenase, mitochondrial 27034 reviewed Enzyme
Q9UQ80 BXGT021806 Proliferation-associated protein 2G4 5036 reviewed
Q9Y478 BXGT022271 5'-AMP-activated protein kinase subunit beta-1 5564 reviewed Kinase
Q9Y5W5 BXGT022303 Wnt inhibitory factor 1 11197 reviewed Calcium-binding protein
Q9Y606 BXGT022312 tRNA pseudouridine synthase A 80324 reviewed Enzyme
P35232 BXGT022663 Prohibitin 5245 reviewed
P25054 BXGT022961 Adenomatous polyposis coli protein 324 reviewed
O43837 BXGT024635 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 3420 reviewed Enzyme
Q8NEZ4 BXGT024850 Histone-lysine N-methyltransferase 2C 58508 reviewed
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease