Showing entry for Disease Exacerbation


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD004781
Disease NameDisease Exacerbation
Disease CUI IdC0235874
MeSH Codes C23  
Disease Class NamePathological Conditions, Signs and Symptoms
Semantic TypeFinding
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id   
Disease Ontology Class Name
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
A0A024RAV5 BXGT000013 V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b 3845 unreviewed
O14746 BXGT004091 Telomerase reverse transcriptase 7015 reviewed Enzyme
O43678 BXGT004613 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 4695 reviewed Enzyme
O60341 BXGT004873 Lysine-specific histone demethylase 1A 23028 reviewed Epigenetic regulator
O95255 BXGT005363 Multidrug resistance-associated protein 6 368 reviewed Transporter
O95786 BXGT005396 Probable ATP-dependent RNA helicase DDX58 23586 reviewed
O96017 BXGT005415 Serine/threonine-protein kinase Chk2 11200 reviewed Kinase
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P01106 BXGT005730 Myc proto-oncogene protein 4609 reviewed Transcription factor
P01112 BXGT005732 GTPase HRas 3265 reviewed Enzyme modulator
P01116 BXGT005733 GTPase KRas 3845 reviewed Enzyme modulator
P01133 BXGT005736 Pro-epidermal growth factor 1950 reviewed
P01215 BXGT005743 Glycoprotein hormones alpha chain 1081 reviewed
P01583 BXGT005771 Interleukin-1 alpha 3552 reviewed
P02649 BXGT005909 Apolipoprotein E 348 reviewed
P03372 BXGT006059 Estrogen receptor 2099 reviewed Nuclear receptor
P04040 BXGT006132 Catalase 847 reviewed Enzyme
P04179 BXGT006163 Superoxide dismutase [Mn], mitochondrial 6648 reviewed Enzyme
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 2064 reviewed Kinase
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P07288 BXGT006591 Prostate-specific antigen 354 reviewed Enzyme
P07858 BXGT006689 Cathepsin B 1508 reviewed Enzyme
P08183 BXGT006741 ATP-dependent translocase ABCB1 5243 reviewed Transporter
P08253 BXGT006757 72 kDa type IV collagenase 4313 reviewed Enzyme
P08559 BXGT006788 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 5160 reviewed
P09038 BXGT006851 Fibroblast growth factor 2 2247 reviewed Signaling
P09211 BXGT006869 Glutathione S-transferase P 2950 reviewed
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10586 BXGT007581 Receptor-type tyrosine-protein phosphatase F 5792 reviewed Enzyme
P11387 BXGT007696 DNA topoisomerase 1 7150 reviewed Enzyme
P11388 BXGT007697 DNA topoisomerase 2-alpha 7153 reviewed
P11509 BXGT007716 Cytochrome P450 2A6 1548 reviewed
P12830 BXGT007852 Cadherin-1 999 reviewed
P14678 BXGT008038 Small nuclear ribonucleoprotein-associated proteins B and B' 6628 reviewed Nucleic acid binding
P14866 BXGT008060 Heterogeneous nuclear ribonucleoprotein L 3191 reviewed
P15336 BXGT008109 Cyclic AMP-dependent transcription factor ATF-2 1386 reviewed Transcription factor
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 2321 reviewed Kinase
P21439 BXGT008649 Phosphatidylcholine translocator ABCB4 5244 reviewed Transporter
P21860 BXGT008698 Receptor tyrosine-protein kinase erbB-3 2065 reviewed Kinase
P23921 BXGT008927 Ribonucleoside-diphosphate reductase large subunit 6240 reviewed Enzyme
P24385 BXGT008965 G1/S-specific cyclin-D1 595 reviewed Enzyme modulator
P24864 BXGT009000 G1/S-specific cyclin-E1 898 reviewed Enzyme modulator
P25101 BXGT009018 Endothelin-1 receptor 1909 reviewed G-protein coupled receptor
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase 328 reviewed
P28331 BXGT009252 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial 4719 reviewed Enzyme
P28702 BXGT009287 Retinoic acid receptor RXR-beta 6257 reviewed Nuclear receptor
P29317 BXGT009331 Ephrin type-A receptor 2 1969 reviewed Kinase
P30153 BXGT009409 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 5518 reviewed Enzyme
P33527 BXGT009728 Multidrug resistance-associated protein 1 4363 reviewed Transporter
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P39019 BXGT010082 40S ribosomal protein S19 6223 reviewed Nucleic acid binding
P42224 BXGT010286 Signal transducer and activator of transcription 1-alpha/beta 6772 reviewed Nucleic acid binding
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P46937 BXGT010554 Transcriptional coactivator YAP1 10413 reviewed Enzyme modulator
P47736 BXGT010579 Rap1 GTPase-activating protein 1 5909 reviewed Enzyme modulator
P48147 BXGT010620 Prolyl endopeptidase 5550 reviewed Enzyme
P49419 BXGT010705 Alpha-aminoadipic semialdehyde dehydrogenase 501 reviewed Enzyme
P49765 BXGT010738 Vascular endothelial growth factor B 7423 reviewed Signaling
P49821 BXGT010748 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial 4723 reviewed
P51790 BXGT010890 H(+)/Cl(-) exchange transporter 3 1182 reviewed Ion channel
P53634 BXGT011007 Dipeptidyl peptidase 1 1075 reviewed Enzyme
P55072 BXGT011103 Transitional endoplasmic reticulum ATPase 7415 reviewed
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P62753 BXGT011454 40S ribosomal protein S6 6194 reviewed Nucleic acid binding
P78540 BXGT011848 Arginase-2, mitochondrial 384 reviewed Enzyme
Q01831 BXGT012621 DNA repair protein complementing XP-C cells 7508 reviewed Nucleic acid binding
Q07020 BXGT012914 60S ribosomal protein L18 6141 reviewed Nucleic acid binding
Q12772 BXGT013262 Sterol regulatory element-binding protein 2 6721 reviewed
Q12931 BXGT013282 Heat shock protein 75 kDa, mitochondrial 10131 reviewed Chaperone
Q14145 BXGT013448 Kelch-like ECH-associated protein 1 9817 reviewed
Q15257 BXGT013554 Serine/threonine-protein phosphatase 2A activator 5524 reviewed Enzyme modulator
Q16531 BXGT013633 DNA damage-binding protein 1 1642 reviewed Nucleic acid binding
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha 3091 reviewed Transcription factor
Q92772 BXGT019371 Cyclin-dependent kinase-like 2 8999 reviewed Kinase
Q96J66 BXGT019680 ATP-binding cassette sub-family C member 11 85320 reviewed Transporter
Q9H3H5 BXGT020461 UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 1798 reviewed Enzyme
Q9H3M7 BXGT020462 Thioredoxin-interacting protein 10628 reviewed
Q9NZQ7 BXGT021281 Programmed cell death 1 ligand 1 29126 reviewed Receptor
Q9UKU7 BXGT021749 Isobutyryl-CoA dehydrogenase, mitochondrial 27034 reviewed Enzyme
Q9UKV5 BXGT021751 E3 ubiquitin-protein ligase AMFR 267 reviewed
Q9UQ80 BXGT021806 Proliferation-associated protein 2G4 5036 reviewed
Q9Y478 BXGT022271 5'-AMP-activated protein kinase subunit beta-1 5564 reviewed Kinase
Q9Y4K1 BXGT022281 Beta/gamma crystallin domain-containing protein 1 202 reviewed
Q9Y606 BXGT022312 tRNA pseudouridine synthase A 80324 reviewed Enzyme
P35232 BXGT022663 Prohibitin 5245 reviewed
Q16254 BXGT023368 Transcription factor E2F4 1874 reviewed Nucleic acid binding
P35670 BXGT023695 Copper-transporting ATPase 2 540 reviewed Transporter
O43837 BXGT024635 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 3420 reviewed Enzyme
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease