Showing entry for Drug-Induced Acute Liver Injury


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD019256
Disease NameDrug-Induced Acute Liver Injury
Disease CUI IdC3658290
MeSH Codes C06   C25  
Disease Class NameDigestive System Diseases; Chemically-Induced Disorders
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id   
Disease Ontology Class Name
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00204 BXGT003893 Sulfotransferase family cytosolic 2B member 1 6820 reviewed
O00401 BXGT003915 Neural Wiskott-Aldrich syndrome protein 8976 reviewed Cellular structure
O00482 BXGT003929 Nuclear receptor subfamily 5 group A member 2 2494 reviewed Nuclear receptor
O00748 BXGT003942 Cocaine esterase 8824 reviewed Enzyme
O15217 BXGT004137 Glutathione S-transferase A4 2941 reviewed
O15254 BXGT004143 Peroxisomal acyl-coenzyme A oxidase 3 8310 reviewed Enzyme
O43707 BXGT004616 Alpha-actinin-4 81 reviewed
O60427 BXGT004875 Acyl-CoA (8-3)-desaturase 3992 reviewed
O60656 BXGT004889 UDP-glucuronosyltransferase 1-9 54600 reviewed
O60885 BXGT004906 Bromodomain-containing protein 4 23476 reviewed Epigenetic regulator
O75460 BXGT005127 Serine/threonine-protein kinase/endoribonuclease IRE1 2081 reviewed Kinase
O75469 BXGT005128 Nuclear receptor subfamily 1 group I member 2 8856 reviewed Nuclear receptor
O75489 BXGT005131 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial 4722 reviewed
O76094 BXGT005177 Signal recognition particle subunit SRP72 6731 reviewed
O95237 BXGT005361 Lecithin retinol acyltransferase 9227 reviewed
O95831 BXGT005399 Apoptosis-inducing factor 1, mitochondrial 9131 reviewed Enzyme
O95861 BXGT005402 3'(2'),5'-bisphosphate nucleotidase 1 10380 reviewed Enzyme
O95864 BXGT005403 Acyl-CoA 6-desaturase 9415 reviewed
P00374 BXGT005520 Dihydrofolate reductase 1719 reviewed Enzyme
P00390 BXGT005526 Glutathione reductase, mitochondrial 2936 reviewed Enzyme
P00439 BXGT005539 Phenylalanine-4-hydroxylase 5053 reviewed
P00441 BXGT005540 Superoxide dismutase [Cu-Zn] 6647 reviewed Enzyme
P00450 BXGT005544 Ceruloplasmin 1356 reviewed Enzyme
P00491 BXGT005555 Purine nucleoside phosphorylase 4860 reviewed Enzyme
P00492 BXGT005556 Hypoxanthine-guanine phosphoribosyltransferase 3251 reviewed Enzyme
P00747 BXGT005639 Plasminogen 5340 reviewed Enzyme
P00750 BXGT005642 Tissue-type plasminogen activator 5327 reviewed Enzyme
P00973 BXGT005711 2'-5'-oligoadenylate synthase 1 4938 reviewed Enzyme
P01019 BXGT005717 Angiotensinogen 183 reviewed Enzyme modulator
P01024 BXGT005719 Complement C3 718 reviewed Enzyme modulator
P01042 BXGT005722 Kininogen-1 3827 reviewed Enzyme modulator
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01579 BXGT005770 Interferon gamma 3458 reviewed
P01583 BXGT005771 Interleukin-1 alpha 3552 reviewed
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P01889 BXGT005809 HLA class I histocompatibility antigen, B-7 alpha chain 3106 reviewed
P01911 BXGT005816 HLA class II histocompatibility antigen, DRB1-15 beta chain 3123 reviewed Immune response
P01920 BXGT005817 HLA class II histocompatibility antigen, DQ beta 1 chain 3119 reviewed Immune response
P02461 BXGT005880 Collagen alpha-1(III) chain 1281 reviewed
P02647 BXGT005908 Apolipoprotein A-I 335 reviewed
P02649 BXGT005909 Apolipoprotein E 348 reviewed
P02671 BXGT005914 Fibrinogen alpha chain 2243 reviewed
P02741 BXGT005936 C-reactive protein 1401 reviewed
P02749 BXGT005941 Beta-2-glycoprotein 1 350 reviewed
P02760 BXGT005948 Protein AMBP 259 reviewed
P02766 BXGT005953 Transthyretin 7276 reviewed Transporter
P02768 BXGT005955 Serum albumin 213 reviewed Transporter
P02774 BXGT005959 Vitamin D-binding protein 2638 reviewed Transporter
P02787 BXGT005962 Serotransferrin 7018 reviewed Enzyme
P02788 BXGT005963 Lactotransferrin 4057 reviewed Enzyme
P02792 BXGT005966 Ferritin light chain 2512 reviewed Storage
P04040 BXGT006132 Catalase 847 reviewed Enzyme
P04179 BXGT006163 Superoxide dismutase [Mn], mitochondrial 6648 reviewed Enzyme
P04275 BXGT006180 von Willebrand factor 7450 reviewed Enzyme modulator
P05062 BXGT006305 Fructose-bisphosphate aldolase B 229 reviewed
P05089 BXGT006310 Arginase-1 383 reviewed Enzyme
P05155 BXGT006328 Plasma protease C1 inhibitor 710 reviewed Enzyme modulator
P05177 BXGT006336 Cytochrome P450 1A2 1544 reviewed Enzyme
P05181 BXGT006337 Cytochrome P450 2E1 1571 reviewed
P05231 BXGT006345 Interleukin-6 3569 reviewed
P05787 BXGT006385 Keratin, type II cytoskeletal 8 3856 reviewed
P06396 BXGT006435 Gelsolin 2934 reviewed Cellular structure
P06733 BXGT006490 Alpha-enolase 2023 reviewed Enzyme
P06737 BXGT006492 Glycogen phosphorylase, liver form 5836 reviewed Enzyme
P07099 BXGT006546 Epoxide hydrolase 1 2052 reviewed
P07237 BXGT006576 Protein disulfide-isomerase 5034 reviewed
P07355 BXGT006609 Annexin A2 302 reviewed
P07451 BXGT006627 Carbonic anhydrase 3 761 reviewed
P08133 BXGT006727 Annexin A6 309 reviewed
P08183 BXGT006741 ATP-dependent translocase ABCB1 5243 reviewed Transporter
P08185 BXGT006742 Corticosteroid-binding globulin 866 reviewed Enzyme modulator
P08253 BXGT006757 72 kDa type IV collagenase 4313 reviewed Enzyme
P08603 BXGT006798 Complement factor H 3075 reviewed
P08670 BXGT006810 Vimentin 7431 reviewed
P08684 BXGT006812 Cytochrome P450 3A4 1576 reviewed Enzyme
P09211 BXGT006869 Glutathione S-transferase P 2950 reviewed
P09429 BXGT006889 High mobility group protein B1 3146 reviewed Nucleic acid binding
P09455 BXGT006890 Retinol-binding protein 1 5947 reviewed
P09488 BXGT006899 Glutathione S-transferase Mu 1 2944 reviewed
P09601 BXGT006909 Heme oxygenase 1 3162 reviewed
P10909 BXGT007630 Clusterin 1191 reviewed
P11021 BXGT007644 Endoplasmic reticulum chaperone BiP 3309 reviewed
P11498 BXGT007714 Pyruvate carboxylase, mitochondrial 5091 reviewed Enzyme
P11509 BXGT007716 Cytochrome P450 2A6 1548 reviewed
P11712 BXGT007738 Cytochrome P450 2C9 1559 reviewed
P12277 BXGT007789 Creatine kinase B-type 1152 reviewed Kinase
P13500 BXGT007916 C-C motif chemokine 2 6347 reviewed Signaling
P13726 BXGT007950 Tissue factor 2152 reviewed Receptor
P14780 BXGT008053 Matrix metalloproteinase-9 4318 reviewed Enzyme
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P17174 BXGT008289 Aspartate aminotransferase, cytoplasmic 2805 reviewed
P17931 BXGT008356 Galectin-3 3958 reviewed Signaling
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 2321 reviewed Kinase
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 1131 reviewed G-protein coupled receptor
P20813 BXGT008603 Cytochrome P450 2B6 1555 reviewed
P20936 BXGT008619 Ras GTPase-activating protein 1 5921 reviewed Enzyme modulator
P21266 BXGT008632 Glutathione S-transferase Mu 3 2947 reviewed
P21583 BXGT008667 Kit ligand 4254 reviewed
P21695 BXGT008682 Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic 2819 reviewed Enzyme
P24298 BXGT008960 Alanine aminotransferase 1 2875 reviewed Enzyme
P24468 BXGT008969 COUP transcription factor 2 7026 reviewed Nuclear receptor
P25021 BXGT009004 Histamine H2 receptor 3274 reviewed G-protein coupled receptor
P27169 BXGT009161 Serum paraoxonase/arylesterase 1 5444 reviewed
P27540 BXGT009190 Aryl hydrocarbon receptor nuclear translocator 405 reviewed Transcription factor
P28161 BXGT009234 Glutathione S-transferase Mu 2 2946 reviewed
P28838 BXGT009295 Cytosol aminopeptidase 51056 reviewed Enzyme
P30043 BXGT009394 Flavin reductase (NADPH) 645 reviewed Enzyme
P30084 BXGT009398 Enoyl-CoA hydratase, mitochondrial 1892 reviewed Enzyme
P30305 BXGT009419 M-phase inducer phosphatase 2 994 reviewed Enzyme
P30411 BXGT009424 B2 bradykinin receptor 624 reviewed G-protein coupled receptor
P30711 BXGT009460 Glutathione S-transferase theta-1 2952 reviewed
P31327 BXGT009523 Carbamoyl-phosphate synthase [ammonia], mitochondrial 1373 reviewed Enzyme
P31513 BXGT009546 Dimethylaniline monooxygenase [N-oxide-forming] 3 2328 reviewed Enzyme
P32298 BXGT009617 G protein-coupled receptor kinase 4 2868 reviewed Kinase
P32754 BXGT009664 4-hydroxyphenylpyruvate dioxygenase 3242 reviewed Enzyme
P33121 BXGT009692 Long-chain-fatty-acid--CoA ligase 1 2180 reviewed Enzyme
P33261 BXGT009707 Cytochrome P450 2C19 1557 reviewed
P33527 BXGT009728 Multidrug resistance-associated protein 1 4363 reviewed Transporter
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35354 BXGT009816 Prostaglandin G/H synthase 2 5743 reviewed Enzyme
P35869 BXGT009877 Aryl hydrocarbon receptor 196 reviewed Transcription factor
P36871 BXGT009936 Phosphoglucomutase-1 5236 reviewed
P36897 BXGT009941 TGF-beta receptor type-1 7046 reviewed Kinase
P37802 BXGT010013 Transgelin-2 8407 reviewed Cellular structure
P40925 BXGT010206 Malate dehydrogenase, cytoplasmic 4190 reviewed Enzyme
P41597 BXGT010268 C-C chemokine receptor type 2 729230 reviewed
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P45974 BXGT010493 Ubiquitin carboxyl-terminal hydrolase 5 8078 reviewed Enzyme
P46531 BXGT010526 Neurogenic locus notch homolog protein 1 4851 reviewed
P48506 BXGT010635 Glutamate--cysteine ligase catalytic subunit 2729 reviewed Enzyme
P48507 BXGT010636 Glutamate--cysteine ligase regulatory subunit 2730 reviewed Enzyme
P48643 BXGT010650 T-complex protein 1 subunit epsilon 22948 reviewed Chaperone
P49327 BXGT010694 Fatty acid synthase 2194 reviewed Enzyme
P49368 BXGT010701 T-complex protein 1 subunit gamma 7203 reviewed Chaperone
P49585 BXGT010712 Choline-phosphate cytidylyltransferase A 5130 reviewed
P49888 BXGT010756 Estrogen sulfotransferase 6783 reviewed
P51617 BXGT010868 Interleukin-1 receptor-associated kinase 1 3654 reviewed Kinase
P51687 BXGT010882 Sulfite oxidase, mitochondrial 6821 reviewed
P54098 BXGT011030 DNA polymerase subunit gamma-1 5428 reviewed Enzyme
P58004 BXGT011222 Sestrin-2 83667 reviewed Enzyme
P60709 BXGT011322 Actin, cytoplasmic 1 60 reviewed Cellular structure
P61158 BXGT011364 Actin-related protein 3 10096 reviewed Cellular structure
P68371 BXGT011597 Tubulin beta-4B chain 10383 reviewed Cellular structure
P69905 BXGT011649 Hemoglobin subunit alpha 3040 reviewed
P78325 BXGT011832 Disintegrin and metalloproteinase domain-containing protein 8 101 reviewed Enzyme
P78417 BXGT011843 Glutathione S-transferase omega-1 9446 reviewed
P78527 BXGT011846 DNA-dependent protein kinase catalytic subunit 5591 reviewed Kinase
P80188 BXGT011882 Neutrophil gelatinase-associated lipocalin 3934 reviewed Enzyme
Q00266 BXGT012515 S-adenosylmethionine synthase isoform type-1 4143 reviewed Enzyme
Q00796 BXGT012549 Sorbitol dehydrogenase 6652 reviewed Enzyme
Q01094 BXGT012568 Transcription factor E2F1 1869 reviewed Nucleic acid binding
Q02487 BXGT012656 Desmocollin-2 1824 reviewed Cell adhesion
Q03013 BXGT012685 Glutathione S-transferase Mu 4 2948 reviewed
Q04912 BXGT012790 Macrophage-stimulating protein receptor 4486 reviewed Kinase
Q05655 BXGT012832 Protein kinase C delta type 5580 reviewed Kinase
Q07812 BXGT012940 Apoptosis regulator BAX 581 reviewed Signaling
Q07869 BXGT012945 Peroxisome proliferator-activated receptor alpha 5465 reviewed Nuclear receptor
Q13133 BXGT013315 Oxysterols receptor LXR-alpha 10062 reviewed Nuclear receptor
Q14116 BXGT013442 Interleukin-18 3606 reviewed
Q14643 BXGT013493 Inositol 1,4,5-trisphosphate receptor type 1 3708 reviewed Ion channel
Q14671 BXGT013496 Pumilio homolog 1 9698 reviewed Nucleic acid binding
Q14697 BXGT013501 Neutral alpha-glucosidase AB 23193 reviewed Enzyme
Q14994 BXGT013519 Nuclear receptor subfamily 1 group I member 3 9970 reviewed Nuclear receptor
Q15113 BXGT013538 Procollagen C-endopeptidase enhancer 1 5118 reviewed
Q15493 BXGT013575 Regucalcin 9104 reviewed Enzyme
Q15722 BXGT013590 Leukotriene B4 receptor 1 1241 reviewed G-protein coupled receptor
Q15848 BXGT013609 Adiponectin 9370 reviewed
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 4780 reviewed Enzyme
Q16531 BXGT013633 DNA damage-binding protein 1 1642 reviewed Nucleic acid binding
Q16654 BXGT013650 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 5166 reviewed Kinase
Q5Y7D3 BXGT015912 HLA class II histocompatibility antigen DQ beta chain 3119 unreviewed
Q71U36 BXGT016705 Tubulin alpha-1A chain 7846 reviewed Cellular structure
Q8N8R3 BXGT018530 Mitochondrial basic amino acids transporter 123096 reviewed Transporter
Q8NBN7 BXGT018540 Retinol dehydrogenase 13 112724 reviewed
Q8TCC7 BXGT018794 Solute carrier family 22 member 8 9376 reviewed Transporter
Q92887 BXGT019389 Canalicular multispecific organic anion transporter 1 1244 reviewed Transporter
Q96D42 BXGT019636 Hepatitis A virus cellular receptor 1 26762 reviewed
Q96ES7 BXGT019654 SAGA-associated factor 29 112869 reviewed
Q96HC4 BXGT019671 PDZ and LIM domain protein 5 10611 reviewed Cellular structure
Q96RI1 BXGT019727 Bile acid receptor 9971 reviewed Nuclear receptor
Q96RQ3 BXGT019732 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial 56922 reviewed Enzyme
Q99497 BXGT019926 Protein/nucleic acid deglycase DJ-1 11315 reviewed Enzyme
Q99683 BXGT019947 Mitogen-activated protein kinase kinase kinase 5 4217 reviewed Kinase
Q9BQI3 BXGT020113 Eukaryotic translation initiation factor 2-alpha kinase 1 27102 reviewed Kinase
Q9GZX6 BXGT020428 Interleukin-22 50616 reviewed
Q9GZZ9 BXGT020430 Ubiquitin-like modifier-activating enzyme 5 79876 reviewed Enzyme
Q9NPH5 BXGT021159 NADPH oxidase 4 50507 reviewed Enzyme
Q9UDR5 BXGT021667 Alpha-aminoadipic semialdehyde synthase, mitochondrial 10157 reviewed
Q9UNI1 BXGT021788 Chymotrypsin-like elastase family member 1 1990 reviewed Enzyme
Q9Y2T3 BXGT022246 Guanine deaminase 9615 reviewed Enzyme
Q9Y572 BXGT022289 Receptor-interacting serine/threonine-protein kinase 3 11035 reviewed Kinase
P04439 BXGT022649 HLA class I histocompatibility antigen, A-3 alpha chain 3105 reviewed
Q9GZQ8 BXGT023414 Microtubule-associated proteins 1A/1B light chain 3B 81631 reviewed Cellular structure
Q16552 BXGT023419 Interleukin-17A 3605 reviewed
P17535 BXGT023437 Transcription factor jun-D 3727 reviewed Transcription factor
O75208 BXGT023882 Ubiquinone biosynthesis protein COQ9, mitochondrial 57017 reviewed
P20809 BXGT025043 Interleukin-11 3589 reviewed
Q96RD7 BXGT025890 Pannexin-1 24145 reviewed Ion channel
P21731 BXGT026174 Thromboxane A2 receptor 6915 reviewed G-protein coupled receptor
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease