Showing entry for Endoribonuclease ZC3H12A


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT015318
Protein NameEndoribonuclease ZC3H12A
Uniport IdQ5D1E8
GeneZC3H12A
Gene Id80149
DomainRegnase_1_C; RNase_Zc3h12a; UBA_6
Pfam PF18561   PF11977   PF18039  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0061158 3'-UTR-mediated mRNA destabilization
Biological Process GO:0001525 angiogenesis
Biological Process GO:0006915 apoptotic process
Biological Process GO:0030154 cell differentiation
Biological Process GO:1990869 cellular response to chemokine
Biological Process GO:0006974 cellular response to DNA damage stimulus
Biological Process GO:0042149 cellular response to glucose starvation
Biological Process GO:0071347 cellular response to interleukin-1
Biological Process GO:1904637 cellular response to ionomycin
Biological Process GO:0071222 cellular response to lipopolysaccharide
Biological Process GO:0034599 cellular response to oxidative stress
Biological Process GO:1903936 cellular response to sodium arsenite
Biological Process GO:0071356 cellular response to tumor necrosis factor
Biological Process GO:0098586 cellular response to virus
Biological Process GO:0051607 defense response to virus
Biological Process GO:0002757 immune response-activating signal transduction
Biological Process GO:0006954 inflammatory response
Biological Process GO:0044828 negative regulation by host of viral genome replication
Biological Process GO:0055118 negative regulation of cardiac muscle contraction
Biological Process GO:1900016 negative regulation of cytokine production involved in inflammatory response
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process GO:0032689 negative regulation of interferon-gamma production
Biological Process GO:0032691 negative regulation of interleukin-1 beta production
Biological Process GO:0032715 negative regulation of interleukin-6 production
Biological Process GO:0043031 negative regulation of macrophage activation
Biological Process GO:0010656 negative regulation of muscle cell apoptotic process
Biological Process GO:0032088 negative regulation of NF-kappaB transcription factor activity
Biological Process GO:1901223 negative regulation of NIK/NF-kappaB signaling
Biological Process GO:0045019 negative regulation of nitric oxide biosynthetic process
Biological Process GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA
Biological Process GO:0001933 negative regulation of protein phosphorylation
Biological Process GO:2000320 negative regulation of T-helper 17 cell differentiation
Biological Process GO:0032720 negative regulation of tumor necrosis factor production
Biological Process GO:1904468 negative regulation of tumor necrosis factor secretion
Biological Process GO:0007399 nervous system development
Biological Process GO:0000294 nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay
Biological Process GO:0045766 positive regulation of angiogenesis
Biological Process GO:0010508 positive regulation of autophagy
Biological Process GO:0010942 positive regulation of cell death
Biological Process GO:0002230 positive regulation of defense response to virus by host
Biological Process GO:0010595 positive regulation of endothelial cell migration
Biological Process GO:1900119 positive regulation of execution phase of apoptosis
Biological Process GO:0045600 positive regulation of fat cell differentiation
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0010884 positive regulation of lipid storage
Biological Process GO:2000627 positive regulation of miRNA catabolic process
Biological Process GO:0061014 positive regulation of mRNA catabolic process
Biological Process GO:1900745 positive regulation of p38MAPK cascade
Biological Process GO:1903003 positive regulation of protein deubiquitination
Biological Process GO:0042307 positive regulation of protein import into nucleus
Biological Process GO:2000379 positive regulation of reactive oxygen species metabolic process
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0051259 protein complex oligomerization
Biological Process GO:0016579 protein deubiquitination
Biological Process GO:0010468 regulation of gene expression
Biological Process GO:0090501 RNA phosphodiester bond hydrolysis
Biological Process GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Biological Process GO:0050852 T cell receptor signaling pathway
Biological Process GO:0016032 viral process
molecular function GO:0003682 chromatin binding
molecular function GO:0003677 DNA binding
molecular function GO:0004521 endoribonuclease activity
molecular function GO:0004532 exoribonuclease activity
molecular function GO:0046872 metal ion binding
molecular function GO:0035198 miRNA binding
molecular function GO:0035925 mRNA 3'-UTR AU-rich region binding
molecular function GO:0003730 mRNA 3'-UTR binding
molecular function GO:0003729 mRNA binding
molecular function GO:0004540 ribonuclease activity
molecular function GO:0043022 ribosome binding
molecular function GO:0003723 RNA binding
molecular function GO:0035613 RNA stem-loop binding
cellular component GO:0005737 cytoplasm
cellular component GO:0036464 cytoplasmic ribonucleoprotein granule
cellular component GO:0005856 cytoskeleton
cellular component GO:0042406 extrinsic component of endoplasmic reticulum membrane
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0000932 P-body
cellular component GO:0032991 protein-containing complex
cellular component GO:0005791 rough endoplasmic reticulum
cellular component GO:0030867 rough endoplasmic reticulum membrane
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002438 BXGD000113 Amebiasis Infections
C0002793 BXGD000130 Anaplasia Pathological Conditions, Signs and Symptoms; Neoplasms
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0003838 BXGD000224 Arterial Occlusive Diseases Cardiovascular Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004623 BXGD000282 Bacterial Infections Infections
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0007786 BXGD000486 Brain Ischemia Nervous System Diseases; Cardiovascular Diseases
C0011603 BXGD000734 Dermatitis Skin and Connective Tissue Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0013370 BXGD000822 Amebic colitis Digestive System Diseases; Infections
C0014057 BXGD000880 Japanese Encephalitis Infections; Nervous System Diseases
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0020455 BXGD001391 Hypergammaglobulinemia Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases
C0021053 BXGD001476 Immune System Diseases Immune System Diseases
C0021670 BXGD001509 insulinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024894 BXGD001810 Mastitis Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026946 BXGD001951 Mycoses Infections
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0037116 BXGD002666 Silicosis Respiratory Tract Diseases; Occupational Diseases
C0037284 BXGD002679 Skin lesion Skin and Connective Tissue Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0153252 BXGD003616 Systemic candidiasis Infections
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0242647 BXGD005184 Mucosa-Associated Lymphoid Tissue Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0276138 BXGD006403 Viral myocarditis Infections; Cardiovascular Diseases
C0276289 BXGD006418 Zika Virus Infection Infections
C0276680 BXGD006443 Infection by Candida albicans Infections
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0345905 BXGD007746 Intrahepatic Cholangiocarcinoma Neoplasms
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0574143 BXGD009503 Liver calculus
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0586358 BXGD009605 Biliary Intraepithelial Neoplasia Digestive System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0740391 BXGD009987 Middle Cerebral Artery Occlusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0740457 BXGD010000 Malignant neoplasm of kidney Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0742343 BXGD010061 Acute Chest Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0745413 BXGD010127 ischemic attack
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1275278 BXGD012074 Extraskeletal Myxoid Chondrosarcoma Neoplasms
C1290884 BXGD012198 Inflammatory disorder Pathological Conditions, Signs and Symptoms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1318973 BXGD012407 Staphylococcus aureus infection Infections
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1378703 BXGD012933 Renal carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C2062441 BXGD016897 Influenza A
C2363741 BXGD017100 HIV-1 infection
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C3875321 BXGD019874 Inflammatory dermatosis Skin and Connective Tissue Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4284013 BXGD022428 Primary cholangiocarcinoma of intrahepatic biliary tract Neoplasms
C4529962 BXGD023178 Fatty Liver Disease
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein