Showing entry for Tau-tubulin kinase 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT015853
Protein NameTau-tubulin kinase 1
Uniport IdQ5TCY1
GeneTTBK1
Gene Id84630
DomainPkinase
Pfam PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007611 learning or memory
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0032091 negative regulation of protein binding
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0018107 peptidyl-threonine phosphorylation
Biological Process GO:0018108 peptidyl-tyrosine phosphorylation
Biological Process GO:0061890 positive regulation of astrocyte activation
Biological Process GO:1904031 positive regulation of cyclin-dependent protein kinase activity
Biological Process GO:2001056 positive regulation of cysteine-type endopeptidase activity
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:1903980 positive regulation of microglial cell activation
Biological Process GO:0032273 positive regulation of protein polymerization
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0021762 substantia nigra development
molecular function GO:0005524 ATP binding
molecular function GO:0004674 protein serine/threonine kinase activity
molecular function GO:0004713 protein tyrosine kinase activity
molecular function GO:0048156 tau protein binding
molecular function GO:0050321 tau-protein kinase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005875 microtubule associated complex
cellular component GO:0043025 neuronal cell body
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0048471 perinuclear region of cytoplasm
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0014772 BXGD000948 Red Blood Cell Count measurement
C0021704 BXGD001510 Intelligence Behavior and Behavior Mechanisms
C0036346 BXGD002602 Schizophrenia, Childhood Mental Disorders
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0278883 BXGD006614 Metastatic melanoma Neoplasms
C0345958 BXGD007751 Large cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0494463 BXGD009029 Alzheimer Disease, Late Onset Nervous System Diseases; Mental Disorders
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0542476 BXGD009276 Forgetful Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0751072 BXGD010312 Frontotemporal Lobar Degeneration Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0949664 BXGD011583 Tauopathies Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000441 Dimethyl sulfoxide 78.13
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein