Showing entry for Frontotemporal Lobar Degeneration


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD010312
Disease NameFrontotemporal Lobar Degeneration
Disease CUI IdC0751072
MeSH Codes C18   C10   F03  
Disease Class NameNutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
Semantic TypeMental or Behavioral Dysfunction
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id   
Disease Ontology Class Name
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
F7VJQ1 BXGT003310 Alternative prion protein 5621 reviewed
O00311 BXGT003908 Cell division cycle 7-related protein kinase 8317 reviewed Kinase
O00451 BXGT003923 GDNF family receptor alpha-2 2675 reviewed
O15118 BXGT004127 NPC intracellular cholesterol transporter 1 4864 reviewed Transporter
O15409 BXGT004166 Forkhead box protein P2 93986 reviewed
O43612 BXGT004605 Orexin 3060 reviewed
O94811 BXGT005336 Tubulin polymerization-promoting protein 11076 reviewed Cellular structure
O94925 BXGT005342 Glutaminase kidney isoform, mitochondrial 2744 reviewed Enzyme
P00441 BXGT005540 Superoxide dismutase [Cu-Zn] 6647 reviewed Enzyme
P00450 BXGT005544 Ceruloplasmin 1356 reviewed Enzyme
P01034 BXGT005721 Cystatin-C 1471 reviewed
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01275 BXGT005747 Glucagon 2641 reviewed
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P02649 BXGT005909 Apolipoprotein E 348 reviewed
P04040 BXGT006132 Catalase 847 reviewed Enzyme
P04156 BXGT006156 Major prion protein 5621 reviewed
P04179 BXGT006163 Superoxide dismutase [Mn], mitochondrial 6648 reviewed Enzyme
P05067 BXGT006306 Amyloid-beta precursor protein 351 reviewed Enzyme modulator
P05121 BXGT006320 Plasminogen activator inhibitor 1 5054 reviewed Enzyme modulator
P05231 BXGT006345 Interleukin-6 3569 reviewed
P06748 BXGT006497 Nucleophosmin 4869 reviewed Chaperone
P07339 BXGT006604 Cathepsin D 1509 reviewed Enzyme
P07602 BXGT006646 Prosaposin 5660 reviewed
P07737 BXGT006663 Profilin-1 5216 reviewed
P08138 BXGT006729 Tumor necrosis factor receptor superfamily member 16 4804 reviewed Receptor
P08397 BXGT006768 Porphobilinogen deaminase 3145 reviewed Enzyme
P09651 BXGT006913 Heterogeneous nuclear ribonucleoprotein A1 3178 reviewed
P10636 BXGT007596 Microtubule-associated protein tau 4137 reviewed
P13500 BXGT007916 C-C motif chemokine 2 6347 reviewed Signaling
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P17516 BXGT008313 Aldo-keto reductase family 1 member C4 1109 reviewed Enzyme
P17861 BXGT008348 X-box-binding protein 1 7494 reviewed
P18850 BXGT008433 Cyclic AMP-dependent transcription factor ATF-6 alpha 22926 reviewed
P19440 BXGT008481 Glutathione hydrolase 1 proenzyme 2678 reviewed Enzyme
P22626 BXGT008787 Heterogeneous nuclear ribonucleoproteins A2/B1 3181 reviewed
P23246 BXGT008840 Splicing factor, proline- and glutamine-rich 6421 reviewed Nucleic acid binding
P23560 BXGT008883 Brain-derived neurotrophic factor 627 reviewed Signaling
P29474 BXGT009352 Nitric oxide synthase, endothelial 4846 reviewed
P29475 BXGT009353 Nitric oxide synthase, brain 4842 reviewed
P30536 BXGT009435 Translocator protein 706 reviewed
P31350 BXGT009526 Ribonucleoside-diphosphate reductase subunit M2 6241 reviewed Enzyme
P31645 BXGT009558 Sodium-dependent serotonin transporter 6532 reviewed Transporter
P35858 BXGT009876 Insulin-like growth factor-binding protein complex acid labile subunit 3483 reviewed Receptor
P36222 BXGT009914 Chitinase-3-like protein 1 1116 reviewed
P37840 BXGT010015 Alpha-synuclein 6622 reviewed Transporter
P42858 BXGT010341 Huntingtin 3064 reviewed
P43003 BXGT010347 Excitatory amino acid transporter 1 6507 reviewed Transporter
P45985 BXGT010496 Dual specificity mitogen-activated protein kinase kinase 4 6416 reviewed Kinase
P47736 BXGT010579 Rap1 GTPase-activating protein 1 5909 reviewed Enzyme modulator
P49711 BXGT010728 Transcriptional repressor CTCF 10664 reviewed Transcription factor
P49768 BXGT010740 Presenilin-1 5663 reviewed Enzyme
P49810 BXGT010747 Presenilin-2 5664 reviewed Enzyme
P52758 BXGT010951 2-iminobutanoate/2-iminopropanoate deaminase 10247 reviewed
P55072 BXGT011103 Transitional endoplasmic reticulum ATPase 7415 reviewed
P55774 BXGT011124 C-C motif chemokine 18 6362 reviewed Signaling
P60880 BXGT011335 Synaptosomal-associated protein 25 6616 reviewed Transporter
P60953 BXGT011342 Cell division control protein 42 homolog 998 reviewed Enzyme modulator
P62826 BXGT011463 GTP-binding nuclear protein Ran 5901 reviewed Enzyme modulator
P78330 BXGT011833 Phosphoserine phosphatase 5723 reviewed Enzyme
P80075 BXGT011876 C-C motif chemokine 8 6355 reviewed Signaling
P80188 BXGT011882 Neutrophil gelatinase-associated lipocalin 3934 reviewed Enzyme
Q00613 BXGT012540 Heat shock factor protein 1 3297 reviewed Transcription factor
Q01959 BXGT012624 Sodium-dependent dopamine transporter 6531 reviewed Transporter
Q13148 BXGT013318 TAR DNA-binding protein 43 23435 reviewed
Q13231 BXGT013329 Chitotriosidase-1 1118 reviewed
Q13283 BXGT013334 Ras GTPase-activating protein-binding protein 1 10146 reviewed Nucleic acid binding
Q13501 BXGT013365 Sequestosome-1 8878 reviewed
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 5300 reviewed
Q14116 BXGT013442 Interleukin-18 3606 reviewed
Q14145 BXGT013448 Kelch-like ECH-associated protein 1 9817 reviewed
Q14203 BXGT013455 Dynactin subunit 1 1639 reviewed Chaperone
Q15078 BXGT013534 Cyclin-dependent kinase 5 activator 1 8851 reviewed Enzyme modulator
Q15118 BXGT013540 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial 5163 reviewed Kinase
Q15366 BXGT013559 Poly(rC)-binding protein 2 5094 reviewed Enzyme
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 4780 reviewed Enzyme
Q30201 BXGT014297 Hereditary hemochromatosis protein 3077 reviewed
Q5S007 BXGT015650 Leucine-rich repeat serine/threonine-protein kinase 2 120892 reviewed Kinase
Q5TCY1 BXGT015853 Tau-tubulin kinase 1 84630 reviewed Kinase
Q99523 BXGT019929 Sortilin 6272 reviewed Transporter
Q99623 BXGT019941 Prohibitin-2 11331 reviewed
Q99700 BXGT019949 Ataxin-2 6311 reviewed Nucleic acid binding
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 10280 reviewed
Q99933 BXGT019976 BAG family molecular chaperone regulator 1 573 reviewed
Q9NZ09 BXGT021267 Ubiquitin-associated protein 1 51271 reviewed
Q9UHD2 BXGT021697 Serine/threonine-protein kinase TBK1 29110 reviewed Kinase
Q9Y4P1 BXGT022283 Cysteine protease ATG4B 23192 reviewed Enzyme
Q9Y6K1 BXGT022331 DNA (cytosine-5)-methyltransferase 3A 1788 reviewed
P35232 BXGT022663 Prohibitin 5245 reviewed
Q53GS7 BXGT023762 Nucleoporin GLE1 2733 reviewed Transporter
Q13432 BXGT024144 Protein unc-119 homolog A 9094 reviewed Receptor
P16104 BXGT024571 Histone H2AX 3014 reviewed Nucleic acid binding
Q9NVA2 BXGT025757 Septin-11 55752 reviewed Enzyme modulator
P61916 BXGT025881 NPC intracellular cholesterol transporter 2 10577 reviewed
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease